Complement component C9
Intramolecular
Cysteine 380 and cysteine 405
Cysteine 380 and cysteine 119
Cysteine 513 and cysteine 528
Cysteine 530 and cysteine 539
Cysteine 57 and cysteine 94
Cysteine 119 and cysteine 134
Cysteine 101 and cysteine 112
Cysteine 510 and cysteine 526
Cysteine 107 and cysteine 125
Cysteine 43 and cysteine 78
More...Cysteine 54 and cysteine 88
Cysteine 142 and cysteine 181
Cysteine 513 and cysteine 539
Cysteine 528 and cysteine 539
Cysteine 513 and cysteine 530
Cysteine 528 and cysteine 530
Cysteine 101 and cysteine 107
Cysteine 510 and cysteine 513
Cysteine 78 and cysteine 510
Cysteine 513 and cysteine 526
Cysteine 510 and cysteine 528
Cysteine 43 and cysteine 510
Cysteine 107 and cysteine 112
Cysteine 101 and cysteine 125
Cysteine 41 and cysteine 529
Cysteine 526 and cysteine 528
Cysteine 112 and cysteine 125
Cysteine 78 and cysteine 526
6h04 G 359 G 384
A redox-regulated disulphide may form within Complement component C9 at these cysteines.
Relevent regions
MACPF
begin
117
end
488
score
94.98411534701859
distance
2.8131235
seq distance
0
chain
G
MACPF
begin
117
end
488
score
94.98411534701859
distance
2.8131235
seq distance
0
chain
G
MACPF
begin
117
end
488
score
94.98411534701859
distance
4.77332
seq distance
False
chain
P
MACPF
begin
117
end
488
score
94.98411534701859
distance
4.77332
seq distance
False
chain
P
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
11.91375
seq distance
False
chain
P
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
11.91375
seq distance
False
chain
P
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
16.295012
seq distance
101
chain
G
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
16.295012
seq distance
101
chain
G
MACPF
begin
117
end
488
score
94.98411534701859
distance
23.214262
seq distance
False
chain
H
MACPF
begin
117
end
488
score
94.98411534701859
distance
23.214262
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
23.264893
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
23.264893
seq distance
False
chain
P
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
28.300947
seq distance
False
chain
H
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
28.300947
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
29.576904
seq distance
97
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
29.576904
seq distance
97
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
31.563448
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
31.563448
seq distance
False
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
226
score
50.0
distance
35.440266
seq distance
False
chain
F
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
226
score
50.0
distance
35.440266
seq distance
False
chain
F
MACPF
begin
117
end
488
score
94.98411534701859
distance
42.67309
seq distance
False
chain
I
MACPF
begin
117
end
488
score
94.98411534701859
distance
42.67309
seq distance
False
chain
I
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
47.472263
seq distance
False
chain
I
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
47.472263
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
47.502476
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
47.502476
seq distance
False
chain
I
EGF-like
begin
489
end
519
score
100.0
distance
56.185562
seq distance
False
chain
P
EGF-like
begin
489
end
519
score
100.0
distance
56.185562
seq distance
False
chain
P
EGF-like
begin
489
end
519
score
100.0
distance
59.871307
seq distance
False
chain
H
EGF-like
begin
489
end
519
score
100.0
distance
59.871307
seq distance
False
chain
H
EGF-like
begin
489
end
519
score
100.0
distance
60.36212
seq distance
105
chain
G
EGF-like
begin
489
end
519
score
100.0
distance
60.36212
seq distance
105
chain
G
MACPF
begin
117
end
488
score
94.98411534701859
distance
60.47623
seq distance
False
chain
J
MACPF
begin
117
end
488
score
94.98411534701859
distance
60.47623
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
64.63288
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
64.63288
seq distance
False
chain
J
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
65.5029
seq distance
False
chain
J
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
65.5029
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
69.08824
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
69.08824
seq distance
False
chain
P
EGF-like
begin
489
end
519
score
100.0
distance
70.15196
seq distance
False
chain
I
EGF-like
begin
489
end
519
score
100.0
distance
70.15196
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
70.60258
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
70.60258
seq distance
False
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
71.7604
seq distance
False
chain
P
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
71.7604
seq distance
False
chain
P
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
72.36267
seq distance
False
chain
P
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
72.36267
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
73.17758
seq distance
21
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
73.17758
seq distance
21
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
73.298546
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
73.298546
seq distance
False
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
73.517044
seq distance
285
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
73.517044
seq distance
285
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
76.6345
seq distance
22
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
76.6345
seq distance
22
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
77.156166
seq distance
False
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
77.156166
seq distance
False
chain
H
MACPF
begin
117
end
488
score
94.98411534701859
distance
77.19868
seq distance
False
chain
K
MACPF
begin
117
end
488
score
94.98411534701859
distance
77.19868
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
77.572
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
77.572
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
79.47044
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
79.47044
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
81.574936
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
81.574936
seq distance
False
chain
K
MACPF
begin
117
end
488
score
94.98411534701859
distance
81.842224
seq distance
False
chain
X
MACPF
begin
117
end
488
score
94.98411534701859
distance
81.842224
seq distance
False
chain
X
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
83.35868
seq distance
False
chain
K
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
83.35868
seq distance
False
chain
K
EGF-like
begin
489
end
519
score
100.0
distance
83.76111
seq distance
False
chain
J
EGF-like
begin
489
end
519
score
100.0
distance
83.76111
seq distance
False
chain
J
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
391
score
68.18181818181817
distance
84.25493
seq distance
False
chain
F
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
391
score
68.18181818181817
distance
84.25493
seq distance
False
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
88.09351
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
88.09351
seq distance
False
chain
J
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
88.171715
seq distance
False
chain
I
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
88.171715
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
89.1253
seq distance
False
chain
P
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
89.1253
seq distance
False
chain
P
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
89.20082
seq distance
False
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
89.20082
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
89.2822
seq distance
False
chain
J
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
89.2822
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
370
score
68.18181818181817
distance
89.83331
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
370
score
68.18181818181817
distance
89.83331
seq distance
False
chain
C
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
92.99095
seq distance
False
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
92.99095
seq distance
False
chain
H
MACPF
begin
117
end
488
score
94.98411534701859
distance
93.26229
seq distance
False
chain
L
MACPF
begin
117
end
488
score
94.98411534701859
distance
93.26229
seq distance
False
chain
L
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
94.11111
seq distance
213
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
94.11111
seq distance
213
chain
G
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
94.15282
seq distance
False
chain
X
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
94.15282
seq distance
False
chain
X
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
94.18355
seq distance
False
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
94.18355
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
94.64139
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
94.64139
seq distance
False
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
96.855225
seq distance
False
chain
P
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
96.855225
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
97.486275
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
97.486275
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
98.70337
seq distance
False
chain
X
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
98.70337
seq distance
False
chain
X
EGF-like
begin
489
end
519
score
100.0
distance
98.75762
seq distance
False
chain
K
EGF-like
begin
489
end
519
score
100.0
distance
98.75762
seq distance
False
chain
K
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
99.423935
seq distance
False
chain
L
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
99.423935
seq distance
False
chain
L
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
99.802986
seq distance
False
chain
J
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
99.802986
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
100.55129
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
100.55129
seq distance
False
chain
K
MACPF
begin
117
end
488
score
94.98411534701859
distance
100.57647
seq distance
False
chain
W
MACPF
begin
117
end
488
score
94.98411534701859
distance
100.57647
seq distance
False
chain
W
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
101.19656
seq distance
False
chain
K
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
101.19656
seq distance
False
chain
K
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
102.15721
seq distance
False
chain
J
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
102.15721
seq distance
False
chain
J
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
104.078094
seq distance
False
chain
J
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
104.078094
seq distance
False
chain
J
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
104.744316
seq distance
177
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
104.744316
seq distance
177
chain
G
MACPF
begin
117
end
488
score
94.98411534701859
distance
107.791626
seq distance
False
chain
M
MACPF
begin
117
end
488
score
94.98411534701859
distance
107.791626
seq distance
False
chain
M
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
108.937294
seq distance
False
chain
K
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
108.937294
seq distance
False
chain
K
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
110.13647
seq distance
False
chain
W
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
110.13647
seq distance
False
chain
W
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
111.612564
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
111.612564
seq distance
False
chain
M
LDL-receptor class A
begin
78
end
115
score
100.0
distance
112.770584
seq distance
False
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
112.770584
seq distance
False
chain
H
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
113.39885
seq distance
False
chain
M
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
113.39885
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
113.45433
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
113.45433
seq distance
False
chain
L
EGF-like
begin
489
end
519
score
100.0
distance
113.57882
seq distance
False
chain
L
EGF-like
begin
489
end
519
score
100.0
distance
113.57882
seq distance
False
chain
L
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
113.70192
seq distance
False
chain
L
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
113.70192
seq distance
False
chain
L
LDL-receptor class A
begin
78
end
115
score
100.0
distance
113.87408
seq distance
False
chain
P
LDL-receptor class A
begin
78
end
115
score
100.0
distance
113.87408
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
113.89431
seq distance
False
chain
W
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
113.89431
seq distance
False
chain
W
EGF-like
begin
489
end
519
score
100.0
distance
114.06871
seq distance
False
chain
X
EGF-like
begin
489
end
519
score
100.0
distance
114.06871
seq distance
False
chain
X
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
442
score
50.0
distance
114.33741
seq distance
False
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
442
score
50.0
distance
114.33741
seq distance
False
chain
B
MACPF
begin
117
end
488
score
94.98411534701859
distance
116.02943
seq distance
False
chain
V
MACPF
begin
117
end
488
score
94.98411534701859
distance
116.02943
seq distance
False
chain
V
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
116.052475
seq distance
False
chain
K
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
116.052475
seq distance
False
chain
K
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
116.16707
seq distance
False
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
116.16707
seq distance
False
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
116.17355
seq distance
False
chain
I
LDL-receptor class A
begin
78
end
115
score
100.0
distance
116.17355
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
116.20358
seq distance
False
chain
P
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
116.20358
seq distance
False
chain
P
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
117.60985
seq distance
False
chain
K
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
117.60985
seq distance
False
chain
K
LDL-receptor class A
begin
78
end
115
score
100.0
distance
118.86784
seq distance
244
chain
G
LDL-receptor class A
begin
78
end
115
score
100.0
distance
118.86784
seq distance
244
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
119.60015
seq distance
False
chain
X
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
119.60015
seq distance
False
chain
X
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
120.0501
seq distance
False
chain
L
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
120.0501
seq distance
False
chain
L
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
120.07224
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
120.07224
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
120.16722
seq distance
253
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
120.16722
seq distance
253
chain
G
MACPF
begin
117
end
488
score
94.98411534701859
distance
120.37937
seq distance
False
chain
N
MACPF
begin
117
end
488
score
94.98411534701859
distance
120.37937
seq distance
False
chain
N
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
121.85454
seq distance
False
chain
X
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
121.85454
seq distance
False
chain
X
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
121.883575
seq distance
False
chain
X
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
121.883575
seq distance
False
chain
X
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
122.13985
seq distance
False
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
122.13985
seq distance
False
chain
H
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
123.16656
seq distance
False
chain
V
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
123.16656
seq distance
False
chain
V
LDL-receptor class A
begin
78
end
115
score
100.0
distance
123.2165
seq distance
False
chain
J
LDL-receptor class A
begin
78
end
115
score
100.0
distance
123.2165
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
123.628746
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
123.628746
seq distance
False
chain
N
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
123.886406
seq distance
False
chain
P
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
123.886406
seq distance
False
chain
P
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
124.442924
seq distance
False
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
124.442924
seq distance
False
chain
I
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
124.79389
seq distance
False
chain
N
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
124.79389
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
125.62824
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
125.62824
seq distance
False
chain
M
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
125.64648
seq distance
False
chain
M
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
125.64648
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
126.09286
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
126.09286
seq distance
False
chain
V
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
93
score
77.27272727272727
distance
126.55068
seq distance
False
chain
F
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
93
score
77.27272727272727
distance
126.55068
seq distance
False
chain
F
EGF-like
begin
489
end
519
score
100.0
distance
127.14916
seq distance
False
chain
M
EGF-like
begin
489
end
519
score
100.0
distance
127.14916
seq distance
False
chain
M
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
127.2057
seq distance
False
chain
J
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
127.2057
seq distance
False
chain
J
MACPF
begin
117
end
488
score
94.98411534701859
distance
128.32687
seq distance
False
chain
U
MACPF
begin
117
end
488
score
94.98411534701859
distance
128.32687
seq distance
False
chain
U
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
128.93645
seq distance
False
chain
L
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
128.93645
seq distance
False
chain
L
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
129.10315
seq distance
261
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
129.10315
seq distance
261
chain
G
EGF-like
begin
489
end
519
score
100.0
distance
129.20587
seq distance
False
chain
W
EGF-like
begin
489
end
519
score
100.0
distance
129.20587
seq distance
False
chain
W
MACPF
begin
117
end
488
score
94.98411534701859
distance
130.09718
seq distance
False
chain
O
MACPF
begin
117
end
488
score
94.98411534701859
distance
130.09718
seq distance
False
chain
O
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
130.30396
seq distance
False
chain
J
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
130.30396
seq distance
False
chain
J
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
94
score
81.81818181818183
distance
130.99544
seq distance
False
chain
C
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
94
score
81.81818181818183
distance
130.99544
seq distance
False
chain
C
LDL-receptor class A
begin
83
end
96
score
70.12987012987013
distance
130.99544
seq distance
False
chain
C
LDL-receptor class A
begin
83
end
96
score
70.12987012987013
distance
130.99544
seq distance
False
chain
C
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
131.97656
seq distance
False
chain
M
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
131.97656
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
132.17548
seq distance
False
chain
W
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
132.17548
seq distance
False
chain
W
LDL-receptor class A
begin
78
end
115
score
100.0
distance
132.50926
seq distance
False
chain
K
LDL-receptor class A
begin
78
end
115
score
100.0
distance
132.50926
seq distance
False
chain
K
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
132.91147
seq distance
False
chain
L
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
132.91147
seq distance
False
chain
L
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
133.20665
seq distance
False
chain
U
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
133.20665
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
133.25253
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
133.25253
seq distance
False
chain
O
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
133.9263
seq distance
False
chain
W
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
133.9263
seq distance
False
chain
W
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
134.41371
seq distance
False
chain
O
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
134.41371
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
135.41245
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
135.41245
seq distance
False
chain
U
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
85
score
72.72727272727273
distance
135.70116
seq distance
False
chain
F
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
85
score
72.72727272727273
distance
135.70116
seq distance
False
chain
F
MACPF
begin
117
end
488
score
94.98411534701859
distance
136.12956
seq distance
False
chain
Q
MACPF
begin
117
end
488
score
94.98411534701859
distance
136.12956
seq distance
False
chain
Q
TSP type-1
begin
507
end
507
score
88.63636363636364
distance
136.27129
seq distance
False
chain
D
TSP type-1
begin
507
end
507
score
88.63636363636364
distance
136.27129
seq distance
False
chain
D
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
136.37529
seq distance
False
chain
N
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
136.37529
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
136.4959
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
136.4959
seq distance
False
chain
N
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
136.65518
seq distance
False
chain
K
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
136.65518
seq distance
False
chain
K
MACPF
begin
117
end
488
score
94.98411534701859
distance
137.89255
seq distance
False
chain
T
MACPF
begin
117
end
488
score
94.98411534701859
distance
137.89255
seq distance
False
chain
T
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
138.1717
seq distance
False
chain
W
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
138.1717
seq distance
False
chain
W
EGF-like
begin
489
end
519
score
100.0
distance
138.90176
seq distance
False
chain
N
EGF-like
begin
489
end
519
score
100.0
distance
138.90176
seq distance
False
chain
N
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
138.92654
seq distance
False
chain
K
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
138.92654
seq distance
False
chain
K
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
139.64462
seq distance
False
chain
X
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
139.64462
seq distance
False
chain
X
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
139.93153
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
139.93153
seq distance
False
chain
Q
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
140.10979
seq distance
False
chain
T
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
140.10979
seq distance
False
chain
T
MACPF
begin
117
end
488
score
94.98411534701859
distance
140.13617
seq distance
False
chain
R
MACPF
begin
117
end
488
score
94.98411534701859
distance
140.13617
seq distance
False
chain
R
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
140.35101
seq distance
False
chain
Q
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
140.35101
seq distance
False
chain
Q
EGF-like
begin
489
end
519
score
100.0
distance
141.33041
seq distance
False
chain
V
EGF-like
begin
489
end
519
score
100.0
distance
141.33041
seq distance
False
chain
V
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
141.51608
seq distance
False
chain
M
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
141.51608
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
141.81186
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
141.81186
seq distance
False
chain
T
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
86
score
72.72727272727273
distance
141.90004
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
86
score
72.72727272727273
distance
141.90004
seq distance
False
chain
C
MACPF
begin
117
end
488
score
94.98411534701859
distance
141.96696
seq distance
False
chain
S
MACPF
begin
117
end
488
score
94.98411534701859
distance
141.96696
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
142.75539
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
142.75539
seq distance
False
chain
V
LDL-receptor class A
begin
78
end
115
score
100.0
distance
142.99312
seq distance
False
chain
L
LDL-receptor class A
begin
78
end
115
score
100.0
distance
142.99312
seq distance
False
chain
L
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
143.47743
seq distance
False
chain
N
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
143.47743
seq distance
False
chain
N
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
143.57727
seq distance
False
chain
R
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
143.57727
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
143.63138
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
143.63138
seq distance
False
chain
R
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
143.6352
seq distance
False
chain
S
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
143.6352
seq distance
False
chain
S
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
143.98094
seq distance
False
chain
V
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
143.98094
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
144.45372
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
144.45372
seq distance
False
chain
S
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
145.34247
seq distance
False
chain
O
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
145.34247
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
145.48564
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
145.48564
seq distance
False
chain
O
LDL-receptor class A
begin
151
end
170
score
51.590909090909086
distance
146.34843
seq distance
False
chain
B
LDL-receptor class A
begin
151
end
170
score
51.590909090909086
distance
146.34843
seq distance
False
chain
B
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
146.91505
seq distance
False
chain
M
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
146.91505
seq distance
False
chain
M
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
166
score
77.27272727272727
distance
147.1174
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
166
score
77.27272727272727
distance
147.1174
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
147.20267
seq distance
False
chain
L
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
147.20267
seq distance
False
chain
L
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
103
score
59.09090909090909
distance
147.31999
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
103
score
59.09090909090909
distance
147.31999
seq distance
False
chain
D
EGF-like
begin
489
end
519
score
100.0
distance
148.43411
seq distance
False
chain
O
EGF-like
begin
489
end
519
score
100.0
distance
148.43411
seq distance
False
chain
O
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
149.10666
seq distance
False
chain
L
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
149.10666
seq distance
False
chain
L
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
149.17981
seq distance
False
chain
X
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
149.17981
seq distance
False
chain
X
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
150.38736
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
150.38736
seq distance
False
chain
U
EGF-like
begin
489
end
519
score
100.0
distance
150.6608
seq distance
False
chain
U
EGF-like
begin
489
end
519
score
100.0
distance
150.6608
seq distance
False
chain
U
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
151.20578
seq distance
False
chain
U
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
151.20578
seq distance
False
chain
U
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
151.90456
seq distance
False
chain
Q
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
151.90456
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
151.98923
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
151.98923
seq distance
False
chain
Q
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
152.0599
seq distance
False
chain
V
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
152.0599
seq distance
False
chain
V
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
152.3189
seq distance
False
chain
W
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
152.3189
seq distance
False
chain
W
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
152.933
seq distance
False
chain
N
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
152.933
seq distance
False
chain
N
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
153.92488
seq distance
False
chain
O
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
153.92488
seq distance
False
chain
O
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
158
score
63.63636363636363
distance
153.96489
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
158
score
63.63636363636363
distance
153.96489
seq distance
False
chain
B
LDL-receptor class A
begin
78
end
115
score
100.0
distance
153.99205
seq distance
False
chain
M
LDL-receptor class A
begin
78
end
115
score
100.0
distance
153.99205
seq distance
False
chain
M
EGF-like
begin
489
end
519
score
100.0
distance
155.07268
seq distance
False
chain
Q
EGF-like
begin
489
end
519
score
100.0
distance
155.07268
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
155.22488
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
155.22488
seq distance
False
chain
T
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
155.52304
seq distance
False
chain
X
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
155.52304
seq distance
False
chain
X
LDL-receptor class A
begin
78
end
115
score
100.0
distance
155.52304
seq distance
False
chain
X
LDL-receptor class A
begin
78
end
115
score
100.0
distance
155.52304
seq distance
False
chain
X
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
155.71164
seq distance
False
chain
T
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
155.71164
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
155.89055
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
155.89055
seq distance
False
chain
R
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
155.95674
seq distance
False
chain
R
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
155.95674
seq distance
False
chain
R
EGF-like
begin
489
end
519
score
100.0
distance
156.73228
seq distance
False
chain
T
EGF-like
begin
489
end
519
score
100.0
distance
156.73228
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
157.12009
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
157.12009
seq distance
False
chain
S
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
157.3155
seq distance
False
chain
S
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
157.3155
seq distance
False
chain
S
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
157.77858
seq distance
False
chain
M
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
157.77858
seq distance
False
chain
M
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
158.74066
seq distance
False
chain
N
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
158.74066
seq distance
False
chain
N
EGF-like
begin
489
end
519
score
100.0
distance
158.74515
seq distance
False
chain
R
EGF-like
begin
489
end
519
score
100.0
distance
158.74515
seq distance
False
chain
R
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
159.33636
seq distance
False
chain
W
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
159.33636
seq distance
False
chain
W
EGF-like
begin
489
end
519
score
100.0
distance
159.39204
seq distance
False
chain
S
EGF-like
begin
489
end
519
score
100.0
distance
159.39204
seq distance
False
chain
S
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
159.77374
seq distance
False
chain
M
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
159.77374
seq distance
False
chain
M
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
162.51279
seq distance
False
chain
Q
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
162.51279
seq distance
False
chain
Q
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
162.63577
seq distance
False
chain
O
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
162.63577
seq distance
False
chain
O
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
162.73013
seq distance
False
chain
V
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
162.73013
seq distance
False
chain
V
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
163.12225
seq distance
False
chain
U
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
163.12225
seq distance
False
chain
U
LDL-receptor class A
begin
78
end
115
score
100.0
distance
164.27248
seq distance
False
chain
N
LDL-receptor class A
begin
78
end
115
score
100.0
distance
164.27248
seq distance
False
chain
N
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
166.82552
seq distance
False
chain
V
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
166.82552
seq distance
False
chain
V
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
166.96729
seq distance
False
chain
X
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
166.96729
seq distance
False
chain
X
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
167.10738
seq distance
False
chain
W
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
167.10738
seq distance
False
chain
W
LDL-receptor class A
begin
78
end
115
score
100.0
distance
167.10738
seq distance
False
chain
W
LDL-receptor class A
begin
78
end
115
score
100.0
distance
167.10738
seq distance
False
chain
W
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
167.4921
seq distance
False
chain
N
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
167.4921
seq distance
False
chain
N
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
168.01042
seq distance
False
chain
O
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
168.01042
seq distance
False
chain
O
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
168.79724
seq distance
False
chain
R
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
168.79724
seq distance
False
chain
R
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
169.8505
seq distance
False
chain
Q
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
169.8505
seq distance
False
chain
Q
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
169.97816
seq distance
False
chain
N
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
169.97816
seq distance
False
chain
N
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
170.142
seq distance
False
chain
U
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
170.142
seq distance
False
chain
U
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
171.19556
seq distance
False
chain
T
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
171.19556
seq distance
False
chain
T
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
171.718
seq distance
False
chain
U
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
171.718
seq distance
False
chain
U
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
172.55684
seq distance
False
chain
S
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
172.55684
seq distance
False
chain
S
LDL-receptor class A
begin
78
end
115
score
100.0
distance
173.27762
seq distance
False
chain
O
LDL-receptor class A
begin
78
end
115
score
100.0
distance
173.27762
seq distance
False
chain
O
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
173.62297
seq distance
False
chain
T
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
173.62297
seq distance
False
chain
T
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
173.92203
seq distance
False
chain
Q
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
173.92203
seq distance
False
chain
Q
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
174.38983
seq distance
False
chain
R
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
174.38983
seq distance
False
chain
R
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
174.62816
seq distance
False
chain
T
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
174.62816
seq distance
False
chain
T
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
175.53026
seq distance
False
chain
S
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
175.53026
seq distance
False
chain
S
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
175.65721
seq distance
False
chain
V
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
175.65721
seq distance
False
chain
V
LDL-receptor class A
begin
78
end
115
score
100.0
distance
175.65721
seq distance
False
chain
V
LDL-receptor class A
begin
78
end
115
score
100.0
distance
175.65721
seq distance
False
chain
V
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
175.8908
seq distance
False
chain
O
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
175.8908
seq distance
False
chain
O
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
176.01793
seq distance
False
chain
S
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
176.01793
seq distance
False
chain
S
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
176.38802
seq distance
False
chain
R
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
176.38802
seq distance
False
chain
R
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
176.95781
seq distance
False
chain
W
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
176.95781
seq distance
False
chain
W
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
1290
score
50.0
distance
179.02174
seq distance
False
chain
A
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
1290
score
50.0
distance
179.02174
seq distance
False
chain
A
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
179.08018
seq distance
False
chain
O
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
179.08018
seq distance
False
chain
O
LDL-receptor class A
begin
78
end
115
score
100.0
distance
180.4514
seq distance
False
chain
Q
LDL-receptor class A
begin
78
end
115
score
100.0
distance
180.4514
seq distance
False
chain
Q
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
182.11838
seq distance
False
chain
Q
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
182.11838
seq distance
False
chain
Q
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
182.13805
seq distance
False
chain
U
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
182.13805
seq distance
False
chain
U
LDL-receptor class A
begin
78
end
115
score
100.0
distance
182.13805
seq distance
False
chain
U
LDL-receptor class A
begin
78
end
115
score
100.0
distance
182.13805
seq distance
False
chain
U
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
184.9969
seq distance
False
chain
V
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
184.9969
seq distance
False
chain
V
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
1067
score
54.54545454545454
distance
185.3762
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
1067
score
54.54545454545454
distance
185.3762
seq distance
False
chain
A
LDL-receptor class A
begin
78
end
115
score
100.0
distance
185.48354
seq distance
False
chain
R
LDL-receptor class A
begin
78
end
115
score
100.0
distance
185.48354
seq distance
False
chain
R
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
186.03183
seq distance
False
chain
R
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
186.03183
seq distance
False
chain
R
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
186.0999
seq distance
False
chain
T
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
186.0999
seq distance
False
chain
T
LDL-receptor class A
begin
78
end
115
score
100.0
distance
186.0999
seq distance
False
chain
T
LDL-receptor class A
begin
78
end
115
score
100.0
distance
186.0999
seq distance
False
chain
T
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
186.25832
seq distance
False
chain
Q
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
186.25832
seq distance
False
chain
Q
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
187.37134
seq distance
False
chain
S
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
187.37134
seq distance
False
chain
S
LDL-receptor class A
begin
78
end
115
score
100.0
distance
187.37134
seq distance
False
chain
S
LDL-receptor class A
begin
78
end
115
score
100.0
distance
187.37134
seq distance
False
chain
S
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
190.673
seq distance
False
chain
U
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
190.673
seq distance
False
chain
U
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
191.25304
seq distance
False
chain
R
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
191.25304
seq distance
False
chain
R
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
193.56903
seq distance
False
chain
T
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
193.56903
seq distance
False
chain
T
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
193.71658
seq distance
False
chain
S
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
193.71658
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
671
score
54.54545454545454
distance
223.66232
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
671
score
54.54545454545454
distance
223.66232
seq distance
False
chain
D
Details
Redox score
77.7
PDB code
6h04
Structure name
closed conformation of the membrane attack complex
Structure deposition date
2018-07-06
Thiol separation (Å)
3.61
Half-sphere exposure sum
59
Minimum pKa
9.72
% buried
37
Peptide accession
P02748
Residue number A
380 (Residue 359 in this structure)
Residue number B
405 (Residue 384 in this structure)
Peptide name
Complement component C9
7nyc I 359 I 384
A redox-regulated disulphide may form within Complement component C9 at these cysteines.
Relevent regions
MACPF
begin
186
end
481
score
65.83230958230959
distance
2.846801
seq distance
0
chain
I
MACPF
begin
186
end
481
score
65.83230958230959
distance
2.846801
seq distance
0
chain
I
MACPF
begin
133
end
488
score
72.36338100102144
distance
13.588332
seq distance
False
chain
H
MACPF
begin
133
end
488
score
72.36338100102144
distance
13.588332
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
18.470924
seq distance
21
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
18.470924
seq distance
21
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
19.546738
seq distance
22
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
19.546738
seq distance
22
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
21.029707
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
21.029707
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
22.049286
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
22.049286
seq distance
False
chain
H
EGF-like
begin
489
end
519
score
98.24046920821115
distance
26.588913
seq distance
False
chain
H
EGF-like
begin
489
end
519
score
98.24046920821115
distance
26.588913
seq distance
False
chain
H
MACPF
begin
133
end
488
score
69.38840653728295
distance
27.77148
seq distance
False
chain
G
MACPF
begin
133
end
488
score
69.38840653728295
distance
27.77148
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
33.205112
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
33.205112
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
34.486565
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
34.486565
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
98.24046920821115
distance
35.583366
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
98.24046920821115
distance
35.583366
seq distance
False
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
38.79067
seq distance
False
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
38.79067
seq distance
False
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
40.416378
seq distance
177
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
40.416378
seq distance
177
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
42.38475
seq distance
False
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
42.38475
seq distance
False
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
42.63343
seq distance
213
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
42.63343
seq distance
213
chain
I
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
44.349384
seq distance
False
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
44.349384
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
48.91984
seq distance
False
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
48.91984
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
391
score
68.18181818181817
distance
49.155933
seq distance
False
chain
E
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
391
score
68.18181818181817
distance
49.155933
seq distance
False
chain
E
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
53.004044
seq distance
False
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
53.004044
seq distance
False
chain
G
LDL-receptor class A
begin
80
end
115
score
98.48484848484848
distance
57.038326
seq distance
244
chain
I
LDL-receptor class A
begin
80
end
115
score
98.48484848484848
distance
57.038326
seq distance
244
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
58.453777
seq distance
253
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
58.453777
seq distance
253
chain
I
LDL-receptor class A
begin
78
end
115
score
100.0
distance
60.925037
seq distance
False
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
60.925037
seq distance
False
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
61.77589
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
61.77589
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
62.612785
seq distance
False
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
62.612785
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
370
score
68.18181818181817
distance
62.782166
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
370
score
68.18181818181817
distance
62.782166
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
65.13233
seq distance
261
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
65.13233
seq distance
261
chain
I
LDL-receptor class A
begin
78
end
115
score
100.0
distance
69.648254
seq distance
False
chain
G
LDL-receptor class A
begin
78
end
115
score
100.0
distance
69.648254
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
69.86679
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
69.86679
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
71.01071
seq distance
False
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
71.01071
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
421
score
68.18181818181817
distance
79.65707
seq distance
False
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
421
score
68.18181818181817
distance
79.65707
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
80.09964
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
80.09964
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
93
score
77.27272727272727
distance
82.09648
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
93
score
77.27272727272727
distance
82.09648
seq distance
False
chain
E
LDL-receptor class A
begin
83
end
96
score
70.12987012987013
distance
87.99531
seq distance
False
chain
D
LDL-receptor class A
begin
83
end
96
score
70.12987012987013
distance
87.99531
seq distance
False
chain
D
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
94
score
81.81818181818183
distance
87.99847
seq distance
False
chain
D
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
94
score
81.81818181818183
distance
87.99847
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
85
score
72.72727272727273
distance
89.1093
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
85
score
72.72727272727273
distance
89.1093
seq distance
False
chain
E
LDL-receptor class A
begin
130
end
149
score
51.590909090909086
distance
93.1962
seq distance
False
chain
B
LDL-receptor class A
begin
130
end
149
score
51.590909090909086
distance
93.1962
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
86
score
72.72727272727273
distance
94.48239
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
86
score
72.72727272727273
distance
94.48239
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
81
score
59.09090909090909
distance
98.84698
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
81
score
59.09090909090909
distance
98.84698
seq distance
False
chain
C
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
145
score
77.27272727272727
distance
99.35539
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
145
score
77.27272727272727
distance
99.35539
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
137
score
63.63636363636363
distance
100.81871
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
137
score
63.63636363636363
distance
100.81871
seq distance
False
chain
B
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
1272
score
50.0
distance
136.78593
seq distance
False
chain
A
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
1272
score
50.0
distance
136.78593
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
1049
score
54.54545454545454
distance
146.90294
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
1049
score
54.54545454545454
distance
146.90294
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
649
score
54.54545454545454
distance
177.0091
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
649
score
54.54545454545454
distance
177.0091
seq distance
False
chain
C
Details
Redox score
77.59
PDB code
7nyc
Structure name
cryoem structure of 3c9-smac
Structure deposition date
2021-03-22
Thiol separation (Å)
2.04
Half-sphere exposure sum
nan
Minimum pKa
nan
% buried
nan
Peptide accession
P02748
Residue number A
380 (Residue 359 in this structure)
Residue number B
119 (Residue 384 in this structure)
Peptide name
Complement component C9
Uncertain whether structure cysteine 384 has been assigned to correct residue at cysteine B.
6dlw P 492 P 507
A redox-regulated disulphide may form within Complement component C9 at these cysteines.
Relevent regions
EGF-like
begin
489
end
519
score
99.12023460410556
distance
2.7955158
seq distance
0
chain
P
EGF-like
begin
489
end
519
score
99.12023460410556
distance
2.7955158
seq distance
0
chain
P
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
7.5152297
seq distance
418
chain
P
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
7.5152297
seq distance
418
chain
P
MACPF
begin
117
end
488
score
87.6099706744868
distance
10.160416
seq distance
4
chain
P
MACPF
begin
117
end
488
score
87.6099706744868
distance
10.160416
seq distance
4
chain
P
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
16.860865
seq distance
False
chain
O
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
16.860865
seq distance
False
chain
O
MACPF
begin
117
end
488
score
87.6099706744868
distance
19.04816
seq distance
False
chain
Q
MACPF
begin
117
end
488
score
87.6099706744868
distance
19.04816
seq distance
False
chain
Q
EGF-like
begin
489
end
519
score
99.12023460410556
distance
19.591839
seq distance
False
chain
O
EGF-like
begin
489
end
519
score
99.12023460410556
distance
19.591839
seq distance
False
chain
O
EGF-like
begin
489
end
519
score
99.12023460410556
distance
20.769526
seq distance
False
chain
Q
EGF-like
begin
489
end
519
score
99.12023460410556
distance
20.769526
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
21.319727
seq distance
87
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
21.319727
seq distance
87
chain
P
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
24.038458
seq distance
86
chain
P
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
24.038458
seq distance
86
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
26.782429
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
26.782429
seq distance
False
chain
Q
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
27.649673
seq distance
346
chain
P
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
27.649673
seq distance
346
chain
P
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
27.656797
seq distance
False
chain
Q
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
27.656797
seq distance
False
chain
Q
MACPF
begin
117
end
488
score
87.6099706744868
distance
30.053936
seq distance
False
chain
R
MACPF
begin
117
end
488
score
87.6099706744868
distance
30.053936
seq distance
False
chain
R
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
30.702728
seq distance
False
chain
Q
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
30.702728
seq distance
False
chain
Q
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
30.99257
seq distance
False
chain
Q
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
30.99257
seq distance
False
chain
Q
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
31.625002
seq distance
False
chain
Q
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
31.625002
seq distance
False
chain
Q
MACPF
begin
117
end
488
score
87.6099706744868
distance
32.44751
seq distance
False
chain
O
MACPF
begin
117
end
488
score
87.6099706744868
distance
32.44751
seq distance
False
chain
O
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
34.62166
seq distance
False
chain
R
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
34.62166
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
35.69429
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
35.69429
seq distance
False
chain
O
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
38.039375
seq distance
False
chain
O
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
38.039375
seq distance
False
chain
O
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
42.863472
seq distance
False
chain
N
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
42.863472
seq distance
False
chain
N
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
43.264168
seq distance
False
chain
O
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
43.264168
seq distance
False
chain
O
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
43.694855
seq distance
310
chain
P
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
43.694855
seq distance
310
chain
P
EGF-like
begin
489
end
519
score
99.12023460410556
distance
44.11767
seq distance
False
chain
N
EGF-like
begin
489
end
519
score
99.12023460410556
distance
44.11767
seq distance
False
chain
N
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
44.652576
seq distance
False
chain
R
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
44.652576
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
44.682438
seq distance
230
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
44.682438
seq distance
230
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
45.18813
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
45.18813
seq distance
False
chain
R
EGF-like
begin
489
end
519
score
99.12023460410556
distance
46.36391
seq distance
False
chain
R
EGF-like
begin
489
end
519
score
99.12023460410556
distance
46.36391
seq distance
False
chain
R
LDL-receptor class A
begin
78
end
115
score
100.0
distance
46.56761
seq distance
False
chain
Q
LDL-receptor class A
begin
78
end
115
score
100.0
distance
46.56761
seq distance
False
chain
Q
MACPF
begin
117
end
488
score
87.6099706744868
distance
47.764866
seq distance
False
chain
S
MACPF
begin
117
end
488
score
87.6099706744868
distance
47.764866
seq distance
False
chain
S
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
48.915733
seq distance
False
chain
R
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
48.915733
seq distance
False
chain
R
LDL-receptor class A
begin
78
end
115
score
100.0
distance
48.957355
seq distance
377
chain
P
LDL-receptor class A
begin
78
end
115
score
100.0
distance
48.957355
seq distance
377
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
50.290928
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
50.290928
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
50.372986
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
50.372986
seq distance
False
chain
Q
MACPF
begin
117
end
488
score
87.6099706744868
distance
50.804977
seq distance
False
chain
N
MACPF
begin
117
end
488
score
87.6099706744868
distance
50.804977
seq distance
False
chain
N
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
51.044212
seq distance
False
chain
S
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
51.044212
seq distance
False
chain
S
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
51.381123
seq distance
386
chain
P
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
51.381123
seq distance
386
chain
P
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
51.405415
seq distance
False
chain
Q
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
51.405415
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
55.77051
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
55.77051
seq distance
False
chain
N
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
56.1245
seq distance
False
chain
Q
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
56.1245
seq distance
False
chain
Q
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
56.48169
seq distance
234
chain
P
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
56.48169
seq distance
234
chain
P
LDL-receptor class A
begin
78
end
115
score
100.0
distance
56.56615
seq distance
False
chain
R
LDL-receptor class A
begin
78
end
115
score
100.0
distance
56.56615
seq distance
False
chain
R
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
57.46872
seq distance
False
chain
R
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
57.46872
seq distance
False
chain
R
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
57.469486
seq distance
False
chain
N
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
57.469486
seq distance
False
chain
N
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
58.91876
seq distance
False
chain
O
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
58.91876
seq distance
False
chain
O
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
61.112305
seq distance
394
chain
P
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
61.112305
seq distance
394
chain
P
LDL-receptor class A
begin
78
end
115
score
100.0
distance
61.491497
seq distance
False
chain
O
LDL-receptor class A
begin
78
end
115
score
100.0
distance
61.491497
seq distance
False
chain
O
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
62.060936
seq distance
False
chain
R
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
62.060936
seq distance
False
chain
R
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
62.781822
seq distance
False
chain
O
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
62.781822
seq distance
False
chain
O
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
62.841103
seq distance
False
chain
R
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
62.841103
seq distance
False
chain
R
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
62.98773
seq distance
False
chain
O
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
62.98773
seq distance
False
chain
O
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
63.04413
seq distance
False
chain
Q
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
63.04413
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
63.979992
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
63.979992
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
64.10787
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
64.10787
seq distance
False
chain
R
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
64.5422
seq distance
False
chain
S
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
64.5422
seq distance
False
chain
S
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
64.6152
seq distance
False
chain
N
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
64.6152
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
65.74102
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
65.74102
seq distance
False
chain
S
MACPF
begin
117
end
488
score
87.6099706744868
distance
67.75093
seq distance
False
chain
T
MACPF
begin
117
end
488
score
87.6099706744868
distance
67.75093
seq distance
False
chain
T
EGF-like
begin
489
end
519
score
99.12023460410556
distance
67.78564
seq distance
False
chain
M
EGF-like
begin
489
end
519
score
99.12023460410556
distance
67.78564
seq distance
False
chain
M
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
68.23345
seq distance
False
chain
M
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
68.23345
seq distance
False
chain
M
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
69.25839
seq distance
False
chain
N
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
69.25839
seq distance
False
chain
N
MACPF
begin
117
end
488
score
87.6099706744868
distance
70.00304
seq distance
False
chain
M
MACPF
begin
117
end
488
score
87.6099706744868
distance
70.00304
seq distance
False
chain
M
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
70.69261
seq distance
False
chain
S
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
70.69261
seq distance
False
chain
S
EGF-like
begin
489
end
519
score
99.12023460410556
distance
70.83287
seq distance
False
chain
S
EGF-like
begin
489
end
519
score
99.12023460410556
distance
70.83287
seq distance
False
chain
S
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
71.18219
seq distance
False
chain
T
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
71.18219
seq distance
False
chain
T
LDL-receptor class A
begin
78
end
115
score
100.0
distance
71.46543
seq distance
False
chain
S
LDL-receptor class A
begin
78
end
115
score
100.0
distance
71.46543
seq distance
False
chain
S
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
74.554726
seq distance
False
chain
O
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
74.554726
seq distance
False
chain
O
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
75.91467
seq distance
False
chain
R
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
75.91467
seq distance
False
chain
R
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
76.05195
seq distance
False
chain
S
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
76.05195
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
76.24856
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
76.24856
seq distance
False
chain
M
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
77.421005
seq distance
False
chain
M
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
77.421005
seq distance
False
chain
M
LDL-receptor class A
begin
78
end
115
score
100.0
distance
80.09099
seq distance
False
chain
N
LDL-receptor class A
begin
78
end
115
score
100.0
distance
80.09099
seq distance
False
chain
N
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
80.259895
seq distance
False
chain
N
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
80.259895
seq distance
False
chain
N
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
80.34055
seq distance
False
chain
S
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
80.34055
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
80.68814
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
80.68814
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
81.15474
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
81.15474
seq distance
False
chain
S
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
82.90326
seq distance
False
chain
S
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
82.90326
seq distance
False
chain
S
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
83.48391
seq distance
False
chain
N
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
83.48391
seq distance
False
chain
N
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
84.000854
seq distance
False
chain
M
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
84.000854
seq distance
False
chain
M
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
84.27726
seq distance
False
chain
T
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
84.27726
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
85.84926
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
85.84926
seq distance
False
chain
T
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
86.52864
seq distance
False
chain
M
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
86.52864
seq distance
False
chain
M
MACPF
begin
117
end
488
score
87.6099706744868
distance
86.8849
seq distance
False
chain
U
MACPF
begin
117
end
488
score
87.6099706744868
distance
86.8849
seq distance
False
chain
U
MACPF
begin
117
end
488
score
87.6099706744868
distance
88.603806
seq distance
False
chain
L
MACPF
begin
117
end
488
score
87.6099706744868
distance
88.603806
seq distance
False
chain
L
EGF-like
begin
489
end
519
score
99.12023460410556
distance
90.09113
seq distance
False
chain
L
EGF-like
begin
489
end
519
score
99.12023460410556
distance
90.09113
seq distance
False
chain
L
LDL-receptor class A
begin
78
end
115
score
100.0
distance
90.18102
seq distance
False
chain
T
LDL-receptor class A
begin
78
end
115
score
100.0
distance
90.18102
seq distance
False
chain
T
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
91.57066
seq distance
False
chain
U
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
91.57066
seq distance
False
chain
U
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
91.70673
seq distance
False
chain
S
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
91.70673
seq distance
False
chain
S
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
92.05192
seq distance
False
chain
N
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
92.05192
seq distance
False
chain
N
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
92.285614
seq distance
False
chain
L
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
92.285614
seq distance
False
chain
L
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
92.439095
seq distance
False
chain
T
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
92.439095
seq distance
False
chain
T
EGF-like
begin
489
end
519
score
99.12023460410556
distance
92.84172
seq distance
False
chain
T
EGF-like
begin
489
end
519
score
99.12023460410556
distance
92.84172
seq distance
False
chain
T
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
93.76397
seq distance
False
chain
T
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
93.76397
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
95.74966
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
95.74966
seq distance
False
chain
L
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
96.4655
seq distance
False
chain
L
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
96.4655
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
98.13007
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
98.13007
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
98.797165
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
98.797165
seq distance
False
chain
T
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
99.69009
seq distance
False
chain
M
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
99.69009
seq distance
False
chain
M
LDL-receptor class A
begin
78
end
115
score
100.0
distance
99.69009
seq distance
False
chain
M
LDL-receptor class A
begin
78
end
115
score
100.0
distance
99.69009
seq distance
False
chain
M
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
99.78483
seq distance
False
chain
T
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
99.78483
seq distance
False
chain
T
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
100.08755
seq distance
False
chain
L
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
100.08755
seq distance
False
chain
L
MACPF
begin
117
end
488
score
87.6099706744868
distance
102.14993
seq distance
False
chain
V
MACPF
begin
117
end
488
score
87.6099706744868
distance
102.14993
seq distance
False
chain
V
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
102.80712
seq distance
False
chain
U
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
102.80712
seq distance
False
chain
U
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
103.3062
seq distance
False
chain
M
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
103.3062
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
104.60515
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
104.60515
seq distance
False
chain
U
MACPF
begin
117
end
488
score
87.6099706744868
distance
106.188156
seq distance
False
chain
K
MACPF
begin
117
end
488
score
87.6099706744868
distance
106.188156
seq distance
False
chain
K
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
106.82569
seq distance
False
chain
T
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
106.82569
seq distance
False
chain
T
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
107.45072
seq distance
False
chain
L
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
107.45072
seq distance
False
chain
L
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
108.14766
seq distance
False
chain
T
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
108.14766
seq distance
False
chain
T
LDL-receptor class A
begin
78
end
115
score
100.0
distance
108.92812
seq distance
False
chain
U
LDL-receptor class A
begin
78
end
115
score
100.0
distance
108.92812
seq distance
False
chain
U
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
110.654915
seq distance
False
chain
M
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
110.654915
seq distance
False
chain
M
EGF-like
begin
489
end
519
score
99.12023460410556
distance
110.660645
seq distance
False
chain
K
EGF-like
begin
489
end
519
score
99.12023460410556
distance
110.660645
seq distance
False
chain
K
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
110.839745
seq distance
False
chain
V
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
110.839745
seq distance
False
chain
V
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
112.39503
seq distance
False
chain
U
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
112.39503
seq distance
False
chain
U
EGF-like
begin
489
end
519
score
99.12023460410556
distance
112.50976
seq distance
False
chain
U
EGF-like
begin
489
end
519
score
99.12023460410556
distance
112.50976
seq distance
False
chain
U
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
112.92089
seq distance
False
chain
U
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
112.92089
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
113.57445
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
113.57445
seq distance
False
chain
K
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
113.87143
seq distance
False
chain
K
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
113.87143
seq distance
False
chain
K
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
114.47446
seq distance
False
chain
K
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
114.47446
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
114.893616
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
114.893616
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
115.67731
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
115.67731
seq distance
False
chain
U
MACPF
begin
117
end
488
score
87.6099706744868
distance
116.0196
seq distance
False
chain
A
MACPF
begin
117
end
488
score
87.6099706744868
distance
116.0196
seq distance
False
chain
A
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
116.142944
seq distance
False
chain
K
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
116.142944
seq distance
False
chain
K
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
118.97304
seq distance
False
chain
L
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
118.97304
seq distance
False
chain
L
LDL-receptor class A
begin
78
end
115
score
100.0
distance
118.97304
seq distance
False
chain
L
LDL-receptor class A
begin
78
end
115
score
100.0
distance
118.97304
seq distance
False
chain
L
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
119.05624
seq distance
False
chain
U
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
119.05624
seq distance
False
chain
U
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
119.497734
seq distance
False
chain
V
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
119.497734
seq distance
False
chain
V
MACPF
begin
117
end
488
score
87.6099706744868
distance
120.59263
seq distance
False
chain
J
MACPF
begin
117
end
488
score
87.6099706744868
distance
120.59263
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
121.42629
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
121.42629
seq distance
False
chain
V
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
121.57159
seq distance
False
chain
L
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
121.57159
seq distance
False
chain
L
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
123.93039
seq distance
False
chain
U
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
123.93039
seq distance
False
chain
U
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
126.55592
seq distance
False
chain
K
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
126.55592
seq distance
False
chain
K
LDL-receptor class A
begin
78
end
115
score
100.0
distance
126.78544
seq distance
False
chain
V
LDL-receptor class A
begin
78
end
115
score
100.0
distance
126.78544
seq distance
False
chain
V
MACPF
begin
117
end
488
score
87.6099706744868
distance
127.54644
seq distance
False
chain
B
MACPF
begin
117
end
488
score
87.6099706744868
distance
127.54644
seq distance
False
chain
B
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
128.07162
seq distance
False
chain
U
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
128.07162
seq distance
False
chain
U
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
128.37425
seq distance
False
chain
A
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
128.37425
seq distance
False
chain
A
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
128.73653
seq distance
False
chain
L
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
128.73653
seq distance
False
chain
L
EGF-like
begin
489
end
519
score
99.12023460410556
distance
129.0239
seq distance
False
chain
J
EGF-like
begin
489
end
519
score
99.12023460410556
distance
129.0239
seq distance
False
chain
J
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
129.14941
seq distance
False
chain
J
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
129.14941
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
129.24294
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
129.24294
seq distance
False
chain
J
EGF-like
begin
489
end
519
score
99.12023460410556
distance
129.84575
seq distance
False
chain
V
EGF-like
begin
489
end
519
score
99.12023460410556
distance
129.84575
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
130.1352
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
130.1352
seq distance
False
chain
J
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
130.33675
seq distance
False
chain
V
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
130.33675
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
130.95967
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
130.95967
seq distance
False
chain
V
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
131.1253
seq distance
False
chain
J
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
131.1253
seq distance
False
chain
J
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
131.40541
seq distance
False
chain
V
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
131.40541
seq distance
False
chain
V
MACPF
begin
117
end
488
score
87.6099706744868
distance
132.27885
seq distance
False
chain
I
MACPF
begin
117
end
488
score
87.6099706744868
distance
132.27885
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
133.98637
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
133.98637
seq distance
False
chain
A
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
134.33395
seq distance
False
chain
J
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
134.33395
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
135.96329
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
135.96329
seq distance
False
chain
A
MACPF
begin
117
end
488
score
87.6099706744868
distance
136.59697
seq distance
False
chain
C
MACPF
begin
117
end
488
score
87.6099706744868
distance
136.59697
seq distance
False
chain
C
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
136.90225
seq distance
False
chain
K
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
136.90225
seq distance
False
chain
K
LDL-receptor class A
begin
78
end
115
score
100.0
distance
136.90225
seq distance
False
chain
K
LDL-receptor class A
begin
78
end
115
score
100.0
distance
136.90225
seq distance
False
chain
K
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
136.95572
seq distance
False
chain
V
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
136.95572
seq distance
False
chain
V
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
137.67535
seq distance
False
chain
K
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
137.67535
seq distance
False
chain
K
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
138.19995
seq distance
False
chain
V
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
138.19995
seq distance
False
chain
V
MACPF
begin
117
end
488
score
87.6099706744868
distance
140.72275
seq distance
False
chain
H
MACPF
begin
117
end
488
score
87.6099706744868
distance
140.72275
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
141.92906
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
141.92906
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
142.38603
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
142.38603
seq distance
False
chain
I
LDL-receptor class A
begin
78
end
115
score
100.0
distance
142.86856
seq distance
False
chain
A
LDL-receptor class A
begin
78
end
115
score
100.0
distance
142.86856
seq distance
False
chain
A
MACPF
begin
117
end
488
score
87.6099706744868
distance
143.13933
seq distance
False
chain
D
MACPF
begin
117
end
488
score
87.6099706744868
distance
143.13933
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
143.26614
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
143.26614
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
143.29904
seq distance
False
chain
J
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
143.29904
seq distance
False
chain
J
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
143.47643
seq distance
False
chain
B
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
143.47643
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
144.06203
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
144.06203
seq distance
False
chain
A
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
144.30518
seq distance
False
chain
I
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
144.30518
seq distance
False
chain
I
EGF-like
begin
489
end
519
score
99.12023460410556
distance
144.63802
seq distance
False
chain
A
EGF-like
begin
489
end
519
score
99.12023460410556
distance
144.63802
seq distance
False
chain
A
EGF-like
begin
489
end
519
score
99.12023460410556
distance
144.78769
seq distance
False
chain
I
EGF-like
begin
489
end
519
score
99.12023460410556
distance
144.78769
seq distance
False
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
145.2601
seq distance
False
chain
K
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
145.2601
seq distance
False
chain
K
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
145.82176
seq distance
False
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
145.82176
seq distance
False
chain
B
MACPF
begin
117
end
488
score
87.6099706744868
distance
146.30853
seq distance
False
chain
G
MACPF
begin
117
end
488
score
87.6099706744868
distance
146.30853
seq distance
False
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
146.58385
seq distance
False
chain
V
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
146.58385
seq distance
False
chain
V
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
146.78328
seq distance
False
chain
A
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
146.78328
seq distance
False
chain
A
MACPF
begin
117
end
488
score
87.6099706744868
distance
146.9813
seq distance
False
chain
E
MACPF
begin
117
end
488
score
87.6099706744868
distance
146.9813
seq distance
False
chain
E
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
147.50507
seq distance
False
chain
A
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
147.50507
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
147.78632
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
147.78632
seq distance
False
chain
B
MACPF
begin
117
end
488
score
87.6099706744868
distance
148.04497
seq distance
False
chain
F
MACPF
begin
117
end
488
score
87.6099706744868
distance
148.04497
seq distance
False
chain
F
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
150.3635
seq distance
False
chain
A
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
150.3635
seq distance
False
chain
A
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
151.18126
seq distance
False
chain
J
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
151.18126
seq distance
False
chain
J
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
151.46388
seq distance
False
chain
I
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
151.46388
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
151.92755
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
151.92755
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
152.7197
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
152.7197
seq distance
False
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
152.72789
seq distance
False
chain
J
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
152.72789
seq distance
False
chain
J
LDL-receptor class A
begin
78
end
115
score
100.0
distance
152.72789
seq distance
False
chain
J
LDL-receptor class A
begin
78
end
115
score
100.0
distance
152.72789
seq distance
False
chain
J
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
152.8814
seq distance
False
chain
A
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
152.8814
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
153.90067
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
153.90067
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
154.53542
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
154.53542
seq distance
False
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
154.771
seq distance
False
chain
C
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
154.771
seq distance
False
chain
C
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
155.2169
seq distance
False
chain
H
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
155.2169
seq distance
False
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
155.83652
seq distance
False
chain
C
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
155.83652
seq distance
False
chain
C
EGF-like
begin
489
end
519
score
99.12023460410556
distance
156.5062
seq distance
False
chain
B
EGF-like
begin
489
end
519
score
99.12023460410556
distance
156.5062
seq distance
False
chain
B
LDL-receptor class A
begin
78
end
115
score
100.0
distance
156.57822
seq distance
False
chain
B
LDL-receptor class A
begin
78
end
115
score
100.0
distance
156.57822
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
156.66203
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
156.66203
seq distance
False
chain
C
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
157.28304
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
157.28304
seq distance
False
chain
I
EGF-like
begin
489
end
519
score
99.12023460410556
distance
157.4374
seq distance
False
chain
H
EGF-like
begin
489
end
519
score
99.12023460410556
distance
157.4374
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
158.9147
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
158.9147
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
159.54884
seq distance
False
chain
J
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
159.54884
seq distance
False
chain
J
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
159.99272
seq distance
False
chain
B
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
159.99272
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
160.00702
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
160.00702
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
160.65561
seq distance
False
chain
D
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
160.65561
seq distance
False
chain
D
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
160.66495
seq distance
False
chain
B
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
160.66495
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
160.83098
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
160.83098
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
161.71793
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
161.71793
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
161.77261
seq distance
False
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
161.77261
seq distance
False
chain
I
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
161.80621
seq distance
False
chain
A
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
161.80621
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
162.1616
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
162.1616
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
162.41782
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
162.41782
seq distance
False
chain
D
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
162.73668
seq distance
False
chain
F
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
162.73668
seq distance
False
chain
F
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
163.3242
seq distance
False
chain
E
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
163.3242
seq distance
False
chain
E
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
163.47746
seq distance
False
chain
G
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
163.47746
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
164.09451
seq distance
False
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
164.09451
seq distance
False
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
164.9072
seq distance
False
chain
E
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
164.9072
seq distance
False
chain
E
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
165.19559
seq distance
False
chain
D
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
165.19559
seq distance
False
chain
D
EGF-like
begin
489
end
519
score
99.12023460410556
distance
165.2047
seq distance
False
chain
C
EGF-like
begin
489
end
519
score
99.12023460410556
distance
165.2047
seq distance
False
chain
C
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
165.51581
seq distance
False
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
165.51581
seq distance
False
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
165.56096
seq distance
False
chain
I
LDL-receptor class A
begin
78
end
115
score
100.0
distance
165.56096
seq distance
False
chain
I
EGF-like
begin
489
end
519
score
99.12023460410556
distance
165.89445
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
99.12023460410556
distance
165.89445
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
165.95103
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
165.95103
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
166.08003
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
166.08003
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
166.52231
seq distance
False
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
166.52231
seq distance
False
chain
F
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
166.75227
seq distance
False
chain
C
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
166.75227
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
166.77673
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
166.77673
seq distance
False
chain
D
LDL-receptor class A
begin
78
end
115
score
100.0
distance
167.60454
seq distance
False
chain
C
LDL-receptor class A
begin
78
end
115
score
100.0
distance
167.60454
seq distance
False
chain
C
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
168.18689
seq distance
False
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
168.18689
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
168.23384
seq distance
False
chain
E
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
168.23384
seq distance
False
chain
E
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
168.85516
seq distance
False
chain
F
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
168.85516
seq distance
False
chain
F
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
169.21475
seq distance
False
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
169.21475
seq distance
False
chain
H
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
170.54868
seq distance
False
chain
D
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
170.54868
seq distance
False
chain
D
EGF-like
begin
489
end
519
score
99.12023460410556
distance
170.57506
seq distance
False
chain
D
EGF-like
begin
489
end
519
score
99.12023460410556
distance
170.57506
seq distance
False
chain
D
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
170.65773
seq distance
False
chain
C
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
170.65773
seq distance
False
chain
C
EGF-like
begin
489
end
519
score
99.12023460410556
distance
170.906
seq distance
False
chain
F
EGF-like
begin
489
end
519
score
99.12023460410556
distance
170.906
seq distance
False
chain
F
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
171.15259
seq distance
False
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
171.15259
seq distance
False
chain
I
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
171.24669
seq distance
False
chain
E
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
171.24669
seq distance
False
chain
E
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
171.30278
seq distance
False
chain
E
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
171.30278
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
172.15024
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
172.15024
seq distance
False
chain
C
EGF-like
begin
489
end
519
score
99.12023460410556
distance
172.4825
seq distance
False
chain
E
EGF-like
begin
489
end
519
score
99.12023460410556
distance
172.4825
seq distance
False
chain
E
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
173.33563
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
173.33563
seq distance
False
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
173.69907
seq distance
False
chain
B
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
173.69907
seq distance
False
chain
B
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
174.03699
seq distance
False
chain
F
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
174.03699
seq distance
False
chain
F
LDL-receptor class A
begin
78
end
115
score
100.0
distance
174.70836
seq distance
False
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
174.70836
seq distance
False
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
175.64107
seq distance
False
chain
D
LDL-receptor class A
begin
78
end
115
score
100.0
distance
175.64107
seq distance
False
chain
D
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
175.76617
seq distance
False
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
175.76617
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
176.19182
seq distance
False
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
176.19182
seq distance
False
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
176.19391
seq distance
False
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
176.19391
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
176.28918
seq distance
False
chain
C
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
176.28918
seq distance
False
chain
C
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
177.28058
seq distance
False
chain
D
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
177.28058
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
179.72871
seq distance
False
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
179.72871
seq distance
False
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
179.8552
seq distance
False
chain
F
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
179.8552
seq distance
False
chain
F
LDL-receptor class A
begin
78
end
115
score
100.0
distance
179.97385
seq distance
False
chain
G
LDL-receptor class A
begin
78
end
115
score
100.0
distance
179.97385
seq distance
False
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
180.3636
seq distance
False
chain
E
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
180.3636
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
180.42462
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
180.42462
seq distance
False
chain
D
LDL-receptor class A
begin
78
end
115
score
100.0
distance
180.44835
seq distance
False
chain
E
LDL-receptor class A
begin
78
end
115
score
100.0
distance
180.44835
seq distance
False
chain
E
LDL-receptor class A
begin
78
end
115
score
100.0
distance
181.90846
seq distance
False
chain
F
LDL-receptor class A
begin
78
end
115
score
100.0
distance
181.90846
seq distance
False
chain
F
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
182.0465
seq distance
False
chain
C
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
182.0465
seq distance
False
chain
C
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
183.18051
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
183.18051
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
183.24687
seq distance
False
chain
D
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
183.24687
seq distance
False
chain
D
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
183.2921
seq distance
False
chain
F
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
183.2921
seq distance
False
chain
F
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
185.0479
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
185.0479
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
185.40234
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
185.40234
seq distance
False
chain
E
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
186.26674
seq distance
False
chain
D
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
186.26674
seq distance
False
chain
D
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
186.67705
seq distance
False
chain
E
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
186.67705
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
186.73593
seq distance
False
chain
F
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
186.73593
seq distance
False
chain
F
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
186.75427
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
186.75427
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
186.96194
seq distance
False
chain
F
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
186.96194
seq distance
False
chain
F
Details
Redox score
77.32
PDB code
6dlw
Structure name
complement component polyc9
Structure deposition date
2018-06-03
Thiol separation (Å)
2.03
Half-sphere exposure sum
56
Minimum pKa
nan
% buried
nan
Peptide accession
P02748
Residue number A
513 (Residue 492 in this structure)
Residue number B
528 (Residue 507 in this structure)
Peptide name
Complement component C9
6h04 P 509 P 518
A redox-regulated disulphide may form within Complement component C9 at these cysteines.
Relevent regions
EGF-like
begin
489
end
519
score
100.0
distance
2.8169444
seq distance
0
chain
P
EGF-like
begin
489
end
519
score
100.0
distance
2.8169444
seq distance
0
chain
P
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
11.157196
seq distance
435
chain
P
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
11.157196
seq distance
435
chain
P
MACPF
begin
117
end
488
score
94.98411534701859
distance
14.431332
seq distance
21
chain
P
MACPF
begin
117
end
488
score
94.98411534701859
distance
14.431332
seq distance
21
chain
P
MACPF
begin
117
end
488
score
94.98411534701859
distance
15.199904
seq distance
False
chain
H
MACPF
begin
117
end
488
score
94.98411534701859
distance
15.199904
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
17.744394
seq distance
104
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
17.744394
seq distance
104
chain
P
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
18.978527
seq distance
False
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
18.978527
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
100.0
distance
19.082092
seq distance
False
chain
H
EGF-like
begin
489
end
519
score
100.0
distance
19.082092
seq distance
False
chain
H
EGF-like
begin
489
end
519
score
100.0
distance
19.456196
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
100.0
distance
19.456196
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
20.99874
seq distance
103
chain
P
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
20.99874
seq distance
103
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
23.151943
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
23.151943
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
23.876541
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
23.876541
seq distance
False
chain
H
MACPF
begin
117
end
488
score
94.98411534701859
distance
26.847887
seq distance
False
chain
G
MACPF
begin
117
end
488
score
94.98411534701859
distance
26.847887
seq distance
False
chain
G
MACPF
begin
117
end
488
score
94.98411534701859
distance
27.166582
seq distance
False
chain
I
MACPF
begin
117
end
488
score
94.98411534701859
distance
27.166582
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
29.573593
seq distance
False
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
29.573593
seq distance
False
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
29.757366
seq distance
363
chain
P
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
29.757366
seq distance
363
chain
P
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
30.775776
seq distance
False
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
30.775776
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
31.379766
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
31.379766
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
33.850666
seq distance
False
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
33.850666
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
34.701706
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
34.701706
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
37.125847
seq distance
False
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
37.125847
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
39.771862
seq distance
247
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
39.771862
seq distance
247
chain
P
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
40.881355
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
40.881355
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
41.750526
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
41.750526
seq distance
False
chain
I
EGF-like
begin
489
end
519
score
100.0
distance
43.336773
seq distance
False
chain
I
EGF-like
begin
489
end
519
score
100.0
distance
43.336773
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
43.987366
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
43.987366
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
45.128227
seq distance
327
chain
P
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
45.128227
seq distance
327
chain
P
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
45.33291
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
45.33291
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
45.40169
seq distance
False
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
45.40169
seq distance
False
chain
G
MACPF
begin
117
end
488
score
94.98411534701859
distance
45.403187
seq distance
False
chain
J
MACPF
begin
117
end
488
score
94.98411534701859
distance
45.403187
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
45.92267
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
45.92267
seq distance
False
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
51.180027
seq distance
False
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
51.180027
seq distance
False
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
51.713825
seq distance
False
chain
J
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
51.713825
seq distance
False
chain
J
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
52.06122
seq distance
251
chain
P
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
52.06122
seq distance
251
chain
P
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
53.097107
seq distance
False
chain
G
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
53.097107
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
391
score
68.18181818181817
distance
54.23653
seq distance
False
chain
F
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
391
score
68.18181818181817
distance
54.23653
seq distance
False
chain
F
LDL-receptor class A
begin
78
end
115
score
100.0
distance
54.30431
seq distance
394
chain
P
LDL-receptor class A
begin
78
end
115
score
100.0
distance
54.30431
seq distance
394
chain
P
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
55.102123
seq distance
False
chain
I
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
55.102123
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
56.00185
seq distance
False
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
56.00185
seq distance
False
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
56.506718
seq distance
403
chain
P
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
56.506718
seq distance
403
chain
P
LDL-receptor class A
begin
78
end
115
score
100.0
distance
58.901814
seq distance
False
chain
I
LDL-receptor class A
begin
78
end
115
score
100.0
distance
58.901814
seq distance
False
chain
I
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
58.965134
seq distance
False
chain
H
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
58.965134
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
59.846058
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
59.846058
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
60.44265
seq distance
False
chain
J
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
60.44265
seq distance
False
chain
J
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
60.71167
seq distance
False
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
60.71167
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
61.880535
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
61.880535
seq distance
False
chain
J
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
63.022278
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
63.022278
seq distance
False
chain
G
MACPF
begin
117
end
488
score
94.98411534701859
distance
64.86487
seq distance
False
chain
K
MACPF
begin
117
end
488
score
94.98411534701859
distance
64.86487
seq distance
False
chain
K
LDL-receptor class A
begin
78
end
115
score
100.0
distance
64.97698
seq distance
False
chain
G
LDL-receptor class A
begin
78
end
115
score
100.0
distance
64.97698
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
65.06857
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
65.06857
seq distance
False
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
65.146286
seq distance
411
chain
P
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
65.146286
seq distance
411
chain
P
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
65.44302
seq distance
False
chain
J
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
65.44302
seq distance
False
chain
J
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
65.89707
seq distance
False
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
65.89707
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
66.28959
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
66.28959
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
100.0
distance
66.50037
seq distance
False
chain
J
EGF-like
begin
489
end
519
score
100.0
distance
66.50037
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
370
score
68.18181818181817
distance
70.279945
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
370
score
68.18181818181817
distance
70.279945
seq distance
False
chain
C
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
70.37441
seq distance
False
chain
K
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
70.37441
seq distance
False
chain
K
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
71.97997
seq distance
False
chain
I
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
71.97997
seq distance
False
chain
I
LDL-receptor class A
begin
78
end
115
score
100.0
distance
72.92347
seq distance
False
chain
J
LDL-receptor class A
begin
78
end
115
score
100.0
distance
72.92347
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
76.70701
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
76.70701
seq distance
False
chain
J
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
77.02081
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
77.02081
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
78.44139
seq distance
False
chain
J
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
78.44139
seq distance
False
chain
J
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
78.753944
seq distance
False
chain
J
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
78.753944
seq distance
False
chain
J
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
93
score
77.27272727272727
distance
79.446365
seq distance
False
chain
F
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
93
score
77.27272727272727
distance
79.446365
seq distance
False
chain
F
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
79.739784
seq distance
False
chain
J
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
79.739784
seq distance
False
chain
J
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
79.916084
seq distance
False
chain
K
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
79.916084
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
81.60952
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
81.60952
seq distance
False
chain
K
MACPF
begin
117
end
488
score
94.98411534701859
distance
83.08314
seq distance
False
chain
L
MACPF
begin
117
end
488
score
94.98411534701859
distance
83.08314
seq distance
False
chain
L
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
86.1928
seq distance
False
chain
K
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
86.1928
seq distance
False
chain
K
EGF-like
begin
489
end
519
score
100.0
distance
87.45128
seq distance
False
chain
K
EGF-like
begin
489
end
519
score
100.0
distance
87.45128
seq distance
False
chain
K
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
87.46335
seq distance
False
chain
J
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
87.46335
seq distance
False
chain
J
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
89.64739
seq distance
False
chain
L
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
89.64739
seq distance
False
chain
L
LDL-receptor class A
begin
78
end
115
score
100.0
distance
89.7707
seq distance
False
chain
K
LDL-receptor class A
begin
78
end
115
score
100.0
distance
89.7707
seq distance
False
chain
K
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
85
score
72.72727272727273
distance
90.83119
seq distance
False
chain
F
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
85
score
72.72727272727273
distance
90.83119
seq distance
False
chain
F
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
94
score
81.81818181818183
distance
91.83605
seq distance
False
chain
C
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
94
score
81.81818181818183
distance
91.83605
seq distance
False
chain
C
LDL-receptor class A
begin
83
end
96
score
70.12987012987013
distance
91.83605
seq distance
False
chain
C
LDL-receptor class A
begin
83
end
96
score
70.12987012987013
distance
91.83605
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
94.07684
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
94.07684
seq distance
False
chain
K
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
94.59641
seq distance
False
chain
K
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
94.59641
seq distance
False
chain
K
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
226
score
50.0
distance
95.562164
seq distance
False
chain
F
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
226
score
50.0
distance
95.562164
seq distance
False
chain
F
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
96.801346
seq distance
False
chain
K
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
96.801346
seq distance
False
chain
K
MACPF
begin
117
end
488
score
94.98411534701859
distance
97.74452
seq distance
False
chain
M
MACPF
begin
117
end
488
score
94.98411534701859
distance
97.74452
seq distance
False
chain
M
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
98.32647
seq distance
False
chain
L
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
98.32647
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
100.14473
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
100.14473
seq distance
False
chain
L
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
101.271996
seq distance
False
chain
K
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
101.271996
seq distance
False
chain
K
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
442
score
50.0
distance
101.99123
seq distance
False
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
442
score
50.0
distance
101.99123
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
86
score
72.72727272727273
distance
103.049126
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
86
score
72.72727272727273
distance
103.049126
seq distance
False
chain
C
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
103.95408
seq distance
False
chain
K
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
103.95408
seq distance
False
chain
K
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
106.06683
seq distance
False
chain
L
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
106.06683
seq distance
False
chain
L
EGF-like
begin
489
end
519
score
100.0
distance
106.865105
seq distance
False
chain
L
EGF-like
begin
489
end
519
score
100.0
distance
106.865105
seq distance
False
chain
L
LDL-receptor class A
begin
78
end
115
score
100.0
distance
107.0818
seq distance
False
chain
L
LDL-receptor class A
begin
78
end
115
score
100.0
distance
107.0818
seq distance
False
chain
L
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
108.13635
seq distance
False
chain
M
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
108.13635
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
110.96692
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
110.96692
seq distance
False
chain
L
MACPF
begin
117
end
488
score
94.98411534701859
distance
111.0621
seq distance
False
chain
N
MACPF
begin
117
end
488
score
94.98411534701859
distance
111.0621
seq distance
False
chain
N
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
111.804825
seq distance
False
chain
L
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
111.804825
seq distance
False
chain
L
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
103
score
59.09090909090909
distance
112.88667
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
103
score
59.09090909090909
distance
112.88667
seq distance
False
chain
D
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
114.019
seq distance
False
chain
L
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
114.019
seq distance
False
chain
L
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
114.922585
seq distance
False
chain
M
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
114.922585
seq distance
False
chain
M
LDL-receptor class A
begin
151
end
170
score
51.590909090909086
distance
115.93795
seq distance
False
chain
B
LDL-receptor class A
begin
151
end
170
score
51.590909090909086
distance
115.93795
seq distance
False
chain
B
MACPF
begin
117
end
488
score
94.98411534701859
distance
116.330605
seq distance
False
chain
X
MACPF
begin
117
end
488
score
94.98411534701859
distance
116.330605
seq distance
False
chain
X
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
166
score
77.27272727272727
distance
116.56358
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
166
score
77.27272727272727
distance
116.56358
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
116.76024
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
116.76024
seq distance
False
chain
M
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
119.90178
seq distance
False
chain
L
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
119.90178
seq distance
False
chain
L
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
158
score
63.63636363636363
distance
121.29193
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
158
score
63.63636363636363
distance
121.29193
seq distance
False
chain
B
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
122.018936
seq distance
False
chain
L
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
122.018936
seq distance
False
chain
L
MACPF
begin
117
end
488
score
94.98411534701859
distance
122.60639
seq distance
False
chain
O
MACPF
begin
117
end
488
score
94.98411534701859
distance
122.60639
seq distance
False
chain
O
EGF-like
begin
489
end
519
score
100.0
distance
123.63966
seq distance
False
chain
X
EGF-like
begin
489
end
519
score
100.0
distance
123.63966
seq distance
False
chain
X
LDL-receptor class A
begin
78
end
115
score
100.0
distance
123.731346
seq distance
False
chain
M
LDL-receptor class A
begin
78
end
115
score
100.0
distance
123.731346
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
123.78581
seq distance
False
chain
X
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
123.78581
seq distance
False
chain
X
EGF-like
begin
489
end
519
score
100.0
distance
124.146805
seq distance
False
chain
M
EGF-like
begin
489
end
519
score
100.0
distance
124.146805
seq distance
False
chain
M
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
124.18166
seq distance
False
chain
M
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
124.18166
seq distance
False
chain
M
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
124.50441
seq distance
False
chain
X
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
124.50441
seq distance
False
chain
X
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
124.97631
seq distance
False
chain
N
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
124.97631
seq distance
False
chain
N
TSP type-1
begin
507
end
507
score
88.63636363636364
distance
125.18622
seq distance
False
chain
D
TSP type-1
begin
507
end
507
score
88.63636363636364
distance
125.18622
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
126.305214
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
126.305214
seq distance
False
chain
M
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
126.40321
seq distance
False
chain
X
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
126.40321
seq distance
False
chain
X
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
126.82187
seq distance
False
chain
X
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
126.82187
seq distance
False
chain
X
MACPF
begin
117
end
488
score
94.98411534701859
distance
127.541374
seq distance
False
chain
W
MACPF
begin
117
end
488
score
94.98411534701859
distance
127.541374
seq distance
False
chain
W
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
128.59695
seq distance
False
chain
M
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
128.59695
seq distance
False
chain
M
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
129.04724
seq distance
False
chain
X
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
129.04724
seq distance
False
chain
X
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
129.45113
seq distance
False
chain
N
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
129.45113
seq distance
False
chain
N
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
130.37592
seq distance
False
chain
M
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
130.37592
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
131.26234
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
131.26234
seq distance
False
chain
N
MACPF
begin
117
end
488
score
94.98411534701859
distance
131.89343
seq distance
False
chain
Q
MACPF
begin
117
end
488
score
94.98411534701859
distance
131.89343
seq distance
False
chain
Q
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
134.35007
seq distance
False
chain
M
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
134.35007
seq distance
False
chain
M
MACPF
begin
117
end
488
score
94.98411534701859
distance
135.85762
seq distance
False
chain
V
MACPF
begin
117
end
488
score
94.98411534701859
distance
135.85762
seq distance
False
chain
V
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
136.96782
seq distance
False
chain
X
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
136.96782
seq distance
False
chain
X
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
137.50685
seq distance
False
chain
W
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
137.50685
seq distance
False
chain
W
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
137.75148
seq distance
False
chain
W
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
137.75148
seq distance
False
chain
W
MACPF
begin
117
end
488
score
94.98411534701859
distance
138.73178
seq distance
False
chain
R
MACPF
begin
117
end
488
score
94.98411534701859
distance
138.73178
seq distance
False
chain
R
EGF-like
begin
489
end
519
score
100.0
distance
139.0385
seq distance
False
chain
N
EGF-like
begin
489
end
519
score
100.0
distance
139.0385
seq distance
False
chain
N
LDL-receptor class A
begin
78
end
115
score
100.0
distance
139.04599
seq distance
False
chain
N
LDL-receptor class A
begin
78
end
115
score
100.0
distance
139.04599
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
139.69527
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
139.69527
seq distance
False
chain
N
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
139.71457
seq distance
False
chain
O
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
139.71457
seq distance
False
chain
O
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
140.10777
seq distance
False
chain
N
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
140.10777
seq distance
False
chain
N
EGF-like
begin
489
end
519
score
100.0
distance
140.2543
seq distance
False
chain
W
EGF-like
begin
489
end
519
score
100.0
distance
140.2543
seq distance
False
chain
W
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
140.35815
seq distance
False
chain
M
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
140.35815
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
140.75674
seq distance
False
chain
W
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
140.75674
seq distance
False
chain
W
MACPF
begin
117
end
488
score
94.98411534701859
distance
140.97287
seq distance
False
chain
U
MACPF
begin
117
end
488
score
94.98411534701859
distance
140.97287
seq distance
False
chain
U
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
141.4989
seq distance
False
chain
O
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
141.4989
seq distance
False
chain
O
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
141.76935
seq distance
False
chain
X
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
141.76935
seq distance
False
chain
X
LDL-receptor class A
begin
78
end
115
score
100.0
distance
141.76935
seq distance
False
chain
X
LDL-receptor class A
begin
78
end
115
score
100.0
distance
141.76935
seq distance
False
chain
X
MACPF
begin
117
end
488
score
94.98411534701859
distance
142.70692
seq distance
False
chain
S
MACPF
begin
117
end
488
score
94.98411534701859
distance
142.70692
seq distance
False
chain
S
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
143.03029
seq distance
False
chain
W
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
143.03029
seq distance
False
chain
W
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
143.21355
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
143.21355
seq distance
False
chain
O
MACPF
begin
117
end
488
score
94.98411534701859
distance
143.25215
seq distance
False
chain
T
MACPF
begin
117
end
488
score
94.98411534701859
distance
143.25215
seq distance
False
chain
T
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
144.00847
seq distance
False
chain
N
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
144.00847
seq distance
False
chain
N
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
144.82224
seq distance
False
chain
N
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
144.82224
seq distance
False
chain
N
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
144.88023
seq distance
False
chain
W
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
144.88023
seq distance
False
chain
W
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
145.44182
seq distance
False
chain
X
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
145.44182
seq distance
False
chain
X
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
146.60333
seq distance
False
chain
N
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
146.60333
seq distance
False
chain
N
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
148.06743
seq distance
False
chain
V
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
148.06743
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
148.33221
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
148.33221
seq distance
False
chain
V
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
150.59315
seq distance
False
chain
Q
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
150.59315
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
150.68398
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
150.68398
seq distance
False
chain
O
EGF-like
begin
489
end
519
score
100.0
distance
151.20375
seq distance
False
chain
O
EGF-like
begin
489
end
519
score
100.0
distance
151.20375
seq distance
False
chain
O
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
151.45894
seq distance
False
chain
W
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
151.45894
seq distance
False
chain
W
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
151.63995
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
151.63995
seq distance
False
chain
V
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
151.7945
seq distance
False
chain
Q
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
151.7945
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
152.16295
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
152.16295
seq distance
False
chain
Q
LDL-receptor class A
begin
78
end
115
score
100.0
distance
152.33105
seq distance
False
chain
O
LDL-receptor class A
begin
78
end
115
score
100.0
distance
152.33105
seq distance
False
chain
O
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
152.81808
seq distance
False
chain
X
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
152.81808
seq distance
False
chain
X
EGF-like
begin
489
end
519
score
100.0
distance
153.09088
seq distance
False
chain
V
EGF-like
begin
489
end
519
score
100.0
distance
153.09088
seq distance
False
chain
V
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
153.43869
seq distance
False
chain
O
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
153.43869
seq distance
False
chain
O
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
154.3231
seq distance
False
chain
V
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
154.3231
seq distance
False
chain
V
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
155.19946
seq distance
False
chain
U
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
155.19946
seq distance
False
chain
U
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
155.40762
seq distance
False
chain
W
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
155.40762
seq distance
False
chain
W
LDL-receptor class A
begin
78
end
115
score
100.0
distance
155.40762
seq distance
False
chain
W
LDL-receptor class A
begin
78
end
115
score
100.0
distance
155.40762
seq distance
False
chain
W
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
155.75941
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
155.75941
seq distance
False
chain
U
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
155.9918
seq distance
False
chain
N
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
155.9918
seq distance
False
chain
N
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
156.35881
seq distance
False
chain
W
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
156.35881
seq distance
False
chain
W
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
156.6975
seq distance
False
chain
R
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
156.6975
seq distance
False
chain
R
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
157.13367
seq distance
False
chain
O
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
157.13367
seq distance
False
chain
O
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
157.18094
seq distance
False
chain
O
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
157.18094
seq distance
False
chain
O
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
157.40666
seq distance
False
chain
O
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
157.40666
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
158.0592
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
158.0592
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
158.76926
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
158.76926
seq distance
False
chain
Q
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
159.11247
seq distance
False
chain
T
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
159.11247
seq distance
False
chain
T
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
159.5415
seq distance
False
chain
V
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
159.5415
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
159.55856
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
159.55856
seq distance
False
chain
U
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
159.61777
seq distance
False
chain
S
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
159.61777
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
160.00592
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
160.00592
seq distance
False
chain
T
EGF-like
begin
489
end
519
score
100.0
distance
160.15808
seq distance
False
chain
Q
EGF-like
begin
489
end
519
score
100.0
distance
160.15808
seq distance
False
chain
Q
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
1290
score
50.0
distance
160.6245
seq distance
False
chain
A
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
1290
score
50.0
distance
160.6245
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
160.82445
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
160.82445
seq distance
False
chain
S
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
160.89003
seq distance
False
chain
R
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
160.89003
seq distance
False
chain
R
EGF-like
begin
489
end
519
score
100.0
distance
161.55843
seq distance
False
chain
U
EGF-like
begin
489
end
519
score
100.0
distance
161.55843
seq distance
False
chain
U
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
162.37544
seq distance
False
chain
V
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
162.37544
seq distance
False
chain
V
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
162.72868
seq distance
False
chain
U
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
162.72868
seq distance
False
chain
U
LDL-receptor class A
begin
78
end
115
score
100.0
distance
162.98444
seq distance
False
chain
Q
LDL-receptor class A
begin
78
end
115
score
100.0
distance
162.98444
seq distance
False
chain
Q
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
163.59903
seq distance
False
chain
Q
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
163.59903
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
163.8303
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
163.8303
seq distance
False
chain
R
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
164.12813
seq distance
False
chain
V
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
164.12813
seq distance
False
chain
V
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
164.31665
seq distance
False
chain
Q
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
164.31665
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
164.45064
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
164.45064
seq distance
False
chain
T
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
164.60797
seq distance
False
chain
W
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
164.60797
seq distance
False
chain
W
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
165.34782
seq distance
False
chain
V
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
165.34782
seq distance
False
chain
V
LDL-receptor class A
begin
78
end
115
score
100.0
distance
165.34782
seq distance
False
chain
V
LDL-receptor class A
begin
78
end
115
score
100.0
distance
165.34782
seq distance
False
chain
V
EGF-like
begin
489
end
519
score
100.0
distance
165.80733
seq distance
False
chain
R
EGF-like
begin
489
end
519
score
100.0
distance
165.80733
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
165.92184
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
165.92184
seq distance
False
chain
S
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
166.51115
seq distance
False
chain
Q
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
166.51115
seq distance
False
chain
Q
EGF-like
begin
489
end
519
score
100.0
distance
166.66011
seq distance
False
chain
T
EGF-like
begin
489
end
519
score
100.0
distance
166.66011
seq distance
False
chain
T
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
166.85776
seq distance
False
chain
S
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
166.85776
seq distance
False
chain
S
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
167.93344
seq distance
False
chain
T
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
167.93344
seq distance
False
chain
T
EGF-like
begin
489
end
519
score
100.0
distance
168.07042
seq distance
False
chain
S
EGF-like
begin
489
end
519
score
100.0
distance
168.07042
seq distance
False
chain
S
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
168.08655
seq distance
False
chain
Q
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
168.08655
seq distance
False
chain
Q
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
168.52957
seq distance
False
chain
O
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
168.52957
seq distance
False
chain
O
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
168.62701
seq distance
False
chain
U
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
168.62701
seq distance
False
chain
U
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
168.74934
seq distance
False
chain
R
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
168.74934
seq distance
False
chain
R
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
169.47772
seq distance
False
chain
T
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
169.47772
seq distance
False
chain
T
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
169.83247
seq distance
False
chain
U
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
169.83247
seq distance
False
chain
U
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
169.98602
seq distance
False
chain
S
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
169.98602
seq distance
False
chain
S
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
170.4464
seq distance
False
chain
U
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
170.4464
seq distance
False
chain
U
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
170.50543
seq distance
False
chain
R
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
170.50543
seq distance
False
chain
R
LDL-receptor class A
begin
78
end
115
score
100.0
distance
170.80502
seq distance
False
chain
R
LDL-receptor class A
begin
78
end
115
score
100.0
distance
170.80502
seq distance
False
chain
R
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
172.23276
seq distance
False
chain
U
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
172.23276
seq distance
False
chain
U
LDL-receptor class A
begin
78
end
115
score
100.0
distance
172.23276
seq distance
False
chain
U
LDL-receptor class A
begin
78
end
115
score
100.0
distance
172.23276
seq distance
False
chain
U
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
1067
score
54.54545454545454
distance
172.54419
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
1067
score
54.54545454545454
distance
172.54419
seq distance
False
chain
A
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
172.85153
seq distance
False
chain
R
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
172.85153
seq distance
False
chain
R
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
173.64725
seq distance
False
chain
V
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
173.64725
seq distance
False
chain
V
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
173.73097
seq distance
False
chain
T
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
173.73097
seq distance
False
chain
T
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
173.91574
seq distance
False
chain
S
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
173.91574
seq distance
False
chain
S
LDL-receptor class A
begin
78
end
115
score
100.0
distance
175.40727
seq distance
False
chain
S
LDL-receptor class A
begin
78
end
115
score
100.0
distance
175.40727
seq distance
False
chain
S
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
175.79373
seq distance
False
chain
T
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
175.79373
seq distance
False
chain
T
LDL-receptor class A
begin
78
end
115
score
100.0
distance
175.79373
seq distance
False
chain
T
LDL-receptor class A
begin
78
end
115
score
100.0
distance
175.79373
seq distance
False
chain
T
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
175.87288
seq distance
False
chain
R
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
175.87288
seq distance
False
chain
R
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
175.9514
seq distance
False
chain
S
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
175.9514
seq distance
False
chain
S
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
176.51433
seq distance
False
chain
Q
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
176.51433
seq distance
False
chain
Q
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
177.96336
seq distance
False
chain
T
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
177.96336
seq distance
False
chain
T
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
179.42505
seq distance
False
chain
U
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
179.42505
seq distance
False
chain
U
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
180.40427
seq distance
False
chain
S
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
180.40427
seq distance
False
chain
S
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
180.85284
seq distance
False
chain
R
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
180.85284
seq distance
False
chain
R
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
181.37721
seq distance
False
chain
S
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
181.37721
seq distance
False
chain
S
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
181.6329
seq distance
False
chain
T
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
181.6329
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
671
score
54.54545454545454
distance
192.39824
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
671
score
54.54545454545454
distance
192.39824
seq distance
False
chain
D
Details
Redox score
77.21
PDB code
6h04
Structure name
closed conformation of the membrane attack complex
Structure deposition date
2018-07-06
Thiol separation (Å)
2.03
Half-sphere exposure sum
51
Minimum pKa
nan
% buried
nan
Peptide accession
P02748
Residue number A
530 (Residue 509 in this structure)
Residue number B
539 (Residue 518 in this structure)
Peptide name
Complement component C9
6h04 N 36 N 73
A redox-regulated disulphide may form within Complement component C9 at these cysteines.
Relevent regions
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
2.8091474
seq distance
0
chain
N
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
2.8091474
seq distance
0
chain
N
MACPF
begin
117
end
488
score
94.98411534701859
distance
9.4106245
seq distance
44
chain
N
MACPF
begin
117
end
488
score
94.98411534701859
distance
9.4106245
seq distance
44
chain
N
LDL-receptor class A
begin
78
end
115
score
100.0
distance
12.733119
seq distance
5
chain
N
LDL-receptor class A
begin
78
end
115
score
100.0
distance
12.733119
seq distance
5
chain
N
MACPF
begin
117
end
488
score
94.98411534701859
distance
16.27148
seq distance
False
chain
O
MACPF
begin
117
end
488
score
94.98411534701859
distance
16.27148
seq distance
False
chain
O
LDL-receptor class A
begin
78
end
115
score
100.0
distance
16.642502
seq distance
False
chain
O
LDL-receptor class A
begin
78
end
115
score
100.0
distance
16.642502
seq distance
False
chain
O
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
19.25177
seq distance
False
chain
M
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
19.25177
seq distance
False
chain
M
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
29.097847
seq distance
False
chain
O
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
29.097847
seq distance
False
chain
O
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
30.739988
seq distance
False
chain
O
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
30.739988
seq distance
False
chain
O
MACPF
begin
117
end
488
score
94.98411534701859
distance
30.771
seq distance
False
chain
M
MACPF
begin
117
end
488
score
94.98411534701859
distance
30.771
seq distance
False
chain
M
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
31.276648
seq distance
33
chain
N
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
31.276648
seq distance
33
chain
N
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
33.968113
seq distance
73
chain
N
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
33.968113
seq distance
73
chain
N
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
34.13681
seq distance
25
chain
N
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
34.13681
seq distance
25
chain
N
EGF-like
begin
489
end
519
score
100.0
distance
35.66062
seq distance
416
chain
N
EGF-like
begin
489
end
519
score
100.0
distance
35.66062
seq distance
416
chain
N
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
35.81626
seq distance
False
chain
O
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
35.81626
seq distance
False
chain
O
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
37.01644
seq distance
False
chain
O
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
37.01644
seq distance
False
chain
O
MACPF
begin
117
end
488
score
94.98411534701859
distance
37.72314
seq distance
False
chain
Q
MACPF
begin
117
end
488
score
94.98411534701859
distance
37.72314
seq distance
False
chain
Q
LDL-receptor class A
begin
78
end
115
score
100.0
distance
38.79512
seq distance
False
chain
M
LDL-receptor class A
begin
78
end
115
score
100.0
distance
38.79512
seq distance
False
chain
M
LDL-receptor class A
begin
78
end
115
score
100.0
distance
38.835735
seq distance
False
chain
Q
LDL-receptor class A
begin
78
end
115
score
100.0
distance
38.835735
seq distance
False
chain
Q
EGF-like
begin
489
end
519
score
100.0
distance
39.24447
seq distance
False
chain
M
EGF-like
begin
489
end
519
score
100.0
distance
39.24447
seq distance
False
chain
M
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
40.11915
seq distance
False
chain
O
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
40.11915
seq distance
False
chain
O
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
44.50742
seq distance
109
chain
N
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
44.50742
seq distance
109
chain
N
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
44.82212
seq distance
False
chain
Q
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
44.82212
seq distance
False
chain
Q
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
45.339417
seq distance
False
chain
M
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
45.339417
seq distance
False
chain
M
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
47.020355
seq distance
False
chain
M
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
47.020355
seq distance
False
chain
M
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
47.607883
seq distance
False
chain
Q
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
47.607883
seq distance
False
chain
Q
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
49.919277
seq distance
False
chain
L
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
49.919277
seq distance
False
chain
L
EGF-like
begin
489
end
519
score
100.0
distance
51.147057
seq distance
False
chain
O
EGF-like
begin
489
end
519
score
100.0
distance
51.147057
seq distance
False
chain
O
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
53.86941
seq distance
333
chain
N
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
53.86941
seq distance
333
chain
N
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
53.9907
seq distance
False
chain
M
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
53.9907
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
55.19853
seq distance
332
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
55.19853
seq distance
332
chain
N
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
56.627636
seq distance
False
chain
Q
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
56.627636
seq distance
False
chain
Q
MACPF
begin
117
end
488
score
94.98411534701859
distance
58.02875
seq distance
False
chain
L
MACPF
begin
117
end
488
score
94.98411534701859
distance
58.02875
seq distance
False
chain
L
EGF-like
begin
489
end
519
score
100.0
distance
58.3242
seq distance
False
chain
L
EGF-like
begin
489
end
519
score
100.0
distance
58.3242
seq distance
False
chain
L
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
58.625
seq distance
False
chain
O
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
58.625
seq distance
False
chain
O
MACPF
begin
117
end
488
score
94.98411534701859
distance
59.58292
seq distance
False
chain
R
MACPF
begin
117
end
488
score
94.98411534701859
distance
59.58292
seq distance
False
chain
R
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
59.629475
seq distance
False
chain
Q
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
59.629475
seq distance
False
chain
Q
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
60.264458
seq distance
False
chain
M
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
60.264458
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
60.595253
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
60.595253
seq distance
False
chain
M
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
60.664867
seq distance
False
chain
Q
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
60.664867
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
60.817265
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
60.817265
seq distance
False
chain
O
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
63.54932
seq distance
False
chain
M
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
63.54932
seq distance
False
chain
M
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
64.10033
seq distance
False
chain
R
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
64.10033
seq distance
False
chain
R
LDL-receptor class A
begin
78
end
115
score
100.0
distance
65.28675
seq distance
False
chain
L
LDL-receptor class A
begin
78
end
115
score
100.0
distance
65.28675
seq distance
False
chain
L
LDL-receptor class A
begin
78
end
115
score
100.0
distance
65.46389
seq distance
False
chain
R
LDL-receptor class A
begin
78
end
115
score
100.0
distance
65.46389
seq distance
False
chain
R
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
67.369095
seq distance
False
chain
L
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
67.369095
seq distance
False
chain
L
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
68.532646
seq distance
False
chain
L
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
68.532646
seq distance
False
chain
L
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
71.01428
seq distance
False
chain
R
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
71.01428
seq distance
False
chain
R
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
72.14299
seq distance
False
chain
Q
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
72.14299
seq distance
False
chain
Q
EGF-like
begin
489
end
519
score
100.0
distance
73.025276
seq distance
False
chain
Q
EGF-like
begin
489
end
519
score
100.0
distance
73.025276
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
74.31883
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
74.31883
seq distance
False
chain
L
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
74.599686
seq distance
False
chain
L
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
74.599686
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
74.81043
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
74.81043
seq distance
False
chain
Q
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
76.152534
seq distance
False
chain
K
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
76.152534
seq distance
False
chain
K
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
77.75677
seq distance
False
chain
L
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
77.75677
seq distance
False
chain
L
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
79.52061
seq distance
False
chain
R
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
79.52061
seq distance
False
chain
R
MACPF
begin
117
end
488
score
94.98411534701859
distance
80.53144
seq distance
False
chain
S
MACPF
begin
117
end
488
score
94.98411534701859
distance
80.53144
seq distance
False
chain
S
EGF-like
begin
489
end
519
score
100.0
distance
82.17928
seq distance
False
chain
K
EGF-like
begin
489
end
519
score
100.0
distance
82.17928
seq distance
False
chain
K
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
82.72976
seq distance
False
chain
R
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
82.72976
seq distance
False
chain
R
MACPF
begin
117
end
488
score
94.98411534701859
distance
85.01368
seq distance
False
chain
K
MACPF
begin
117
end
488
score
94.98411534701859
distance
85.01368
seq distance
False
chain
K
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
85.45102
seq distance
False
chain
L
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
85.45102
seq distance
False
chain
L
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
86.11479
seq distance
False
chain
S
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
86.11479
seq distance
False
chain
S
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
89.79917
seq distance
False
chain
R
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
89.79917
seq distance
False
chain
R
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
90.47638
seq distance
False
chain
K
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
90.47638
seq distance
False
chain
K
LDL-receptor class A
begin
78
end
115
score
100.0
distance
90.47638
seq distance
False
chain
K
LDL-receptor class A
begin
78
end
115
score
100.0
distance
90.47638
seq distance
False
chain
K
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
91.30962
seq distance
False
chain
R
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
91.30962
seq distance
False
chain
R
LDL-receptor class A
begin
78
end
115
score
100.0
distance
91.60606
seq distance
False
chain
S
LDL-receptor class A
begin
78
end
115
score
100.0
distance
91.60606
seq distance
False
chain
S
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
91.80381
seq distance
False
chain
K
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
91.80381
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
92.097496
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
92.097496
seq distance
False
chain
K
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
92.600586
seq distance
False
chain
K
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
92.600586
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
92.63764
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
92.63764
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
93.92563
seq distance
189
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
93.92563
seq distance
189
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
95.04584
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
95.04584
seq distance
False
chain
M
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
95.0838
seq distance
False
chain
S
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
95.0838
seq distance
False
chain
S
EGF-like
begin
489
end
519
score
100.0
distance
96.08825
seq distance
False
chain
R
EGF-like
begin
489
end
519
score
100.0
distance
96.08825
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
99.09266
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
99.09266
seq distance
False
chain
O
MACPF
begin
117
end
488
score
94.98411534701859
distance
100.665985
seq distance
False
chain
T
MACPF
begin
117
end
488
score
94.98411534701859
distance
100.665985
seq distance
False
chain
T
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
101.034836
seq distance
False
chain
J
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
101.034836
seq distance
False
chain
J
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
101.566444
seq distance
False
chain
K
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
101.566444
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
102.297745
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
102.297745
seq distance
False
chain
L
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
102.333084
seq distance
False
chain
S
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
102.333084
seq distance
False
chain
S
MACPF
begin
117
end
488
score
94.98411534701859
distance
104.22818
seq distance
False
chain
J
MACPF
begin
117
end
488
score
94.98411534701859
distance
104.22818
seq distance
False
chain
J
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
105.59446
seq distance
False
chain
M
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
105.59446
seq distance
False
chain
M
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
105.78315
seq distance
False
chain
S
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
105.78315
seq distance
False
chain
S
EGF-like
begin
489
end
519
score
100.0
distance
105.960365
seq distance
False
chain
J
EGF-like
begin
489
end
519
score
100.0
distance
105.960365
seq distance
False
chain
J
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
106.14508
seq distance
185
chain
N
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
106.14508
seq distance
185
chain
N
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
107.34917
seq distance
False
chain
K
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
107.34917
seq distance
False
chain
K
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
107.91744
seq distance
False
chain
T
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
107.91744
seq distance
False
chain
T
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
108.464836
seq distance
False
chain
S
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
108.464836
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
109.54687
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
109.54687
seq distance
False
chain
Q
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
110.81522
seq distance
False
chain
L
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
110.81522
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
110.958565
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
110.958565
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
111.26238
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
111.26238
seq distance
False
chain
S
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
111.449234
seq distance
False
chain
J
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
111.449234
seq distance
False
chain
J
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
111.9985
seq distance
False
chain
O
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
111.9985
seq distance
False
chain
O
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
113.15522
seq distance
False
chain
J
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
113.15522
seq distance
False
chain
J
LDL-receptor class A
begin
78
end
115
score
100.0
distance
113.15522
seq distance
False
chain
J
LDL-receptor class A
begin
78
end
115
score
100.0
distance
113.15522
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
114.08874
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
114.08874
seq distance
False
chain
K
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
114.520515
seq distance
False
chain
J
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
114.520515
seq distance
False
chain
J
LDL-receptor class A
begin
78
end
115
score
100.0
distance
114.7235
seq distance
False
chain
T
LDL-receptor class A
begin
78
end
115
score
100.0
distance
114.7235
seq distance
False
chain
T
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
118.10715
seq distance
False
chain
T
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
118.10715
seq distance
False
chain
T
EGF-like
begin
489
end
519
score
100.0
distance
118.43704
seq distance
False
chain
S
EGF-like
begin
489
end
519
score
100.0
distance
118.43704
seq distance
False
chain
S
MACPF
begin
117
end
488
score
94.98411534701859
distance
118.81444
seq distance
False
chain
U
MACPF
begin
117
end
488
score
94.98411534701859
distance
118.81444
seq distance
False
chain
U
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
120.107445
seq distance
False
chain
S
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
120.107445
seq distance
False
chain
S
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
120.73524
seq distance
False
chain
K
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
120.73524
seq distance
False
chain
K
MACPF
begin
117
end
488
score
94.98411534701859
distance
121.135376
seq distance
False
chain
I
MACPF
begin
117
end
488
score
94.98411534701859
distance
121.135376
seq distance
False
chain
I
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
122.3477
seq distance
False
chain
Q
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
122.3477
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
123.11307
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
123.11307
seq distance
False
chain
R
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
123.892166
seq distance
False
chain
T
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
123.892166
seq distance
False
chain
T
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
124.076294
seq distance
False
chain
J
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
124.076294
seq distance
False
chain
J
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
125.08973
seq distance
False
chain
I
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
125.08973
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
126.46368
seq distance
False
chain
T
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
126.46368
seq distance
False
chain
T
EGF-like
begin
489
end
519
score
100.0
distance
127.168785
seq distance
False
chain
I
EGF-like
begin
489
end
519
score
100.0
distance
127.168785
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
127.45554
seq distance
False
chain
T
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
127.45554
seq distance
False
chain
T
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
127.98943
seq distance
False
chain
J
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
127.98943
seq distance
False
chain
J
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
128.38931
seq distance
False
chain
U
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
128.38931
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
128.42296
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
128.42296
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
129.24614
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
129.24614
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
129.27536
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
129.27536
seq distance
False
chain
T
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
129.59702
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
129.59702
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
133.87614
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
133.87614
seq distance
False
chain
I
LDL-receptor class A
begin
78
end
115
score
100.0
distance
133.87614
seq distance
False
chain
I
LDL-receptor class A
begin
78
end
115
score
100.0
distance
133.87614
seq distance
False
chain
I
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
134.04213
seq distance
False
chain
J
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
134.04213
seq distance
False
chain
J
MACPF
begin
117
end
488
score
94.98411534701859
distance
135.3547
seq distance
False
chain
V
MACPF
begin
117
end
488
score
94.98411534701859
distance
135.3547
seq distance
False
chain
V
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
135.36813
seq distance
False
chain
R
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
135.36813
seq distance
False
chain
R
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
135.59526
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
135.59526
seq distance
False
chain
I
LDL-receptor class A
begin
78
end
115
score
100.0
distance
135.65662
seq distance
False
chain
U
LDL-receptor class A
begin
78
end
115
score
100.0
distance
135.65662
seq distance
False
chain
U
MACPF
begin
117
end
488
score
94.98411534701859
distance
136.85844
seq distance
False
chain
H
MACPF
begin
117
end
488
score
94.98411534701859
distance
136.85844
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
137.9437
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
137.9437
seq distance
False
chain
S
EGF-like
begin
489
end
519
score
100.0
distance
138.66202
seq distance
False
chain
T
EGF-like
begin
489
end
519
score
100.0
distance
138.66202
seq distance
False
chain
T
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
139.05777
seq distance
False
chain
U
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
139.05777
seq distance
False
chain
U
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
142.87498
seq distance
False
chain
U
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
142.87498
seq distance
False
chain
U
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
143.30627
seq distance
False
chain
U
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
143.30627
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
143.49614
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
143.49614
seq distance
False
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
144.57585
seq distance
False
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
144.57585
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
145.60117
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
145.60117
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
146.35236
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
146.35236
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
146.40565
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
146.40565
seq distance
False
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
146.47127
seq distance
False
chain
T
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
146.47127
seq distance
False
chain
T
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
146.53876
seq distance
False
chain
V
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
146.53876
seq distance
False
chain
V
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
146.61134
seq distance
False
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
146.61134
seq distance
False
chain
I
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
146.6287
seq distance
False
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
146.6287
seq distance
False
chain
H
EGF-like
begin
489
end
519
score
100.0
distance
146.83156
seq distance
False
chain
H
EGF-like
begin
489
end
519
score
100.0
distance
146.83156
seq distance
False
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
146.85365
seq distance
False
chain
U
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
146.85365
seq distance
False
chain
U
MACPF
begin
117
end
488
score
94.98411534701859
distance
147.36588
seq distance
False
chain
W
MACPF
begin
117
end
488
score
94.98411534701859
distance
147.36588
seq distance
False
chain
W
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
147.79666
seq distance
False
chain
I
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
147.79666
seq distance
False
chain
I
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
149.39409
seq distance
False
chain
S
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
149.39409
seq distance
False
chain
S
MACPF
begin
117
end
488
score
94.98411534701859
distance
150.80502
seq distance
False
chain
P
MACPF
begin
117
end
488
score
94.98411534701859
distance
150.80502
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
152.4645
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
152.4645
seq distance
False
chain
T
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
152.48996
seq distance
False
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
152.48996
seq distance
False
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
152.48996
seq distance
False
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
152.48996
seq distance
False
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
153.5336
seq distance
False
chain
V
LDL-receptor class A
begin
78
end
115
score
100.0
distance
153.5336
seq distance
False
chain
V
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
154.53992
seq distance
False
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
154.53992
seq distance
False
chain
H
EGF-like
begin
489
end
519
score
100.0
distance
155.37068
seq distance
False
chain
U
EGF-like
begin
489
end
519
score
100.0
distance
155.37068
seq distance
False
chain
U
MACPF
begin
117
end
488
score
94.98411534701859
distance
155.47845
seq distance
False
chain
X
MACPF
begin
117
end
488
score
94.98411534701859
distance
155.47845
seq distance
False
chain
X
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
157.00356
seq distance
False
chain
V
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
157.00356
seq distance
False
chain
V
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
157.32121
seq distance
False
chain
V
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
157.32121
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
158.79897
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
158.79897
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
159.5728
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
159.5728
seq distance
False
chain
V
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
159.97188
seq distance
False
chain
V
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
159.97188
seq distance
False
chain
V
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
161.16846
seq distance
False
chain
P
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
161.16846
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
161.42589
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
161.42589
seq distance
False
chain
P
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
161.87238
seq distance
False
chain
W
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
161.87238
seq distance
False
chain
W
MACPF
begin
117
end
488
score
94.98411534701859
distance
162.30971
seq distance
False
chain
G
MACPF
begin
117
end
488
score
94.98411534701859
distance
162.30971
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
162.4219
seq distance
False
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
162.4219
seq distance
False
chain
H
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
162.66066
seq distance
False
chain
H
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
162.66066
seq distance
False
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
162.85196
seq distance
False
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
162.85196
seq distance
False
chain
H
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
162.93602
seq distance
False
chain
T
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
162.93602
seq distance
False
chain
T
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
163.45627
seq distance
False
chain
V
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
163.45627
seq distance
False
chain
V
EGF-like
begin
489
end
519
score
100.0
distance
164.52678
seq distance
False
chain
P
EGF-like
begin
489
end
519
score
100.0
distance
164.52678
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
165.92162
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
165.92162
seq distance
False
chain
U
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
165.94293
seq distance
False
chain
P
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
165.94293
seq distance
False
chain
P
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
168.0798
seq distance
False
chain
W
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
168.0798
seq distance
False
chain
W
LDL-receptor class A
begin
78
end
115
score
100.0
distance
168.2313
seq distance
False
chain
W
LDL-receptor class A
begin
78
end
115
score
100.0
distance
168.2313
seq distance
False
chain
W
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
168.27698
seq distance
False
chain
P
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
168.27698
seq distance
False
chain
P
LDL-receptor class A
begin
78
end
115
score
100.0
distance
168.27698
seq distance
False
chain
P
LDL-receptor class A
begin
78
end
115
score
100.0
distance
168.27698
seq distance
False
chain
P
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
168.33339
seq distance
False
chain
U
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
168.33339
seq distance
False
chain
U
EGF-like
begin
489
end
519
score
100.0
distance
169.48222
seq distance
False
chain
V
EGF-like
begin
489
end
519
score
100.0
distance
169.48222
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
170.43466
seq distance
False
chain
W
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
170.43466
seq distance
False
chain
W
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
170.80223
seq distance
False
chain
P
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
170.80223
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
171.9304
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
171.9304
seq distance
False
chain
G
LDL-receptor class A
begin
151
end
170
score
51.590909090909086
distance
171.93124
seq distance
False
chain
B
LDL-receptor class A
begin
151
end
170
score
51.590909090909086
distance
171.93124
seq distance
False
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
171.98947
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
171.98947
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
172.30664
seq distance
False
chain
W
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
172.30664
seq distance
False
chain
W
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
172.8693
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
172.8693
seq distance
False
chain
P
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
173.27457
seq distance
False
chain
W
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
173.27457
seq distance
False
chain
W
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
174.14824
seq distance
False
chain
X
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
174.14824
seq distance
False
chain
X
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
158
score
63.63636363636363
distance
175.41585
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
158
score
63.63636363636363
distance
175.41585
seq distance
False
chain
B
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
175.519
seq distance
False
chain
U
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
175.519
seq distance
False
chain
U
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
176.01488
seq distance
False
chain
X
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
176.01488
seq distance
False
chain
X
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
176.39896
seq distance
False
chain
P
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
176.39896
seq distance
False
chain
P
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
176.59581
seq distance
False
chain
W
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
176.59581
seq distance
False
chain
W
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
176.72406
seq distance
False
chain
P
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
176.72406
seq distance
False
chain
P
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
442
score
50.0
distance
176.78969
seq distance
False
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
442
score
50.0
distance
176.78969
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
177.33365
seq distance
False
chain
P
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
177.33365
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
177.40184
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
177.40184
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
178.08107
seq distance
False
chain
X
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
178.08107
seq distance
False
chain
X
LDL-receptor class A
begin
78
end
115
score
100.0
distance
179.08992
seq distance
False
chain
X
LDL-receptor class A
begin
78
end
115
score
100.0
distance
179.08992
seq distance
False
chain
X
EGF-like
begin
489
end
519
score
100.0
distance
179.1199
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
100.0
distance
179.1199
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
100.0
distance
180.37897
seq distance
False
chain
W
EGF-like
begin
489
end
519
score
100.0
distance
180.37897
seq distance
False
chain
W
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
180.93246
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
180.93246
seq distance
False
chain
G
LDL-receptor class A
begin
78
end
115
score
100.0
distance
180.93246
seq distance
False
chain
G
LDL-receptor class A
begin
78
end
115
score
100.0
distance
180.93246
seq distance
False
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
181.96506
seq distance
False
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
181.96506
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
182.57573
seq distance
False
chain
X
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
182.57573
seq distance
False
chain
X
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
183.33606
seq distance
False
chain
X
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
183.33606
seq distance
False
chain
X
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
166
score
77.27272727272727
distance
183.69489
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
166
score
77.27272727272727
distance
183.69489
seq distance
False
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
391
score
68.18181818181817
distance
183.7108
seq distance
False
chain
F
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
391
score
68.18181818181817
distance
183.7108
seq distance
False
chain
F
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
183.77216
seq distance
False
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
183.77216
seq distance
False
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
183.8849
seq distance
False
chain
V
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
183.8849
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
184.1944
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
184.1944
seq distance
False
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
186.17763
seq distance
False
chain
X
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
186.17763
seq distance
False
chain
X
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
186.32065
seq distance
False
chain
V
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
186.32065
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
186.33347
seq distance
False
chain
W
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
186.33347
seq distance
False
chain
W
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
187.06793
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
187.06793
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
100.0
distance
187.6989
seq distance
False
chain
X
EGF-like
begin
489
end
519
score
100.0
distance
187.6989
seq distance
False
chain
X
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
187.77472
seq distance
False
chain
G
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
187.77472
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
370
score
68.18181818181817
distance
188.37912
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
370
score
68.18181818181817
distance
188.37912
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
188.70972
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
188.70972
seq distance
False
chain
G
LDL-receptor class A
begin
83
end
96
score
70.12987012987013
distance
188.72128
seq distance
False
chain
C
LDL-receptor class A
begin
83
end
96
score
70.12987012987013
distance
188.72128
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
103
score
59.09090909090909
distance
188.95828
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
103
score
59.09090909090909
distance
188.95828
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
192.39691
seq distance
False
chain
X
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
192.39691
seq distance
False
chain
X
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
86
score
72.72727272727273
distance
193.04988
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
86
score
72.72727272727273
distance
193.04988
seq distance
False
chain
C
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
194.31712
seq distance
False
chain
W
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
194.31712
seq distance
False
chain
W
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
195.27754
seq distance
False
chain
W
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
195.27754
seq distance
False
chain
W
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
94
score
81.81818181818183
distance
195.60974
seq distance
False
chain
C
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
94
score
81.81818181818183
distance
195.60974
seq distance
False
chain
C
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
93
score
77.27272727272727
distance
198.2594
seq distance
False
chain
F
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
93
score
77.27272727272727
distance
198.2594
seq distance
False
chain
F
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
85
score
72.72727272727273
distance
198.76353
seq distance
False
chain
F
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
85
score
72.72727272727273
distance
198.76353
seq distance
False
chain
F
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
199.31653
seq distance
False
chain
X
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
199.31653
seq distance
False
chain
X
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
201.25389
seq distance
False
chain
X
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
201.25389
seq distance
False
chain
X
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
1290
score
50.0
distance
209.14241
seq distance
False
chain
A
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
1290
score
50.0
distance
209.14241
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
1067
score
54.54545454545454
distance
209.31676
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
1067
score
54.54545454545454
distance
209.31676
seq distance
False
chain
A
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
226
score
50.0
distance
219.2817
seq distance
False
chain
F
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
226
score
50.0
distance
219.2817
seq distance
False
chain
F
TSP type-1
begin
507
end
507
score
88.63636363636364
distance
222.23837
seq distance
False
chain
D
TSP type-1
begin
507
end
507
score
88.63636363636364
distance
222.23837
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
671
score
54.54545454545454
distance
255.2628
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
671
score
54.54545454545454
distance
255.2628
seq distance
False
chain
D
Details
Redox score
76.92
PDB code
6h04
Structure name
closed conformation of the membrane attack complex
Structure deposition date
2018-07-06
Thiol separation (Å)
2.03
Half-sphere exposure sum
38
Minimum pKa
nan
% buried
nan
Peptide accession
P02748
Residue number A
57 (Residue 36 in this structure)
Residue number B
94 (Residue 73 in this structure)
Peptide name
Complement component C9
6dlw G 98 G 113
A redox-regulated disulphide may form within Complement component C9 at these cysteines.
Relevent regions
LDL-receptor class A
begin
78
end
115
score
100.0
distance
2.7786887
seq distance
0
chain
G
LDL-receptor class A
begin
78
end
115
score
100.0
distance
2.7786887
seq distance
0
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
2.8106897
seq distance
0
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
2.8106897
seq distance
0
chain
G
MACPF
begin
117
end
488
score
87.6099706744868
distance
6.5157804
seq distance
4
chain
G
MACPF
begin
117
end
488
score
87.6099706744868
distance
6.5157804
seq distance
4
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
13.859589
seq distance
7
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
13.859589
seq distance
7
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
16.858831
seq distance
False
chain
F
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
16.858831
seq distance
False
chain
F
LDL-receptor class A
begin
78
end
115
score
100.0
distance
16.858831
seq distance
False
chain
F
LDL-receptor class A
begin
78
end
115
score
100.0
distance
16.858831
seq distance
False
chain
F
MACPF
begin
117
end
488
score
87.6099706744868
distance
17.684896
seq distance
False
chain
H
MACPF
begin
117
end
488
score
87.6099706744868
distance
17.684896
seq distance
False
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
21.375645
seq distance
False
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
21.375645
seq distance
False
chain
H
MACPF
begin
117
end
488
score
87.6099706744868
distance
23.26764
seq distance
False
chain
F
MACPF
begin
117
end
488
score
87.6099706744868
distance
23.26764
seq distance
False
chain
F
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
23.972214
seq distance
False
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
23.972214
seq distance
False
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
24.961218
seq distance
False
chain
F
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
24.961218
seq distance
False
chain
F
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
30.359684
seq distance
False
chain
F
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
30.359684
seq distance
False
chain
F
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
33.184597
seq distance
69
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
33.184597
seq distance
69
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
34.77083
seq distance
False
chain
F
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
34.77083
seq distance
False
chain
F
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
35.05825
seq distance
24
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
35.05825
seq distance
24
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
35.225918
seq distance
False
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
35.225918
seq distance
False
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
35.834656
seq distance
33
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
35.834656
seq distance
33
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
36.406025
seq distance
False
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
36.406025
seq distance
False
chain
H
MACPF
begin
117
end
488
score
87.6099706744868
distance
37.48405
seq distance
False
chain
I
MACPF
begin
117
end
488
score
87.6099706744868
distance
37.48405
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
39.648064
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
39.648064
seq distance
False
chain
E
LDL-receptor class A
begin
78
end
115
score
100.0
distance
39.648064
seq distance
False
chain
E
LDL-receptor class A
begin
78
end
115
score
100.0
distance
39.648064
seq distance
False
chain
E
MACPF
begin
117
end
488
score
87.6099706744868
distance
42.310623
seq distance
False
chain
E
MACPF
begin
117
end
488
score
87.6099706744868
distance
42.310623
seq distance
False
chain
E
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
42.34817
seq distance
False
chain
E
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
42.34817
seq distance
False
chain
E
LDL-receptor class A
begin
78
end
115
score
100.0
distance
44.96968
seq distance
False
chain
I
LDL-receptor class A
begin
78
end
115
score
100.0
distance
44.96968
seq distance
False
chain
I
EGF-like
begin
489
end
519
score
99.12023460410556
distance
45.201668
seq distance
False
chain
F
EGF-like
begin
489
end
519
score
99.12023460410556
distance
45.201668
seq distance
False
chain
F
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
45.51062
seq distance
False
chain
F
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
45.51062
seq distance
False
chain
F
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
47.954502
seq distance
False
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
47.954502
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
48.335693
seq distance
False
chain
E
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
48.335693
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
48.712406
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
48.712406
seq distance
False
chain
E
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
49.75972
seq distance
False
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
49.75972
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
50.5453
seq distance
False
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
50.5453
seq distance
False
chain
H
EGF-like
begin
489
end
519
score
99.12023460410556
distance
51.78924
seq distance
False
chain
E
EGF-like
begin
489
end
519
score
99.12023460410556
distance
51.78924
seq distance
False
chain
E
EGF-like
begin
489
end
519
score
99.12023460410556
distance
52.005177
seq distance
376
chain
G
EGF-like
begin
489
end
519
score
99.12023460410556
distance
52.005177
seq distance
376
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
53.73248
seq distance
False
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
53.73248
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
54.192287
seq distance
False
chain
F
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
54.192287
seq distance
False
chain
F
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
55.114452
seq distance
293
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
55.114452
seq distance
293
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
56.51676
seq distance
False
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
56.51676
seq distance
False
chain
F
MACPF
begin
117
end
488
score
87.6099706744868
distance
57.64219
seq distance
False
chain
J
MACPF
begin
117
end
488
score
87.6099706744868
distance
57.64219
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
58.001392
seq distance
292
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
58.001392
seq distance
292
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
59.9168
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
59.9168
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
61.84684
seq distance
False
chain
E
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
61.84684
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
62.800095
seq distance
False
chain
D
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
62.800095
seq distance
False
chain
D
LDL-receptor class A
begin
78
end
115
score
100.0
distance
62.800095
seq distance
False
chain
D
LDL-receptor class A
begin
78
end
115
score
100.0
distance
62.800095
seq distance
False
chain
D
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
63.168823
seq distance
False
chain
D
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
63.168823
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
63.54397
seq distance
False
chain
E
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
63.54397
seq distance
False
chain
E
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
63.82431
seq distance
False
chain
E
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
63.82431
seq distance
False
chain
E
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
64.172264
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
64.172264
seq distance
False
chain
H
MACPF
begin
117
end
488
score
87.6099706744868
distance
64.27695
seq distance
False
chain
D
MACPF
begin
117
end
488
score
87.6099706744868
distance
64.27695
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
67.32872
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
67.32872
seq distance
False
chain
H
EGF-like
begin
489
end
519
score
99.12023460410556
distance
67.588295
seq distance
False
chain
D
EGF-like
begin
489
end
519
score
99.12023460410556
distance
67.588295
seq distance
False
chain
D
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
67.61753
seq distance
False
chain
D
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
67.61753
seq distance
False
chain
D
EGF-like
begin
489
end
519
score
99.12023460410556
distance
67.78623
seq distance
False
chain
H
EGF-like
begin
489
end
519
score
99.12023460410556
distance
67.78623
seq distance
False
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
67.859535
seq distance
False
chain
J
LDL-receptor class A
begin
78
end
115
score
100.0
distance
67.859535
seq distance
False
chain
J
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
68.62314
seq distance
False
chain
J
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
68.62314
seq distance
False
chain
J
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
70.10263
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
70.10263
seq distance
False
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
71.027596
seq distance
False
chain
J
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
71.027596
seq distance
False
chain
J
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
71.57579
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
71.57579
seq distance
False
chain
D
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
75.01792
seq distance
False
chain
D
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
75.01792
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
76.320366
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
76.320366
seq distance
False
chain
D
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
77.48674
seq distance
False
chain
I
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
77.48674
seq distance
False
chain
I
MACPF
begin
117
end
488
score
87.6099706744868
distance
77.58502
seq distance
False
chain
K
MACPF
begin
117
end
488
score
87.6099706744868
distance
77.58502
seq distance
False
chain
K
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
78.01502
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
78.01502
seq distance
False
chain
I
MACPF
begin
117
end
488
score
87.6099706744868
distance
80.333466
seq distance
False
chain
C
MACPF
begin
117
end
488
score
87.6099706744868
distance
80.333466
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
81.24964
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
81.24964
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
82.49393
seq distance
False
chain
J
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
82.49393
seq distance
False
chain
J
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
83.12805
seq distance
False
chain
D
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
83.12805
seq distance
False
chain
D
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
85.02809
seq distance
False
chain
C
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
85.02809
seq distance
False
chain
C
LDL-receptor class A
begin
78
end
115
score
100.0
distance
85.02809
seq distance
False
chain
C
LDL-receptor class A
begin
78
end
115
score
100.0
distance
85.02809
seq distance
False
chain
C
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
85.06998
seq distance
False
chain
C
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
85.06998
seq distance
False
chain
C
EGF-like
begin
489
end
519
score
99.12023460410556
distance
86.358215
seq distance
False
chain
I
EGF-like
begin
489
end
519
score
99.12023460410556
distance
86.358215
seq distance
False
chain
I
EGF-like
begin
489
end
519
score
99.12023460410556
distance
86.890755
seq distance
False
chain
C
EGF-like
begin
489
end
519
score
99.12023460410556
distance
86.890755
seq distance
False
chain
C
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
87.802734
seq distance
False
chain
C
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
87.802734
seq distance
False
chain
C
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
88.07893
seq distance
False
chain
K
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
88.07893
seq distance
False
chain
K
LDL-receptor class A
begin
78
end
115
score
100.0
distance
89.39875
seq distance
False
chain
K
LDL-receptor class A
begin
78
end
115
score
100.0
distance
89.39875
seq distance
False
chain
K
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
90.41827
seq distance
False
chain
J
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
90.41827
seq distance
False
chain
J
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
90.55725
seq distance
False
chain
C
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
90.55725
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
91.713806
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
91.713806
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
92.654945
seq distance
False
chain
K
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
92.654945
seq distance
False
chain
K
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
93.03553
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
93.03553
seq distance
False
chain
C
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
93.734474
seq distance
False
chain
J
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
93.734474
seq distance
False
chain
J
MACPF
begin
117
end
488
score
87.6099706744868
distance
95.59319
seq distance
False
chain
B
MACPF
begin
117
end
488
score
87.6099706744868
distance
95.59319
seq distance
False
chain
B
MACPF
begin
117
end
488
score
87.6099706744868
distance
96.358826
seq distance
False
chain
L
MACPF
begin
117
end
488
score
87.6099706744868
distance
96.358826
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
96.98242
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
96.98242
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
99.75765
seq distance
False
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
99.75765
seq distance
False
chain
F
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
101.64768
seq distance
False
chain
J
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
101.64768
seq distance
False
chain
J
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
101.8395
seq distance
False
chain
C
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
101.8395
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
102.03115
seq distance
149
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
102.03115
seq distance
149
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
102.42137
seq distance
False
chain
E
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
102.42137
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
103.47488
seq distance
False
chain
K
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
103.47488
seq distance
False
chain
K
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
105.63834
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
105.63834
seq distance
False
chain
B
LDL-receptor class A
begin
78
end
115
score
100.0
distance
105.63834
seq distance
False
chain
B
LDL-receptor class A
begin
78
end
115
score
100.0
distance
105.63834
seq distance
False
chain
B
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
105.71951
seq distance
False
chain
B
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
105.71951
seq distance
False
chain
B
EGF-like
begin
489
end
519
score
99.12023460410556
distance
105.74211
seq distance
False
chain
J
EGF-like
begin
489
end
519
score
99.12023460410556
distance
105.74211
seq distance
False
chain
J
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
106.44706
seq distance
False
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
106.44706
seq distance
False
chain
B
EGF-like
begin
489
end
519
score
99.12023460410556
distance
106.602005
seq distance
False
chain
B
EGF-like
begin
489
end
519
score
99.12023460410556
distance
106.602005
seq distance
False
chain
B
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
106.66823
seq distance
False
chain
L
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
106.66823
seq distance
False
chain
L
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
107.21802
seq distance
False
chain
B
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
107.21802
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
107.63525
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
107.63525
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
108.75658
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
108.75658
seq distance
False
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
109.045906
seq distance
False
chain
L
LDL-receptor class A
begin
78
end
115
score
100.0
distance
109.045906
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
109.45762
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
109.45762
seq distance
False
chain
D
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
109.5379
seq distance
False
chain
K
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
109.5379
seq distance
False
chain
K
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
109.86963
seq distance
False
chain
K
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
109.86963
seq distance
False
chain
K
MACPF
begin
117
end
488
score
87.6099706744868
distance
110.028854
seq distance
False
chain
A
MACPF
begin
117
end
488
score
87.6099706744868
distance
110.028854
seq distance
False
chain
A
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
112.41027
seq distance
False
chain
L
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
112.41027
seq distance
False
chain
L
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
112.498405
seq distance
False
chain
F
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
112.498405
seq distance
False
chain
F
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
112.609436
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
112.609436
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
112.77197
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
112.77197
seq distance
False
chain
K
MACPF
begin
117
end
488
score
87.6099706744868
distance
112.85249
seq distance
False
chain
M
MACPF
begin
117
end
488
score
87.6099706744868
distance
112.85249
seq distance
False
chain
M
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
113.846565
seq distance
False
chain
E
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
113.846565
seq distance
False
chain
E
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
115.50482
seq distance
145
chain
G
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
115.50482
seq distance
145
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
118.6672
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
118.6672
seq distance
False
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
119.11024
seq distance
False
chain
B
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
119.11024
seq distance
False
chain
B
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
119.29704
seq distance
False
chain
D
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
119.29704
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
119.59585
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
119.59585
seq distance
False
chain
C
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
121.37141
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
121.37141
seq distance
False
chain
A
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
122.31463
seq distance
False
chain
H
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
122.31463
seq distance
False
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
122.41622
seq distance
False
chain
L
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
122.41622
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
122.728874
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
122.728874
seq distance
False
chain
A
MACPF
begin
117
end
488
score
87.6099706744868
distance
123.06407
seq distance
False
chain
V
MACPF
begin
117
end
488
score
87.6099706744868
distance
123.06407
seq distance
False
chain
V
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
123.61106
seq distance
False
chain
M
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
123.61106
seq distance
False
chain
M
LDL-receptor class A
begin
78
end
115
score
100.0
distance
123.963806
seq distance
False
chain
A
LDL-receptor class A
begin
78
end
115
score
100.0
distance
123.963806
seq distance
False
chain
A
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
124.175835
seq distance
False
chain
A
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
124.175835
seq distance
False
chain
A
EGF-like
begin
489
end
519
score
99.12023460410556
distance
124.28719
seq distance
False
chain
K
EGF-like
begin
489
end
519
score
99.12023460410556
distance
124.28719
seq distance
False
chain
K
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
124.35959
seq distance
False
chain
L
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
124.35959
seq distance
False
chain
L
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
124.5589
seq distance
False
chain
K
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
124.5589
seq distance
False
chain
K
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
124.976105
seq distance
False
chain
A
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
124.976105
seq distance
False
chain
A
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
125.09449
seq distance
False
chain
A
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
125.09449
seq distance
False
chain
A
EGF-like
begin
489
end
519
score
99.12023460410556
distance
125.251335
seq distance
False
chain
A
EGF-like
begin
489
end
519
score
99.12023460410556
distance
125.251335
seq distance
False
chain
A
LDL-receptor class A
begin
78
end
115
score
100.0
distance
126.45948
seq distance
False
chain
M
LDL-receptor class A
begin
78
end
115
score
100.0
distance
126.45948
seq distance
False
chain
M
MACPF
begin
117
end
488
score
87.6099706744868
distance
126.61917
seq distance
False
chain
N
MACPF
begin
117
end
488
score
87.6099706744868
distance
126.61917
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
127.55926
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
127.55926
seq distance
False
chain
L
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
127.63495
seq distance
False
chain
L
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
127.63495
seq distance
False
chain
L
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
127.920845
seq distance
False
chain
C
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
127.920845
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
129.74217
seq distance
False
chain
M
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
129.74217
seq distance
False
chain
M
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
129.91026
seq distance
False
chain
A
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
129.91026
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
130.36554
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
130.36554
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
131.3961
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
131.3961
seq distance
False
chain
B
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
131.81146
seq distance
False
chain
I
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
131.81146
seq distance
False
chain
I
MACPF
begin
117
end
488
score
87.6099706744868
distance
134.01624
seq distance
False
chain
U
MACPF
begin
117
end
488
score
87.6099706744868
distance
134.01624
seq distance
False
chain
U
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
134.34782
seq distance
False
chain
A
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
134.34782
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
134.8951
seq distance
False
chain
V
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
134.8951
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
136.4367
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
136.4367
seq distance
False
chain
V
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
137.51659
seq distance
False
chain
M
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
137.51659
seq distance
False
chain
M
MACPF
begin
117
end
488
score
87.6099706744868
distance
137.6751
seq distance
False
chain
O
MACPF
begin
117
end
488
score
87.6099706744868
distance
137.6751
seq distance
False
chain
O
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
138.3248
seq distance
False
chain
N
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
138.3248
seq distance
False
chain
N
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
138.49413
seq distance
False
chain
B
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
138.49413
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
138.75327
seq distance
False
chain
M
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
138.75327
seq distance
False
chain
M
LDL-receptor class A
begin
78
end
115
score
100.0
distance
139.31375
seq distance
False
chain
V
LDL-receptor class A
begin
78
end
115
score
100.0
distance
139.31375
seq distance
False
chain
V
EGF-like
begin
489
end
519
score
99.12023460410556
distance
139.83723
seq distance
False
chain
L
EGF-like
begin
489
end
519
score
99.12023460410556
distance
139.83723
seq distance
False
chain
L
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
140.28651
seq distance
False
chain
V
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
140.28651
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
140.65732
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
140.65732
seq distance
False
chain
M
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
140.91498
seq distance
False
chain
V
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
140.91498
seq distance
False
chain
V
EGF-like
begin
489
end
519
score
99.12023460410556
distance
141.02592
seq distance
False
chain
V
EGF-like
begin
489
end
519
score
99.12023460410556
distance
141.02592
seq distance
False
chain
V
LDL-receptor class A
begin
78
end
115
score
100.0
distance
141.28716
seq distance
False
chain
N
LDL-receptor class A
begin
78
end
115
score
100.0
distance
141.28716
seq distance
False
chain
N
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
142.26767
seq distance
False
chain
V
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
142.26767
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
142.59433
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
142.59433
seq distance
False
chain
K
MACPF
begin
117
end
488
score
87.6099706744868
distance
142.64383
seq distance
False
chain
T
MACPF
begin
117
end
488
score
87.6099706744868
distance
142.64383
seq distance
False
chain
T
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
142.80415
seq distance
False
chain
J
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
142.80415
seq distance
False
chain
J
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
143.15637
seq distance
False
chain
M
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
143.15637
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
143.60553
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
143.60553
seq distance
False
chain
A
MACPF
begin
117
end
488
score
87.6099706744868
distance
143.98914
seq distance
False
chain
P
MACPF
begin
117
end
488
score
87.6099706744868
distance
143.98914
seq distance
False
chain
P
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
144.42145
seq distance
False
chain
N
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
144.42145
seq distance
False
chain
N
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
144.62337
seq distance
False
chain
V
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
144.62337
seq distance
False
chain
V
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
145.3961
seq distance
False
chain
L
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
145.3961
seq distance
False
chain
L
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
146.25285
seq distance
False
chain
U
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
146.25285
seq distance
False
chain
U
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
147.20503
seq distance
False
chain
V
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
147.20503
seq distance
False
chain
V
MACPF
begin
117
end
488
score
87.6099706744868
distance
147.55367
seq distance
False
chain
S
MACPF
begin
117
end
488
score
87.6099706744868
distance
147.55367
seq distance
False
chain
S
MACPF
begin
117
end
488
score
87.6099706744868
distance
147.78764
seq distance
False
chain
Q
MACPF
begin
117
end
488
score
87.6099706744868
distance
147.78764
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
148.01016
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
148.01016
seq distance
False
chain
U
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
148.46568
seq distance
False
chain
N
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
148.46568
seq distance
False
chain
N
MACPF
begin
117
end
488
score
87.6099706744868
distance
148.99026
seq distance
False
chain
R
MACPF
begin
117
end
488
score
87.6099706744868
distance
148.99026
seq distance
False
chain
R
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
149.8311
seq distance
False
chain
A
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
149.8311
seq distance
False
chain
A
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
150.40602
seq distance
False
chain
O
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
150.40602
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
151.51932
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
151.51932
seq distance
False
chain
N
LDL-receptor class A
begin
78
end
115
score
100.0
distance
151.75626
seq distance
False
chain
U
LDL-receptor class A
begin
78
end
115
score
100.0
distance
151.75626
seq distance
False
chain
U
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
152.25858
seq distance
False
chain
N
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
152.25858
seq distance
False
chain
N
LDL-receptor class A
begin
78
end
115
score
100.0
distance
152.75674
seq distance
False
chain
O
LDL-receptor class A
begin
78
end
115
score
100.0
distance
152.75674
seq distance
False
chain
O
EGF-like
begin
489
end
519
score
99.12023460410556
distance
152.89435
seq distance
False
chain
M
EGF-like
begin
489
end
519
score
99.12023460410556
distance
152.89435
seq distance
False
chain
M
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
153.48357
seq distance
False
chain
U
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
153.48357
seq distance
False
chain
U
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
154.0411
seq distance
False
chain
U
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
154.0411
seq distance
False
chain
U
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
154.18718
seq distance
False
chain
K
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
154.18718
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
154.3502
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
154.3502
seq distance
False
chain
L
EGF-like
begin
489
end
519
score
99.12023460410556
distance
154.52686
seq distance
False
chain
U
EGF-like
begin
489
end
519
score
99.12023460410556
distance
154.52686
seq distance
False
chain
U
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
155.17204
seq distance
False
chain
T
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
155.17204
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
155.42593
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
155.42593
seq distance
False
chain
V
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
155.94633
seq distance
False
chain
N
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
155.94633
seq distance
False
chain
N
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
156.1799
seq distance
False
chain
O
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
156.1799
seq distance
False
chain
O
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
156.3216
seq distance
False
chain
U
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
156.3216
seq distance
False
chain
U
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
156.8952
seq distance
False
chain
O
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
156.8952
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
157.15793
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
157.15793
seq distance
False
chain
T
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
157.1793
seq distance
False
chain
U
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
157.1793
seq distance
False
chain
U
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
157.3755
seq distance
False
chain
U
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
157.3755
seq distance
False
chain
U
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
159.51898
seq distance
False
chain
P
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
159.51898
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
159.83
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
159.83
seq distance
False
chain
O
LDL-receptor class A
begin
78
end
115
score
100.0
distance
160.89021
seq distance
False
chain
T
LDL-receptor class A
begin
78
end
115
score
100.0
distance
160.89021
seq distance
False
chain
T
LDL-receptor class A
begin
78
end
115
score
100.0
distance
161.05243
seq distance
False
chain
P
LDL-receptor class A
begin
78
end
115
score
100.0
distance
161.05243
seq distance
False
chain
P
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
161.13336
seq distance
False
chain
V
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
161.13336
seq distance
False
chain
V
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
161.3936
seq distance
False
chain
S
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
161.3936
seq distance
False
chain
S
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
162.11841
seq distance
False
chain
M
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
162.11841
seq distance
False
chain
M
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
162.4516
seq distance
False
chain
P
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
162.4516
seq distance
False
chain
P
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
162.69696
seq distance
False
chain
O
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
162.69696
seq distance
False
chain
O
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
163.58582
seq distance
False
chain
T
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
163.58582
seq distance
False
chain
T
EGF-like
begin
489
end
519
score
99.12023460410556
distance
163.59157
seq distance
False
chain
N
EGF-like
begin
489
end
519
score
99.12023460410556
distance
163.59157
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
163.60779
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
163.60779
seq distance
False
chain
S
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
164.1237
seq distance
False
chain
T
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
164.1237
seq distance
False
chain
T
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
164.24443
seq distance
False
chain
T
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
164.24443
seq distance
False
chain
T
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
164.71446
seq distance
False
chain
R
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
164.71446
seq distance
False
chain
R
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
164.7576
seq distance
False
chain
P
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
164.7576
seq distance
False
chain
P
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
164.84998
seq distance
False
chain
T
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
164.84998
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
164.92177
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
164.92177
seq distance
False
chain
M
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
165.04758
seq distance
False
chain
L
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
165.04758
seq distance
False
chain
L
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
165.06827
seq distance
False
chain
Q
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
165.06827
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
165.25983
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
165.25983
seq distance
False
chain
P
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
165.54863
seq distance
False
chain
Q
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
165.54863
seq distance
False
chain
Q
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
165.64078
seq distance
False
chain
O
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
165.64078
seq distance
False
chain
O
EGF-like
begin
489
end
519
score
99.12023460410556
distance
165.67308
seq distance
False
chain
T
EGF-like
begin
489
end
519
score
99.12023460410556
distance
165.67308
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
165.83116
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
165.83116
seq distance
False
chain
U
LDL-receptor class A
begin
78
end
115
score
100.0
distance
166.0004
seq distance
False
chain
S
LDL-receptor class A
begin
78
end
115
score
100.0
distance
166.0004
seq distance
False
chain
S
LDL-receptor class A
begin
78
end
115
score
100.0
distance
166.08606
seq distance
False
chain
Q
LDL-receptor class A
begin
78
end
115
score
100.0
distance
166.08606
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
167.14613
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
167.14613
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
167.69919
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
167.69919
seq distance
False
chain
Q
LDL-receptor class A
begin
78
end
115
score
100.0
distance
167.74127
seq distance
False
chain
R
LDL-receptor class A
begin
78
end
115
score
100.0
distance
167.74127
seq distance
False
chain
R
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
167.88402
seq distance
False
chain
S
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
167.88402
seq distance
False
chain
S
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
168.3593
seq distance
False
chain
R
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
168.3593
seq distance
False
chain
R
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
169.83443
seq distance
False
chain
P
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
169.83443
seq distance
False
chain
P
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
169.89256
seq distance
False
chain
T
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
169.89256
seq distance
False
chain
T
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
169.98784
seq distance
False
chain
Q
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
169.98784
seq distance
False
chain
Q
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
170.03078
seq distance
False
chain
S
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
170.03078
seq distance
False
chain
S
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
170.378
seq distance
False
chain
S
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
170.378
seq distance
False
chain
S
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
171.28271
seq distance
False
chain
S
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
171.28271
seq distance
False
chain
S
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
171.31934
seq distance
False
chain
U
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
171.31934
seq distance
False
chain
U
EGF-like
begin
489
end
519
score
99.12023460410556
distance
171.6089
seq distance
False
chain
O
EGF-like
begin
489
end
519
score
99.12023460410556
distance
171.6089
seq distance
False
chain
O
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
171.752
seq distance
False
chain
R
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
171.752
seq distance
False
chain
R
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
172.12416
seq distance
False
chain
P
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
172.12416
seq distance
False
chain
P
EGF-like
begin
489
end
519
score
99.12023460410556
distance
173.06146
seq distance
False
chain
S
EGF-like
begin
489
end
519
score
99.12023460410556
distance
173.06146
seq distance
False
chain
S
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
173.53658
seq distance
False
chain
Q
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
173.53658
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
173.6648
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
173.6648
seq distance
False
chain
N
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
173.71286
seq distance
False
chain
R
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
173.71286
seq distance
False
chain
R
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
174.30315
seq distance
False
chain
N
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
174.30315
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
174.38834
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
174.38834
seq distance
False
chain
T
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
174.72511
seq distance
False
chain
M
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
174.72511
seq distance
False
chain
M
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
174.97534
seq distance
False
chain
R
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
174.97534
seq distance
False
chain
R
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
175.26085
seq distance
False
chain
Q
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
175.26085
seq distance
False
chain
Q
EGF-like
begin
489
end
519
score
99.12023460410556
distance
176.6743
seq distance
False
chain
P
EGF-like
begin
489
end
519
score
99.12023460410556
distance
176.6743
seq distance
False
chain
P
EGF-like
begin
489
end
519
score
99.12023460410556
distance
177.35118
seq distance
False
chain
R
EGF-like
begin
489
end
519
score
99.12023460410556
distance
177.35118
seq distance
False
chain
R
EGF-like
begin
489
end
519
score
99.12023460410556
distance
178.56541
seq distance
False
chain
Q
EGF-like
begin
489
end
519
score
99.12023460410556
distance
178.56541
seq distance
False
chain
Q
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
179.44296
seq distance
False
chain
S
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
179.44296
seq distance
False
chain
S
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
179.90968
seq distance
False
chain
T
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
179.90968
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
180.22787
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
180.22787
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
180.73561
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
180.73561
seq distance
False
chain
S
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
182.60481
seq distance
False
chain
N
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
182.60481
seq distance
False
chain
N
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
182.88715
seq distance
False
chain
O
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
182.88715
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
184.30855
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
184.30855
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
184.56618
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
184.56618
seq distance
False
chain
R
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
185.73131
seq distance
False
chain
R
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
185.73131
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
185.763
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
185.763
seq distance
False
chain
Q
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
186.49864
seq distance
False
chain
S
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
186.49864
seq distance
False
chain
S
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
187.71494
seq distance
False
chain
P
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
187.71494
seq distance
False
chain
P
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
188.35178
seq distance
False
chain
O
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
188.35178
seq distance
False
chain
O
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
188.62453
seq distance
False
chain
Q
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
188.62453
seq distance
False
chain
Q
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
190.73564
seq distance
False
chain
R
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
190.73564
seq distance
False
chain
R
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
191.68411
seq distance
False
chain
P
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
191.68411
seq distance
False
chain
P
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
192.47823
seq distance
False
chain
Q
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
192.47823
seq distance
False
chain
Q
Details
Redox score
76.72
PDB code
6dlw
Structure name
complement component polyc9
Structure deposition date
2018-06-03
Thiol separation (Å)
2.03
Half-sphere exposure sum
41
Minimum pKa
nan
% buried
nan
Peptide accession
P02748
Residue number A
119 (Residue 98 in this structure)
Residue number B
134 (Residue 113 in this structure)
Peptide name
Complement component C9
6dlw D 80 D 91
A redox-regulated disulphide may form within Complement component C9 at these cysteines.
Relevent regions
LDL-receptor class A
begin
78
end
115
score
100.0
distance
2.8061337
seq distance
0
chain
D
LDL-receptor class A
begin
78
end
115
score
100.0
distance
2.8061337
seq distance
0
chain
D
MACPF
begin
117
end
488
score
87.6099706744868
distance
9.462832
seq distance
26
chain
D
MACPF
begin
117
end
488
score
87.6099706744868
distance
9.462832
seq distance
26
chain
D
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
13.816456
seq distance
15
chain
D
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
13.816456
seq distance
15
chain
D
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
16.444025
seq distance
False
chain
C
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
16.444025
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
17.365393
seq distance
7
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
17.365393
seq distance
7
chain
D
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
18.41074
seq distance
6
chain
D
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
18.41074
seq distance
6
chain
D
LDL-receptor class A
begin
78
end
115
score
100.0
distance
18.738468
seq distance
False
chain
E
LDL-receptor class A
begin
78
end
115
score
100.0
distance
18.738468
seq distance
False
chain
E
MACPF
begin
117
end
488
score
87.6099706744868
distance
19.40658
seq distance
False
chain
E
MACPF
begin
117
end
488
score
87.6099706744868
distance
19.40658
seq distance
False
chain
E
MACPF
begin
117
end
488
score
87.6099706744868
distance
19.846266
seq distance
False
chain
C
MACPF
begin
117
end
488
score
87.6099706744868
distance
19.846266
seq distance
False
chain
C
LDL-receptor class A
begin
78
end
115
score
100.0
distance
21.364855
seq distance
False
chain
C
LDL-receptor class A
begin
78
end
115
score
100.0
distance
21.364855
seq distance
False
chain
C
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
23.925264
seq distance
False
chain
C
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
23.925264
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
26.254272
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
26.254272
seq distance
False
chain
E
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
28.086157
seq distance
55
chain
D
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
28.086157
seq distance
55
chain
D
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
31.08365
seq distance
False
chain
E
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
31.08365
seq distance
False
chain
E
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
31.209791
seq distance
False
chain
C
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
31.209791
seq distance
False
chain
C
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
32.485683
seq distance
91
chain
D
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
32.485683
seq distance
91
chain
D
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
35.115986
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
35.115986
seq distance
False
chain
E
EGF-like
begin
489
end
519
score
99.12023460410556
distance
35.34206
seq distance
False
chain
C
EGF-like
begin
489
end
519
score
99.12023460410556
distance
35.34206
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
35.920135
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
35.920135
seq distance
False
chain
C
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
37.47756
seq distance
False
chain
B
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
37.47756
seq distance
False
chain
B
MACPF
begin
117
end
488
score
87.6099706744868
distance
40.533157
seq distance
False
chain
F
MACPF
begin
117
end
488
score
87.6099706744868
distance
40.533157
seq distance
False
chain
F
EGF-like
begin
489
end
519
score
99.12023460410556
distance
41.51855
seq distance
398
chain
D
EGF-like
begin
489
end
519
score
99.12023460410556
distance
41.51855
seq distance
398
chain
D
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
43.744373
seq distance
False
chain
E
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
43.744373
seq distance
False
chain
E
LDL-receptor class A
begin
78
end
115
score
100.0
distance
44.489704
seq distance
False
chain
F
LDL-receptor class A
begin
78
end
115
score
100.0
distance
44.489704
seq distance
False
chain
F
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
44.683525
seq distance
False
chain
E
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
44.683525
seq distance
False
chain
E
MACPF
begin
117
end
488
score
87.6099706744868
distance
45.16833
seq distance
False
chain
B
MACPF
begin
117
end
488
score
87.6099706744868
distance
45.16833
seq distance
False
chain
B
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
46.456753
seq distance
False
chain
F
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
46.456753
seq distance
False
chain
F
EGF-like
begin
489
end
519
score
99.12023460410556
distance
47.682873
seq distance
False
chain
B
EGF-like
begin
489
end
519
score
99.12023460410556
distance
47.682873
seq distance
False
chain
B
LDL-receptor class A
begin
78
end
115
score
100.0
distance
48.163227
seq distance
False
chain
B
LDL-receptor class A
begin
78
end
115
score
100.0
distance
48.163227
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
48.427467
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
48.427467
seq distance
False
chain
B
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
49.18602
seq distance
False
chain
C
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
49.18602
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
49.380745
seq distance
False
chain
F
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
49.380745
seq distance
False
chain
F
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
50.355053
seq distance
False
chain
B
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
50.355053
seq distance
False
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
50.895233
seq distance
315
chain
D
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
50.895233
seq distance
315
chain
D
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
51.95353
seq distance
False
chain
C
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
51.95353
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
52.87488
seq distance
314
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
52.87488
seq distance
314
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
53.19562
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
53.19562
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
60.023994
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
60.023994
seq distance
False
chain
B
EGF-like
begin
489
end
519
score
99.12023460410556
distance
60.085224
seq distance
False
chain
E
EGF-like
begin
489
end
519
score
99.12023460410556
distance
60.085224
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
60.14385
seq distance
False
chain
F
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
60.14385
seq distance
False
chain
F
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
60.20232
seq distance
False
chain
E
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
60.20232
seq distance
False
chain
E
MACPF
begin
117
end
488
score
87.6099706744868
distance
60.749607
seq distance
False
chain
G
MACPF
begin
117
end
488
score
87.6099706744868
distance
60.749607
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
62.675446
seq distance
False
chain
E
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
62.675446
seq distance
False
chain
E
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
62.766907
seq distance
False
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
62.766907
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
63.442623
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
63.442623
seq distance
False
chain
B
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
65.19652
seq distance
False
chain
A
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
65.19652
seq distance
False
chain
A
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
67.08498
seq distance
False
chain
F
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
67.08498
seq distance
False
chain
F
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
67.35433
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
67.35433
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
99.12023460410556
distance
68.67026
seq distance
False
chain
A
EGF-like
begin
489
end
519
score
99.12023460410556
distance
68.67026
seq distance
False
chain
A
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
70.31929
seq distance
False
chain
B
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
70.31929
seq distance
False
chain
B
LDL-receptor class A
begin
78
end
115
score
100.0
distance
70.38107
seq distance
False
chain
G
LDL-receptor class A
begin
78
end
115
score
100.0
distance
70.38107
seq distance
False
chain
G
MACPF
begin
117
end
488
score
87.6099706744868
distance
70.59755
seq distance
False
chain
A
MACPF
begin
117
end
488
score
87.6099706744868
distance
70.59755
seq distance
False
chain
A
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
72.22981
seq distance
False
chain
F
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
72.22981
seq distance
False
chain
F
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
73.13698
seq distance
False
chain
A
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
73.13698
seq distance
False
chain
A
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
73.30162
seq distance
False
chain
A
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
73.30162
seq distance
False
chain
A
LDL-receptor class A
begin
78
end
115
score
100.0
distance
73.30162
seq distance
False
chain
A
LDL-receptor class A
begin
78
end
115
score
100.0
distance
73.30162
seq distance
False
chain
A
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
73.52527
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
73.52527
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
75.61031
seq distance
False
chain
F
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
75.61031
seq distance
False
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
78.32563
seq distance
False
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
78.32563
seq distance
False
chain
F
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
78.812546
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
78.812546
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
79.27553
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
79.27553
seq distance
False
chain
A
MACPF
begin
117
end
488
score
87.6099706744868
distance
81.598434
seq distance
False
chain
H
MACPF
begin
117
end
488
score
87.6099706744868
distance
81.598434
seq distance
False
chain
H
EGF-like
begin
489
end
519
score
99.12023460410556
distance
81.65298
seq distance
False
chain
F
EGF-like
begin
489
end
519
score
99.12023460410556
distance
81.65298
seq distance
False
chain
F
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
84.002
seq distance
False
chain
A
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
84.002
seq distance
False
chain
A
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
84.54743
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
84.54743
seq distance
False
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
88.74296
seq distance
False
chain
V
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
88.74296
seq distance
False
chain
V
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
88.92749
seq distance
False
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
88.92749
seq distance
False
chain
H
MACPF
begin
117
end
488
score
87.6099706744868
distance
89.09501
seq distance
False
chain
V
MACPF
begin
117
end
488
score
87.6099706744868
distance
89.09501
seq distance
False
chain
V
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
89.989265
seq distance
False
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
89.989265
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
99.12023460410556
distance
91.66892
seq distance
False
chain
V
EGF-like
begin
489
end
519
score
99.12023460410556
distance
91.66892
seq distance
False
chain
V
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
91.818214
seq distance
False
chain
A
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
91.818214
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
92.79661
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
92.79661
seq distance
False
chain
C
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
93.28
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
93.28
seq distance
False
chain
G
LDL-receptor class A
begin
78
end
115
score
100.0
distance
94.27601
seq distance
False
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
94.27601
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
94.411476
seq distance
171
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
94.411476
seq distance
171
chain
D
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
95.95689
seq distance
False
chain
V
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
95.95689
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
96.12374
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
96.12374
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
96.710205
seq distance
False
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
96.710205
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
96.731476
seq distance
False
chain
V
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
96.731476
seq distance
False
chain
V
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
97.05291
seq distance
False
chain
V
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
97.05291
seq distance
False
chain
V
LDL-receptor class A
begin
78
end
115
score
100.0
distance
97.05291
seq distance
False
chain
V
LDL-receptor class A
begin
78
end
115
score
100.0
distance
97.05291
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
97.228676
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
97.228676
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
97.233925
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
97.233925
seq distance
False
chain
B
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
99.92599
seq distance
False
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
99.92599
seq distance
False
chain
G
MACPF
begin
117
end
488
score
87.6099706744868
distance
101.64614
seq distance
False
chain
I
MACPF
begin
117
end
488
score
87.6099706744868
distance
101.64614
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
101.6985
seq distance
False
chain
E
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
101.6985
seq distance
False
chain
E
EGF-like
begin
489
end
519
score
99.12023460410556
distance
103.56113
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
99.12023460410556
distance
103.56113
seq distance
False
chain
G
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
104.90692
seq distance
False
chain
C
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
104.90692
seq distance
False
chain
C
MACPF
begin
117
end
488
score
87.6099706744868
distance
105.73249
seq distance
False
chain
U
MACPF
begin
117
end
488
score
87.6099706744868
distance
105.73249
seq distance
False
chain
U
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
106.550285
seq distance
False
chain
V
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
106.550285
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
106.644936
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
106.644936
seq distance
False
chain
A
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
107.43278
seq distance
False
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
107.43278
seq distance
False
chain
H
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
107.57394
seq distance
167
chain
D
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
107.57394
seq distance
167
chain
D
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
107.61293
seq distance
False
chain
B
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
107.61293
seq distance
False
chain
B
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
109.51967
seq distance
False
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
109.51967
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
111.0582
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
111.0582
seq distance
False
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
111.68917
seq distance
False
chain
U
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
111.68917
seq distance
False
chain
U
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
111.794655
seq distance
False
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
111.794655
seq distance
False
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
112.3142
seq distance
False
chain
V
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
112.3142
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
113.042595
seq distance
False
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
113.042595
seq distance
False
chain
F
EGF-like
begin
489
end
519
score
99.12023460410556
distance
113.81895
seq distance
False
chain
U
EGF-like
begin
489
end
519
score
99.12023460410556
distance
113.81895
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
113.97312
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
113.97312
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
114.34454
seq distance
False
chain
U
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
114.34454
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
115.005745
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
115.005745
seq distance
False
chain
U
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
115.06869
seq distance
False
chain
E
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
115.06869
seq distance
False
chain
E
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
115.101
seq distance
False
chain
A
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
115.101
seq distance
False
chain
A
LDL-receptor class A
begin
78
end
115
score
100.0
distance
115.48346
seq distance
False
chain
I
LDL-receptor class A
begin
78
end
115
score
100.0
distance
115.48346
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
117.29267
seq distance
False
chain
U
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
117.29267
seq distance
False
chain
U
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
118.136116
seq distance
False
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
118.136116
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
118.85606
seq distance
False
chain
U
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
118.85606
seq distance
False
chain
U
LDL-receptor class A
begin
78
end
115
score
100.0
distance
118.85606
seq distance
False
chain
U
LDL-receptor class A
begin
78
end
115
score
100.0
distance
118.85606
seq distance
False
chain
U
MACPF
begin
117
end
488
score
87.6099706744868
distance
118.8831
seq distance
False
chain
J
MACPF
begin
117
end
488
score
87.6099706744868
distance
118.8831
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
119.39749
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
119.39749
seq distance
False
chain
V
MACPF
begin
117
end
488
score
87.6099706744868
distance
121.18116
seq distance
False
chain
T
MACPF
begin
117
end
488
score
87.6099706744868
distance
121.18116
seq distance
False
chain
T
EGF-like
begin
489
end
519
score
99.12023460410556
distance
124.566956
seq distance
False
chain
H
EGF-like
begin
489
end
519
score
99.12023460410556
distance
124.566956
seq distance
False
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
125.827484
seq distance
False
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
125.827484
seq distance
False
chain
H
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
125.98572
seq distance
False
chain
F
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
125.98572
seq distance
False
chain
F
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
126.181656
seq distance
False
chain
V
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
126.181656
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
126.61601
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
126.61601
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
127.00555
seq distance
False
chain
U
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
127.00555
seq distance
False
chain
U
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
127.72674
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
127.72674
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
128.20926
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
128.20926
seq distance
False
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
128.3449
seq distance
False
chain
J
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
128.3449
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
130.66751
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
130.66751
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
130.71574
seq distance
False
chain
T
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
130.71574
seq distance
False
chain
T
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
130.82137
seq distance
False
chain
U
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
130.82137
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
131.60945
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
131.60945
seq distance
False
chain
T
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
131.67366
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
131.67366
seq distance
False
chain
I
EGF-like
begin
489
end
519
score
99.12023460410556
distance
132.45474
seq distance
False
chain
T
EGF-like
begin
489
end
519
score
99.12023460410556
distance
132.45474
seq distance
False
chain
T
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
132.6225
seq distance
False
chain
T
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
132.6225
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
133.41335
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
133.41335
seq distance
False
chain
U
MACPF
begin
117
end
488
score
87.6099706744868
distance
134.07835
seq distance
False
chain
K
MACPF
begin
117
end
488
score
87.6099706744868
distance
134.07835
seq distance
False
chain
K
LDL-receptor class A
begin
78
end
115
score
100.0
distance
134.5667
seq distance
False
chain
J
LDL-receptor class A
begin
78
end
115
score
100.0
distance
134.5667
seq distance
False
chain
J
MACPF
begin
117
end
488
score
87.6099706744868
distance
134.83633
seq distance
False
chain
S
MACPF
begin
117
end
488
score
87.6099706744868
distance
134.83633
seq distance
False
chain
S
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
136.57281
seq distance
False
chain
T
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
136.57281
seq distance
False
chain
T
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
137.2894
seq distance
False
chain
J
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
137.2894
seq distance
False
chain
J
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
138.32257
seq distance
False
chain
T
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
138.32257
seq distance
False
chain
T
LDL-receptor class A
begin
78
end
115
score
100.0
distance
138.32257
seq distance
False
chain
T
LDL-receptor class A
begin
78
end
115
score
100.0
distance
138.32257
seq distance
False
chain
T
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
138.78557
seq distance
False
chain
G
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
138.78557
seq distance
False
chain
G
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
138.95973
seq distance
False
chain
U
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
138.95973
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
140.83246
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
140.83246
seq distance
False
chain
H
EGF-like
begin
489
end
519
score
99.12023460410556
distance
142.08102
seq distance
False
chain
I
EGF-like
begin
489
end
519
score
99.12023460410556
distance
142.08102
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
142.57162
seq distance
False
chain
J
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
142.57162
seq distance
False
chain
J
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
144.8183
seq distance
False
chain
K
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
144.8183
seq distance
False
chain
K
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
144.98405
seq distance
False
chain
T
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
144.98405
seq distance
False
chain
T
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
145.14583
seq distance
False
chain
S
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
145.14583
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
145.49777
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
145.49777
seq distance
False
chain
J
MACPF
begin
117
end
488
score
87.6099706744868
distance
145.72502
seq distance
False
chain
L
MACPF
begin
117
end
488
score
87.6099706744868
distance
145.72502
seq distance
False
chain
L
MACPF
begin
117
end
488
score
87.6099706744868
distance
146.228
seq distance
False
chain
R
MACPF
begin
117
end
488
score
87.6099706744868
distance
146.228
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
146.30743
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
146.30743
seq distance
False
chain
S
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
146.44281
seq distance
False
chain
J
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
146.44281
seq distance
False
chain
J
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
146.93251
seq distance
False
chain
T
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
146.93251
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
147.46576
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
147.46576
seq distance
False
chain
T
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
149.10919
seq distance
False
chain
J
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
149.10919
seq distance
False
chain
J
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
149.2696
seq distance
False
chain
I
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
149.2696
seq distance
False
chain
I
EGF-like
begin
489
end
519
score
99.12023460410556
distance
149.41473
seq distance
False
chain
S
EGF-like
begin
489
end
519
score
99.12023460410556
distance
149.41473
seq distance
False
chain
S
LDL-receptor class A
begin
78
end
115
score
100.0
distance
150.57077
seq distance
False
chain
K
LDL-receptor class A
begin
78
end
115
score
100.0
distance
150.57077
seq distance
False
chain
K
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
151.56096
seq distance
False
chain
S
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
151.56096
seq distance
False
chain
S
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
152.08116
seq distance
False
chain
H
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
152.08116
seq distance
False
chain
H
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
152.21495
seq distance
False
chain
T
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
152.21495
seq distance
False
chain
T
MACPF
begin
117
end
488
score
87.6099706744868
distance
153.17332
seq distance
False
chain
M
MACPF
begin
117
end
488
score
87.6099706744868
distance
153.17332
seq distance
False
chain
M
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
153.27277
seq distance
False
chain
S
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
153.27277
seq distance
False
chain
S
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
153.71065
seq distance
False
chain
K
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
153.71065
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
154.48804
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
154.48804
seq distance
False
chain
I
LDL-receptor class A
begin
78
end
115
score
100.0
distance
154.84166
seq distance
False
chain
S
LDL-receptor class A
begin
78
end
115
score
100.0
distance
154.84166
seq distance
False
chain
S
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
155.01364
seq distance
False
chain
S
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
155.01364
seq distance
False
chain
S
MACPF
begin
117
end
488
score
87.6099706744868
distance
155.02611
seq distance
False
chain
Q
MACPF
begin
117
end
488
score
87.6099706744868
distance
155.02611
seq distance
False
chain
Q
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
155.0553
seq distance
False
chain
K
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
155.0553
seq distance
False
chain
K
EGF-like
begin
489
end
519
score
99.12023460410556
distance
157.02641
seq distance
False
chain
J
EGF-like
begin
489
end
519
score
99.12023460410556
distance
157.02641
seq distance
False
chain
J
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
157.13513
seq distance
False
chain
R
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
157.13513
seq distance
False
chain
R
MACPF
begin
117
end
488
score
87.6099706744868
distance
157.90842
seq distance
False
chain
N
MACPF
begin
117
end
488
score
87.6099706744868
distance
157.90842
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
157.92325
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
157.92325
seq distance
False
chain
K
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
158.54074
seq distance
False
chain
L
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
158.54074
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
158.5772
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
158.5772
seq distance
False
chain
R
MACPF
begin
117
end
488
score
87.6099706744868
distance
158.87633
seq distance
False
chain
P
MACPF
begin
117
end
488
score
87.6099706744868
distance
158.87633
seq distance
False
chain
P
MACPF
begin
117
end
488
score
87.6099706744868
distance
159.83481
seq distance
False
chain
O
MACPF
begin
117
end
488
score
87.6099706744868
distance
159.83481
seq distance
False
chain
O
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
160.074
seq distance
False
chain
S
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
160.074
seq distance
False
chain
S
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
160.2358
seq distance
False
chain
S
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
160.2358
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
160.56276
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
160.56276
seq distance
False
chain
S
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
161.71892
seq distance
False
chain
K
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
161.71892
seq distance
False
chain
K
LDL-receptor class A
begin
78
end
115
score
100.0
distance
163.5156
seq distance
False
chain
L
LDL-receptor class A
begin
78
end
115
score
100.0
distance
163.5156
seq distance
False
chain
L
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
163.65147
seq distance
False
chain
K
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
163.65147
seq distance
False
chain
K
EGF-like
begin
489
end
519
score
99.12023460410556
distance
164.02586
seq distance
False
chain
R
EGF-like
begin
489
end
519
score
99.12023460410556
distance
164.02586
seq distance
False
chain
R
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
164.76884
seq distance
False
chain
I
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
164.76884
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
164.8141
seq distance
False
chain
L
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
164.8141
seq distance
False
chain
L
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
164.89917
seq distance
False
chain
S
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
164.89917
seq distance
False
chain
S
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
166.34227
seq distance
False
chain
Q
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
166.34227
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
166.7765
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
166.7765
seq distance
False
chain
J
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
166.99086
seq distance
False
chain
R
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
166.99086
seq distance
False
chain
R
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
167.06868
seq distance
False
chain
L
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
167.06868
seq distance
False
chain
L
LDL-receptor class A
begin
78
end
115
score
100.0
distance
167.57564
seq distance
False
chain
R
LDL-receptor class A
begin
78
end
115
score
100.0
distance
167.57564
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
167.58221
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
167.58221
seq distance
False
chain
L
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
167.86697
seq distance
False
chain
R
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
167.86697
seq distance
False
chain
R
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
168.00644
seq distance
False
chain
J
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
168.00644
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
168.06232
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
168.06232
seq distance
False
chain
Q
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
168.58359
seq distance
False
chain
R
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
168.58359
seq distance
False
chain
R
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
169.19511
seq distance
False
chain
M
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
169.19511
seq distance
False
chain
M
EGF-like
begin
489
end
519
score
99.12023460410556
distance
169.39899
seq distance
False
chain
K
EGF-like
begin
489
end
519
score
99.12023460410556
distance
169.39899
seq distance
False
chain
K
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
170.41916
seq distance
False
chain
R
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
170.41916
seq distance
False
chain
R
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
171.59349
seq distance
False
chain
M
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
171.59349
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
171.94762
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
171.94762
seq distance
False
chain
R
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
171.95909
seq distance
False
chain
R
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
171.95909
seq distance
False
chain
R
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
172.51648
seq distance
False
chain
P
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
172.51648
seq distance
False
chain
P
LDL-receptor class A
begin
78
end
115
score
100.0
distance
173.18585
seq distance
False
chain
M
LDL-receptor class A
begin
78
end
115
score
100.0
distance
173.18585
seq distance
False
chain
M
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
173.74234
seq distance
False
chain
L
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
173.74234
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
174.22057
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
174.22057
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
174.5038
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
174.5038
seq distance
False
chain
P
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
174.98631
seq distance
False
chain
L
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
174.98631
seq distance
False
chain
L
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
175.17108
seq distance
False
chain
N
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
175.17108
seq distance
False
chain
N
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
175.48901
seq distance
False
chain
O
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
175.48901
seq distance
False
chain
O
EGF-like
begin
489
end
519
score
99.12023460410556
distance
175.84021
seq distance
False
chain
Q
EGF-like
begin
489
end
519
score
99.12023460410556
distance
175.84021
seq distance
False
chain
Q
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
176.09364
seq distance
False
chain
J
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
176.09364
seq distance
False
chain
J
LDL-receptor class A
begin
78
end
115
score
100.0
distance
176.14734
seq distance
False
chain
Q
LDL-receptor class A
begin
78
end
115
score
100.0
distance
176.14734
seq distance
False
chain
Q
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
176.18073
seq distance
False
chain
R
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
176.18073
seq distance
False
chain
R
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
176.49603
seq distance
False
chain
N
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
176.49603
seq distance
False
chain
N
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
177.06381
seq distance
False
chain
M
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
177.06381
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
177.0656
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
177.0656
seq distance
False
chain
K
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
177.25198
seq distance
False
chain
Q
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
177.25198
seq distance
False
chain
Q
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
177.42923
seq distance
False
chain
Q
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
177.42923
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
177.61855
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
177.61855
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
177.72073
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
177.72073
seq distance
False
chain
O
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
178.75302
seq distance
False
chain
Q
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
178.75302
seq distance
False
chain
Q
EGF-like
begin
489
end
519
score
99.12023460410556
distance
178.83145
seq distance
False
chain
L
EGF-like
begin
489
end
519
score
99.12023460410556
distance
178.83145
seq distance
False
chain
L
LDL-receptor class A
begin
78
end
115
score
100.0
distance
179.36775
seq distance
False
chain
N
LDL-receptor class A
begin
78
end
115
score
100.0
distance
179.36775
seq distance
False
chain
N
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
180.33003
seq distance
False
chain
O
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
180.33003
seq distance
False
chain
O
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
180.38696
seq distance
False
chain
Q
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
180.38696
seq distance
False
chain
Q
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
180.58284
seq distance
False
chain
P
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
180.58284
seq distance
False
chain
P
LDL-receptor class A
begin
78
end
115
score
100.0
distance
180.87332
seq distance
False
chain
P
LDL-receptor class A
begin
78
end
115
score
100.0
distance
180.87332
seq distance
False
chain
P
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
181.1136
seq distance
False
chain
Q
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
181.1136
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
181.12183
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
181.12183
seq distance
False
chain
Q
LDL-receptor class A
begin
78
end
115
score
100.0
distance
181.95229
seq distance
False
chain
O
LDL-receptor class A
begin
78
end
115
score
100.0
distance
181.95229
seq distance
False
chain
O
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
182.05716
seq distance
False
chain
K
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
182.05716
seq distance
False
chain
K
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
182.24911
seq distance
False
chain
M
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
182.24911
seq distance
False
chain
M
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
182.8656
seq distance
False
chain
M
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
182.8656
seq distance
False
chain
M
EGF-like
begin
489
end
519
score
99.12023460410556
distance
183.24738
seq distance
False
chain
P
EGF-like
begin
489
end
519
score
99.12023460410556
distance
183.24738
seq distance
False
chain
P
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
183.48027
seq distance
False
chain
N
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
183.48027
seq distance
False
chain
N
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
184.34721
seq distance
False
chain
P
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
184.34721
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
184.92175
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
184.92175
seq distance
False
chain
L
EGF-like
begin
489
end
519
score
99.12023460410556
distance
185.07715
seq distance
False
chain
M
EGF-like
begin
489
end
519
score
99.12023460410556
distance
185.07715
seq distance
False
chain
M
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
185.16965
seq distance
False
chain
P
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
185.16965
seq distance
False
chain
P
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
185.2979
seq distance
False
chain
P
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
185.2979
seq distance
False
chain
P
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
185.44658
seq distance
False
chain
K
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
185.44658
seq distance
False
chain
K
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
185.50682
seq distance
False
chain
Q
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
185.50682
seq distance
False
chain
Q
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
186.20497
seq distance
False
chain
O
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
186.20497
seq distance
False
chain
O
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
187.05797
seq distance
False
chain
N
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
187.05797
seq distance
False
chain
N
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
187.09065
seq distance
False
chain
N
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
187.09065
seq distance
False
chain
N
EGF-like
begin
489
end
519
score
99.12023460410556
distance
187.30843
seq distance
False
chain
O
EGF-like
begin
489
end
519
score
99.12023460410556
distance
187.30843
seq distance
False
chain
O
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
187.59286
seq distance
False
chain
O
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
187.59286
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
187.72842
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
187.72842
seq distance
False
chain
P
EGF-like
begin
489
end
519
score
99.12023460410556
distance
187.91612
seq distance
False
chain
N
EGF-like
begin
489
end
519
score
99.12023460410556
distance
187.91612
seq distance
False
chain
N
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
188.08441
seq distance
False
chain
O
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
188.08441
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
190.0841
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
190.0841
seq distance
False
chain
M
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
190.95508
seq distance
False
chain
P
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
190.95508
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
191.50394
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
191.50394
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
192.28664
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
192.28664
seq distance
False
chain
N
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
192.38951
seq distance
False
chain
L
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
192.38951
seq distance
False
chain
L
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
192.41093
seq distance
False
chain
L
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
192.41093
seq distance
False
chain
L
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
192.47122
seq distance
False
chain
P
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
192.47122
seq distance
False
chain
P
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
196.74532
seq distance
False
chain
M
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
196.74532
seq distance
False
chain
M
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
196.76775
seq distance
False
chain
O
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
196.76775
seq distance
False
chain
O
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
197.1421
seq distance
False
chain
O
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
197.1421
seq distance
False
chain
O
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
198.03935
seq distance
False
chain
M
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
198.03935
seq distance
False
chain
M
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
198.19934
seq distance
False
chain
N
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
198.19934
seq distance
False
chain
N
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
199.51964
seq distance
False
chain
N
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
199.51964
seq distance
False
chain
N
Details
Redox score
76.63
PDB code
6dlw
Structure name
complement component polyc9
Structure deposition date
2018-06-03
Thiol separation (Å)
2.03
Half-sphere exposure sum
44
Minimum pKa
nan
% buried
nan
Peptide accession
P02748
Residue number A
101 (Residue 80 in this structure)
Residue number B
112 (Residue 91 in this structure)
Peptide name
Complement component C9
6dlw D 489 D 505
A redox-regulated disulphide may form within Complement component C9 at these cysteines.
Relevent regions
EGF-like
begin
489
end
519
score
99.12023460410556
distance
2.7876127
seq distance
0
chain
D
EGF-like
begin
489
end
519
score
99.12023460410556
distance
2.7876127
seq distance
0
chain
D
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
4.4966216
seq distance
415
chain
D
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
4.4966216
seq distance
415
chain
D
MACPF
begin
117
end
488
score
87.6099706744868
distance
5.324645
seq distance
1
chain
D
MACPF
begin
117
end
488
score
87.6099706744868
distance
5.324645
seq distance
1
chain
D
MACPF
begin
117
end
488
score
87.6099706744868
distance
14.370874
seq distance
False
chain
E
MACPF
begin
117
end
488
score
87.6099706744868
distance
14.370874
seq distance
False
chain
E
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
16.505919
seq distance
False
chain
C
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
16.505919
seq distance
False
chain
C
EGF-like
begin
489
end
519
score
99.12023460410556
distance
22.283836
seq distance
False
chain
C
EGF-like
begin
489
end
519
score
99.12023460410556
distance
22.283836
seq distance
False
chain
C
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
23.399658
seq distance
343
chain
D
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
23.399658
seq distance
343
chain
D
EGF-like
begin
489
end
519
score
99.12023460410556
distance
23.983425
seq distance
False
chain
E
EGF-like
begin
489
end
519
score
99.12023460410556
distance
23.983425
seq distance
False
chain
E
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
24.734558
seq distance
84
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
24.734558
seq distance
84
chain
D
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
26.623114
seq distance
83
chain
D
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
26.623114
seq distance
83
chain
D
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
27.526688
seq distance
False
chain
E
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
27.526688
seq distance
False
chain
E
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
27.832893
seq distance
False
chain
E
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
27.832893
seq distance
False
chain
E
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
30.102467
seq distance
False
chain
E
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
30.102467
seq distance
False
chain
E
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
30.394585
seq distance
False
chain
E
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
30.394585
seq distance
False
chain
E
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
30.921732
seq distance
False
chain
E
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
30.921732
seq distance
False
chain
E
MACPF
begin
117
end
488
score
87.6099706744868
distance
30.996227
seq distance
False
chain
F
MACPF
begin
117
end
488
score
87.6099706744868
distance
30.996227
seq distance
False
chain
F
MACPF
begin
117
end
488
score
87.6099706744868
distance
32.06987
seq distance
False
chain
C
MACPF
begin
117
end
488
score
87.6099706744868
distance
32.06987
seq distance
False
chain
C
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
32.344383
seq distance
False
chain
F
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
32.344383
seq distance
False
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
38.04541
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
38.04541
seq distance
False
chain
C
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
39.957676
seq distance
False
chain
C
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
39.957676
seq distance
False
chain
C
LDL-receptor class A
begin
78
end
115
score
100.0
distance
40.49391
seq distance
False
chain
E
LDL-receptor class A
begin
78
end
115
score
100.0
distance
40.49391
seq distance
False
chain
E
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
40.972473
seq distance
False
chain
C
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
40.972473
seq distance
False
chain
C
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
41.732693
seq distance
307
chain
D
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
41.732693
seq distance
307
chain
D
LDL-receptor class A
begin
78
end
115
score
100.0
distance
42.761757
seq distance
374
chain
D
LDL-receptor class A
begin
78
end
115
score
100.0
distance
42.761757
seq distance
374
chain
D
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
43.19391
seq distance
False
chain
B
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
43.19391
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
45.912514
seq distance
383
chain
D
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
45.912514
seq distance
383
chain
D
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
46.210426
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
46.210426
seq distance
False
chain
E
EGF-like
begin
489
end
519
score
99.12023460410556
distance
46.31864
seq distance
False
chain
B
EGF-like
begin
489
end
519
score
99.12023460410556
distance
46.31864
seq distance
False
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
47.15804
seq distance
False
chain
F
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
47.15804
seq distance
False
chain
F
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
47.883976
seq distance
False
chain
F
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
47.883976
seq distance
False
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
48.022587
seq distance
False
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
48.022587
seq distance
False
chain
F
MACPF
begin
117
end
488
score
87.6099706744868
distance
48.60802
seq distance
False
chain
G
MACPF
begin
117
end
488
score
87.6099706744868
distance
48.60802
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
99.12023460410556
distance
49.09775
seq distance
False
chain
F
EGF-like
begin
489
end
519
score
99.12023460410556
distance
49.09775
seq distance
False
chain
F
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
50.339188
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
50.339188
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
50.635757
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
50.635757
seq distance
False
chain
E
LDL-receptor class A
begin
78
end
115
score
100.0
distance
52.019657
seq distance
False
chain
F
LDL-receptor class A
begin
78
end
115
score
100.0
distance
52.019657
seq distance
False
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
52.96589
seq distance
227
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
52.96589
seq distance
227
chain
D
MACPF
begin
117
end
488
score
87.6099706744868
distance
55.001526
seq distance
False
chain
B
MACPF
begin
117
end
488
score
87.6099706744868
distance
55.001526
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
56.118202
seq distance
391
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
56.118202
seq distance
391
chain
D
LDL-receptor class A
begin
78
end
115
score
100.0
distance
57.060726
seq distance
False
chain
C
LDL-receptor class A
begin
78
end
115
score
100.0
distance
57.060726
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
57.483128
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
57.483128
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
57.6298
seq distance
False
chain
F
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
57.6298
seq distance
False
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
57.829407
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
57.829407
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
58.450645
seq distance
False
chain
E
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
58.450645
seq distance
False
chain
E
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
58.506054
seq distance
False
chain
F
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
58.506054
seq distance
False
chain
F
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
58.65767
seq distance
False
chain
C
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
58.65767
seq distance
False
chain
C
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
59.28178
seq distance
False
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
59.28178
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
59.35336
seq distance
False
chain
F
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
59.35336
seq distance
False
chain
F
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
62.201096
seq distance
False
chain
C
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
62.201096
seq distance
False
chain
C
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
63.712112
seq distance
False
chain
B
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
63.712112
seq distance
False
chain
B
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
64.91673
seq distance
231
chain
D
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
64.91673
seq distance
231
chain
D
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
66.73797
seq distance
False
chain
C
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
66.73797
seq distance
False
chain
C
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
67.11548
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
67.11548
seq distance
False
chain
G
LDL-receptor class A
begin
78
end
115
score
100.0
distance
68.27211
seq distance
False
chain
G
LDL-receptor class A
begin
78
end
115
score
100.0
distance
68.27211
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
68.553505
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
68.553505
seq distance
False
chain
G
MACPF
begin
117
end
488
score
87.6099706744868
distance
69.04919
seq distance
False
chain
H
MACPF
begin
117
end
488
score
87.6099706744868
distance
69.04919
seq distance
False
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
69.18128
seq distance
False
chain
A
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
69.18128
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
69.77811
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
69.77811
seq distance
False
chain
B
EGF-like
begin
489
end
519
score
99.12023460410556
distance
70.15468
seq distance
False
chain
A
EGF-like
begin
489
end
519
score
99.12023460410556
distance
70.15468
seq distance
False
chain
A
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
70.90938
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
70.90938
seq distance
False
chain
C
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
70.91342
seq distance
False
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
70.91342
seq distance
False
chain
G
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
71.24106
seq distance
False
chain
E
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
71.24106
seq distance
False
chain
E
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
71.311
seq distance
False
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
71.311
seq distance
False
chain
F
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
71.548965
seq distance
False
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
71.548965
seq distance
False
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
73.197044
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
73.197044
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
99.12023460410556
distance
73.942
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
99.12023460410556
distance
73.942
seq distance
False
chain
G
MACPF
begin
117
end
488
score
87.6099706744868
distance
74.17585
seq distance
False
chain
A
MACPF
begin
117
end
488
score
87.6099706744868
distance
74.17585
seq distance
False
chain
A
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
75.96625
seq distance
False
chain
B
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
75.96625
seq distance
False
chain
B
LDL-receptor class A
begin
78
end
115
score
100.0
distance
77.48623
seq distance
False
chain
B
LDL-receptor class A
begin
78
end
115
score
100.0
distance
77.48623
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
77.6325
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
77.6325
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
78.427635
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
78.427635
seq distance
False
chain
A
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
78.46175
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
78.46175
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
79.42999
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
79.42999
seq distance
False
chain
A
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
83.45427
seq distance
False
chain
F
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
83.45427
seq distance
False
chain
F
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
83.568054
seq distance
False
chain
B
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
83.568054
seq distance
False
chain
B
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
84.639755
seq distance
False
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
84.639755
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
85.86553
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
85.86553
seq distance
False
chain
A
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
86.60725
seq distance
False
chain
A
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
86.60725
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
87.07288
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
87.07288
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
87.63947
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
87.63947
seq distance
False
chain
G
MACPF
begin
117
end
488
score
87.6099706744868
distance
88.20685
seq distance
False
chain
I
MACPF
begin
117
end
488
score
87.6099706744868
distance
88.20685
seq distance
False
chain
I
LDL-receptor class A
begin
78
end
115
score
100.0
distance
88.63715
seq distance
False
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
88.63715
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
88.842255
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
88.842255
seq distance
False
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
89.71983
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
89.71983
seq distance
False
chain
B
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
89.764
seq distance
False
chain
A
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
89.764
seq distance
False
chain
A
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
92.25689
seq distance
False
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
92.25689
seq distance
False
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
92.68309
seq distance
False
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
92.68309
seq distance
False
chain
I
EGF-like
begin
489
end
519
score
99.12023460410556
distance
92.715866
seq distance
False
chain
V
EGF-like
begin
489
end
519
score
99.12023460410556
distance
92.715866
seq distance
False
chain
V
MACPF
begin
117
end
488
score
87.6099706744868
distance
93.09614
seq distance
False
chain
V
MACPF
begin
117
end
488
score
87.6099706744868
distance
93.09614
seq distance
False
chain
V
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
93.512726
seq distance
False
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
93.512726
seq distance
False
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
93.8622
seq distance
False
chain
V
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
93.8622
seq distance
False
chain
V
EGF-like
begin
489
end
519
score
99.12023460410556
distance
96.467735
seq distance
False
chain
H
EGF-like
begin
489
end
519
score
99.12023460410556
distance
96.467735
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
98.23817
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
98.23817
seq distance
False
chain
V
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
98.298615
seq distance
False
chain
A
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
98.298615
seq distance
False
chain
A
LDL-receptor class A
begin
78
end
115
score
100.0
distance
98.298615
seq distance
False
chain
A
LDL-receptor class A
begin
78
end
115
score
100.0
distance
98.298615
seq distance
False
chain
A
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
98.65944
seq distance
False
chain
G
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
98.65944
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
98.81177
seq distance
False
chain
V
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
98.81177
seq distance
False
chain
V
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
99.1174
seq distance
False
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
99.1174
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
103.15356
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
103.15356
seq distance
False
chain
V
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
104.10764
seq distance
False
chain
A
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
104.10764
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
104.83822
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
104.83822
seq distance
False
chain
H
MACPF
begin
117
end
488
score
87.6099706744868
distance
105.15881
seq distance
False
chain
J
MACPF
begin
117
end
488
score
87.6099706744868
distance
105.15881
seq distance
False
chain
J
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
105.64669
seq distance
False
chain
V
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
105.64669
seq distance
False
chain
V
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
105.84021
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
105.84021
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
107.81148
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
107.81148
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
108.30024
seq distance
False
chain
V
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
108.30024
seq distance
False
chain
V
LDL-receptor class A
begin
78
end
115
score
100.0
distance
108.55872
seq distance
False
chain
I
LDL-receptor class A
begin
78
end
115
score
100.0
distance
108.55872
seq distance
False
chain
I
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
109.08189
seq distance
False
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
109.08189
seq distance
False
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
109.43026
seq distance
False
chain
A
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
109.43026
seq distance
False
chain
A
MACPF
begin
117
end
488
score
87.6099706744868
distance
109.74706
seq distance
False
chain
U
MACPF
begin
117
end
488
score
87.6099706744868
distance
109.74706
seq distance
False
chain
U
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
111.91855
seq distance
False
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
111.91855
seq distance
False
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
112.56133
seq distance
False
chain
J
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
112.56133
seq distance
False
chain
J
EGF-like
begin
489
end
519
score
99.12023460410556
distance
113.55372
seq distance
False
chain
U
EGF-like
begin
489
end
519
score
99.12023460410556
distance
113.55372
seq distance
False
chain
U
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
114.61492
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
114.61492
seq distance
False
chain
I
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
114.70129
seq distance
False
chain
H
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
114.70129
seq distance
False
chain
H
EGF-like
begin
489
end
519
score
99.12023460410556
distance
116.21235
seq distance
False
chain
I
EGF-like
begin
489
end
519
score
99.12023460410556
distance
116.21235
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
116.34565
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
116.34565
seq distance
False
chain
U
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
116.51757
seq distance
False
chain
U
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
116.51757
seq distance
False
chain
U
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
116.55129
seq distance
False
chain
U
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
116.55129
seq distance
False
chain
U
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
118.52794
seq distance
False
chain
V
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
118.52794
seq distance
False
chain
V
LDL-receptor class A
begin
78
end
115
score
100.0
distance
118.52794
seq distance
False
chain
V
LDL-receptor class A
begin
78
end
115
score
100.0
distance
118.52794
seq distance
False
chain
V
MACPF
begin
117
end
488
score
87.6099706744868
distance
119.156876
seq distance
False
chain
K
MACPF
begin
117
end
488
score
87.6099706744868
distance
119.156876
seq distance
False
chain
K
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
119.28383
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
119.28383
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
119.84134
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
119.84134
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
121.41152
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
121.41152
seq distance
False
chain
I
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
121.56823
seq distance
False
chain
U
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
121.56823
seq distance
False
chain
U
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
122.78944
seq distance
False
chain
J
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
122.78944
seq distance
False
chain
J
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
122.97526
seq distance
False
chain
V
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
122.97526
seq distance
False
chain
V
MACPF
begin
117
end
488
score
87.6099706744868
distance
123.80459
seq distance
False
chain
T
MACPF
begin
117
end
488
score
87.6099706744868
distance
123.80459
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
124.87465
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
124.87465
seq distance
False
chain
J
LDL-receptor class A
begin
78
end
115
score
100.0
distance
127.340454
seq distance
False
chain
J
LDL-receptor class A
begin
78
end
115
score
100.0
distance
127.340454
seq distance
False
chain
J
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
127.99883
seq distance
False
chain
U
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
127.99883
seq distance
False
chain
U
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
128.36975
seq distance
False
chain
V
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
128.36975
seq distance
False
chain
V
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
130.17924
seq distance
False
chain
I
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
130.17924
seq distance
False
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
130.46375
seq distance
False
chain
K
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
130.46375
seq distance
False
chain
K
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
130.68642
seq distance
False
chain
J
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
130.68642
seq distance
False
chain
J
MACPF
begin
117
end
488
score
87.6099706744868
distance
130.9998
seq distance
False
chain
L
MACPF
begin
117
end
488
score
87.6099706744868
distance
130.9998
seq distance
False
chain
L
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
131.0165
seq distance
False
chain
I
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
131.0165
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
132.09335
seq distance
False
chain
T
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
132.09335
seq distance
False
chain
T
EGF-like
begin
489
end
519
score
99.12023460410556
distance
132.21768
seq distance
False
chain
T
EGF-like
begin
489
end
519
score
99.12023460410556
distance
132.21768
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
132.3013
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
132.3013
seq distance
False
chain
T
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
133.61905
seq distance
False
chain
J
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
133.61905
seq distance
False
chain
J
EGF-like
begin
489
end
519
score
99.12023460410556
distance
133.75932
seq distance
False
chain
J
EGF-like
begin
489
end
519
score
99.12023460410556
distance
133.75932
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
135.1007
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
135.1007
seq distance
False
chain
T
MACPF
begin
117
end
488
score
87.6099706744868
distance
135.7068
seq distance
False
chain
S
MACPF
begin
117
end
488
score
87.6099706744868
distance
135.7068
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
136.50597
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
136.50597
seq distance
False
chain
J
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
136.51474
seq distance
False
chain
T
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
136.51474
seq distance
False
chain
T
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
136.87108
seq distance
False
chain
T
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
136.87108
seq distance
False
chain
T
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
137.20026
seq distance
False
chain
U
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
137.20026
seq distance
False
chain
U
LDL-receptor class A
begin
78
end
115
score
100.0
distance
137.20026
seq distance
False
chain
U
LDL-receptor class A
begin
78
end
115
score
100.0
distance
137.20026
seq distance
False
chain
U
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
137.43251
seq distance
False
chain
K
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
137.43251
seq distance
False
chain
K
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
137.90039
seq distance
False
chain
J
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
137.90039
seq distance
False
chain
J
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
139.54855
seq distance
False
chain
U
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
139.54855
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
139.5586
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
139.5586
seq distance
False
chain
K
MACPF
begin
117
end
488
score
87.6099706744868
distance
140.17773
seq distance
False
chain
M
MACPF
begin
117
end
488
score
87.6099706744868
distance
140.17773
seq distance
False
chain
M
LDL-receptor class A
begin
78
end
115
score
100.0
distance
143.88191
seq distance
False
chain
K
LDL-receptor class A
begin
78
end
115
score
100.0
distance
143.88191
seq distance
False
chain
K
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
144.24495
seq distance
False
chain
J
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
144.24495
seq distance
False
chain
J
MACPF
begin
117
end
488
score
87.6099706744868
distance
144.45155
seq distance
False
chain
R
MACPF
begin
117
end
488
score
87.6099706744868
distance
144.45155
seq distance
False
chain
R
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
145.1518
seq distance
False
chain
S
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
145.1518
seq distance
False
chain
S
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
145.24997
seq distance
False
chain
T
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
145.24997
seq distance
False
chain
T
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
145.57814
seq distance
False
chain
U
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
145.57814
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
145.71883
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
145.71883
seq distance
False
chain
S
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
145.93411
seq distance
False
chain
L
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
145.93411
seq distance
False
chain
L
MACPF
begin
117
end
488
score
87.6099706744868
distance
146.78107
seq distance
False
chain
N
MACPF
begin
117
end
488
score
87.6099706744868
distance
146.78107
seq distance
False
chain
N
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
147.6274
seq distance
False
chain
K
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
147.6274
seq distance
False
chain
K
EGF-like
begin
489
end
519
score
99.12023460410556
distance
148.28217
seq distance
False
chain
S
EGF-like
begin
489
end
519
score
99.12023460410556
distance
148.28217
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
148.33287
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
148.33287
seq distance
False
chain
S
EGF-like
begin
489
end
519
score
99.12023460410556
distance
148.68845
seq distance
False
chain
K
EGF-like
begin
489
end
519
score
99.12023460410556
distance
148.68845
seq distance
False
chain
K
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
149.43048
seq distance
False
chain
L
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
149.43048
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
149.49858
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
149.49858
seq distance
False
chain
K
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
149.75963
seq distance
False
chain
S
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
149.75963
seq distance
False
chain
S
MACPF
begin
117
end
488
score
87.6099706744868
distance
149.8943
seq distance
False
chain
Q
MACPF
begin
117
end
488
score
87.6099706744868
distance
149.8943
seq distance
False
chain
Q
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
149.93773
seq distance
False
chain
J
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
149.93773
seq distance
False
chain
J
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
150.02293
seq distance
False
chain
K
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
150.02293
seq distance
False
chain
K
MACPF
begin
117
end
488
score
87.6099706744868
distance
150.66788
seq distance
False
chain
O
MACPF
begin
117
end
488
score
87.6099706744868
distance
150.66788
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
151.53435
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
151.53435
seq distance
False
chain
L
MACPF
begin
117
end
488
score
87.6099706744868
distance
151.70926
seq distance
False
chain
P
MACPF
begin
117
end
488
score
87.6099706744868
distance
151.70926
seq distance
False
chain
P
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
153.45491
seq distance
False
chain
T
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
153.45491
seq distance
False
chain
T
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
153.64789
seq distance
False
chain
T
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
153.64789
seq distance
False
chain
T
LDL-receptor class A
begin
78
end
115
score
100.0
distance
153.64789
seq distance
False
chain
T
LDL-receptor class A
begin
78
end
115
score
100.0
distance
153.64789
seq distance
False
chain
T
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
154.24416
seq distance
False
chain
K
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
154.24416
seq distance
False
chain
K
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
154.41222
seq distance
False
chain
S
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
154.41222
seq distance
False
chain
S
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
155.37679
seq distance
False
chain
R
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
155.37679
seq distance
False
chain
R
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
156.26282
seq distance
False
chain
K
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
156.26282
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
156.27704
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
156.27704
seq distance
False
chain
R
LDL-receptor class A
begin
78
end
115
score
100.0
distance
158.05394
seq distance
False
chain
L
LDL-receptor class A
begin
78
end
115
score
100.0
distance
158.05394
seq distance
False
chain
L
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
158.51576
seq distance
False
chain
M
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
158.51576
seq distance
False
chain
M
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
158.59209
seq distance
False
chain
M
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
158.59209
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
159.06285
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
159.06285
seq distance
False
chain
R
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
159.65332
seq distance
False
chain
S
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
159.65332
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
159.9673
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
159.9673
seq distance
False
chain
L
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
160.44122
seq distance
False
chain
T
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
160.44122
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
160.53922
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
160.53922
seq distance
False
chain
M
EGF-like
begin
489
end
519
score
99.12023460410556
distance
160.6822
seq distance
False
chain
L
EGF-like
begin
489
end
519
score
99.12023460410556
distance
160.6822
seq distance
False
chain
L
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
160.73526
seq distance
False
chain
R
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
160.73526
seq distance
False
chain
R
EGF-like
begin
489
end
519
score
99.12023460410556
distance
161.3805
seq distance
False
chain
R
EGF-like
begin
489
end
519
score
99.12023460410556
distance
161.3805
seq distance
False
chain
R
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
162.16566
seq distance
False
chain
L
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
162.16566
seq distance
False
chain
L
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
162.54498
seq distance
False
chain
Q
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
162.54498
seq distance
False
chain
Q
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
163.4789
seq distance
False
chain
L
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
163.4789
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
163.74812
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
163.74812
seq distance
False
chain
Q
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
164.37299
seq distance
False
chain
S
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
164.37299
seq distance
False
chain
S
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
164.4546
seq distance
False
chain
N
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
164.4546
seq distance
False
chain
N
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
165.48666
seq distance
False
chain
K
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
165.48666
seq distance
False
chain
K
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
165.80118
seq distance
False
chain
L
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
165.80118
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
166.34364
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
166.34364
seq distance
False
chain
N
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
166.49721
seq distance
False
chain
P
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
166.49721
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
166.99278
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
166.99278
seq distance
False
chain
Q
LDL-receptor class A
begin
78
end
115
score
100.0
distance
167.1328
seq distance
False
chain
S
LDL-receptor class A
begin
78
end
115
score
100.0
distance
167.1328
seq distance
False
chain
S
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
167.14417
seq distance
False
chain
O
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
167.14417
seq distance
False
chain
O
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
167.36632
seq distance
False
chain
S
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
167.36632
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
167.64508
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
167.64508
seq distance
False
chain
M
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
167.8554
seq distance
False
chain
L
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
167.8554
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
167.97116
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
167.97116
seq distance
False
chain
P
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
168.12006
seq distance
False
chain
N
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
168.12006
seq distance
False
chain
N
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
168.80128
seq distance
False
chain
R
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
168.80128
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
168.84778
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
168.84778
seq distance
False
chain
O
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
169.09471
seq distance
False
chain
Q
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
169.09471
seq distance
False
chain
Q
LDL-receptor class A
begin
78
end
115
score
100.0
distance
169.40765
seq distance
False
chain
M
LDL-receptor class A
begin
78
end
115
score
100.0
distance
169.40765
seq distance
False
chain
M
EGF-like
begin
489
end
519
score
99.12023460410556
distance
169.49573
seq distance
False
chain
M
EGF-like
begin
489
end
519
score
99.12023460410556
distance
169.49573
seq distance
False
chain
M
EGF-like
begin
489
end
519
score
99.12023460410556
distance
169.98546
seq distance
False
chain
Q
EGF-like
begin
489
end
519
score
99.12023460410556
distance
169.98546
seq distance
False
chain
Q
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
170.8879
seq distance
False
chain
R
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
170.8879
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
171.92169
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
171.92169
seq distance
False
chain
P
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
172.05766
seq distance
False
chain
R
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
172.05766
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
172.24622
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
172.24622
seq distance
False
chain
N
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
172.49689
seq distance
False
chain
S
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
172.49689
seq distance
False
chain
S
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
172.59807
seq distance
False
chain
M
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
172.59807
seq distance
False
chain
M
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
173.68805
seq distance
False
chain
M
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
173.68805
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
173.69803
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
173.69803
seq distance
False
chain
O
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
173.83376
seq distance
False
chain
M
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
173.83376
seq distance
False
chain
M
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
174.34822
seq distance
False
chain
O
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
174.34822
seq distance
False
chain
O
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
174.59738
seq distance
False
chain
P
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
174.59738
seq distance
False
chain
P
EGF-like
begin
489
end
519
score
99.12023460410556
distance
174.89833
seq distance
False
chain
N
EGF-like
begin
489
end
519
score
99.12023460410556
distance
174.89833
seq distance
False
chain
N
EGF-like
begin
489
end
519
score
99.12023460410556
distance
175.15187
seq distance
False
chain
P
EGF-like
begin
489
end
519
score
99.12023460410556
distance
175.15187
seq distance
False
chain
P
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
176.33318
seq distance
False
chain
Q
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
176.33318
seq distance
False
chain
Q
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
176.37025
seq distance
False
chain
N
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
176.37025
seq distance
False
chain
N
LDL-receptor class A
begin
78
end
115
score
100.0
distance
176.49814
seq distance
False
chain
R
LDL-receptor class A
begin
78
end
115
score
100.0
distance
176.49814
seq distance
False
chain
R
EGF-like
begin
489
end
519
score
99.12023460410556
distance
176.80705
seq distance
False
chain
O
EGF-like
begin
489
end
519
score
99.12023460410556
distance
176.80705
seq distance
False
chain
O
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
177.05632
seq distance
False
chain
O
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
177.05632
seq distance
False
chain
O
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
177.10233
seq distance
False
chain
P
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
177.10233
seq distance
False
chain
P
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
177.55997
seq distance
False
chain
L
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
177.55997
seq distance
False
chain
L
LDL-receptor class A
begin
78
end
115
score
100.0
distance
177.64125
seq distance
False
chain
N
LDL-receptor class A
begin
78
end
115
score
100.0
distance
177.64125
seq distance
False
chain
N
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
177.99242
seq distance
False
chain
R
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
177.99242
seq distance
False
chain
R
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
178.34673
seq distance
False
chain
M
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
178.34673
seq distance
False
chain
M
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
178.71658
seq distance
False
chain
Q
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
178.71658
seq distance
False
chain
Q
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
179.768
seq distance
False
chain
Q
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
179.768
seq distance
False
chain
Q
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
180.4147
seq distance
False
chain
N
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
180.4147
seq distance
False
chain
N
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
181.4171
seq distance
False
chain
R
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
181.4171
seq distance
False
chain
R
LDL-receptor class A
begin
78
end
115
score
100.0
distance
181.98257
seq distance
False
chain
Q
LDL-receptor class A
begin
78
end
115
score
100.0
distance
181.98257
seq distance
False
chain
Q
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
182.31863
seq distance
False
chain
N
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
182.31863
seq distance
False
chain
N
LDL-receptor class A
begin
78
end
115
score
100.0
distance
182.55803
seq distance
False
chain
O
LDL-receptor class A
begin
78
end
115
score
100.0
distance
182.55803
seq distance
False
chain
O
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
182.96158
seq distance
False
chain
P
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
182.96158
seq distance
False
chain
P
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
183.5354
seq distance
False
chain
O
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
183.5354
seq distance
False
chain
O
LDL-receptor class A
begin
78
end
115
score
100.0
distance
184.01616
seq distance
False
chain
P
LDL-receptor class A
begin
78
end
115
score
100.0
distance
184.01616
seq distance
False
chain
P
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
185.2552
seq distance
False
chain
Q
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
185.2552
seq distance
False
chain
Q
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
185.45932
seq distance
False
chain
N
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
185.45932
seq distance
False
chain
N
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
185.97678
seq distance
False
chain
M
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
185.97678
seq distance
False
chain
M
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
186.96207
seq distance
False
chain
Q
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
186.96207
seq distance
False
chain
Q
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
187.08655
seq distance
False
chain
P
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
187.08655
seq distance
False
chain
P
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
187.41556
seq distance
False
chain
O
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
187.41556
seq distance
False
chain
O
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
188.96187
seq distance
False
chain
P
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
188.96187
seq distance
False
chain
P
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
188.976
seq distance
False
chain
P
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
188.976
seq distance
False
chain
P
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
189.0321
seq distance
False
chain
O
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
189.0321
seq distance
False
chain
O
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
190.22021
seq distance
False
chain
N
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
190.22021
seq distance
False
chain
N
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
190.59818
seq distance
False
chain
O
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
190.59818
seq distance
False
chain
O
Details
Redox score
76.52
PDB code
6dlw
Structure name
complement component polyc9
Structure deposition date
2018-06-03
Thiol separation (Å)
2.03
Half-sphere exposure sum
66
Minimum pKa
nan
% buried
nan
Peptide accession
P02748
Residue number A
510 (Residue 489 in this structure)
Residue number B
526 (Residue 505 in this structure)
Peptide name
Complement component C9
6dlw A 86 A 104
A redox-regulated disulphide may form within Complement component C9 at these cysteines.
Relevent regions
LDL-receptor class A
begin
78
end
115
score
100.0
distance
2.7896197
seq distance
0
chain
A
LDL-receptor class A
begin
78
end
115
score
100.0
distance
2.7896197
seq distance
0
chain
A
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
6.7369537
seq distance
2
chain
A
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
6.7369537
seq distance
2
chain
A
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
9.904644
seq distance
6
chain
A
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
9.904644
seq distance
6
chain
A
MACPF
begin
117
end
488
score
87.6099706744868
distance
10.515679
seq distance
13
chain
A
MACPF
begin
117
end
488
score
87.6099706744868
distance
10.515679
seq distance
13
chain
A
MACPF
begin
117
end
488
score
87.6099706744868
distance
14.056648
seq distance
False
chain
B
MACPF
begin
117
end
488
score
87.6099706744868
distance
14.056648
seq distance
False
chain
B
LDL-receptor class A
begin
78
end
115
score
100.0
distance
15.324272
seq distance
False
chain
B
LDL-receptor class A
begin
78
end
115
score
100.0
distance
15.324272
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
20.594276
seq distance
False
chain
V
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
20.594276
seq distance
False
chain
V
LDL-receptor class A
begin
78
end
115
score
100.0
distance
20.594276
seq distance
False
chain
V
LDL-receptor class A
begin
78
end
115
score
100.0
distance
20.594276
seq distance
False
chain
V
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
20.720596
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
20.720596
seq distance
False
chain
B
MACPF
begin
117
end
488
score
87.6099706744868
distance
21.270819
seq distance
False
chain
V
MACPF
begin
117
end
488
score
87.6099706744868
distance
21.270819
seq distance
False
chain
V
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
23.00416
seq distance
False
chain
V
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
23.00416
seq distance
False
chain
V
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
23.925045
seq distance
12
chain
A
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
23.925045
seq distance
12
chain
A
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
27.305305
seq distance
42
chain
A
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
27.305305
seq distance
42
chain
A
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
28.235228
seq distance
False
chain
B
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
28.235228
seq distance
False
chain
B
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
30.004957
seq distance
78
chain
A
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
30.004957
seq distance
78
chain
A
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
30.820747
seq distance
False
chain
V
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
30.820747
seq distance
False
chain
V
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
31.256115
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
31.256115
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
32.335255
seq distance
False
chain
V
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
32.335255
seq distance
False
chain
V
MACPF
begin
117
end
488
score
87.6099706744868
distance
34.68793
seq distance
False
chain
C
MACPF
begin
117
end
488
score
87.6099706744868
distance
34.68793
seq distance
False
chain
C
EGF-like
begin
489
end
519
score
99.12023460410556
distance
37.271763
seq distance
False
chain
V
EGF-like
begin
489
end
519
score
99.12023460410556
distance
37.271763
seq distance
False
chain
V
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
40.70818
seq distance
False
chain
U
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
40.70818
seq distance
False
chain
U
LDL-receptor class A
begin
78
end
115
score
100.0
distance
41.248165
seq distance
False
chain
C
LDL-receptor class A
begin
78
end
115
score
100.0
distance
41.248165
seq distance
False
chain
C
EGF-like
begin
489
end
519
score
99.12023460410556
distance
42.188965
seq distance
385
chain
A
EGF-like
begin
489
end
519
score
99.12023460410556
distance
42.188965
seq distance
385
chain
A
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
42.784756
seq distance
False
chain
B
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
42.784756
seq distance
False
chain
B
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
43.20687
seq distance
False
chain
C
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
43.20687
seq distance
False
chain
C
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
44.637554
seq distance
False
chain
B
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
44.637554
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
44.808296
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
44.808296
seq distance
False
chain
C
MACPF
begin
117
end
488
score
87.6099706744868
distance
45.080006
seq distance
False
chain
U
MACPF
begin
117
end
488
score
87.6099706744868
distance
45.080006
seq distance
False
chain
U
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
45.573414
seq distance
False
chain
U
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
45.573414
seq distance
False
chain
U
LDL-receptor class A
begin
78
end
115
score
100.0
distance
45.573414
seq distance
False
chain
U
LDL-receptor class A
begin
78
end
115
score
100.0
distance
45.573414
seq distance
False
chain
U
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
46.737087
seq distance
False
chain
V
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
46.737087
seq distance
False
chain
V
EGF-like
begin
489
end
519
score
99.12023460410556
distance
48.77823
seq distance
False
chain
U
EGF-like
begin
489
end
519
score
99.12023460410556
distance
48.77823
seq distance
False
chain
U
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
48.896065
seq distance
302
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
48.896065
seq distance
302
chain
A
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
49.06855
seq distance
False
chain
U
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
49.06855
seq distance
False
chain
U
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
50.249935
seq distance
False
chain
V
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
50.249935
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
51.351543
seq distance
301
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
51.351543
seq distance
301
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
51.997543
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
51.997543
seq distance
False
chain
V
MACPF
begin
117
end
488
score
87.6099706744868
distance
55.068874
seq distance
False
chain
D
MACPF
begin
117
end
488
score
87.6099706744868
distance
55.068874
seq distance
False
chain
D
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
56.010498
seq distance
False
chain
C
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
56.010498
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
56.473675
seq distance
False
chain
U
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
56.473675
seq distance
False
chain
U
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
57.632526
seq distance
False
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
57.632526
seq distance
False
chain
B
EGF-like
begin
489
end
519
score
99.12023460410556
distance
59.385212
seq distance
False
chain
B
EGF-like
begin
489
end
519
score
99.12023460410556
distance
59.385212
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
60.478832
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
60.478832
seq distance
False
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
60.69097
seq distance
False
chain
U
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
60.69097
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
61.81757
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
61.81757
seq distance
False
chain
U
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
63.435085
seq distance
False
chain
D
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
63.435085
seq distance
False
chain
D
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
64.04122
seq distance
False
chain
C
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
64.04122
seq distance
False
chain
C
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
65.359276
seq distance
False
chain
T
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
65.359276
seq distance
False
chain
T
LDL-receptor class A
begin
78
end
115
score
100.0
distance
66.2592
seq distance
False
chain
D
LDL-receptor class A
begin
78
end
115
score
100.0
distance
66.2592
seq distance
False
chain
D
MACPF
begin
117
end
488
score
87.6099706744868
distance
67.114
seq distance
False
chain
T
MACPF
begin
117
end
488
score
87.6099706744868
distance
67.114
seq distance
False
chain
T
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
67.22759
seq distance
False
chain
U
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
67.22759
seq distance
False
chain
U
EGF-like
begin
489
end
519
score
99.12023460410556
distance
68.158806
seq distance
False
chain
T
EGF-like
begin
489
end
519
score
99.12023460410556
distance
68.158806
seq distance
False
chain
T
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
68.60742
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
68.60742
seq distance
False
chain
D
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
69.79805
seq distance
False
chain
T
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
69.79805
seq distance
False
chain
T
LDL-receptor class A
begin
78
end
115
score
100.0
distance
69.79805
seq distance
False
chain
T
LDL-receptor class A
begin
78
end
115
score
100.0
distance
69.79805
seq distance
False
chain
T
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
70.77731
seq distance
False
chain
T
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
70.77731
seq distance
False
chain
T
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
70.962234
seq distance
False
chain
C
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
70.962234
seq distance
False
chain
C
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
72.24962
seq distance
False
chain
C
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
72.24962
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
75.236336
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
75.236336
seq distance
False
chain
C
MACPF
begin
117
end
488
score
87.6099706744868
distance
75.71569
seq distance
False
chain
E
MACPF
begin
117
end
488
score
87.6099706744868
distance
75.71569
seq distance
False
chain
E
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
76.065735
seq distance
False
chain
T
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
76.065735
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
76.9012
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
76.9012
seq distance
False
chain
T
EGF-like
begin
489
end
519
score
99.12023460410556
distance
79.612335
seq distance
False
chain
C
EGF-like
begin
489
end
519
score
99.12023460410556
distance
79.612335
seq distance
False
chain
C
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
79.71054
seq distance
False
chain
D
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
79.71054
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
79.737854
seq distance
False
chain
T
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
79.737854
seq distance
False
chain
T
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
84.21856
seq distance
False
chain
E
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
84.21856
seq distance
False
chain
E
MACPF
begin
117
end
488
score
87.6099706744868
distance
84.246925
seq distance
False
chain
S
MACPF
begin
117
end
488
score
87.6099706744868
distance
84.246925
seq distance
False
chain
S
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
85.89385
seq distance
False
chain
D
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
85.89385
seq distance
False
chain
D
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
87.71566
seq distance
False
chain
S
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
87.71566
seq distance
False
chain
S
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
87.91869
seq distance
False
chain
T
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
87.91869
seq distance
False
chain
T
LDL-receptor class A
begin
78
end
115
score
100.0
distance
88.49459
seq distance
False
chain
E
LDL-receptor class A
begin
78
end
115
score
100.0
distance
88.49459
seq distance
False
chain
E
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
89.08286
seq distance
False
chain
D
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
89.08286
seq distance
False
chain
D
EGF-like
begin
489
end
519
score
99.12023460410556
distance
89.57101
seq distance
False
chain
S
EGF-like
begin
489
end
519
score
99.12023460410556
distance
89.57101
seq distance
False
chain
S
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
91.12844
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
91.12844
seq distance
False
chain
E
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
92.12193
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
92.12193
seq distance
False
chain
D
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
92.42027
seq distance
False
chain
S
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
92.42027
seq distance
False
chain
S
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
92.62875
seq distance
False
chain
S
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
92.62875
seq distance
False
chain
S
LDL-receptor class A
begin
78
end
115
score
100.0
distance
92.62875
seq distance
False
chain
S
LDL-receptor class A
begin
78
end
115
score
100.0
distance
92.62875
seq distance
False
chain
S
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
93.058365
seq distance
False
chain
S
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
93.058365
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
93.42347
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
93.42347
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
93.85518
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
93.85518
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
94.65138
seq distance
158
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
94.65138
seq distance
158
chain
A
MACPF
begin
117
end
488
score
87.6099706744868
distance
95.34198
seq distance
False
chain
F
MACPF
begin
117
end
488
score
87.6099706744868
distance
95.34198
seq distance
False
chain
F
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
97.044365
seq distance
False
chain
D
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
97.044365
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
97.58646
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
97.58646
seq distance
False
chain
U
MACPF
begin
117
end
488
score
87.6099706744868
distance
100.325584
seq distance
False
chain
R
MACPF
begin
117
end
488
score
87.6099706744868
distance
100.325584
seq distance
False
chain
R
EGF-like
begin
489
end
519
score
99.12023460410556
distance
100.3349
seq distance
False
chain
D
EGF-like
begin
489
end
519
score
99.12023460410556
distance
100.3349
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
101.26233
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
101.26233
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
101.45557
seq distance
False
chain
S
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
101.45557
seq distance
False
chain
S
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
101.79247
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
101.79247
seq distance
False
chain
E
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
104.05575
seq distance
False
chain
F
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
104.05575
seq distance
False
chain
F
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
105.7777
seq distance
False
chain
V
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
105.7777
seq distance
False
chain
V
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
106.05651
seq distance
False
chain
E
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
106.05651
seq distance
False
chain
E
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
106.3328
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
106.3328
seq distance
False
chain
T
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
106.73146
seq distance
False
chain
E
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
106.73146
seq distance
False
chain
E
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
107.47857
seq distance
False
chain
S
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
107.47857
seq distance
False
chain
S
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
107.98131
seq distance
154
chain
A
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
107.98131
seq distance
154
chain
A
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
108.34541
seq distance
False
chain
U
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
108.34541
seq distance
False
chain
U
LDL-receptor class A
begin
78
end
115
score
100.0
distance
109.08148
seq distance
False
chain
F
LDL-receptor class A
begin
78
end
115
score
100.0
distance
109.08148
seq distance
False
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
109.11533
seq distance
False
chain
E
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
109.11533
seq distance
False
chain
E
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
109.13704
seq distance
False
chain
R
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
109.13704
seq distance
False
chain
R
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
109.87425
seq distance
False
chain
R
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
109.87425
seq distance
False
chain
R
EGF-like
begin
489
end
519
score
99.12023460410556
distance
110.61998
seq distance
False
chain
R
EGF-like
begin
489
end
519
score
99.12023460410556
distance
110.61998
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
110.778465
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
110.778465
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
111.66223
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
111.66223
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
111.87269
seq distance
False
chain
F
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
111.87269
seq distance
False
chain
F
MACPF
begin
117
end
488
score
87.6099706744868
distance
112.21599
seq distance
False
chain
G
MACPF
begin
117
end
488
score
87.6099706744868
distance
112.21599
seq distance
False
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
112.77792
seq distance
False
chain
R
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
112.77792
seq distance
False
chain
R
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
113.59695
seq distance
False
chain
R
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
113.59695
seq distance
False
chain
R
LDL-receptor class A
begin
78
end
115
score
100.0
distance
113.59695
seq distance
False
chain
R
LDL-receptor class A
begin
78
end
115
score
100.0
distance
113.59695
seq distance
False
chain
R
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
114.787766
seq distance
False
chain
B
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
114.787766
seq distance
False
chain
B
MACPF
begin
117
end
488
score
87.6099706744868
distance
115.23612
seq distance
False
chain
Q
MACPF
begin
117
end
488
score
87.6099706744868
distance
115.23612
seq distance
False
chain
Q
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
115.29966
seq distance
False
chain
T
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
115.29966
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
118.0304
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
118.0304
seq distance
False
chain
S
EGF-like
begin
489
end
519
score
99.12023460410556
distance
120.16556
seq distance
False
chain
E
EGF-like
begin
489
end
519
score
99.12023460410556
distance
120.16556
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
121.15841
seq distance
False
chain
R
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
121.15841
seq distance
False
chain
R
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
121.46872
seq distance
False
chain
E
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
121.46872
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
121.83617
seq distance
False
chain
F
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
121.83617
seq distance
False
chain
F
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
122.028786
seq distance
False
chain
F
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
122.028786
seq distance
False
chain
F
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
122.17384
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
122.17384
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
124.20884
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
124.20884
seq distance
False
chain
D
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
124.78184
seq distance
False
chain
C
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
124.78184
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
125.079124
seq distance
False
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
125.079124
seq distance
False
chain
F
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
125.21301
seq distance
False
chain
R
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
125.21301
seq distance
False
chain
R
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
125.402626
seq distance
False
chain
S
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
125.402626
seq distance
False
chain
S
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
125.49658
seq distance
False
chain
Q
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
125.49658
seq distance
False
chain
Q
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
125.78706
seq distance
False
chain
F
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
125.78706
seq distance
False
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
126.589294
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
126.589294
seq distance
False
chain
Q
MACPF
begin
117
end
488
score
87.6099706744868
distance
126.96397
seq distance
False
chain
H
MACPF
begin
117
end
488
score
87.6099706744868
distance
126.96397
seq distance
False
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
127.53183
seq distance
False
chain
G
LDL-receptor class A
begin
78
end
115
score
100.0
distance
127.53183
seq distance
False
chain
G
MACPF
begin
117
end
488
score
87.6099706744868
distance
128.37746
seq distance
False
chain
P
MACPF
begin
117
end
488
score
87.6099706744868
distance
128.37746
seq distance
False
chain
P
EGF-like
begin
489
end
519
score
99.12023460410556
distance
128.5343
seq distance
False
chain
Q
EGF-like
begin
489
end
519
score
99.12023460410556
distance
128.5343
seq distance
False
chain
Q
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
128.85213
seq distance
False
chain
Q
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
128.85213
seq distance
False
chain
Q
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
130.35701
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
130.35701
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
131.07256
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
131.07256
seq distance
False
chain
R
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
131.17097
seq distance
False
chain
Q
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
131.17097
seq distance
False
chain
Q
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
132.26476
seq distance
False
chain
Q
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
132.26476
seq distance
False
chain
Q
LDL-receptor class A
begin
78
end
115
score
100.0
distance
132.26476
seq distance
False
chain
Q
LDL-receptor class A
begin
78
end
115
score
100.0
distance
132.26476
seq distance
False
chain
Q
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
136.2846
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
136.2846
seq distance
False
chain
G
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
136.58134
seq distance
False
chain
D
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
136.58134
seq distance
False
chain
D
EGF-like
begin
489
end
519
score
99.12023460410556
distance
136.86537
seq distance
False
chain
F
EGF-like
begin
489
end
519
score
99.12023460410556
distance
136.86537
seq distance
False
chain
F
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
137.2292
seq distance
False
chain
R
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
137.2292
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
137.45833
seq distance
False
chain
E
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
137.45833
seq distance
False
chain
E
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
138.04369
seq distance
False
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
138.04369
seq distance
False
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
138.41978
seq distance
False
chain
Q
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
138.41978
seq distance
False
chain
Q
MACPF
begin
117
end
488
score
87.6099706744868
distance
138.50755
seq distance
False
chain
I
MACPF
begin
117
end
488
score
87.6099706744868
distance
138.50755
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
139.26028
seq distance
False
chain
P
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
139.26028
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
139.29744
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
139.29744
seq distance
False
chain
G
MACPF
begin
117
end
488
score
87.6099706744868
distance
139.30792
seq distance
False
chain
O
MACPF
begin
117
end
488
score
87.6099706744868
distance
139.30792
seq distance
False
chain
O
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
139.39597
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
139.39597
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
140.58759
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
140.58759
seq distance
False
chain
P
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
140.62437
seq distance
False
chain
Q
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
140.62437
seq distance
False
chain
Q
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
142.51604
seq distance
False
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
142.51604
seq distance
False
chain
G
LDL-receptor class A
begin
78
end
115
score
100.0
distance
143.06163
seq distance
False
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
143.06163
seq distance
False
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
143.73209
seq distance
False
chain
F
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
143.73209
seq distance
False
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
144.21147
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
144.21147
seq distance
False
chain
Q
EGF-like
begin
489
end
519
score
99.12023460410556
distance
144.5704
seq distance
False
chain
P
EGF-like
begin
489
end
519
score
99.12023460410556
distance
144.5704
seq distance
False
chain
P
MACPF
begin
117
end
488
score
87.6099706744868
distance
145.71184
seq distance
False
chain
J
MACPF
begin
117
end
488
score
87.6099706744868
distance
145.71184
seq distance
False
chain
J
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
146.21268
seq distance
False
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
146.21268
seq distance
False
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
146.74684
seq distance
False
chain
P
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
146.74684
seq distance
False
chain
P
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
147.09616
seq distance
False
chain
P
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
147.09616
seq distance
False
chain
P
MACPF
begin
117
end
488
score
87.6099706744868
distance
147.72057
seq distance
False
chain
N
MACPF
begin
117
end
488
score
87.6099706744868
distance
147.72057
seq distance
False
chain
N
LDL-receptor class A
begin
78
end
115
score
100.0
distance
147.80286
seq distance
False
chain
P
LDL-receptor class A
begin
78
end
115
score
100.0
distance
147.80286
seq distance
False
chain
P
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
148.24422
seq distance
False
chain
P
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
148.24422
seq distance
False
chain
P
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
148.30046
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
148.30046
seq distance
False
chain
H
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
148.93292
seq distance
False
chain
E
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
148.93292
seq distance
False
chain
E
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
149.56253
seq distance
False
chain
Q
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
149.56253
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
150.28557
seq distance
False
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
150.28557
seq distance
False
chain
F
MACPF
begin
117
end
488
score
87.6099706744868
distance
150.31982
seq distance
False
chain
K
MACPF
begin
117
end
488
score
87.6099706744868
distance
150.31982
seq distance
False
chain
K
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
150.68909
seq distance
False
chain
O
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
150.68909
seq distance
False
chain
O
EGF-like
begin
489
end
519
score
99.12023460410556
distance
151.11935
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
99.12023460410556
distance
151.11935
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
151.24362
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
151.24362
seq distance
False
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
151.24902
seq distance
False
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
151.24902
seq distance
False
chain
I
MACPF
begin
117
end
488
score
87.6099706744868
distance
151.3656
seq distance
False
chain
M
MACPF
begin
117
end
488
score
87.6099706744868
distance
151.3656
seq distance
False
chain
M
MACPF
begin
117
end
488
score
87.6099706744868
distance
152.21587
seq distance
False
chain
L
MACPF
begin
117
end
488
score
87.6099706744868
distance
152.21587
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
152.26979
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
152.26979
seq distance
False
chain
O
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
152.87814
seq distance
False
chain
P
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
152.87814
seq distance
False
chain
P
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
153.33342
seq distance
False
chain
P
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
153.33342
seq distance
False
chain
P
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
154.13019
seq distance
False
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
154.13019
seq distance
False
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
155.55956
seq distance
False
chain
I
LDL-receptor class A
begin
78
end
115
score
100.0
distance
155.55956
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
156.49385
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
156.49385
seq distance
False
chain
P
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
156.50237
seq distance
False
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
156.50237
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
157.68683
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
157.68683
seq distance
False
chain
I
EGF-like
begin
489
end
519
score
99.12023460410556
distance
158.41396
seq distance
False
chain
O
EGF-like
begin
489
end
519
score
99.12023460410556
distance
158.41396
seq distance
False
chain
O
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
159.09645
seq distance
False
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
159.09645
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
159.43997
seq distance
False
chain
N
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
159.43997
seq distance
False
chain
N
LDL-receptor class A
begin
78
end
115
score
100.0
distance
159.91457
seq distance
False
chain
O
LDL-receptor class A
begin
78
end
115
score
100.0
distance
159.91457
seq distance
False
chain
O
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
160.16151
seq distance
False
chain
O
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
160.16151
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
160.52264
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
160.52264
seq distance
False
chain
I
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
160.81564
seq distance
False
chain
F
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
160.81564
seq distance
False
chain
F
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
161.19495
seq distance
False
chain
O
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
161.19495
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
161.27791
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
161.27791
seq distance
False
chain
N
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
161.40636
seq distance
False
chain
P
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
161.40636
seq distance
False
chain
P
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
161.45427
seq distance
False
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
161.45427
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
161.51674
seq distance
False
chain
J
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
161.51674
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
161.91399
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
161.91399
seq distance
False
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
162.1873
seq distance
False
chain
O
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
162.1873
seq distance
False
chain
O
EGF-like
begin
489
end
519
score
99.12023460410556
distance
162.96425
seq distance
False
chain
H
EGF-like
begin
489
end
519
score
99.12023460410556
distance
162.96425
seq distance
False
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
163.02939
seq distance
False
chain
O
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
163.02939
seq distance
False
chain
O
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
164.21611
seq distance
False
chain
J
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
164.21611
seq distance
False
chain
J
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
164.21638
seq distance
False
chain
O
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
164.21638
seq distance
False
chain
O
LDL-receptor class A
begin
78
end
115
score
100.0
distance
164.92033
seq distance
False
chain
J
LDL-receptor class A
begin
78
end
115
score
100.0
distance
164.92033
seq distance
False
chain
J
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
165.2869
seq distance
False
chain
M
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
165.2869
seq distance
False
chain
M
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
165.71785
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
165.71785
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
166.91081
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
166.91081
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
167.21617
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
167.21617
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
167.37206
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
167.37206
seq distance
False
chain
M
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
167.40063
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
167.40063
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
167.69707
seq distance
False
chain
K
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
167.69707
seq distance
False
chain
K
LDL-receptor class A
begin
78
end
115
score
100.0
distance
168.03508
seq distance
False
chain
N
LDL-receptor class A
begin
78
end
115
score
100.0
distance
168.03508
seq distance
False
chain
N
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
168.05083
seq distance
False
chain
L
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
168.05083
seq distance
False
chain
L
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
168.58818
seq distance
False
chain
K
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
168.58818
seq distance
False
chain
K
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
168.76335
seq distance
False
chain
J
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
168.76335
seq distance
False
chain
J
EGF-like
begin
489
end
519
score
99.12023460410556
distance
169.47034
seq distance
False
chain
N
EGF-like
begin
489
end
519
score
99.12023460410556
distance
169.47034
seq distance
False
chain
N
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
169.50546
seq distance
False
chain
N
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
169.50546
seq distance
False
chain
N
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
170.07661
seq distance
False
chain
N
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
170.07661
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
170.2161
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
170.2161
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
170.36517
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
170.36517
seq distance
False
chain
L
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
170.87325
seq distance
False
chain
N
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
170.87325
seq distance
False
chain
N
LDL-receptor class A
begin
78
end
115
score
100.0
distance
170.93306
seq distance
False
chain
K
LDL-receptor class A
begin
78
end
115
score
100.0
distance
170.93306
seq distance
False
chain
K
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
171.50624
seq distance
False
chain
G
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
171.50624
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
171.69788
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
171.69788
seq distance
False
chain
H
EGF-like
begin
489
end
519
score
99.12023460410556
distance
171.99463
seq distance
False
chain
I
EGF-like
begin
489
end
519
score
99.12023460410556
distance
171.99463
seq distance
False
chain
I
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
171.99866
seq distance
False
chain
O
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
171.99866
seq distance
False
chain
O
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
172.22917
seq distance
False
chain
N
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
172.22917
seq distance
False
chain
N
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
172.31656
seq distance
False
chain
L
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
172.31656
seq distance
False
chain
L
LDL-receptor class A
begin
78
end
115
score
100.0
distance
172.50858
seq distance
False
chain
M
LDL-receptor class A
begin
78
end
115
score
100.0
distance
172.50858
seq distance
False
chain
M
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
172.6361
seq distance
False
chain
M
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
172.6361
seq distance
False
chain
M
LDL-receptor class A
begin
78
end
115
score
100.0
distance
173.48013
seq distance
False
chain
L
LDL-receptor class A
begin
78
end
115
score
100.0
distance
173.48013
seq distance
False
chain
L
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
173.94579
seq distance
False
chain
J
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
173.94579
seq distance
False
chain
J
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
174.71986
seq distance
False
chain
N
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
174.71986
seq distance
False
chain
N
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
174.91536
seq distance
False
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
174.91536
seq distance
False
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
174.99693
seq distance
False
chain
J
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
174.99693
seq distance
False
chain
J
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
174.99911
seq distance
False
chain
K
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
174.99911
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
175.83989
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
175.83989
seq distance
False
chain
N
EGF-like
begin
489
end
519
score
99.12023460410556
distance
176.44157
seq distance
False
chain
M
EGF-like
begin
489
end
519
score
99.12023460410556
distance
176.44157
seq distance
False
chain
M
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
176.62262
seq distance
False
chain
M
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
176.62262
seq distance
False
chain
M
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
176.75012
seq distance
False
chain
M
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
176.75012
seq distance
False
chain
M
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
177.0776
seq distance
False
chain
M
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
177.0776
seq distance
False
chain
M
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
177.67975
seq distance
False
chain
L
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
177.67975
seq distance
False
chain
L
EGF-like
begin
489
end
519
score
99.12023460410556
distance
177.9853
seq distance
False
chain
J
EGF-like
begin
489
end
519
score
99.12023460410556
distance
177.9853
seq distance
False
chain
J
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
178.63011
seq distance
False
chain
K
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
178.63011
seq distance
False
chain
K
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
179.10718
seq distance
False
chain
K
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
179.10718
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
179.17038
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
179.17038
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
179.64949
seq distance
False
chain
L
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
179.64949
seq distance
False
chain
L
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
179.68164
seq distance
False
chain
L
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
179.68164
seq distance
False
chain
L
EGF-like
begin
489
end
519
score
99.12023460410556
distance
180.22137
seq distance
False
chain
L
EGF-like
begin
489
end
519
score
99.12023460410556
distance
180.22137
seq distance
False
chain
L
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
180.38306
seq distance
False
chain
H
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
180.38306
seq distance
False
chain
H
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
180.74075
seq distance
False
chain
N
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
180.74075
seq distance
False
chain
N
EGF-like
begin
489
end
519
score
99.12023460410556
distance
180.7479
seq distance
False
chain
K
EGF-like
begin
489
end
519
score
99.12023460410556
distance
180.7479
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
182.03079
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
182.03079
seq distance
False
chain
M
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
184.00229
seq distance
False
chain
M
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
184.00229
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
184.07788
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
184.07788
seq distance
False
chain
J
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
184.81505
seq distance
False
chain
I
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
184.81505
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
185.50716
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
185.50716
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
186.20961
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
186.20961
seq distance
False
chain
K
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
186.99348
seq distance
False
chain
I
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
186.99348
seq distance
False
chain
I
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
187.25005
seq distance
False
chain
M
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
187.25005
seq distance
False
chain
M
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
189.80531
seq distance
False
chain
L
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
189.80531
seq distance
False
chain
L
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
190.53279
seq distance
False
chain
J
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
190.53279
seq distance
False
chain
J
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
191.10448
seq distance
False
chain
J
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
191.10448
seq distance
False
chain
J
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
191.20544
seq distance
False
chain
L
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
191.20544
seq distance
False
chain
L
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
192.00417
seq distance
False
chain
K
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
192.00417
seq distance
False
chain
K
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
192.5198
seq distance
False
chain
K
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
192.5198
seq distance
False
chain
K
Details
Redox score
76.43
PDB code
6dlw
Structure name
complement component polyc9
Structure deposition date
2018-06-03
Thiol separation (Å)
2.03
Half-sphere exposure sum
58
Minimum pKa
nan
% buried
nan
Peptide accession
P02748
Residue number A
107 (Residue 86 in this structure)
Residue number B
125 (Residue 104 in this structure)
Peptide name
Complement component C9
6dlw F 22 F 57
A redox-regulated disulphide may form within Complement component C9 at these cysteines.
Relevent regions
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
2.7583358
seq distance
0
chain
F
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
2.7583358
seq distance
0
chain
F
EGF-like
begin
489
end
519
score
99.12023460410556
distance
5.626146
seq distance
432
chain
F
EGF-like
begin
489
end
519
score
99.12023460410556
distance
5.626146
seq distance
432
chain
F
MACPF
begin
117
end
488
score
87.6099706744868
distance
10.0263815
seq distance
60
chain
F
MACPF
begin
117
end
488
score
87.6099706744868
distance
10.0263815
seq distance
60
chain
F
MACPF
begin
117
end
488
score
87.6099706744868
distance
11.002913
seq distance
False
chain
G
MACPF
begin
117
end
488
score
87.6099706744868
distance
11.002913
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
99.12023460410556
distance
22.088293
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
99.12023460410556
distance
22.088293
seq distance
False
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
22.26662
seq distance
False
chain
E
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
22.26662
seq distance
False
chain
E
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
23.594234
seq distance
False
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
23.594234
seq distance
False
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
23.96828
seq distance
False
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
23.96828
seq distance
False
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
24.487253
seq distance
89
chain
F
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
24.487253
seq distance
89
chain
F
MACPF
begin
117
end
488
score
87.6099706744868
distance
28.423923
seq distance
False
chain
H
MACPF
begin
117
end
488
score
87.6099706744868
distance
28.423923
seq distance
False
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
29.06722
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
29.06722
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
99.12023460410556
distance
29.390205
seq distance
False
chain
E
EGF-like
begin
489
end
519
score
99.12023460410556
distance
29.390205
seq distance
False
chain
E
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
30.059404
seq distance
False
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
30.059404
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
31.231262
seq distance
348
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
31.231262
seq distance
348
chain
F
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
32.669098
seq distance
349
chain
F
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
32.669098
seq distance
349
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
32.836563
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
32.836563
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
33.033924
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
33.033924
seq distance
False
chain
G
LDL-receptor class A
begin
78
end
115
score
100.0
distance
34.758034
seq distance
False
chain
G
LDL-receptor class A
begin
78
end
115
score
100.0
distance
34.758034
seq distance
False
chain
G
MACPF
begin
117
end
488
score
87.6099706744868
distance
37.75532
seq distance
False
chain
E
MACPF
begin
117
end
488
score
87.6099706744868
distance
37.75532
seq distance
False
chain
E
LDL-receptor class A
begin
78
end
115
score
100.0
distance
40.279884
seq distance
21
chain
F
LDL-receptor class A
begin
78
end
115
score
100.0
distance
40.279884
seq distance
21
chain
F
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
41.305332
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
41.305332
seq distance
False
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
43.832085
seq distance
False
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
43.832085
seq distance
False
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
43.909966
seq distance
49
chain
F
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
43.909966
seq distance
49
chain
F
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
44.975372
seq distance
False
chain
E
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
44.975372
seq distance
False
chain
E
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
45.28687
seq distance
False
chain
E
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
45.28687
seq distance
False
chain
E
LDL-receptor class A
begin
78
end
115
score
100.0
distance
45.303005
seq distance
False
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
45.303005
seq distance
False
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
45.59402
seq distance
125
chain
F
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
45.59402
seq distance
125
chain
F
MACPF
begin
117
end
488
score
87.6099706744868
distance
46.716095
seq distance
False
chain
I
MACPF
begin
117
end
488
score
87.6099706744868
distance
46.716095
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
46.821342
seq distance
False
chain
E
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
46.821342
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
46.829052
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
46.829052
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
99.12023460410556
distance
47.157936
seq distance
False
chain
H
EGF-like
begin
489
end
519
score
99.12023460410556
distance
47.157936
seq distance
False
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
47.382454
seq distance
False
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
47.382454
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
47.57662
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
47.57662
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
48.500233
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
48.500233
seq distance
False
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
49.852657
seq distance
False
chain
D
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
49.852657
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
52.37849
seq distance
False
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
52.37849
seq distance
False
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
52.57506
seq distance
False
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
52.57506
seq distance
False
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
53.768856
seq distance
False
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
53.768856
seq distance
False
chain
H
EGF-like
begin
489
end
519
score
99.12023460410556
distance
54.002666
seq distance
False
chain
D
EGF-like
begin
489
end
519
score
99.12023460410556
distance
54.002666
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
55.223026
seq distance
41
chain
F
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
55.223026
seq distance
41
chain
F
LDL-receptor class A
begin
78
end
115
score
100.0
distance
58.03846
seq distance
False
chain
E
LDL-receptor class A
begin
78
end
115
score
100.0
distance
58.03846
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
59.71704
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
59.71704
seq distance
False
chain
E
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
59.90842
seq distance
205
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
59.90842
seq distance
205
chain
F
LDL-receptor class A
begin
78
end
115
score
100.0
distance
62.234184
seq distance
False
chain
I
LDL-receptor class A
begin
78
end
115
score
100.0
distance
62.234184
seq distance
False
chain
I
MACPF
begin
117
end
488
score
87.6099706744868
distance
63.089542
seq distance
False
chain
D
MACPF
begin
117
end
488
score
87.6099706744868
distance
63.089542
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
63.489777
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
63.489777
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
64.93986
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
64.93986
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
65.63259
seq distance
False
chain
E
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
65.63259
seq distance
False
chain
E
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
66.13852
seq distance
False
chain
D
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
66.13852
seq distance
False
chain
D
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
66.986435
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
66.986435
seq distance
False
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
67.11328
seq distance
False
chain
E
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
67.11328
seq distance
False
chain
E
MACPF
begin
117
end
488
score
87.6099706744868
distance
67.24737
seq distance
False
chain
J
MACPF
begin
117
end
488
score
87.6099706744868
distance
67.24737
seq distance
False
chain
J
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
67.56428
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
67.56428
seq distance
False
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
67.990974
seq distance
False
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
67.990974
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
68.49952
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
68.49952
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
68.75393
seq distance
False
chain
D
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
68.75393
seq distance
False
chain
D
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
68.942566
seq distance
False
chain
J
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
68.942566
seq distance
False
chain
J
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
71.351135
seq distance
201
chain
F
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
71.351135
seq distance
201
chain
F
EGF-like
begin
489
end
519
score
99.12023460410556
distance
72.14461
seq distance
False
chain
I
EGF-like
begin
489
end
519
score
99.12023460410556
distance
72.14461
seq distance
False
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
72.41036
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
72.41036
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
73.590744
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
73.590744
seq distance
False
chain
I
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
74.414696
seq distance
False
chain
E
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
74.414696
seq distance
False
chain
E
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
74.82888
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
74.82888
seq distance
False
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
75.91886
seq distance
False
chain
C
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
75.91886
seq distance
False
chain
C
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
76.15033
seq distance
False
chain
G
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
76.15033
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
99.12023460410556
distance
77.682106
seq distance
False
chain
C
EGF-like
begin
489
end
519
score
99.12023460410556
distance
77.682106
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
78.29289
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
78.29289
seq distance
False
chain
D
LDL-receptor class A
begin
78
end
115
score
100.0
distance
80.45868
seq distance
False
chain
D
LDL-receptor class A
begin
78
end
115
score
100.0
distance
80.45868
seq distance
False
chain
D
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
80.52742
seq distance
False
chain
D
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
80.52742
seq distance
False
chain
D
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
80.888275
seq distance
False
chain
I
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
80.888275
seq distance
False
chain
I
MACPF
begin
117
end
488
score
87.6099706744868
distance
82.41372
seq distance
False
chain
C
MACPF
begin
117
end
488
score
87.6099706744868
distance
82.41372
seq distance
False
chain
C
LDL-receptor class A
begin
78
end
115
score
100.0
distance
83.685875
seq distance
False
chain
J
LDL-receptor class A
begin
78
end
115
score
100.0
distance
83.685875
seq distance
False
chain
J
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
84.287315
seq distance
False
chain
D
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
84.287315
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
85.44031
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
85.44031
seq distance
False
chain
C
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
86.246796
seq distance
False
chain
C
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
86.246796
seq distance
False
chain
C
MACPF
begin
117
end
488
score
87.6099706744868
distance
87.00152
seq distance
False
chain
K
MACPF
begin
117
end
488
score
87.6099706744868
distance
87.00152
seq distance
False
chain
K
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
87.08164
seq distance
False
chain
J
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
87.08164
seq distance
False
chain
J
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
87.21148
seq distance
False
chain
H
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
87.21148
seq distance
False
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
87.961136
seq distance
False
chain
J
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
87.961136
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
88.93755
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
88.93755
seq distance
False
chain
J
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
89.00966
seq distance
False
chain
D
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
89.00966
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
90.344246
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
90.344246
seq distance
False
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
90.87206
seq distance
False
chain
K
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
90.87206
seq distance
False
chain
K
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
91.16607
seq distance
False
chain
J
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
91.16607
seq distance
False
chain
J
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
92.17227
seq distance
False
chain
C
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
92.17227
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
92.70091
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
92.70091
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
94.38031
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
94.38031
seq distance
False
chain
C
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
95.39402
seq distance
False
chain
J
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
95.39402
seq distance
False
chain
J
EGF-like
begin
489
end
519
score
99.12023460410556
distance
96.28134
seq distance
False
chain
J
EGF-like
begin
489
end
519
score
99.12023460410556
distance
96.28134
seq distance
False
chain
J
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
98.30319
seq distance
False
chain
C
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
98.30319
seq distance
False
chain
C
EGF-like
begin
489
end
519
score
99.12023460410556
distance
100.029465
seq distance
False
chain
B
EGF-like
begin
489
end
519
score
99.12023460410556
distance
100.029465
seq distance
False
chain
B
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
100.630875
seq distance
False
chain
B
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
100.630875
seq distance
False
chain
B
MACPF
begin
117
end
488
score
87.6099706744868
distance
100.68397
seq distance
False
chain
B
MACPF
begin
117
end
488
score
87.6099706744868
distance
100.68397
seq distance
False
chain
B
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
101.780754
seq distance
False
chain
I
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
101.780754
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
102.228584
seq distance
False
chain
C
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
102.228584
seq distance
False
chain
C
LDL-receptor class A
begin
78
end
115
score
100.0
distance
102.228584
seq distance
False
chain
C
LDL-receptor class A
begin
78
end
115
score
100.0
distance
102.228584
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
105.10999
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
105.10999
seq distance
False
chain
B
LDL-receptor class A
begin
78
end
115
score
100.0
distance
105.49847
seq distance
False
chain
K
LDL-receptor class A
begin
78
end
115
score
100.0
distance
105.49847
seq distance
False
chain
K
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
105.52218
seq distance
False
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
105.52218
seq distance
False
chain
B
MACPF
begin
117
end
488
score
87.6099706744868
distance
105.811226
seq distance
False
chain
L
MACPF
begin
117
end
488
score
87.6099706744868
distance
105.811226
seq distance
False
chain
L
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
106.29503
seq distance
False
chain
K
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
106.29503
seq distance
False
chain
K
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
107.04394
seq distance
False
chain
J
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
107.04394
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
107.306366
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
107.306366
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
108.362045
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
108.362045
seq distance
False
chain
K
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
108.762726
seq distance
False
chain
K
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
108.762726
seq distance
False
chain
K
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
109.820724
seq distance
False
chain
C
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
109.820724
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
111.41636
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
111.41636
seq distance
False
chain
B
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
111.61509
seq distance
False
chain
L
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
111.61509
seq distance
False
chain
L
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
113.28184
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
113.28184
seq distance
False
chain
C
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
113.36441
seq distance
False
chain
K
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
113.36441
seq distance
False
chain
K
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
114.03955
seq distance
False
chain
B
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
114.03955
seq distance
False
chain
B
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
114.1084
seq distance
False
chain
B
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
114.1084
seq distance
False
chain
B
MACPF
begin
117
end
488
score
87.6099706744868
distance
116.41411
seq distance
False
chain
A
MACPF
begin
117
end
488
score
87.6099706744868
distance
116.41411
seq distance
False
chain
A
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
116.78698
seq distance
False
chain
K
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
116.78698
seq distance
False
chain
K
EGF-like
begin
489
end
519
score
99.12023460410556
distance
116.9806
seq distance
False
chain
K
EGF-like
begin
489
end
519
score
99.12023460410556
distance
116.9806
seq distance
False
chain
K
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
117.64495
seq distance
False
chain
J
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
117.64495
seq distance
False
chain
J
MACPF
begin
117
end
488
score
87.6099706744868
distance
120.77534
seq distance
False
chain
M
MACPF
begin
117
end
488
score
87.6099706744868
distance
120.77534
seq distance
False
chain
M
EGF-like
begin
489
end
519
score
99.12023460410556
distance
120.78495
seq distance
False
chain
A
EGF-like
begin
489
end
519
score
99.12023460410556
distance
120.78495
seq distance
False
chain
A
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
123.04723
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
123.04723
seq distance
False
chain
B
LDL-receptor class A
begin
78
end
115
score
100.0
distance
123.04723
seq distance
False
chain
B
LDL-receptor class A
begin
78
end
115
score
100.0
distance
123.04723
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
123.12653
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
123.12653
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
123.15249
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
123.15249
seq distance
False
chain
A
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
123.40197
seq distance
False
chain
A
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
123.40197
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
123.83709
seq distance
False
chain
L
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
123.83709
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
124.03896
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
124.03896
seq distance
False
chain
K
LDL-receptor class A
begin
78
end
115
score
100.0
distance
125.50439
seq distance
False
chain
L
LDL-receptor class A
begin
78
end
115
score
100.0
distance
125.50439
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
126.02574
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
126.02574
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
127.91727
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
127.91727
seq distance
False
chain
A
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
128.66316
seq distance
False
chain
L
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
128.66316
seq distance
False
chain
L
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
128.76909
seq distance
False
chain
B
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
128.76909
seq distance
False
chain
B
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
129.83151
seq distance
False
chain
A
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
129.83151
seq distance
False
chain
A
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
130.3358
seq distance
False
chain
K
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
130.3358
seq distance
False
chain
K
MACPF
begin
117
end
488
score
87.6099706744868
distance
130.36057
seq distance
False
chain
V
MACPF
begin
117
end
488
score
87.6099706744868
distance
130.36057
seq distance
False
chain
V
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
130.37889
seq distance
False
chain
M
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
130.37889
seq distance
False
chain
M
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
132.72667
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
132.72667
seq distance
False
chain
B
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
133.29404
seq distance
False
chain
K
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
133.29404
seq distance
False
chain
K
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
133.29704
seq distance
False
chain
L
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
133.29704
seq distance
False
chain
L
MACPF
begin
117
end
488
score
87.6099706744868
distance
133.36774
seq distance
False
chain
N
MACPF
begin
117
end
488
score
87.6099706744868
distance
133.36774
seq distance
False
chain
N
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
133.94775
seq distance
False
chain
A
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
133.94775
seq distance
False
chain
A
EGF-like
begin
489
end
519
score
99.12023460410556
distance
135.17003
seq distance
False
chain
L
EGF-like
begin
489
end
519
score
99.12023460410556
distance
135.17003
seq distance
False
chain
L
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
136.49089
seq distance
False
chain
L
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
136.49089
seq distance
False
chain
L
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
138.63498
seq distance
False
chain
V
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
138.63498
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
138.98782
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
138.98782
seq distance
False
chain
V
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
139.17615
seq distance
False
chain
M
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
139.17615
seq distance
False
chain
M
EGF-like
begin
489
end
519
score
99.12023460410556
distance
139.40103
seq distance
False
chain
V
EGF-like
begin
489
end
519
score
99.12023460410556
distance
139.40103
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
139.49915
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
139.49915
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
141.41367
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
141.41367
seq distance
False
chain
M
MACPF
begin
117
end
488
score
87.6099706744868
distance
142.01614
seq distance
False
chain
U
MACPF
begin
117
end
488
score
87.6099706744868
distance
142.01614
seq distance
False
chain
U
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
142.06609
seq distance
False
chain
A
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
142.06609
seq distance
False
chain
A
LDL-receptor class A
begin
78
end
115
score
100.0
distance
142.06609
seq distance
False
chain
A
LDL-receptor class A
begin
78
end
115
score
100.0
distance
142.06609
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
143.07092
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
143.07092
seq distance
False
chain
V
LDL-receptor class A
begin
78
end
115
score
100.0
distance
143.11786
seq distance
False
chain
M
LDL-receptor class A
begin
78
end
115
score
100.0
distance
143.11786
seq distance
False
chain
M
MACPF
begin
117
end
488
score
87.6099706744868
distance
143.15187
seq distance
False
chain
O
MACPF
begin
117
end
488
score
87.6099706744868
distance
143.15187
seq distance
False
chain
O
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
143.77484
seq distance
False
chain
V
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
143.77484
seq distance
False
chain
V
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
144.72325
seq distance
False
chain
V
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
144.72325
seq distance
False
chain
V
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
145.33693
seq distance
False
chain
A
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
145.33693
seq distance
False
chain
A
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
146.61531
seq distance
False
chain
M
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
146.61531
seq distance
False
chain
M
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
146.68681
seq distance
False
chain
N
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
146.68681
seq distance
False
chain
N
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
147.7151
seq distance
False
chain
L
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
147.7151
seq distance
False
chain
L
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
150.21158
seq distance
False
chain
A
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
150.21158
seq distance
False
chain
A
MACPF
begin
117
end
488
score
87.6099706744868
distance
150.32492
seq distance
False
chain
P
MACPF
begin
117
end
488
score
87.6099706744868
distance
150.32492
seq distance
False
chain
P
MACPF
begin
117
end
488
score
87.6099706744868
distance
150.3615
seq distance
False
chain
T
MACPF
begin
117
end
488
score
87.6099706744868
distance
150.3615
seq distance
False
chain
T
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
150.574
seq distance
False
chain
L
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
150.574
seq distance
False
chain
L
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
150.63057
seq distance
False
chain
M
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
150.63057
seq distance
False
chain
M
EGF-like
begin
489
end
519
score
99.12023460410556
distance
150.84682
seq distance
False
chain
M
EGF-like
begin
489
end
519
score
99.12023460410556
distance
150.84682
seq distance
False
chain
M
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
151.21906
seq distance
False
chain
V
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
151.21906
seq distance
False
chain
V
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
151.44778
seq distance
False
chain
U
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
151.44778
seq distance
False
chain
U
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
151.87587
seq distance
False
chain
N
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
151.87587
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
152.15741
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
152.15741
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
153.0379
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
153.0379
seq distance
False
chain
M
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
153.84303
seq distance
False
chain
M
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
153.84303
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
154.0975
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
154.0975
seq distance
False
chain
N
MACPF
begin
117
end
488
score
87.6099706744868
distance
154.75249
seq distance
False
chain
Q
MACPF
begin
117
end
488
score
87.6099706744868
distance
154.75249
seq distance
False
chain
Q
MACPF
begin
117
end
488
score
87.6099706744868
distance
154.98682
seq distance
False
chain
S
MACPF
begin
117
end
488
score
87.6099706744868
distance
154.98682
seq distance
False
chain
S
EGF-like
begin
489
end
519
score
99.12023460410556
distance
155.25076
seq distance
False
chain
U
EGF-like
begin
489
end
519
score
99.12023460410556
distance
155.25076
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
156.02899
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
156.02899
seq distance
False
chain
U
MACPF
begin
117
end
488
score
87.6099706744868
distance
156.32104
seq distance
False
chain
R
MACPF
begin
117
end
488
score
87.6099706744868
distance
156.32104
seq distance
False
chain
R
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
157.72525
seq distance
False
chain
U
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
157.72525
seq distance
False
chain
U
LDL-receptor class A
begin
78
end
115
score
100.0
distance
158.20416
seq distance
False
chain
N
LDL-receptor class A
begin
78
end
115
score
100.0
distance
158.20416
seq distance
False
chain
N
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
158.6345
seq distance
False
chain
V
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
158.6345
seq distance
False
chain
V
LDL-receptor class A
begin
78
end
115
score
100.0
distance
158.6345
seq distance
False
chain
V
LDL-receptor class A
begin
78
end
115
score
100.0
distance
158.6345
seq distance
False
chain
V
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
159.12466
seq distance
False
chain
V
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
159.12466
seq distance
False
chain
V
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
160.18513
seq distance
False
chain
O
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
160.18513
seq distance
False
chain
O
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
160.26303
seq distance
False
chain
M
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
160.26303
seq distance
False
chain
M
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
161.1687
seq distance
False
chain
U
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
161.1687
seq distance
False
chain
U
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
161.33398
seq distance
False
chain
T
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
161.33398
seq distance
False
chain
T
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
161.65872
seq distance
False
chain
O
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
161.65872
seq distance
False
chain
O
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
162.10797
seq distance
False
chain
N
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
162.10797
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
162.37482
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
162.37482
seq distance
False
chain
T
EGF-like
begin
489
end
519
score
99.12023460410556
distance
163.58441
seq distance
False
chain
N
EGF-like
begin
489
end
519
score
99.12023460410556
distance
163.58441
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
163.80399
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
163.80399
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
164.08978
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
164.08978
seq distance
False
chain
N
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
164.97018
seq distance
False
chain
N
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
164.97018
seq distance
False
chain
N
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
165.12671
seq distance
False
chain
V
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
165.12671
seq distance
False
chain
V
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
165.44598
seq distance
False
chain
U
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
165.44598
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
166.41397
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
166.41397
seq distance
False
chain
T
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
167.25902
seq distance
False
chain
M
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
167.25902
seq distance
False
chain
M
EGF-like
begin
489
end
519
score
99.12023460410556
distance
167.98224
seq distance
False
chain
T
EGF-like
begin
489
end
519
score
99.12023460410556
distance
167.98224
seq distance
False
chain
T
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
168.08139
seq distance
False
chain
S
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
168.08139
seq distance
False
chain
S
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
168.26944
seq distance
False
chain
P
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
168.26944
seq distance
False
chain
P
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
168.38867
seq distance
False
chain
T
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
168.38867
seq distance
False
chain
T
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
168.39925
seq distance
False
chain
N
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
168.39925
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
169.42383
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
169.42383
seq distance
False
chain
S
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
169.75021
seq distance
False
chain
U
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
169.75021
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
170.28403
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
170.28403
seq distance
False
chain
P
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
170.36705
seq distance
False
chain
N
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
170.36705
seq distance
False
chain
N
LDL-receptor class A
begin
78
end
115
score
100.0
distance
170.45209
seq distance
False
chain
O
LDL-receptor class A
begin
78
end
115
score
100.0
distance
170.45209
seq distance
False
chain
O
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
170.52359
seq distance
False
chain
P
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
170.52359
seq distance
False
chain
P
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
171.51682
seq distance
False
chain
R
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
171.51682
seq distance
False
chain
R
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
171.57907
seq distance
False
chain
Q
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
171.57907
seq distance
False
chain
Q
LDL-receptor class A
begin
78
end
115
score
100.0
distance
171.97966
seq distance
False
chain
U
LDL-receptor class A
begin
78
end
115
score
100.0
distance
171.97966
seq distance
False
chain
U
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
172.25014
seq distance
False
chain
U
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
172.25014
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
172.35347
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
172.35347
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
173.12494
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
173.12494
seq distance
False
chain
R
EGF-like
begin
489
end
519
score
99.12023460410556
distance
173.12721
seq distance
False
chain
O
EGF-like
begin
489
end
519
score
99.12023460410556
distance
173.12721
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
173.41208
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
173.41208
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
173.94229
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
173.94229
seq distance
False
chain
S
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
174.70763
seq distance
False
chain
O
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
174.70763
seq distance
False
chain
O
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
175.29507
seq distance
False
chain
T
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
175.29507
seq distance
False
chain
T
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
176.03226
seq distance
False
chain
O
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
176.03226
seq distance
False
chain
O
EGF-like
begin
489
end
519
score
99.12023460410556
distance
176.11104
seq distance
False
chain
S
EGF-like
begin
489
end
519
score
99.12023460410556
distance
176.11104
seq distance
False
chain
S
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
176.36778
seq distance
False
chain
T
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
176.36778
seq distance
False
chain
T
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
176.37589
seq distance
False
chain
S
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
176.37589
seq distance
False
chain
S
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
177.01396
seq distance
False
chain
T
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
177.01396
seq distance
False
chain
T
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
177.02357
seq distance
False
chain
U
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
177.02357
seq distance
False
chain
U
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
177.49142
seq distance
False
chain
Q
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
177.49142
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
177.55208
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
177.55208
seq distance
False
chain
P
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
177.72447
seq distance
False
chain
O
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
177.72447
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
178.35672
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
178.35672
seq distance
False
chain
R
EGF-like
begin
489
end
519
score
99.12023460410556
distance
179.23152
seq distance
False
chain
P
EGF-like
begin
489
end
519
score
99.12023460410556
distance
179.23152
seq distance
False
chain
P
LDL-receptor class A
begin
78
end
115
score
100.0
distance
179.5128
seq distance
False
chain
P
LDL-receptor class A
begin
78
end
115
score
100.0
distance
179.5128
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
179.56102
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
179.56102
seq distance
False
chain
Q
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
179.80106
seq distance
False
chain
O
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
179.80106
seq distance
False
chain
O
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
180.20988
seq distance
False
chain
N
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
180.20988
seq distance
False
chain
N
EGF-like
begin
489
end
519
score
99.12023460410556
distance
180.73831
seq distance
False
chain
R
EGF-like
begin
489
end
519
score
99.12023460410556
distance
180.73831
seq distance
False
chain
R
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
180.77127
seq distance
False
chain
S
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
180.77127
seq distance
False
chain
S
LDL-receptor class A
begin
78
end
115
score
100.0
distance
180.77748
seq distance
False
chain
T
LDL-receptor class A
begin
78
end
115
score
100.0
distance
180.77748
seq distance
False
chain
T
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
180.93123
seq distance
False
chain
R
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
180.93123
seq distance
False
chain
R
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
181.38168
seq distance
False
chain
R
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
181.38168
seq distance
False
chain
R
EGF-like
begin
489
end
519
score
99.12023460410556
distance
181.78265
seq distance
False
chain
Q
EGF-like
begin
489
end
519
score
99.12023460410556
distance
181.78265
seq distance
False
chain
Q
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
182.06837
seq distance
False
chain
P
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
182.06837
seq distance
False
chain
P
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
182.60573
seq distance
False
chain
T
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
182.60573
seq distance
False
chain
T
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
183.2872
seq distance
False
chain
Q
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
183.2872
seq distance
False
chain
Q
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
183.55173
seq distance
False
chain
P
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
183.55173
seq distance
False
chain
P
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
183.76036
seq distance
False
chain
S
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
183.76036
seq distance
False
chain
S
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
184.05067
seq distance
False
chain
P
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
184.05067
seq distance
False
chain
P
LDL-receptor class A
begin
78
end
115
score
100.0
distance
185.17609
seq distance
False
chain
Q
LDL-receptor class A
begin
78
end
115
score
100.0
distance
185.17609
seq distance
False
chain
Q
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
185.61911
seq distance
False
chain
T
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
185.61911
seq distance
False
chain
T
LDL-receptor class A
begin
78
end
115
score
100.0
distance
185.80598
seq distance
False
chain
S
LDL-receptor class A
begin
78
end
115
score
100.0
distance
185.80598
seq distance
False
chain
S
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
185.8758
seq distance
False
chain
S
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
185.8758
seq distance
False
chain
S
LDL-receptor class A
begin
78
end
115
score
100.0
distance
187.28389
seq distance
False
chain
R
LDL-receptor class A
begin
78
end
115
score
100.0
distance
187.28389
seq distance
False
chain
R
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
187.38887
seq distance
False
chain
Q
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
187.38887
seq distance
False
chain
Q
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
187.4557
seq distance
False
chain
R
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
187.4557
seq distance
False
chain
R
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
187.74379
seq distance
False
chain
P
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
187.74379
seq distance
False
chain
P
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
189.45155
seq distance
False
chain
S
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
189.45155
seq distance
False
chain
S
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
189.49748
seq distance
False
chain
O
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
189.49748
seq distance
False
chain
O
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
189.91739
seq distance
False
chain
Q
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
189.91739
seq distance
False
chain
Q
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
190.70163
seq distance
False
chain
S
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
190.70163
seq distance
False
chain
S
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
192.05803
seq distance
False
chain
Q
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
192.05803
seq distance
False
chain
Q
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
192.14558
seq distance
False
chain
R
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
192.14558
seq distance
False
chain
R
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
192.62492
seq distance
False
chain
R
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
192.62492
seq distance
False
chain
R
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
192.67027
seq distance
False
chain
R
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
192.67027
seq distance
False
chain
R
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
194.50381
seq distance
False
chain
P
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
194.50381
seq distance
False
chain
P
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
195.56575
seq distance
False
chain
Q
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
195.56575
seq distance
False
chain
Q
Details
Redox score
76.33
PDB code
6dlw
Structure name
complement component polyc9
Structure deposition date
2018-06-03
Thiol separation (Å)
2.03
Half-sphere exposure sum
62
Minimum pKa
nan
% buried
nan
Peptide accession
P02748
Residue number A
43 (Residue 22 in this structure)
Residue number B
78 (Residue 57 in this structure)
Peptide name
Complement component C9
6h04 H 33 H 67
A redox-regulated disulphide may form within Complement component C9 at these cysteines.
Relevent regions
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
2.8171916
seq distance
0
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
2.8171916
seq distance
0
chain
H
MACPF
begin
117
end
488
score
94.98411534701859
distance
11.11102
seq distance
False
chain
I
MACPF
begin
117
end
488
score
94.98411534701859
distance
11.11102
seq distance
False
chain
I
MACPF
begin
117
end
488
score
94.98411534701859
distance
12.177355
seq distance
50
chain
H
MACPF
begin
117
end
488
score
94.98411534701859
distance
12.177355
seq distance
50
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
18.054144
seq distance
False
chain
I
LDL-receptor class A
begin
78
end
115
score
100.0
distance
18.054144
seq distance
False
chain
I
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
21.022554
seq distance
False
chain
I
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
21.022554
seq distance
False
chain
I
LDL-receptor class A
begin
78
end
115
score
100.0
distance
25.774181
seq distance
11
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
25.774181
seq distance
11
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
28.264154
seq distance
False
chain
P
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
28.264154
seq distance
False
chain
P
EGF-like
begin
489
end
519
score
100.0
distance
31.94485
seq distance
422
chain
H
EGF-like
begin
489
end
519
score
100.0
distance
31.94485
seq distance
422
chain
H
MACPF
begin
117
end
488
score
94.98411534701859
distance
33.7896
seq distance
False
chain
J
MACPF
begin
117
end
488
score
94.98411534701859
distance
33.7896
seq distance
False
chain
J
LDL-receptor class A
begin
78
end
115
score
100.0
distance
35.494873
seq distance
False
chain
J
LDL-receptor class A
begin
78
end
115
score
100.0
distance
35.494873
seq distance
False
chain
J
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
36.19434
seq distance
False
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
36.19434
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
36.678444
seq distance
79
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
36.678444
seq distance
79
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
36.773624
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
36.773624
seq distance
False
chain
I
MACPF
begin
117
end
488
score
94.98411534701859
distance
37.245316
seq distance
False
chain
P
MACPF
begin
117
end
488
score
94.98411534701859
distance
37.245316
seq distance
False
chain
P
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
38.56856
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
38.56856
seq distance
False
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
38.73879
seq distance
False
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
38.73879
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
40.033463
seq distance
39
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
40.033463
seq distance
39
chain
H
EGF-like
begin
489
end
519
score
100.0
distance
41.601364
seq distance
False
chain
P
EGF-like
begin
489
end
519
score
100.0
distance
41.601364
seq distance
False
chain
P
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
42.24713
seq distance
False
chain
J
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
42.24713
seq distance
False
chain
J
EGF-like
begin
489
end
519
score
100.0
distance
43.885334
seq distance
False
chain
I
EGF-like
begin
489
end
519
score
100.0
distance
43.885334
seq distance
False
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
45.43167
seq distance
31
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
45.43167
seq distance
31
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
46.186188
seq distance
False
chain
J
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
46.186188
seq distance
False
chain
J
LDL-receptor class A
begin
78
end
115
score
100.0
distance
50.1407
seq distance
False
chain
P
LDL-receptor class A
begin
78
end
115
score
100.0
distance
50.1407
seq distance
False
chain
P
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
51.38949
seq distance
115
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
51.38949
seq distance
115
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
51.620457
seq distance
False
chain
J
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
51.620457
seq distance
False
chain
J
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
53.382107
seq distance
False
chain
J
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
53.382107
seq distance
False
chain
J
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
53.663467
seq distance
False
chain
J
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
53.663467
seq distance
False
chain
J
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
53.716835
seq distance
False
chain
P
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
53.716835
seq distance
False
chain
P
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
54.048454
seq distance
339
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
54.048454
seq distance
339
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
54.552536
seq distance
338
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
54.552536
seq distance
338
chain
H
MACPF
begin
117
end
488
score
94.98411534701859
distance
55.30473
seq distance
False
chain
K
MACPF
begin
117
end
488
score
94.98411534701859
distance
55.30473
seq distance
False
chain
K
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
55.717495
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
55.717495
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
56.500027
seq distance
False
chain
P
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
56.500027
seq distance
False
chain
P
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
56.917812
seq distance
False
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
56.917812
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
57.32294
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
57.32294
seq distance
False
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
59.034073
seq distance
False
chain
K
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
59.034073
seq distance
False
chain
K
LDL-receptor class A
begin
78
end
115
score
100.0
distance
59.529015
seq distance
False
chain
K
LDL-receptor class A
begin
78
end
115
score
100.0
distance
59.529015
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
63.223347
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
63.223347
seq distance
False
chain
P
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
63.60415
seq distance
False
chain
P
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
63.60415
seq distance
False
chain
P
EGF-like
begin
489
end
519
score
100.0
distance
63.907066
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
100.0
distance
63.907066
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
100.0
distance
64.95783
seq distance
False
chain
J
EGF-like
begin
489
end
519
score
100.0
distance
64.95783
seq distance
False
chain
J
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
65.73177
seq distance
False
chain
P
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
65.73177
seq distance
False
chain
P
MACPF
begin
117
end
488
score
94.98411534701859
distance
65.87524
seq distance
False
chain
G
MACPF
begin
117
end
488
score
94.98411534701859
distance
65.87524
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
66.959946
seq distance
False
chain
K
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
66.959946
seq distance
False
chain
K
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
67.53065
seq distance
False
chain
J
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
67.53065
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
69.87306
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
69.87306
seq distance
False
chain
J
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
71.804634
seq distance
False
chain
P
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
71.804634
seq distance
False
chain
P
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
75.52209
seq distance
False
chain
K
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
75.52209
seq distance
False
chain
K
LDL-receptor class A
begin
78
end
115
score
100.0
distance
75.95403
seq distance
False
chain
G
LDL-receptor class A
begin
78
end
115
score
100.0
distance
75.95403
seq distance
False
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
76.10787
seq distance
False
chain
K
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
76.10787
seq distance
False
chain
K
MACPF
begin
117
end
488
score
94.98411534701859
distance
76.19797
seq distance
False
chain
L
MACPF
begin
117
end
488
score
94.98411534701859
distance
76.19797
seq distance
False
chain
L
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
76.501
seq distance
False
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
76.501
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
77.281166
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
77.281166
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
78.32773
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
78.32773
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
78.51985
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
78.51985
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
80.678474
seq distance
False
chain
L
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
80.678474
seq distance
False
chain
L
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
82.54565
seq distance
False
chain
K
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
82.54565
seq distance
False
chain
K
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
84.755905
seq distance
False
chain
K
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
84.755905
seq distance
False
chain
K
LDL-receptor class A
begin
78
end
115
score
100.0
distance
85.76708
seq distance
False
chain
L
LDL-receptor class A
begin
78
end
115
score
100.0
distance
85.76708
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
87.42722
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
87.42722
seq distance
False
chain
K
EGF-like
begin
489
end
519
score
100.0
distance
88.517525
seq distance
False
chain
K
EGF-like
begin
489
end
519
score
100.0
distance
88.517525
seq distance
False
chain
K
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
88.78657
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
88.78657
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
89.43744
seq distance
195
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
89.43744
seq distance
195
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
90.448074
seq distance
False
chain
L
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
90.448074
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
92.6092
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
92.6092
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
93.30058
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
93.30058
seq distance
False
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
94.47714
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
94.47714
seq distance
False
chain
G
MACPF
begin
117
end
488
score
94.98411534701859
distance
97.4177
seq distance
False
chain
M
MACPF
begin
117
end
488
score
94.98411534701859
distance
97.4177
seq distance
False
chain
M
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
98.43323
seq distance
False
chain
L
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
98.43323
seq distance
False
chain
L
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
391
score
68.18181818181817
distance
98.65679
seq distance
False
chain
F
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
391
score
68.18181818181817
distance
98.65679
seq distance
False
chain
F
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
93
score
77.27272727272727
distance
98.69343
seq distance
False
chain
F
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
93
score
77.27272727272727
distance
98.69343
seq distance
False
chain
F
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
99.8612
seq distance
False
chain
L
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
99.8612
seq distance
False
chain
L
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
100.68385
seq distance
191
chain
H
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
100.68385
seq distance
191
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
100.852135
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
100.852135
seq distance
False
chain
G
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
102.052605
seq distance
False
chain
P
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
102.052605
seq distance
False
chain
P
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
103.04414
seq distance
False
chain
M
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
103.04414
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
103.27687
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
103.27687
seq distance
False
chain
J
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
104.0454
seq distance
False
chain
L
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
104.0454
seq distance
False
chain
L
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
105.67977
seq distance
False
chain
I
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
105.67977
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
106.83582
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
106.83582
seq distance
False
chain
L
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
108.112015
seq distance
False
chain
G
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
108.112015
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
85
score
72.72727272727273
distance
109.95128
seq distance
False
chain
F
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
85
score
72.72727272727273
distance
109.95128
seq distance
False
chain
F
LDL-receptor class A
begin
78
end
115
score
100.0
distance
110.29022
seq distance
False
chain
M
LDL-receptor class A
begin
78
end
115
score
100.0
distance
110.29022
seq distance
False
chain
M
EGF-like
begin
489
end
519
score
100.0
distance
111.85247
seq distance
False
chain
L
EGF-like
begin
489
end
519
score
100.0
distance
111.85247
seq distance
False
chain
L
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
112.162796
seq distance
False
chain
L
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
112.162796
seq distance
False
chain
L
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
113.74098
seq distance
False
chain
M
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
113.74098
seq distance
False
chain
M
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
115.85459
seq distance
False
chain
J
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
115.85459
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
370
score
68.18181818181817
distance
116.248886
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
370
score
68.18181818181817
distance
116.248886
seq distance
False
chain
C
MACPF
begin
117
end
488
score
94.98411534701859
distance
116.453255
seq distance
False
chain
N
MACPF
begin
117
end
488
score
94.98411534701859
distance
116.453255
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
117.10787
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
117.10787
seq distance
False
chain
K
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
94
score
81.81818181818183
distance
117.54466
seq distance
False
chain
C
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
94
score
81.81818181818183
distance
117.54466
seq distance
False
chain
C
LDL-receptor class A
begin
83
end
96
score
70.12987012987013
distance
117.54466
seq distance
False
chain
C
LDL-receptor class A
begin
83
end
96
score
70.12987012987013
distance
117.54466
seq distance
False
chain
C
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
120.81707
seq distance
False
chain
M
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
120.81707
seq distance
False
chain
M
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
122.67399
seq distance
False
chain
M
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
122.67399
seq distance
False
chain
M
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
123.19711
seq distance
False
chain
M
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
123.19711
seq distance
False
chain
M
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
124.53918
seq distance
False
chain
N
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
124.53918
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
126.01154
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
126.01154
seq distance
False
chain
M
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
86
score
72.72727272727273
distance
126.16524
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
86
score
72.72727272727273
distance
126.16524
seq distance
False
chain
C
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
129.37877
seq distance
False
chain
K
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
129.37877
seq distance
False
chain
K
LDL-receptor class A
begin
78
end
115
score
100.0
distance
132.18315
seq distance
False
chain
N
LDL-receptor class A
begin
78
end
115
score
100.0
distance
132.18315
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
133.06119
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
133.06119
seq distance
False
chain
L
MACPF
begin
117
end
488
score
94.98411534701859
distance
134.15598
seq distance
False
chain
O
MACPF
begin
117
end
488
score
94.98411534701859
distance
134.15598
seq distance
False
chain
O
EGF-like
begin
489
end
519
score
100.0
distance
134.18396
seq distance
False
chain
M
EGF-like
begin
489
end
519
score
100.0
distance
134.18396
seq distance
False
chain
M
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
135.6062
seq distance
False
chain
N
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
135.6062
seq distance
False
chain
N
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
103
score
59.09090909090909
distance
138.05469
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
103
score
59.09090909090909
distance
138.05469
seq distance
False
chain
D
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
139.75676
seq distance
False
chain
M
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
139.75676
seq distance
False
chain
M
LDL-receptor class A
begin
151
end
170
score
51.590909090909086
distance
140.34846
seq distance
False
chain
B
LDL-receptor class A
begin
151
end
170
score
51.590909090909086
distance
140.34846
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
141.23203
seq distance
False
chain
N
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
141.23203
seq distance
False
chain
N
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
141.23746
seq distance
False
chain
N
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
141.23746
seq distance
False
chain
N
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
143.7462
seq distance
False
chain
N
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
143.7462
seq distance
False
chain
N
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
442
score
50.0
distance
143.9906
seq distance
False
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
442
score
50.0
distance
143.9906
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
144.01639
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
144.01639
seq distance
False
chain
N
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
166
score
77.27272727272727
distance
144.04118
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
166
score
77.27272727272727
distance
144.04118
seq distance
False
chain
B
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
144.26016
seq distance
False
chain
O
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
144.26016
seq distance
False
chain
O
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
144.68288
seq distance
False
chain
L
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
144.68288
seq distance
False
chain
L
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
158
score
63.63636363636363
distance
144.77208
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
158
score
63.63636363636363
distance
144.77208
seq distance
False
chain
B
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
226
score
50.0
distance
148.06485
seq distance
False
chain
F
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
226
score
50.0
distance
148.06485
seq distance
False
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
149.25516
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
149.25516
seq distance
False
chain
M
MACPF
begin
117
end
488
score
94.98411534701859
distance
149.81168
seq distance
False
chain
Q
MACPF
begin
117
end
488
score
94.98411534701859
distance
149.81168
seq distance
False
chain
Q
LDL-receptor class A
begin
78
end
115
score
100.0
distance
151.63272
seq distance
False
chain
O
LDL-receptor class A
begin
78
end
115
score
100.0
distance
151.63272
seq distance
False
chain
O
EGF-like
begin
489
end
519
score
100.0
distance
153.35165
seq distance
False
chain
N
EGF-like
begin
489
end
519
score
100.0
distance
153.35165
seq distance
False
chain
N
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
155.29851
seq distance
False
chain
O
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
155.29851
seq distance
False
chain
O
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
157.31686
seq distance
False
chain
O
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
157.31686
seq distance
False
chain
O
MACPF
begin
117
end
488
score
94.98411534701859
distance
159.2028
seq distance
False
chain
X
MACPF
begin
117
end
488
score
94.98411534701859
distance
159.2028
seq distance
False
chain
X
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
159.45303
seq distance
False
chain
O
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
159.45303
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
159.9752
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
159.9752
seq distance
False
chain
O
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
160.0825
seq distance
False
chain
M
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
160.0825
seq distance
False
chain
M
MACPF
begin
117
end
488
score
94.98411534701859
distance
160.67686
seq distance
False
chain
R
MACPF
begin
117
end
488
score
94.98411534701859
distance
160.67686
seq distance
False
chain
R
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
161.48877
seq distance
False
chain
Q
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
161.48877
seq distance
False
chain
Q
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
162.37926
seq distance
False
chain
O
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
162.37926
seq distance
False
chain
O
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
164.70425
seq distance
False
chain
N
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
164.70425
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
164.70831
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
164.70831
seq distance
False
chain
N
TSP type-1
begin
507
end
507
score
88.63636363636364
distance
167.52835
seq distance
False
chain
D
TSP type-1
begin
507
end
507
score
88.63636363636364
distance
167.52835
seq distance
False
chain
D
LDL-receptor class A
begin
78
end
115
score
100.0
distance
168.12688
seq distance
False
chain
Q
LDL-receptor class A
begin
78
end
115
score
100.0
distance
168.12688
seq distance
False
chain
Q
MACPF
begin
117
end
488
score
94.98411534701859
distance
168.62303
seq distance
False
chain
S
MACPF
begin
117
end
488
score
94.98411534701859
distance
168.62303
seq distance
False
chain
S
MACPF
begin
117
end
488
score
94.98411534701859
distance
168.94334
seq distance
False
chain
W
MACPF
begin
117
end
488
score
94.98411534701859
distance
168.94334
seq distance
False
chain
W
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
169.57178
seq distance
False
chain
X
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
169.57178
seq distance
False
chain
X
EGF-like
begin
489
end
519
score
100.0
distance
169.71844
seq distance
False
chain
O
EGF-like
begin
489
end
519
score
100.0
distance
169.71844
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
169.76302
seq distance
False
chain
X
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
169.76302
seq distance
False
chain
X
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
170.7295
seq distance
False
chain
Q
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
170.7295
seq distance
False
chain
Q
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
172.07744
seq distance
False
chain
Q
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
172.07744
seq distance
False
chain
Q
EGF-like
begin
489
end
519
score
100.0
distance
172.83054
seq distance
False
chain
X
EGF-like
begin
489
end
519
score
100.0
distance
172.83054
seq distance
False
chain
X
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
173.24635
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
173.24635
seq distance
False
chain
Q
MACPF
begin
117
end
488
score
94.98411534701859
distance
173.33781
seq distance
False
chain
T
MACPF
begin
117
end
488
score
94.98411534701859
distance
173.33781
seq distance
False
chain
T
MACPF
begin
117
end
488
score
94.98411534701859
distance
173.52283
seq distance
False
chain
V
MACPF
begin
117
end
488
score
94.98411534701859
distance
173.52283
seq distance
False
chain
V
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
174.45245
seq distance
False
chain
N
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
174.45245
seq distance
False
chain
N
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
174.57516
seq distance
False
chain
Q
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
174.57516
seq distance
False
chain
Q
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
174.58179
seq distance
False
chain
X
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
174.58179
seq distance
False
chain
X
MACPF
begin
117
end
488
score
94.98411534701859
distance
175.04434
seq distance
False
chain
U
MACPF
begin
117
end
488
score
94.98411534701859
distance
175.04434
seq distance
False
chain
U
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
175.76724
seq distance
False
chain
R
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
175.76724
seq distance
False
chain
R
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
177.20352
seq distance
False
chain
X
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
177.20352
seq distance
False
chain
X
LDL-receptor class A
begin
78
end
115
score
100.0
distance
177.20352
seq distance
False
chain
X
LDL-receptor class A
begin
78
end
115
score
100.0
distance
177.20352
seq distance
False
chain
X
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
177.90608
seq distance
False
chain
Q
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
177.90608
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
178.53859
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
178.53859
seq distance
False
chain
O
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
179.35834
seq distance
False
chain
X
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
179.35834
seq distance
False
chain
X
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
180.00049
seq distance
False
chain
X
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
180.00049
seq distance
False
chain
X
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
180.50676
seq distance
False
chain
W
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
180.50676
seq distance
False
chain
W
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
181.16817
seq distance
False
chain
W
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
181.16817
seq distance
False
chain
W
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
181.2421
seq distance
False
chain
R
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
181.2421
seq distance
False
chain
R
LDL-receptor class A
begin
78
end
115
score
100.0
distance
181.62273
seq distance
False
chain
R
LDL-receptor class A
begin
78
end
115
score
100.0
distance
181.62273
seq distance
False
chain
R
EGF-like
begin
489
end
519
score
100.0
distance
183.16615
seq distance
False
chain
Q
EGF-like
begin
489
end
519
score
100.0
distance
183.16615
seq distance
False
chain
Q
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
183.49712
seq distance
False
chain
O
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
183.49712
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
183.55048
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
183.55048
seq distance
False
chain
R
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
183.56506
seq distance
False
chain
X
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
183.56506
seq distance
False
chain
X
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
184.77052
seq distance
False
chain
X
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
184.77052
seq distance
False
chain
X
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
185.72766
seq distance
False
chain
R
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
185.72766
seq distance
False
chain
R
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
186.37418
seq distance
False
chain
R
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
186.37418
seq distance
False
chain
R
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
186.49133
seq distance
False
chain
X
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
186.49133
seq distance
False
chain
X
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
186.7987
seq distance
False
chain
S
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
186.7987
seq distance
False
chain
S
EGF-like
begin
489
end
519
score
100.0
distance
187.46881
seq distance
False
chain
W
EGF-like
begin
489
end
519
score
100.0
distance
187.46881
seq distance
False
chain
W
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
187.72821
seq distance
False
chain
O
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
187.72821
seq distance
False
chain
O
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
188.01865
seq distance
False
chain
V
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
188.01865
seq distance
False
chain
V
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
188.46855
seq distance
False
chain
S
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
188.46855
seq distance
False
chain
S
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
188.96635
seq distance
False
chain
W
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
188.96635
seq distance
False
chain
W
LDL-receptor class A
begin
78
end
115
score
100.0
distance
188.96635
seq distance
False
chain
W
LDL-receptor class A
begin
78
end
115
score
100.0
distance
188.96635
seq distance
False
chain
W
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
189.18309
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
189.18309
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
189.9877
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
189.9877
seq distance
False
chain
Q
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
190.10788
seq distance
False
chain
R
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
190.10788
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
190.59854
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
190.59854
seq distance
False
chain
S
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
191.16405
seq distance
False
chain
W
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
191.16405
seq distance
False
chain
W
LDL-receptor class A
begin
78
end
115
score
100.0
distance
191.55481
seq distance
False
chain
S
LDL-receptor class A
begin
78
end
115
score
100.0
distance
191.55481
seq distance
False
chain
S
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
191.64496
seq distance
False
chain
W
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
191.64496
seq distance
False
chain
W
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
191.64958
seq distance
False
chain
W
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
191.64958
seq distance
False
chain
W
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
191.86893
seq distance
False
chain
U
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
191.86893
seq distance
False
chain
U
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
192.0726
seq distance
False
chain
T
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
192.0726
seq distance
False
chain
T
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
192.92554
seq distance
False
chain
W
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
192.92554
seq distance
False
chain
W
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
1290
score
50.0
distance
192.98935
seq distance
False
chain
A
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
1290
score
50.0
distance
192.98935
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
193.3342
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
193.3342
seq distance
False
chain
U
EGF-like
begin
489
end
519
score
100.0
distance
193.39876
seq distance
False
chain
R
EGF-like
begin
489
end
519
score
100.0
distance
193.39876
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
193.90347
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
193.90347
seq distance
False
chain
T
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
194.19151
seq distance
False
chain
T
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
194.19151
seq distance
False
chain
T
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
194.5888
seq distance
False
chain
S
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
194.5888
seq distance
False
chain
S
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
195.5378
seq distance
False
chain
W
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
195.5378
seq distance
False
chain
W
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
195.74312
seq distance
False
chain
S
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
195.74312
seq distance
False
chain
S
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
196.30351
seq distance
False
chain
W
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
196.30351
seq distance
False
chain
W
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
196.35126
seq distance
False
chain
V
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
196.35126
seq distance
False
chain
V
LDL-receptor class A
begin
78
end
115
score
100.0
distance
196.35126
seq distance
False
chain
V
LDL-receptor class A
begin
78
end
115
score
100.0
distance
196.35126
seq distance
False
chain
V
EGF-like
begin
489
end
519
score
100.0
distance
196.45738
seq distance
False
chain
V
EGF-like
begin
489
end
519
score
100.0
distance
196.45738
seq distance
False
chain
V
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
197.35768
seq distance
False
chain
V
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
197.35768
seq distance
False
chain
V
LDL-receptor class A
begin
78
end
115
score
100.0
distance
197.80063
seq distance
False
chain
T
LDL-receptor class A
begin
78
end
115
score
100.0
distance
197.80063
seq distance
False
chain
T
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
197.82925
seq distance
False
chain
U
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
197.82925
seq distance
False
chain
U
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
197.87126
seq distance
False
chain
Q
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
197.87126
seq distance
False
chain
Q
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
198.07819
seq distance
False
chain
Q
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
198.07819
seq distance
False
chain
Q
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
198.57263
seq distance
False
chain
S
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
198.57263
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
198.62291
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
198.62291
seq distance
False
chain
R
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
199.1321
seq distance
False
chain
T
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
199.1321
seq distance
False
chain
T
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
199.62054
seq distance
False
chain
V
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
199.62054
seq distance
False
chain
V
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
199.7335
seq distance
False
chain
U
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
199.7335
seq distance
False
chain
U
LDL-receptor class A
begin
78
end
115
score
100.0
distance
199.7335
seq distance
False
chain
U
LDL-receptor class A
begin
78
end
115
score
100.0
distance
199.7335
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
199.88046
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
199.88046
seq distance
False
chain
V
EGF-like
begin
489
end
519
score
100.0
distance
200.13023
seq distance
False
chain
S
EGF-like
begin
489
end
519
score
100.0
distance
200.13023
seq distance
False
chain
S
EGF-like
begin
489
end
519
score
100.0
distance
201.56087
seq distance
False
chain
U
EGF-like
begin
489
end
519
score
100.0
distance
201.56087
seq distance
False
chain
U
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
202.00107
seq distance
False
chain
T
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
202.00107
seq distance
False
chain
T
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
202.32779
seq distance
False
chain
V
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
202.32779
seq distance
False
chain
V
EGF-like
begin
489
end
519
score
100.0
distance
202.87694
seq distance
False
chain
T
EGF-like
begin
489
end
519
score
100.0
distance
202.87694
seq distance
False
chain
T
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
203.1046
seq distance
False
chain
T
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
203.1046
seq distance
False
chain
T
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
203.1956
seq distance
False
chain
V
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
203.1956
seq distance
False
chain
V
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
203.47612
seq distance
False
chain
U
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
203.47612
seq distance
False
chain
U
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
204.2747
seq distance
False
chain
U
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
204.2747
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
204.3067
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
204.3067
seq distance
False
chain
S
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
204.37852
seq distance
False
chain
V
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
204.37852
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
204.77937
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
204.77937
seq distance
False
chain
U
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
205.95235
seq distance
False
chain
R
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
205.95235
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
206.33267
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
206.33267
seq distance
False
chain
T
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
1067
score
54.54545454545454
distance
207.08539
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
1067
score
54.54545454545454
distance
207.08539
seq distance
False
chain
A
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
207.94922
seq distance
False
chain
R
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
207.94922
seq distance
False
chain
R
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
209.89766
seq distance
False
chain
U
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
209.89766
seq distance
False
chain
U
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
210.66383
seq distance
False
chain
S
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
210.66383
seq distance
False
chain
S
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
210.8065
seq distance
False
chain
U
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
210.8065
seq distance
False
chain
U
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
211.93661
seq distance
False
chain
T
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
211.93661
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
671
score
54.54545454545454
distance
213.32272
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
671
score
54.54545454545454
distance
213.32272
seq distance
False
chain
D
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
213.398
seq distance
False
chain
S
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
213.398
seq distance
False
chain
S
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
214.45294
seq distance
False
chain
T
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
214.45294
seq distance
False
chain
T
Details
Redox score
76.32
PDB code
6h04
Structure name
closed conformation of the membrane attack complex
Structure deposition date
2018-07-06
Thiol separation (Å)
2.03
Half-sphere exposure sum
52
Minimum pKa
nan
% buried
nan
Peptide accession
P02748
Residue number A
54 (Residue 33 in this structure)
Residue number B
88 (Residue 67 in this structure)
Peptide name
Complement component C9
7nyc I 121 I 160
A redox-regulated disulphide may form within Complement component C9 at these cysteines.
Relevent regions
LDL-receptor class A
begin
78
end
115
score
100.0
distance
9.29201
seq distance
False
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
9.29201
seq distance
False
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
9.681188
seq distance
False
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
9.681188
seq distance
False
chain
H
LDL-receptor class A
begin
80
end
115
score
98.48484848484848
distance
9.902361
seq distance
6
chain
I
LDL-receptor class A
begin
80
end
115
score
98.48484848484848
distance
9.902361
seq distance
6
chain
I
MACPF
begin
133
end
488
score
72.36338100102144
distance
10.6032295
seq distance
False
chain
H
MACPF
begin
133
end
488
score
72.36338100102144
distance
10.6032295
seq distance
False
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
13.81435
seq distance
23
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
13.81435
seq distance
23
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
17.031454
seq distance
22
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
17.031454
seq distance
22
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
19.276438
seq distance
False
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
19.276438
seq distance
False
chain
H
MACPF
begin
186
end
481
score
65.83230958230959
distance
19.281487
seq distance
26
chain
I
MACPF
begin
186
end
481
score
65.83230958230959
distance
19.281487
seq distance
26
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
19.856323
seq distance
15
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
19.856323
seq distance
15
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
22.01644
seq distance
False
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
22.01644
seq distance
False
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
25.553299
seq distance
False
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
25.553299
seq distance
False
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
27.591656
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
27.591656
seq distance
False
chain
G
LDL-receptor class A
begin
78
end
115
score
100.0
distance
27.591656
seq distance
False
chain
G
LDL-receptor class A
begin
78
end
115
score
100.0
distance
27.591656
seq distance
False
chain
G
MACPF
begin
133
end
488
score
69.38840653728295
distance
28.599415
seq distance
False
chain
G
MACPF
begin
133
end
488
score
69.38840653728295
distance
28.599415
seq distance
False
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
29.838884
seq distance
False
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
29.838884
seq distance
False
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
30.628204
seq distance
14
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
30.628204
seq distance
14
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
33.23719
seq distance
False
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
33.23719
seq distance
False
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
34.41663
seq distance
False
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
34.41663
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
98.24046920821115
distance
34.54142
seq distance
False
chain
H
EGF-like
begin
489
end
519
score
98.24046920821115
distance
34.54142
seq distance
False
chain
H
EGF-like
begin
489
end
519
score
98.24046920821115
distance
36.359573
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
98.24046920821115
distance
36.359573
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
37.947544
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
37.947544
seq distance
False
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
39.446323
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
39.446323
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
40.8913
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
40.8913
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
42.856323
seq distance
246
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
42.856323
seq distance
246
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
43.59261
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
43.59261
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
45.617386
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
45.617386
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
45.64905
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
45.64905
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
46.426643
seq distance
245
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
46.426643
seq distance
245
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
93
score
77.27272727272727
distance
48.66937
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
93
score
77.27272727272727
distance
48.66937
seq distance
False
chain
E
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
391
score
68.18181818181817
distance
56.370792
seq distance
False
chain
E
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
391
score
68.18181818181817
distance
56.370792
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
85
score
72.72727272727273
distance
56.781456
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
85
score
72.72727272727273
distance
56.781456
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
94
score
81.81818181818183
distance
63.88854
seq distance
False
chain
D
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
94
score
81.81818181818183
distance
63.88854
seq distance
False
chain
D
LDL-receptor class A
begin
83
end
96
score
70.12987012987013
distance
63.88854
seq distance
False
chain
D
LDL-receptor class A
begin
83
end
96
score
70.12987012987013
distance
63.88854
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
86
score
72.72727272727273
distance
69.218796
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
86
score
72.72727272727273
distance
69.218796
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
370
score
68.18181818181817
distance
72.362335
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
370
score
68.18181818181817
distance
72.362335
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
81
score
59.09090909090909
distance
79.4791
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
81
score
59.09090909090909
distance
79.4791
seq distance
False
chain
C
LDL-receptor class A
begin
130
end
149
score
51.590909090909086
distance
80.294266
seq distance
False
chain
B
LDL-receptor class A
begin
130
end
149
score
51.590909090909086
distance
80.294266
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
137
score
63.63636363636363
distance
84.476456
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
137
score
63.63636363636363
distance
84.476456
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
145
score
77.27272727272727
distance
85.667076
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
145
score
77.27272727272727
distance
85.667076
seq distance
False
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
421
score
68.18181818181817
distance
92.27288
seq distance
False
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
421
score
68.18181818181817
distance
92.27288
seq distance
False
chain
B
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
1272
score
50.0
distance
133.11456
seq distance
False
chain
A
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
1272
score
50.0
distance
133.11456
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
1049
score
54.54545454545454
distance
148.79141
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
1049
score
54.54545454545454
distance
148.79141
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
649
score
54.54545454545454
distance
152.98238
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
649
score
54.54545454545454
distance
152.98238
seq distance
False
chain
C
Details
Redox score
75.84
PDB code
7nyc
Structure name
cryoem structure of 3c9-smac
Structure deposition date
2021-03-22
Thiol separation (Å)
2.03
Half-sphere exposure sum
60
Minimum pKa
nan
% buried
nan
Peptide accession
P02748
Residue number A
142 (Residue 121 in this structure)
Residue number B
181 (Residue 160 in this structure)
Peptide name
Complement component C9
7nyc H 492 H 518
A redox-regulated disulphide may form within Complement component C9 at these cysteines.
Relevent regions
EGF-like
begin
489
end
519
score
98.24046920821115
distance
2.8278036
seq distance
0
chain
H
EGF-like
begin
489
end
519
score
98.24046920821115
distance
2.8278036
seq distance
0
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
10.275767
seq distance
418
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
10.275767
seq distance
418
chain
H
MACPF
begin
133
end
488
score
72.36338100102144
distance
12.374993
seq distance
4
chain
H
MACPF
begin
133
end
488
score
72.36338100102144
distance
12.374993
seq distance
4
chain
H
MACPF
begin
186
end
481
score
65.83230958230959
distance
13.896037
seq distance
False
chain
I
MACPF
begin
186
end
481
score
65.83230958230959
distance
13.896037
seq distance
False
chain
I
EGF-like
begin
489
end
519
score
98.24046920821115
distance
16.045946
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
98.24046920821115
distance
16.045946
seq distance
False
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
17.466532
seq distance
False
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
17.466532
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
19.282272
seq distance
87
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
19.282272
seq distance
87
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
22.453028
seq distance
86
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
22.453028
seq distance
86
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
24.827898
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
24.827898
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
26.107113
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
26.107113
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
28.85461
seq distance
346
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
28.85461
seq distance
346
chain
H
MACPF
begin
133
end
488
score
69.38840653728295
distance
29.693218
seq distance
False
chain
G
MACPF
begin
133
end
488
score
69.38840653728295
distance
29.693218
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
33.21946
seq distance
False
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
33.21946
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
33.934605
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
33.934605
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
36.54028
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
36.54028
seq distance
False
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
37.568783
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
37.568783
seq distance
False
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
44.03744
seq distance
310
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
44.03744
seq distance
310
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
44.604797
seq distance
False
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
44.604797
seq distance
False
chain
G
LDL-receptor class A
begin
78
end
115
score
100.0
distance
50.341335
seq distance
377
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
50.341335
seq distance
377
chain
H
LDL-receptor class A
begin
80
end
115
score
98.48484848484848
distance
51.063694
seq distance
False
chain
I
LDL-receptor class A
begin
80
end
115
score
98.48484848484848
distance
51.063694
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
53.359516
seq distance
386
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
53.359516
seq distance
386
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
54.52216
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
54.52216
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
391
score
68.18181818181817
distance
55.366238
seq distance
False
chain
E
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
391
score
68.18181818181817
distance
55.366238
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
59.191093
seq distance
False
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
59.191093
seq distance
False
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
61.768795
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
61.768795
seq distance
False
chain
G
LDL-receptor class A
begin
78
end
115
score
100.0
distance
61.893543
seq distance
False
chain
G
LDL-receptor class A
begin
78
end
115
score
100.0
distance
61.893543
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
62.444206
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
62.444206
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
63.105644
seq distance
394
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
63.105644
seq distance
394
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
370
score
68.18181818181817
distance
73.25479
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
370
score
68.18181818181817
distance
73.25479
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
75.49634
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
75.49634
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
93
score
77.27272727272727
distance
76.57089
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
93
score
77.27272727272727
distance
76.57089
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
85
score
72.72727272727273
distance
87.835884
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
85
score
72.72727272727273
distance
87.835884
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
94
score
81.81818181818183
distance
90.35125
seq distance
False
chain
D
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
94
score
81.81818181818183
distance
90.35125
seq distance
False
chain
D
LDL-receptor class A
begin
83
end
96
score
70.12987012987013
distance
90.35125
seq distance
False
chain
D
LDL-receptor class A
begin
83
end
96
score
70.12987012987013
distance
90.35125
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
86
score
72.72727272727273
distance
100.21087
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
86
score
72.72727272727273
distance
100.21087
seq distance
False
chain
D
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
421
score
68.18181818181817
distance
101.652855
seq distance
False
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
421
score
68.18181818181817
distance
101.652855
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
81
score
59.09090909090909
distance
109.66028
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
81
score
59.09090909090909
distance
109.66028
seq distance
False
chain
C
LDL-receptor class A
begin
130
end
149
score
51.590909090909086
distance
109.73907
seq distance
False
chain
B
LDL-receptor class A
begin
130
end
149
score
51.590909090909086
distance
109.73907
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
145
score
77.27272727272727
distance
114.00955
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
145
score
77.27272727272727
distance
114.00955
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
137
score
63.63636363636363
distance
116.676285
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
137
score
63.63636363636363
distance
116.676285
seq distance
False
chain
B
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
1272
score
50.0
distance
155.75116
seq distance
False
chain
A
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
1272
score
50.0
distance
155.75116
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
1049
score
54.54545454545454
distance
168.8463
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
1049
score
54.54545454545454
distance
168.8463
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
649
score
54.54545454545454
distance
185.68596
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
649
score
54.54545454545454
distance
185.68596
seq distance
False
chain
C
Details
Redox score
74.03
PDB code
7nyc
Structure name
cryoem structure of 3c9-smac
Structure deposition date
2021-03-22
Thiol separation (Å)
3.98
Half-sphere exposure sum
53
Minimum pKa
nan
% buried
nan
Peptide accession
P02748
Residue number A
513 (Residue 492 in this structure)
Residue number B
539 (Residue 518 in this structure)
Peptide name
Complement component C9
7nyc H 507 H 518
A redox-regulated disulphide may form within Complement component C9 at these cysteines.
Relevent regions
EGF-like
begin
489
end
519
score
98.24046920821115
distance
2.8359196
seq distance
0
chain
H
EGF-like
begin
489
end
519
score
98.24046920821115
distance
2.8359196
seq distance
0
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
8.445774
seq distance
433
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
8.445774
seq distance
433
chain
H
MACPF
begin
133
end
488
score
72.36338100102144
distance
12.183504
seq distance
19
chain
H
MACPF
begin
133
end
488
score
72.36338100102144
distance
12.183504
seq distance
19
chain
H
MACPF
begin
186
end
481
score
65.83230958230959
distance
13.896037
seq distance
False
chain
I
MACPF
begin
186
end
481
score
65.83230958230959
distance
13.896037
seq distance
False
chain
I
EGF-like
begin
489
end
519
score
98.24046920821115
distance
17.117353
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
98.24046920821115
distance
17.117353
seq distance
False
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
18.272135
seq distance
False
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
18.272135
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
19.282272
seq distance
102
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
19.282272
seq distance
102
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
22.453028
seq distance
101
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
22.453028
seq distance
101
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
24.827898
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
24.827898
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
26.107113
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
26.107113
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
28.058481
seq distance
361
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
28.058481
seq distance
361
chain
H
MACPF
begin
133
end
488
score
69.38840653728295
distance
29.693218
seq distance
False
chain
G
MACPF
begin
133
end
488
score
69.38840653728295
distance
29.693218
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
32.415733
seq distance
False
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
32.415733
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
33.934605
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
33.934605
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
36.54028
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
36.54028
seq distance
False
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
36.801556
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
36.801556
seq distance
False
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
43.86594
seq distance
325
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
43.86594
seq distance
325
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
44.820038
seq distance
False
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
44.820038
seq distance
False
chain
G
LDL-receptor class A
begin
78
end
115
score
100.0
distance
49.42817
seq distance
392
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
49.42817
seq distance
392
chain
H
LDL-receptor class A
begin
80
end
115
score
98.48484848484848
distance
49.47556
seq distance
False
chain
I
LDL-receptor class A
begin
80
end
115
score
98.48484848484848
distance
49.47556
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
52.36279
seq distance
401
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
52.36279
seq distance
401
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
53.206913
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
53.206913
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
391
score
68.18181818181817
distance
55.366238
seq distance
False
chain
E
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
391
score
68.18181818181817
distance
55.366238
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
57.78637
seq distance
False
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
57.78637
seq distance
False
chain
I
LDL-receptor class A
begin
78
end
115
score
100.0
distance
61.692795
seq distance
False
chain
G
LDL-receptor class A
begin
78
end
115
score
100.0
distance
61.692795
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
61.93613
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
61.93613
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
62.121857
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
62.121857
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
62.342205
seq distance
409
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
62.342205
seq distance
409
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
370
score
68.18181818181817
distance
73.25479
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
370
score
68.18181818181817
distance
73.25479
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
75.27211
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
75.27211
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
93
score
77.27272727272727
distance
76.704544
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
93
score
77.27272727272727
distance
76.704544
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
85
score
72.72727272727273
distance
87.90436
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
85
score
72.72727272727273
distance
87.90436
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
94
score
81.81818181818183
distance
90.57683
seq distance
False
chain
D
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
94
score
81.81818181818183
distance
90.57683
seq distance
False
chain
D
LDL-receptor class A
begin
83
end
96
score
70.12987012987013
distance
90.57683
seq distance
False
chain
D
LDL-receptor class A
begin
83
end
96
score
70.12987012987013
distance
90.57683
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
86
score
72.72727272727273
distance
100.21087
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
86
score
72.72727272727273
distance
100.21087
seq distance
False
chain
D
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
421
score
68.18181818181817
distance
101.652855
seq distance
False
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
421
score
68.18181818181817
distance
101.652855
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
81
score
59.09090909090909
distance
109.66028
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
81
score
59.09090909090909
distance
109.66028
seq distance
False
chain
C
LDL-receptor class A
begin
130
end
149
score
51.590909090909086
distance
109.73907
seq distance
False
chain
B
LDL-receptor class A
begin
130
end
149
score
51.590909090909086
distance
109.73907
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
145
score
77.27272727272727
distance
114.00955
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
145
score
77.27272727272727
distance
114.00955
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
137
score
63.63636363636363
distance
116.676285
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
137
score
63.63636363636363
distance
116.676285
seq distance
False
chain
B
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
1272
score
50.0
distance
155.75116
seq distance
False
chain
A
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
1272
score
50.0
distance
155.75116
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
1049
score
54.54545454545454
distance
168.8463
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
1049
score
54.54545454545454
distance
168.8463
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
649
score
54.54545454545454
distance
185.68596
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
649
score
54.54545454545454
distance
185.68596
seq distance
False
chain
C
Details
Redox score
73.66
PDB code
7nyc
Structure name
cryoem structure of 3c9-smac
Structure deposition date
2021-03-22
Thiol separation (Å)
3.72
Half-sphere exposure sum
55
Minimum pKa
nan
% buried
nan
Peptide accession
P02748
Residue number A
528 (Residue 507 in this structure)
Residue number B
539 (Residue 518 in this structure)
Peptide name
Complement component C9
6dlw O 492 O 509
A redox-regulated disulphide may form within Complement component C9 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.
Relevent regions
EGF-like
begin
489
end
519
score
99.12023460410556
distance
2.798275
seq distance
0
chain
O
EGF-like
begin
489
end
519
score
99.12023460410556
distance
2.798275
seq distance
0
chain
O
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
7.5150433
seq distance
418
chain
O
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
7.5150433
seq distance
418
chain
O
MACPF
begin
117
end
488
score
87.6099706744868
distance
11.386614
seq distance
4
chain
O
MACPF
begin
117
end
488
score
87.6099706744868
distance
11.386614
seq distance
4
chain
O
MACPF
begin
117
end
488
score
87.6099706744868
distance
15.5827465
seq distance
False
chain
P
MACPF
begin
117
end
488
score
87.6099706744868
distance
15.5827465
seq distance
False
chain
P
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
18.05601
seq distance
False
chain
N
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
18.05601
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
18.565075
seq distance
87
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
18.565075
seq distance
87
chain
O
EGF-like
begin
489
end
519
score
99.12023460410556
distance
18.844563
seq distance
False
chain
P
EGF-like
begin
489
end
519
score
99.12023460410556
distance
18.844563
seq distance
False
chain
P
EGF-like
begin
489
end
519
score
99.12023460410556
distance
19.728773
seq distance
False
chain
N
EGF-like
begin
489
end
519
score
99.12023460410556
distance
19.728773
seq distance
False
chain
N
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
21.909594
seq distance
86
chain
O
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
21.909594
seq distance
86
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
22.59152
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
22.59152
seq distance
False
chain
P
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
24.00413
seq distance
False
chain
P
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
24.00413
seq distance
False
chain
P
MACPF
begin
117
end
488
score
87.6099706744868
distance
26.425621
seq distance
False
chain
Q
MACPF
begin
117
end
488
score
87.6099706744868
distance
26.425621
seq distance
False
chain
Q
MACPF
begin
117
end
488
score
87.6099706744868
distance
28.960642
seq distance
False
chain
N
MACPF
begin
117
end
488
score
87.6099706744868
distance
28.960642
seq distance
False
chain
N
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
29.605946
seq distance
346
chain
O
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
29.605946
seq distance
346
chain
O
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
31.617882
seq distance
False
chain
P
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
31.617882
seq distance
False
chain
P
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
31.88707
seq distance
False
chain
P
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
31.88707
seq distance
False
chain
P
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
32.985756
seq distance
False
chain
P
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
32.985756
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
34.612648
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
34.612648
seq distance
False
chain
N
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
35.429127
seq distance
False
chain
Q
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
35.429127
seq distance
False
chain
Q
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
37.12137
seq distance
False
chain
N
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
37.12137
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
39.588863
seq distance
230
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
39.588863
seq distance
230
chain
O
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
40.72635
seq distance
False
chain
Q
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
40.72635
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
41.00933
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
41.00933
seq distance
False
chain
Q
EGF-like
begin
489
end
519
score
99.12023460410556
distance
43.47972
seq distance
False
chain
Q
EGF-like
begin
489
end
519
score
99.12023460410556
distance
43.47972
seq distance
False
chain
Q
EGF-like
begin
489
end
519
score
99.12023460410556
distance
43.94913
seq distance
False
chain
M
EGF-like
begin
489
end
519
score
99.12023460410556
distance
43.94913
seq distance
False
chain
M
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
43.996452
seq distance
False
chain
M
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
43.996452
seq distance
False
chain
M
MACPF
begin
117
end
488
score
87.6099706744868
distance
44.871635
seq distance
False
chain
R
MACPF
begin
117
end
488
score
87.6099706744868
distance
44.871635
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
44.97011
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
44.97011
seq distance
False
chain
P
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
45.09787
seq distance
False
chain
N
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
45.09787
seq distance
False
chain
N
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
45.62954
seq distance
310
chain
O
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
45.62954
seq distance
310
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
45.993847
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
45.993847
seq distance
False
chain
N
MACPF
begin
117
end
488
score
87.6099706744868
distance
47.79658
seq distance
False
chain
M
MACPF
begin
117
end
488
score
87.6099706744868
distance
47.79658
seq distance
False
chain
M
LDL-receptor class A
begin
78
end
115
score
100.0
distance
47.923668
seq distance
False
chain
P
LDL-receptor class A
begin
78
end
115
score
100.0
distance
47.923668
seq distance
False
chain
P
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
48.281147
seq distance
False
chain
Q
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
48.281147
seq distance
False
chain
Q
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
49.96015
seq distance
False
chain
R
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
49.96015
seq distance
False
chain
R
LDL-receptor class A
begin
78
end
115
score
100.0
distance
50.666283
seq distance
377
chain
O
LDL-receptor class A
begin
78
end
115
score
100.0
distance
50.666283
seq distance
377
chain
O
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
51.75333
seq distance
234
chain
O
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
51.75333
seq distance
234
chain
O
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
52.863777
seq distance
False
chain
P
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
52.863777
seq distance
False
chain
P
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
53.22201
seq distance
386
chain
O
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
53.22201
seq distance
386
chain
O
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
54.70208
seq distance
False
chain
N
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
54.70208
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
54.78193
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
54.78193
seq distance
False
chain
M
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
56.02245
seq distance
False
chain
Q
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
56.02245
seq distance
False
chain
Q
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
56.54186
seq distance
False
chain
M
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
56.54186
seq distance
False
chain
M
LDL-receptor class A
begin
78
end
115
score
100.0
distance
57.666286
seq distance
False
chain
Q
LDL-receptor class A
begin
78
end
115
score
100.0
distance
57.666286
seq distance
False
chain
Q
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
57.81535
seq distance
False
chain
P
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
57.81535
seq distance
False
chain
P
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
57.97678
seq distance
False
chain
P
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
57.97678
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
58.66703
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
58.66703
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
60.165543
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
60.165543
seq distance
False
chain
M
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
60.336407
seq distance
False
chain
R
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
60.336407
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
61.357594
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
61.357594
seq distance
False
chain
R
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
63.028378
seq distance
394
chain
O
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
63.028378
seq distance
394
chain
O
LDL-receptor class A
begin
78
end
115
score
100.0
distance
63.326572
seq distance
False
chain
N
LDL-receptor class A
begin
78
end
115
score
100.0
distance
63.326572
seq distance
False
chain
N
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
63.357044
seq distance
False
chain
Q
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
63.357044
seq distance
False
chain
Q
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
63.85206
seq distance
False
chain
Q
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
63.85206
seq distance
False
chain
Q
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
64.19581
seq distance
False
chain
N
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
64.19581
seq distance
False
chain
N
MACPF
begin
117
end
488
score
87.6099706744868
distance
64.43182
seq distance
False
chain
S
MACPF
begin
117
end
488
score
87.6099706744868
distance
64.43182
seq distance
False
chain
S
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
64.698166
seq distance
False
chain
N
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
64.698166
seq distance
False
chain
N
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
65.38182
seq distance
False
chain
M
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
65.38182
seq distance
False
chain
M
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
66.18428
seq distance
False
chain
M
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
66.18428
seq distance
False
chain
M
EGF-like
begin
489
end
519
score
99.12023460410556
distance
66.61456
seq distance
False
chain
R
EGF-like
begin
489
end
519
score
99.12023460410556
distance
66.61456
seq distance
False
chain
R
EGF-like
begin
489
end
519
score
99.12023460410556
distance
66.984764
seq distance
False
chain
L
EGF-like
begin
489
end
519
score
99.12023460410556
distance
66.984764
seq distance
False
chain
L
MACPF
begin
117
end
488
score
87.6099706744868
distance
67.09566
seq distance
False
chain
L
MACPF
begin
117
end
488
score
87.6099706744868
distance
67.09566
seq distance
False
chain
L
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
68.60292
seq distance
False
chain
R
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
68.60292
seq distance
False
chain
R
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
68.87174
seq distance
False
chain
S
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
68.87174
seq distance
False
chain
S
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
68.90647
seq distance
False
chain
L
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
68.90647
seq distance
False
chain
L
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
70.59447
seq distance
False
chain
Q
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
70.59447
seq distance
False
chain
Q
LDL-receptor class A
begin
78
end
115
score
100.0
distance
71.97973
seq distance
False
chain
R
LDL-receptor class A
begin
78
end
115
score
100.0
distance
71.97973
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
74.9013
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
74.9013
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
75.59556
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
75.59556
seq distance
False
chain
R
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
76.10873
seq distance
False
chain
L
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
76.10873
seq distance
False
chain
L
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
76.49087
seq distance
False
chain
N
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
76.49087
seq distance
False
chain
N
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
76.70094
seq distance
False
chain
R
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
76.70094
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
77.19388
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
77.19388
seq distance
False
chain
L
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
79.75942
seq distance
False
chain
S
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
79.75942
seq distance
False
chain
S
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
80.040215
seq distance
False
chain
R
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
80.040215
seq distance
False
chain
R
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
80.09784
seq distance
False
chain
R
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
80.09784
seq distance
False
chain
R
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
80.13083
seq distance
False
chain
L
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
80.13083
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
81.18578
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
81.18578
seq distance
False
chain
S
LDL-receptor class A
begin
78
end
115
score
100.0
distance
81.94123
seq distance
False
chain
M
LDL-receptor class A
begin
78
end
115
score
100.0
distance
81.94123
seq distance
False
chain
M
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
82.13563
seq distance
False
chain
M
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
82.13563
seq distance
False
chain
M
MACPF
begin
117
end
488
score
87.6099706744868
distance
82.269775
seq distance
False
chain
T
MACPF
begin
117
end
488
score
87.6099706744868
distance
82.269775
seq distance
False
chain
T
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
83.7511
seq distance
False
chain
M
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
83.7511
seq distance
False
chain
M
MACPF
begin
117
end
488
score
87.6099706744868
distance
85.37524
seq distance
False
chain
K
MACPF
begin
117
end
488
score
87.6099706744868
distance
85.37524
seq distance
False
chain
K
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
86.13043
seq distance
False
chain
R
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
86.13043
seq distance
False
chain
R
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
87.03385
seq distance
False
chain
L
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
87.03385
seq distance
False
chain
L
EGF-like
begin
489
end
519
score
99.12023460410556
distance
87.93488
seq distance
False
chain
S
EGF-like
begin
489
end
519
score
99.12023460410556
distance
87.93488
seq distance
False
chain
S
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
88.399704
seq distance
False
chain
T
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
88.399704
seq distance
False
chain
T
EGF-like
begin
489
end
519
score
99.12023460410556
distance
88.68488
seq distance
False
chain
K
EGF-like
begin
489
end
519
score
99.12023460410556
distance
88.68488
seq distance
False
chain
K
LDL-receptor class A
begin
78
end
115
score
100.0
distance
88.97118
seq distance
False
chain
S
LDL-receptor class A
begin
78
end
115
score
100.0
distance
88.97118
seq distance
False
chain
S
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
89.39009
seq distance
False
chain
S
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
89.39009
seq distance
False
chain
S
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
91.957146
seq distance
False
chain
K
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
91.957146
seq distance
False
chain
K
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
92.97535
seq distance
False
chain
S
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
92.97535
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
93.03199
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
93.03199
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
93.87038
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
93.87038
seq distance
False
chain
K
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
93.95107
seq distance
False
chain
M
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
93.95107
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
94.57674
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
94.57674
seq distance
False
chain
K
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
94.611664
seq distance
False
chain
K
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
94.611664
seq distance
False
chain
K
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
96.23061
seq distance
False
chain
K
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
96.23061
seq distance
False
chain
K
MACPF
begin
117
end
488
score
87.6099706744868
distance
97.33053
seq distance
False
chain
U
MACPF
begin
117
end
488
score
87.6099706744868
distance
97.33053
seq distance
False
chain
U
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
97.974106
seq distance
False
chain
T
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
97.974106
seq distance
False
chain
T
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
98.1955
seq distance
False
chain
S
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
98.1955
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
99.64405
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
99.64405
seq distance
False
chain
T
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
101.09228
seq distance
False
chain
L
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
101.09228
seq distance
False
chain
L
LDL-receptor class A
begin
78
end
115
score
100.0
distance
101.09228
seq distance
False
chain
L
LDL-receptor class A
begin
78
end
115
score
100.0
distance
101.09228
seq distance
False
chain
L
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
102.304504
seq distance
False
chain
S
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
102.304504
seq distance
False
chain
S
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
102.70825
seq distance
False
chain
S
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
102.70825
seq distance
False
chain
S
MACPF
begin
117
end
488
score
87.6099706744868
distance
102.70997
seq distance
False
chain
J
MACPF
begin
117
end
488
score
87.6099706744868
distance
102.70997
seq distance
False
chain
J
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
102.72126
seq distance
False
chain
L
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
102.72126
seq distance
False
chain
L
LDL-receptor class A
begin
78
end
115
score
100.0
distance
106.83743
seq distance
False
chain
T
LDL-receptor class A
begin
78
end
115
score
100.0
distance
106.83743
seq distance
False
chain
T
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
106.980095
seq distance
False
chain
K
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
106.980095
seq distance
False
chain
K
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
107.06888
seq distance
False
chain
U
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
107.06888
seq distance
False
chain
U
EGF-like
begin
489
end
519
score
99.12023460410556
distance
107.20122
seq distance
False
chain
T
EGF-like
begin
489
end
519
score
99.12023460410556
distance
107.20122
seq distance
False
chain
T
EGF-like
begin
489
end
519
score
99.12023460410556
distance
108.586655
seq distance
False
chain
J
EGF-like
begin
489
end
519
score
99.12023460410556
distance
108.586655
seq distance
False
chain
J
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
109.16228
seq distance
False
chain
T
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
109.16228
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
109.63103
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
109.63103
seq distance
False
chain
T
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
110.50376
seq distance
False
chain
T
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
110.50376
seq distance
False
chain
T
MACPF
begin
117
end
488
score
87.6099706744868
distance
110.958435
seq distance
False
chain
V
MACPF
begin
117
end
488
score
87.6099706744868
distance
110.958435
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
111.07038
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
111.07038
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
111.10885
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
111.10885
seq distance
False
chain
J
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
111.43106
seq distance
False
chain
J
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
111.43106
seq distance
False
chain
J
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
111.70128
seq distance
False
chain
L
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
111.70128
seq distance
False
chain
L
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
112.09078
seq distance
False
chain
J
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
112.09078
seq distance
False
chain
J
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
113.23173
seq distance
False
chain
J
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
113.23173
seq distance
False
chain
J
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
114.42956
seq distance
False
chain
U
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
114.42956
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
116.239716
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
116.239716
seq distance
False
chain
U
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
116.50876
seq distance
False
chain
T
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
116.50876
seq distance
False
chain
T
MACPF
begin
117
end
488
score
87.6099706744868
distance
117.24163
seq distance
False
chain
I
MACPF
begin
117
end
488
score
87.6099706744868
distance
117.24163
seq distance
False
chain
I
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
117.78612
seq distance
False
chain
T
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
117.78612
seq distance
False
chain
T
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
119.312065
seq distance
False
chain
K
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
119.312065
seq distance
False
chain
K
LDL-receptor class A
begin
78
end
115
score
100.0
distance
119.312065
seq distance
False
chain
K
LDL-receptor class A
begin
78
end
115
score
100.0
distance
119.312065
seq distance
False
chain
K
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
120.171844
seq distance
False
chain
K
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
120.171844
seq distance
False
chain
K
MACPF
begin
117
end
488
score
87.6099706744868
distance
122.32495
seq distance
False
chain
A
MACPF
begin
117
end
488
score
87.6099706744868
distance
122.32495
seq distance
False
chain
A
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
123.32338
seq distance
False
chain
T
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
123.32338
seq distance
False
chain
T
LDL-receptor class A
begin
78
end
115
score
100.0
distance
123.930305
seq distance
False
chain
U
LDL-receptor class A
begin
78
end
115
score
100.0
distance
123.930305
seq distance
False
chain
U
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
124.04774
seq distance
False
chain
V
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
124.04774
seq distance
False
chain
V
EGF-like
begin
489
end
519
score
99.12023460410556
distance
124.32553
seq distance
False
chain
U
EGF-like
begin
489
end
519
score
99.12023460410556
distance
124.32553
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
124.66086
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
124.66086
seq distance
False
chain
U
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
125.196976
seq distance
False
chain
J
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
125.196976
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
125.918564
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
125.918564
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
126.13103
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
126.13103
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
126.19482
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
126.19482
seq distance
False
chain
I
EGF-like
begin
489
end
519
score
99.12023460410556
distance
126.28112
seq distance
False
chain
I
EGF-like
begin
489
end
519
score
99.12023460410556
distance
126.28112
seq distance
False
chain
I
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
126.7267
seq distance
False
chain
I
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
126.7267
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
127.16134
seq distance
False
chain
U
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
127.16134
seq distance
False
chain
U
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
127.65751
seq distance
False
chain
U
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
127.65751
seq distance
False
chain
U
MACPF
begin
117
end
488
score
87.6099706744868
distance
128.46509
seq distance
False
chain
H
MACPF
begin
117
end
488
score
87.6099706744868
distance
128.46509
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
128.67583
seq distance
False
chain
V
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
128.67583
seq distance
False
chain
V
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
128.78447
seq distance
False
chain
K
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
128.78447
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
130.54892
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
130.54892
seq distance
False
chain
V
MACPF
begin
117
end
488
score
87.6099706744868
distance
131.35886
seq distance
False
chain
B
MACPF
begin
117
end
488
score
87.6099706744868
distance
131.35886
seq distance
False
chain
B
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
131.79945
seq distance
False
chain
U
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
131.79945
seq distance
False
chain
U
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
132.25664
seq distance
False
chain
I
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
132.25664
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
133.7402
seq distance
False
chain
U
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
133.7402
seq distance
False
chain
U
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
135.52132
seq distance
False
chain
J
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
135.52132
seq distance
False
chain
J
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
136.27283
seq distance
False
chain
J
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
136.27283
seq distance
False
chain
J
LDL-receptor class A
begin
78
end
115
score
100.0
distance
136.27283
seq distance
False
chain
J
LDL-receptor class A
begin
78
end
115
score
100.0
distance
136.27283
seq distance
False
chain
J
MACPF
begin
117
end
488
score
87.6099706744868
distance
136.34193
seq distance
False
chain
G
MACPF
begin
117
end
488
score
87.6099706744868
distance
136.34193
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
137.578
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
137.578
seq distance
False
chain
V
MACPF
begin
117
end
488
score
87.6099706744868
distance
137.93799
seq distance
False
chain
C
MACPF
begin
117
end
488
score
87.6099706744868
distance
137.93799
seq distance
False
chain
C
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
138.37314
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
138.37314
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
138.63635
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
138.63635
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
138.79388
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
138.79388
seq distance
False
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
138.9155
seq distance
False
chain
A
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
138.9155
seq distance
False
chain
A
EGF-like
begin
489
end
519
score
99.12023460410556
distance
138.91817
seq distance
False
chain
V
EGF-like
begin
489
end
519
score
99.12023460410556
distance
138.91817
seq distance
False
chain
V
LDL-receptor class A
begin
78
end
115
score
100.0
distance
139.34642
seq distance
False
chain
V
LDL-receptor class A
begin
78
end
115
score
100.0
distance
139.34642
seq distance
False
chain
V
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
139.5267
seq distance
False
chain
H
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
139.5267
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
140.45457
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
140.45457
seq distance
False
chain
A
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
141.15334
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
141.15334
seq distance
False
chain
I
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
141.36069
seq distance
False
chain
U
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
141.36069
seq distance
False
chain
U
EGF-like
begin
489
end
519
score
99.12023460410556
distance
141.41304
seq distance
False
chain
H
EGF-like
begin
489
end
519
score
99.12023460410556
distance
141.41304
seq distance
False
chain
H
MACPF
begin
117
end
488
score
87.6099706744868
distance
141.60204
seq distance
False
chain
F
MACPF
begin
117
end
488
score
87.6099706744868
distance
141.60204
seq distance
False
chain
F
MACPF
begin
117
end
488
score
87.6099706744868
distance
141.91699
seq distance
False
chain
D
MACPF
begin
117
end
488
score
87.6099706744868
distance
141.91699
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
142.31842
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
142.31842
seq distance
False
chain
A
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
142.82124
seq distance
False
chain
V
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
142.82124
seq distance
False
chain
V
MACPF
begin
117
end
488
score
87.6099706744868
distance
143.17226
seq distance
False
chain
E
MACPF
begin
117
end
488
score
87.6099706744868
distance
143.17226
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
143.39052
seq distance
False
chain
V
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
143.39052
seq distance
False
chain
V
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
143.77095
seq distance
False
chain
V
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
143.77095
seq distance
False
chain
V
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
144.39447
seq distance
False
chain
J
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
144.39447
seq distance
False
chain
J
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
147.87935
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
147.87935
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
148.01154
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
148.01154
seq distance
False
chain
A
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
148.36078
seq distance
False
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
148.36078
seq distance
False
chain
I
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
148.62375
seq distance
False
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
148.62375
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
148.6243
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
148.6243
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
148.83765
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
148.83765
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
149.06607
seq distance
False
chain
V
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
149.06607
seq distance
False
chain
V
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
149.40636
seq distance
False
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
149.40636
seq distance
False
chain
B
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
150.01863
seq distance
False
chain
G
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
150.01863
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
99.12023460410556
distance
150.73244
seq distance
False
chain
A
EGF-like
begin
489
end
519
score
99.12023460410556
distance
150.73244
seq distance
False
chain
A
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
151.1025
seq distance
False
chain
B
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
151.1025
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
151.2067
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
151.2067
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
151.25554
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
151.25554
seq distance
False
chain
I
LDL-receptor class A
begin
78
end
115
score
100.0
distance
151.25554
seq distance
False
chain
I
LDL-receptor class A
begin
78
end
115
score
100.0
distance
151.25554
seq distance
False
chain
I
LDL-receptor class A
begin
78
end
115
score
100.0
distance
152.8061
seq distance
False
chain
A
LDL-receptor class A
begin
78
end
115
score
100.0
distance
152.8061
seq distance
False
chain
A
EGF-like
begin
489
end
519
score
99.12023460410556
distance
153.23495
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
99.12023460410556
distance
153.23495
seq distance
False
chain
G
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
153.29285
seq distance
False
chain
A
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
153.29285
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
154.43695
seq distance
False
chain
F
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
154.43695
seq distance
False
chain
F
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
154.43724
seq distance
False
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
154.43724
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
155.37047
seq distance
False
chain
C
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
155.37047
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
155.47505
seq distance
False
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
155.47505
seq distance
False
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
155.73709
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
155.73709
seq distance
False
chain
B
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
155.84196
seq distance
False
chain
A
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
155.84196
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
156.26007
seq distance
False
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
156.26007
seq distance
False
chain
F
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
156.30643
seq distance
False
chain
V
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
156.30643
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
157.0514
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
157.0514
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
157.16011
seq distance
False
chain
A
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
157.16011
seq distance
False
chain
A
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
157.89107
seq distance
False
chain
F
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
157.89107
seq distance
False
chain
F
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
157.89487
seq distance
False
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
157.89487
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
157.91652
seq distance
False
chain
E
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
157.91652
seq distance
False
chain
E
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
158.23515
seq distance
False
chain
D
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
158.23515
seq distance
False
chain
D
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
158.37752
seq distance
False
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
158.37752
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
159.21162
seq distance
False
chain
E
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
159.21162
seq distance
False
chain
E
EGF-like
begin
489
end
519
score
99.12023460410556
distance
159.47101
seq distance
False
chain
B
EGF-like
begin
489
end
519
score
99.12023460410556
distance
159.47101
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
159.74617
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
159.74617
seq distance
False
chain
D
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
160.17003
seq distance
False
chain
B
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
160.17003
seq distance
False
chain
B
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
160.38019
seq distance
False
chain
C
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
160.38019
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
160.48932
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
160.48932
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
160.75543
seq distance
False
chain
E
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
160.75543
seq distance
False
chain
E
EGF-like
begin
489
end
519
score
99.12023460410556
distance
161.20695
seq distance
False
chain
F
EGF-like
begin
489
end
519
score
99.12023460410556
distance
161.20695
seq distance
False
chain
F
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
161.98436
seq distance
False
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
161.98436
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
162.06166
seq distance
False
chain
A
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
162.06166
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
162.1863
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
162.1863
seq distance
False
chain
D
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
162.96466
seq distance
False
chain
E
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
162.96466
seq distance
False
chain
E
LDL-receptor class A
begin
78
end
115
score
100.0
distance
163.12646
seq distance
False
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
163.12646
seq distance
False
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
163.61897
seq distance
False
chain
B
LDL-receptor class A
begin
78
end
115
score
100.0
distance
163.61897
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
163.74065
seq distance
False
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
163.74065
seq distance
False
chain
H
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
164.11942
seq distance
False
chain
C
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
164.11942
seq distance
False
chain
C
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
164.73401
seq distance
False
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
164.73401
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
99.12023460410556
distance
164.95885
seq distance
False
chain
C
EGF-like
begin
489
end
519
score
99.12023460410556
distance
164.95885
seq distance
False
chain
C
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
165.07004
seq distance
False
chain
D
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
165.07004
seq distance
False
chain
D
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
165.335
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
165.335
seq distance
False
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
165.76317
seq distance
False
chain
B
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
165.76317
seq distance
False
chain
B
EGF-like
begin
489
end
519
score
99.12023460410556
distance
165.83775
seq distance
False
chain
E
EGF-like
begin
489
end
519
score
99.12023460410556
distance
165.83775
seq distance
False
chain
E
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
166.56326
seq distance
False
chain
D
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
166.56326
seq distance
False
chain
D
EGF-like
begin
489
end
519
score
99.12023460410556
distance
167.10304
seq distance
False
chain
D
EGF-like
begin
489
end
519
score
99.12023460410556
distance
167.10304
seq distance
False
chain
D
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
168.13284
seq distance
False
chain
A
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
168.13284
seq distance
False
chain
A
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
168.24716
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
168.24716
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
168.8147
seq distance
False
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
168.8147
seq distance
False
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
169.0629
seq distance
False
chain
F
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
169.0629
seq distance
False
chain
F
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
169.4753
seq distance
False
chain
E
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
169.4753
seq distance
False
chain
E
LDL-receptor class A
begin
78
end
115
score
100.0
distance
171.57913
seq distance
False
chain
C
LDL-receptor class A
begin
78
end
115
score
100.0
distance
171.57913
seq distance
False
chain
C
LDL-receptor class A
begin
78
end
115
score
100.0
distance
171.72455
seq distance
False
chain
G
LDL-receptor class A
begin
78
end
115
score
100.0
distance
171.72455
seq distance
False
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
171.80432
seq distance
False
chain
F
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
171.80432
seq distance
False
chain
F
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
172.06995
seq distance
False
chain
F
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
172.06995
seq distance
False
chain
F
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
172.11816
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
172.11816
seq distance
False
chain
B
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
172.42778
seq distance
False
chain
C
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
172.42778
seq distance
False
chain
C
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
173.35754
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
173.35754
seq distance
False
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
175.48753
seq distance
False
chain
E
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
175.48753
seq distance
False
chain
E
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
175.70091
seq distance
False
chain
D
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
175.70091
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
176.43059
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
176.43059
seq distance
False
chain
C
LDL-receptor class A
begin
78
end
115
score
100.0
distance
176.47029
seq distance
False
chain
D
LDL-receptor class A
begin
78
end
115
score
100.0
distance
176.47029
seq distance
False
chain
D
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
176.51866
seq distance
False
chain
B
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
176.51866
seq distance
False
chain
B
LDL-receptor class A
begin
78
end
115
score
100.0
distance
176.54585
seq distance
False
chain
F
LDL-receptor class A
begin
78
end
115
score
100.0
distance
176.54585
seq distance
False
chain
F
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
176.82703
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
176.82703
seq distance
False
chain
G
LDL-receptor class A
begin
78
end
115
score
100.0
distance
178.13985
seq distance
False
chain
E
LDL-receptor class A
begin
78
end
115
score
100.0
distance
178.13985
seq distance
False
chain
E
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
178.68262
seq distance
False
chain
E
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
178.68262
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
179.06487
seq distance
False
chain
C
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
179.06487
seq distance
False
chain
C
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
179.8318
seq distance
False
chain
F
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
179.8318
seq distance
False
chain
F
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
180.9656
seq distance
False
chain
C
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
180.9656
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
181.48676
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
181.48676
seq distance
False
chain
D
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
181.67311
seq distance
False
chain
D
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
181.67311
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
181.6909
seq distance
False
chain
F
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
181.6909
seq distance
False
chain
F
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
182.72237
seq distance
False
chain
D
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
182.72237
seq distance
False
chain
D
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
182.97803
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
182.97803
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
183.25461
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
183.25461
seq distance
False
chain
E
Details
Redox score
69.63
PDB code
6dlw
Structure name
complement component polyc9
Structure deposition date
2018-06-03
Thiol separation (Å)
6.85
Half-sphere exposure sum
50
Minimum pKa
nan
% buried
nan
Peptide accession
P02748
Residue number A
513 (Residue 492 in this structure)
Residue number B
530 (Residue 509 in this structure)
Peptide name
Complement component C9
6dlw F 507 F 509
A redox-regulated disulphide may form within Complement component C9 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.
Relevent regions
EGF-like
begin
489
end
519
score
99.12023460410556
distance
2.7952158
seq distance
0
chain
F
EGF-like
begin
489
end
519
score
99.12023460410556
distance
2.7952158
seq distance
0
chain
F
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
7.9420485
seq distance
433
chain
F
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
7.9420485
seq distance
433
chain
F
MACPF
begin
117
end
488
score
87.6099706744868
distance
10.160334
seq distance
19
chain
F
MACPF
begin
117
end
488
score
87.6099706744868
distance
10.160334
seq distance
19
chain
F
MACPF
begin
117
end
488
score
87.6099706744868
distance
15.570882
seq distance
False
chain
G
MACPF
begin
117
end
488
score
87.6099706744868
distance
15.570882
seq distance
False
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
16.87156
seq distance
False
chain
E
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
16.87156
seq distance
False
chain
E
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
18.56458
seq distance
102
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
18.56458
seq distance
102
chain
F
EGF-like
begin
489
end
519
score
99.12023460410556
distance
18.864311
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
99.12023460410556
distance
18.864311
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
99.12023460410556
distance
19.595743
seq distance
False
chain
E
EGF-like
begin
489
end
519
score
99.12023460410556
distance
19.595743
seq distance
False
chain
E
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
21.909178
seq distance
101
chain
F
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
21.909178
seq distance
101
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
22.581211
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
22.581211
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
23.988907
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
23.988907
seq distance
False
chain
G
MACPF
begin
117
end
488
score
87.6099706744868
distance
26.413506
seq distance
False
chain
H
MACPF
begin
117
end
488
score
87.6099706744868
distance
26.413506
seq distance
False
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
27.649807
seq distance
361
chain
F
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
27.649807
seq distance
361
chain
F
MACPF
begin
117
end
488
score
87.6099706744868
distance
28.94494
seq distance
False
chain
E
MACPF
begin
117
end
488
score
87.6099706744868
distance
28.94494
seq distance
False
chain
E
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
30.690838
seq distance
False
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
30.690838
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
30.970823
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
30.970823
seq distance
False
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
31.746494
seq distance
False
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
31.746494
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
34.603756
seq distance
False
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
34.603756
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
34.612423
seq distance
False
chain
E
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
34.612423
seq distance
False
chain
E
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
37.122345
seq distance
False
chain
E
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
37.122345
seq distance
False
chain
E
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
39.589344
seq distance
245
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
39.589344
seq distance
245
chain
F
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
40.721584
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
40.721584
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
41.008682
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
41.008682
seq distance
False
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
42.86806
seq distance
False
chain
D
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
42.86806
seq distance
False
chain
D
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
43.276894
seq distance
False
chain
E
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
43.276894
seq distance
False
chain
E
EGF-like
begin
489
end
519
score
99.12023460410556
distance
43.505558
seq distance
False
chain
H
EGF-like
begin
489
end
519
score
99.12023460410556
distance
43.505558
seq distance
False
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
43.694828
seq distance
325
chain
F
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
43.694828
seq distance
325
chain
F
EGF-like
begin
489
end
519
score
99.12023460410556
distance
43.950157
seq distance
False
chain
D
EGF-like
begin
489
end
519
score
99.12023460410556
distance
43.950157
seq distance
False
chain
D
MACPF
begin
117
end
488
score
87.6099706744868
distance
44.86004
seq distance
False
chain
I
MACPF
begin
117
end
488
score
87.6099706744868
distance
44.86004
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
44.983936
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
44.983936
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
45.969822
seq distance
False
chain
E
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
45.969822
seq distance
False
chain
E
LDL-receptor class A
begin
78
end
115
score
100.0
distance
46.555225
seq distance
False
chain
G
LDL-receptor class A
begin
78
end
115
score
100.0
distance
46.555225
seq distance
False
chain
G
MACPF
begin
117
end
488
score
87.6099706744868
distance
47.781727
seq distance
False
chain
D
MACPF
begin
117
end
488
score
87.6099706744868
distance
47.781727
seq distance
False
chain
D
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
48.27043
seq distance
False
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
48.27043
seq distance
False
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
48.956604
seq distance
392
chain
F
LDL-receptor class A
begin
78
end
115
score
100.0
distance
48.956604
seq distance
392
chain
F
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
49.94712
seq distance
False
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
49.94712
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
51.38076
seq distance
401
chain
F
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
51.38076
seq distance
401
chain
F
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
51.39148
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
51.39148
seq distance
False
chain
G
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
51.754654
seq distance
249
chain
F
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
51.754654
seq distance
249
chain
F
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
54.676765
seq distance
False
chain
E
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
54.676765
seq distance
False
chain
E
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
54.778175
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
54.778175
seq distance
False
chain
D
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
56.037777
seq distance
False
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
56.037777
seq distance
False
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
56.108215
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
56.108215
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
56.53816
seq distance
False
chain
D
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
56.53816
seq distance
False
chain
D
LDL-receptor class A
begin
78
end
115
score
100.0
distance
56.550476
seq distance
False
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
56.550476
seq distance
False
chain
H
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
57.993385
seq distance
False
chain
G
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
57.993385
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
58.702442
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
58.702442
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
60.14588
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
60.14588
seq distance
False
chain
D
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
60.327152
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
60.327152
seq distance
False
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
61.11316
seq distance
409
chain
F
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
61.11316
seq distance
409
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
61.349613
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
61.349613
seq distance
False
chain
I
LDL-receptor class A
begin
78
end
115
score
100.0
distance
61.50565
seq distance
False
chain
E
LDL-receptor class A
begin
78
end
115
score
100.0
distance
61.50565
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
62.043797
seq distance
False
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
62.043797
seq distance
False
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
62.796055
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
62.796055
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
62.826134
seq distance
False
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
62.826134
seq distance
False
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
62.999416
seq distance
False
chain
E
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
62.999416
seq distance
False
chain
E
MACPF
begin
117
end
488
score
87.6099706744868
distance
64.42725
seq distance
False
chain
J
MACPF
begin
117
end
488
score
87.6099706744868
distance
64.42725
seq distance
False
chain
J
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
64.62348
seq distance
False
chain
D
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
64.62348
seq distance
False
chain
D
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
65.35974
seq distance
False
chain
D
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
65.35974
seq distance
False
chain
D
EGF-like
begin
489
end
519
score
99.12023460410556
distance
66.61209
seq distance
False
chain
I
EGF-like
begin
489
end
519
score
99.12023460410556
distance
66.61209
seq distance
False
chain
I
EGF-like
begin
489
end
519
score
99.12023460410556
distance
66.97623
seq distance
False
chain
C
EGF-like
begin
489
end
519
score
99.12023460410556
distance
66.97623
seq distance
False
chain
C
MACPF
begin
117
end
488
score
87.6099706744868
distance
67.08711
seq distance
False
chain
C
MACPF
begin
117
end
488
score
87.6099706744868
distance
67.08711
seq distance
False
chain
C
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
68.25144
seq distance
False
chain
C
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
68.25144
seq distance
False
chain
C
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
68.59346
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
68.59346
seq distance
False
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
68.87525
seq distance
False
chain
J
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
68.87525
seq distance
False
chain
J
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
70.6337
seq distance
False
chain
H
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
70.6337
seq distance
False
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
71.463
seq distance
False
chain
I
LDL-receptor class A
begin
78
end
115
score
100.0
distance
71.463
seq distance
False
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
74.5684
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
74.5684
seq distance
False
chain
E
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
74.881065
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
74.881065
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
75.597946
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
75.597946
seq distance
False
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
76.048645
seq distance
False
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
76.048645
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
76.08692
seq distance
False
chain
C
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
76.08692
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
77.1863
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
77.1863
seq distance
False
chain
C
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
79.745056
seq distance
False
chain
J
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
79.745056
seq distance
False
chain
J
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
80.02784
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
80.02784
seq distance
False
chain
I
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
80.09422
seq distance
False
chain
I
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
80.09422
seq distance
False
chain
I
LDL-receptor class A
begin
78
end
115
score
100.0
distance
80.102165
seq distance
False
chain
D
LDL-receptor class A
begin
78
end
115
score
100.0
distance
80.102165
seq distance
False
chain
D
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
80.1281
seq distance
False
chain
C
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
80.1281
seq distance
False
chain
C
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
80.27235
seq distance
False
chain
D
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
80.27235
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
81.170334
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
81.170334
seq distance
False
chain
J
MACPF
begin
117
end
488
score
87.6099706744868
distance
82.24411
seq distance
False
chain
K
MACPF
begin
117
end
488
score
87.6099706744868
distance
82.24411
seq distance
False
chain
K
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
83.489044
seq distance
False
chain
D
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
83.489044
seq distance
False
chain
D
MACPF
begin
117
end
488
score
87.6099706744868
distance
85.361755
seq distance
False
chain
B
MACPF
begin
117
end
488
score
87.6099706744868
distance
85.361755
seq distance
False
chain
B
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
86.13436
seq distance
False
chain
I
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
86.13436
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
86.5409
seq distance
False
chain
C
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
86.5409
seq distance
False
chain
C
EGF-like
begin
489
end
519
score
99.12023460410556
distance
87.92043
seq distance
False
chain
J
EGF-like
begin
489
end
519
score
99.12023460410556
distance
87.92043
seq distance
False
chain
J
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
88.391174
seq distance
False
chain
K
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
88.391174
seq distance
False
chain
K
EGF-like
begin
489
end
519
score
99.12023460410556
distance
88.658554
seq distance
False
chain
B
EGF-like
begin
489
end
519
score
99.12023460410556
distance
88.658554
seq distance
False
chain
B
LDL-receptor class A
begin
78
end
115
score
100.0
distance
88.97748
seq distance
False
chain
J
LDL-receptor class A
begin
78
end
115
score
100.0
distance
88.97748
seq distance
False
chain
J
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
89.38819
seq distance
False
chain
J
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
89.38819
seq distance
False
chain
J
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
91.92692
seq distance
False
chain
B
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
91.92692
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
92.0624
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
92.0624
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
92.984344
seq distance
False
chain
J
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
92.984344
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
93.005974
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
93.005974
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
93.84021
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
93.84021
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
94.56707
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
94.56707
seq distance
False
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
94.58064
seq distance
False
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
94.58064
seq distance
False
chain
B
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
96.228165
seq distance
False
chain
B
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
96.228165
seq distance
False
chain
B
MACPF
begin
117
end
488
score
87.6099706744868
distance
97.29988
seq distance
False
chain
L
MACPF
begin
117
end
488
score
87.6099706744868
distance
97.29988
seq distance
False
chain
L
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
97.95153
seq distance
False
chain
K
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
97.95153
seq distance
False
chain
K
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
98.20097
seq distance
False
chain
J
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
98.20097
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
99.620056
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
99.620056
seq distance
False
chain
K
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
99.70295
seq distance
False
chain
C
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
99.70295
seq distance
False
chain
C
LDL-receptor class A
begin
78
end
115
score
100.0
distance
99.70295
seq distance
False
chain
C
LDL-receptor class A
begin
78
end
115
score
100.0
distance
99.70295
seq distance
False
chain
C
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
102.27658
seq distance
False
chain
J
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
102.27658
seq distance
False
chain
J
MACPF
begin
117
end
488
score
87.6099706744868
distance
102.683495
seq distance
False
chain
A
MACPF
begin
117
end
488
score
87.6099706744868
distance
102.683495
seq distance
False
chain
A
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
102.69641
seq distance
False
chain
C
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
102.69641
seq distance
False
chain
C
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
102.700645
seq distance
False
chain
J
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
102.700645
seq distance
False
chain
J
LDL-receptor class A
begin
78
end
115
score
100.0
distance
106.83092
seq distance
False
chain
K
LDL-receptor class A
begin
78
end
115
score
100.0
distance
106.83092
seq distance
False
chain
K
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
106.94291
seq distance
False
chain
B
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
106.94291
seq distance
False
chain
B
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
107.0474
seq distance
False
chain
L
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
107.0474
seq distance
False
chain
L
EGF-like
begin
489
end
519
score
99.12023460410556
distance
107.177605
seq distance
False
chain
K
EGF-like
begin
489
end
519
score
99.12023460410556
distance
107.177605
seq distance
False
chain
K
EGF-like
begin
489
end
519
score
99.12023460410556
distance
108.56317
seq distance
False
chain
A
EGF-like
begin
489
end
519
score
99.12023460410556
distance
108.56317
seq distance
False
chain
A
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
109.148964
seq distance
False
chain
K
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
109.148964
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
109.600296
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
109.600296
seq distance
False
chain
K
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
110.49989
seq distance
False
chain
K
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
110.49989
seq distance
False
chain
K
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
110.66454
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
110.66454
seq distance
False
chain
C
MACPF
begin
117
end
488
score
87.6099706744868
distance
110.94215
seq distance
False
chain
M
MACPF
begin
117
end
488
score
87.6099706744868
distance
110.94215
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
111.0434
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
111.0434
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
111.08787
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
111.08787
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
111.411026
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
111.411026
seq distance
False
chain
A
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
112.0633
seq distance
False
chain
A
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
112.0633
seq distance
False
chain
A
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
113.21
seq distance
False
chain
A
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
113.21
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
114.3954
seq distance
False
chain
L
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
114.3954
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
116.20563
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
116.20563
seq distance
False
chain
L
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
116.500626
seq distance
False
chain
K
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
116.500626
seq distance
False
chain
K
MACPF
begin
117
end
488
score
87.6099706744868
distance
117.262054
seq distance
False
chain
V
MACPF
begin
117
end
488
score
87.6099706744868
distance
117.262054
seq distance
False
chain
V
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
117.75364
seq distance
False
chain
K
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
117.75364
seq distance
False
chain
K
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
118.95422
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
118.95422
seq distance
False
chain
B
LDL-receptor class A
begin
78
end
115
score
100.0
distance
118.95422
seq distance
False
chain
B
LDL-receptor class A
begin
78
end
115
score
100.0
distance
118.95422
seq distance
False
chain
B
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
120.13611
seq distance
False
chain
B
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
120.13611
seq distance
False
chain
B
MACPF
begin
117
end
488
score
87.6099706744868
distance
122.25773
seq distance
False
chain
N
MACPF
begin
117
end
488
score
87.6099706744868
distance
122.25773
seq distance
False
chain
N
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
123.30478
seq distance
False
chain
K
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
123.30478
seq distance
False
chain
K
LDL-receptor class A
begin
78
end
115
score
100.0
distance
123.91684
seq distance
False
chain
L
LDL-receptor class A
begin
78
end
115
score
100.0
distance
123.91684
seq distance
False
chain
L
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
124.037895
seq distance
False
chain
M
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
124.037895
seq distance
False
chain
M
EGF-like
begin
489
end
519
score
99.12023460410556
distance
124.2876
seq distance
False
chain
L
EGF-like
begin
489
end
519
score
99.12023460410556
distance
124.2876
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
124.61311
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
124.61311
seq distance
False
chain
L
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
125.178535
seq distance
False
chain
A
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
125.178535
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
125.987175
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
125.987175
seq distance
False
chain
V
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
126.151054
seq distance
False
chain
V
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
126.151054
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
126.21869
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
126.21869
seq distance
False
chain
V
EGF-like
begin
489
end
519
score
99.12023460410556
distance
126.32116
seq distance
False
chain
V
EGF-like
begin
489
end
519
score
99.12023460410556
distance
126.32116
seq distance
False
chain
V
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
126.80878
seq distance
False
chain
V
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
126.80878
seq distance
False
chain
V
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
127.13471
seq distance
False
chain
L
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
127.13471
seq distance
False
chain
L
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
127.64507
seq distance
False
chain
L
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
127.64507
seq distance
False
chain
L
MACPF
begin
117
end
488
score
87.6099706744868
distance
128.47833
seq distance
False
chain
U
MACPF
begin
117
end
488
score
87.6099706744868
distance
128.47833
seq distance
False
chain
U
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
128.66182
seq distance
False
chain
M
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
128.66182
seq distance
False
chain
M
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
128.7175
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
128.7175
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
130.53535
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
130.53535
seq distance
False
chain
M
MACPF
begin
117
end
488
score
87.6099706744868
distance
131.29988
seq distance
False
chain
O
MACPF
begin
117
end
488
score
87.6099706744868
distance
131.29988
seq distance
False
chain
O
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
131.75035
seq distance
False
chain
L
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
131.75035
seq distance
False
chain
L
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
132.28935
seq distance
False
chain
V
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
132.28935
seq distance
False
chain
V
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
133.72282
seq distance
False
chain
L
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
133.72282
seq distance
False
chain
L
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
135.505
seq distance
False
chain
A
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
135.505
seq distance
False
chain
A
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
136.25792
seq distance
False
chain
A
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
136.25792
seq distance
False
chain
A
LDL-receptor class A
begin
78
end
115
score
100.0
distance
136.25792
seq distance
False
chain
A
LDL-receptor class A
begin
78
end
115
score
100.0
distance
136.25792
seq distance
False
chain
A
MACPF
begin
117
end
488
score
87.6099706744868
distance
136.33311
seq distance
False
chain
T
MACPF
begin
117
end
488
score
87.6099706744868
distance
136.33311
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
137.5695
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
137.5695
seq distance
False
chain
M
MACPF
begin
117
end
488
score
87.6099706744868
distance
137.881
seq distance
False
chain
P
MACPF
begin
117
end
488
score
87.6099706744868
distance
137.881
seq distance
False
chain
P
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
138.3866
seq distance
False
chain
U
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
138.3866
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
138.70712
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
138.70712
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
138.81163
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
138.81163
seq distance
False
chain
U
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
138.81313
seq distance
False
chain
N
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
138.81313
seq distance
False
chain
N
EGF-like
begin
489
end
519
score
99.12023460410556
distance
138.90613
seq distance
False
chain
M
EGF-like
begin
489
end
519
score
99.12023460410556
distance
138.90613
seq distance
False
chain
M
LDL-receptor class A
begin
78
end
115
score
100.0
distance
139.33241
seq distance
False
chain
M
LDL-receptor class A
begin
78
end
115
score
100.0
distance
139.33241
seq distance
False
chain
M
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
139.61137
seq distance
False
chain
U
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
139.61137
seq distance
False
chain
U
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
140.3927
seq distance
False
chain
N
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
140.3927
seq distance
False
chain
N
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
141.15962
seq distance
False
chain
V
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
141.15962
seq distance
False
chain
V
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
141.32552
seq distance
False
chain
L
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
141.32552
seq distance
False
chain
L
EGF-like
begin
489
end
519
score
99.12023460410556
distance
141.44867
seq distance
False
chain
U
EGF-like
begin
489
end
519
score
99.12023460410556
distance
141.44867
seq distance
False
chain
U
MACPF
begin
117
end
488
score
87.6099706744868
distance
141.58865
seq distance
False
chain
S
MACPF
begin
117
end
488
score
87.6099706744868
distance
141.58865
seq distance
False
chain
S
MACPF
begin
117
end
488
score
87.6099706744868
distance
141.85457
seq distance
False
chain
Q
MACPF
begin
117
end
488
score
87.6099706744868
distance
141.85457
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
142.26205
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
142.26205
seq distance
False
chain
N
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
142.80852
seq distance
False
chain
M
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
142.80852
seq distance
False
chain
M
MACPF
begin
117
end
488
score
87.6099706744868
distance
143.12389
seq distance
False
chain
R
MACPF
begin
117
end
488
score
87.6099706744868
distance
143.12389
seq distance
False
chain
R
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
143.37695
seq distance
False
chain
M
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
143.37695
seq distance
False
chain
M
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
143.76253
seq distance
False
chain
M
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
143.76253
seq distance
False
chain
M
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
144.38046
seq distance
False
chain
A
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
144.38046
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
147.87329
seq distance
False
chain
T
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
147.87329
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
148.01881
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
148.01881
seq distance
False
chain
N
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
148.36128
seq distance
False
chain
V
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
148.36128
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
148.62401
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
148.62401
seq distance
False
chain
T
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
148.65213
seq distance
False
chain
U
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
148.65213
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
148.89725
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
148.89725
seq distance
False
chain
T
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
149.05154
seq distance
False
chain
M
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
149.05154
seq distance
False
chain
M
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
149.35283
seq distance
False
chain
O
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
149.35283
seq distance
False
chain
O
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
150.09616
seq distance
False
chain
T
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
150.09616
seq distance
False
chain
T
EGF-like
begin
489
end
519
score
99.12023460410556
distance
150.69028
seq distance
False
chain
N
EGF-like
begin
489
end
519
score
99.12023460410556
distance
150.69028
seq distance
False
chain
N
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
151.01695
seq distance
False
chain
O
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
151.01695
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
151.15657
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
151.15657
seq distance
False
chain
O
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
151.2432
seq distance
False
chain
V
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
151.2432
seq distance
False
chain
V
LDL-receptor class A
begin
78
end
115
score
100.0
distance
151.2432
seq distance
False
chain
V
LDL-receptor class A
begin
78
end
115
score
100.0
distance
151.2432
seq distance
False
chain
V
LDL-receptor class A
begin
78
end
115
score
100.0
distance
152.68213
seq distance
False
chain
N
LDL-receptor class A
begin
78
end
115
score
100.0
distance
152.68213
seq distance
False
chain
N
EGF-like
begin
489
end
519
score
99.12023460410556
distance
153.25987
seq distance
False
chain
T
EGF-like
begin
489
end
519
score
99.12023460410556
distance
153.25987
seq distance
False
chain
T
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
153.31758
seq distance
False
chain
N
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
153.31758
seq distance
False
chain
N
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
154.42406
seq distance
False
chain
S
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
154.42406
seq distance
False
chain
S
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
154.4362
seq distance
False
chain
U
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
154.4362
seq distance
False
chain
U
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
155.31718
seq distance
False
chain
P
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
155.31718
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
155.46771
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
155.46771
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
155.73242
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
155.73242
seq distance
False
chain
O
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
155.75551
seq distance
False
chain
N
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
155.75551
seq distance
False
chain
N
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
156.29384
seq distance
False
chain
M
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
156.29384
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
156.33014
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
156.33014
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
157.00099
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
157.00099
seq distance
False
chain
P
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
157.03209
seq distance
False
chain
N
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
157.03209
seq distance
False
chain
N
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
157.8742
seq distance
False
chain
V
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
157.8742
seq distance
False
chain
V
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
157.8798
seq distance
False
chain
R
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
157.8798
seq distance
False
chain
R
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
157.98447
seq distance
False
chain
S
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
157.98447
seq distance
False
chain
S
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
158.17923
seq distance
False
chain
Q
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
158.17923
seq distance
False
chain
Q
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
158.36601
seq distance
False
chain
U
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
158.36601
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
159.17876
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
159.17876
seq distance
False
chain
R
EGF-like
begin
489
end
519
score
99.12023460410556
distance
159.43158
seq distance
False
chain
O
EGF-like
begin
489
end
519
score
99.12023460410556
distance
159.43158
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
159.69218
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
159.69218
seq distance
False
chain
Q
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
160.17865
seq distance
False
chain
O
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
160.17865
seq distance
False
chain
O
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
160.30731
seq distance
False
chain
P
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
160.30731
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
160.47896
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
160.47896
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
160.78073
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
160.78073
seq distance
False
chain
R
EGF-like
begin
489
end
519
score
99.12023460410556
distance
161.22252
seq distance
False
chain
S
EGF-like
begin
489
end
519
score
99.12023460410556
distance
161.22252
seq distance
False
chain
S
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
161.94681
seq distance
False
chain
N
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
161.94681
seq distance
False
chain
N
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
162.00328
seq distance
False
chain
T
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
162.00328
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
162.16504
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
162.16504
seq distance
False
chain
Q
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
163.00627
seq distance
False
chain
R
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
163.00627
seq distance
False
chain
R
LDL-receptor class A
begin
78
end
115
score
100.0
distance
163.10042
seq distance
False
chain
U
LDL-receptor class A
begin
78
end
115
score
100.0
distance
163.10042
seq distance
False
chain
U
LDL-receptor class A
begin
78
end
115
score
100.0
distance
163.5205
seq distance
False
chain
O
LDL-receptor class A
begin
78
end
115
score
100.0
distance
163.5205
seq distance
False
chain
O
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
163.716
seq distance
False
chain
U
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
163.716
seq distance
False
chain
U
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
164.1203
seq distance
False
chain
P
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
164.1203
seq distance
False
chain
P
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
164.7131
seq distance
False
chain
T
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
164.7131
seq distance
False
chain
T
EGF-like
begin
489
end
519
score
99.12023460410556
distance
164.91833
seq distance
False
chain
P
EGF-like
begin
489
end
519
score
99.12023460410556
distance
164.91833
seq distance
False
chain
P
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
165.0588
seq distance
False
chain
Q
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
165.0588
seq distance
False
chain
Q
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
165.29471
seq distance
False
chain
T
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
165.29471
seq distance
False
chain
T
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
165.69214
seq distance
False
chain
O
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
165.69214
seq distance
False
chain
O
EGF-like
begin
489
end
519
score
99.12023460410556
distance
165.82138
seq distance
False
chain
R
EGF-like
begin
489
end
519
score
99.12023460410556
distance
165.82138
seq distance
False
chain
R
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
166.48643
seq distance
False
chain
Q
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
166.48643
seq distance
False
chain
Q
EGF-like
begin
489
end
519
score
99.12023460410556
distance
167.05855
seq distance
False
chain
Q
EGF-like
begin
489
end
519
score
99.12023460410556
distance
167.05855
seq distance
False
chain
Q
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
168.08112
seq distance
False
chain
N
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
168.08112
seq distance
False
chain
N
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
168.14502
seq distance
False
chain
O
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
168.14502
seq distance
False
chain
O
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
168.78087
seq distance
False
chain
U
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
168.78087
seq distance
False
chain
U
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
169.00516
seq distance
False
chain
S
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
169.00516
seq distance
False
chain
S
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
169.4061
seq distance
False
chain
R
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
169.4061
seq distance
False
chain
R
LDL-receptor class A
begin
78
end
115
score
100.0
distance
171.49133
seq distance
False
chain
P
LDL-receptor class A
begin
78
end
115
score
100.0
distance
171.49133
seq distance
False
chain
P
LDL-receptor class A
begin
78
end
115
score
100.0
distance
171.66434
seq distance
False
chain
T
LDL-receptor class A
begin
78
end
115
score
100.0
distance
171.66434
seq distance
False
chain
T
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
171.7677
seq distance
False
chain
S
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
171.7677
seq distance
False
chain
S
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
172.02682
seq distance
False
chain
O
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
172.02682
seq distance
False
chain
O
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
172.08292
seq distance
False
chain
S
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
172.08292
seq distance
False
chain
S
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
172.36171
seq distance
False
chain
P
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
172.36171
seq distance
False
chain
P
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
173.30952
seq distance
False
chain
T
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
173.30952
seq distance
False
chain
T
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
175.43222
seq distance
False
chain
R
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
175.43222
seq distance
False
chain
R
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
175.635
seq distance
False
chain
Q
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
175.635
seq distance
False
chain
Q
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
176.3412
seq distance
False
chain
P
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
176.3412
seq distance
False
chain
P
LDL-receptor class A
begin
78
end
115
score
100.0
distance
176.386
seq distance
False
chain
Q
LDL-receptor class A
begin
78
end
115
score
100.0
distance
176.386
seq distance
False
chain
Q
LDL-receptor class A
begin
78
end
115
score
100.0
distance
176.46143
seq distance
False
chain
S
LDL-receptor class A
begin
78
end
115
score
100.0
distance
176.46143
seq distance
False
chain
S
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
176.47441
seq distance
False
chain
O
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
176.47441
seq distance
False
chain
O
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
176.76494
seq distance
False
chain
T
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
176.76494
seq distance
False
chain
T
LDL-receptor class A
begin
78
end
115
score
100.0
distance
178.05043
seq distance
False
chain
R
LDL-receptor class A
begin
78
end
115
score
100.0
distance
178.05043
seq distance
False
chain
R
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
178.66121
seq distance
False
chain
R
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
178.66121
seq distance
False
chain
R
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
178.9813
seq distance
False
chain
P
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
178.9813
seq distance
False
chain
P
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
179.7607
seq distance
False
chain
S
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
179.7607
seq distance
False
chain
S
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
180.91962
seq distance
False
chain
P
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
180.91962
seq distance
False
chain
P
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
181.40033
seq distance
False
chain
Q
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
181.40033
seq distance
False
chain
Q
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
181.60367
seq distance
False
chain
S
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
181.60367
seq distance
False
chain
S
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
181.6266
seq distance
False
chain
Q
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
181.6266
seq distance
False
chain
Q
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
182.64293
seq distance
False
chain
Q
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
182.64293
seq distance
False
chain
Q
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
182.89818
seq distance
False
chain
R
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
182.89818
seq distance
False
chain
R
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
183.16354
seq distance
False
chain
R
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
183.16354
seq distance
False
chain
R
Details
Redox score
69.01
PDB code
6dlw
Structure name
complement component polyc9
Structure deposition date
2018-06-03
Thiol separation (Å)
6.99
Half-sphere exposure sum
53
Minimum pKa
nan
% buried
nan
Peptide accession
P02748
Residue number A
528 (Residue 507 in this structure)
Residue number B
530 (Residue 509 in this structure)
Peptide name
Complement component C9
7nyc I 80 I 86
A redox-regulated disulphide may form within Complement component C9 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.
Relevent regions
LDL-receptor class A
begin
80
end
115
score
98.48484848484848
distance
2.8282738
seq distance
0
chain
I
LDL-receptor class A
begin
80
end
115
score
98.48484848484848
distance
2.8282738
seq distance
0
chain
I
MACPF
begin
186
end
481
score
65.83230958230959
distance
7.5534477
seq distance
100
chain
I
MACPF
begin
186
end
481
score
65.83230958230959
distance
7.5534477
seq distance
100
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
8.787507
seq distance
20
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
8.787507
seq distance
20
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
13.528044
seq distance
12
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
13.528044
seq distance
12
chain
I
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
16.390522
seq distance
False
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
16.390522
seq distance
False
chain
H
MACPF
begin
133
end
488
score
72.36338100102144
distance
19.099207
seq distance
False
chain
H
MACPF
begin
133
end
488
score
72.36338100102144
distance
19.099207
seq distance
False
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
19.8645
seq distance
False
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
19.8645
seq distance
False
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
22.71228
seq distance
False
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
22.71228
seq distance
False
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
23.759352
seq distance
60
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
23.759352
seq distance
60
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
29.76311
seq distance
96
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
29.76311
seq distance
96
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
32.939518
seq distance
False
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
32.939518
seq distance
False
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
33.5651
seq distance
False
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
33.5651
seq distance
False
chain
H
EGF-like
begin
489
end
519
score
98.24046920821115
distance
35.986828
seq distance
False
chain
H
EGF-like
begin
489
end
519
score
98.24046920821115
distance
35.986828
seq distance
False
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
36.462547
seq distance
False
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
36.462547
seq distance
False
chain
G
MACPF
begin
133
end
488
score
69.38840653728295
distance
44.522797
seq distance
False
chain
G
MACPF
begin
133
end
488
score
69.38840653728295
distance
44.522797
seq distance
False
chain
G
LDL-receptor class A
begin
78
end
115
score
100.0
distance
45.569782
seq distance
False
chain
G
LDL-receptor class A
begin
78
end
115
score
100.0
distance
45.569782
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
45.619057
seq distance
320
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
45.619057
seq distance
320
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
45.65565
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
45.65565
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
46.0891
seq distance
False
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
46.0891
seq distance
False
chain
H
EGF-like
begin
489
end
519
score
98.24046920821115
distance
48.47856
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
98.24046920821115
distance
48.47856
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
48.80657
seq distance
319
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
48.80657
seq distance
319
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
49.342697
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
49.342697
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
51.042957
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
51.042957
seq distance
False
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
52.691086
seq distance
False
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
52.691086
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
57.47498
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
57.47498
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
61.0634
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
61.0634
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
62.179005
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
62.179005
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
93
score
77.27272727272727
distance
67.386826
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
93
score
77.27272727272727
distance
67.386826
seq distance
False
chain
E
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
67.57461
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
67.57461
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
85
score
72.72727272727273
distance
76.55007
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
85
score
72.72727272727273
distance
76.55007
seq distance
False
chain
E
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
391
score
68.18181818181817
distance
76.65346
seq distance
False
chain
E
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
391
score
68.18181818181817
distance
76.65346
seq distance
False
chain
E
LDL-receptor class A
begin
83
end
96
score
70.12987012987013
distance
85.662476
seq distance
False
chain
D
LDL-receptor class A
begin
83
end
96
score
70.12987012987013
distance
85.662476
seq distance
False
chain
D
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
94
score
81.81818181818183
distance
85.67332
seq distance
False
chain
D
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
94
score
81.81818181818183
distance
85.67332
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
86
score
72.72727272727273
distance
90.58405
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
86
score
72.72727272727273
distance
90.58405
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
370
score
68.18181818181817
distance
93.57031
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
370
score
68.18181818181817
distance
93.57031
seq distance
False
chain
D
LDL-receptor class A
begin
130
end
149
score
51.590909090909086
distance
100.43015
seq distance
False
chain
B
LDL-receptor class A
begin
130
end
149
score
51.590909090909086
distance
100.43015
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
81
score
59.09090909090909
distance
100.68711
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
81
score
59.09090909090909
distance
100.68711
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
137
score
63.63636363636363
distance
104.0493
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
137
score
63.63636363636363
distance
104.0493
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
145
score
77.27272727272727
distance
106.58234
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
145
score
77.27272727272727
distance
106.58234
seq distance
False
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
421
score
68.18181818181817
distance
112.87605
seq distance
False
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
421
score
68.18181818181817
distance
112.87605
seq distance
False
chain
B
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
1272
score
50.0
distance
153.99902
seq distance
False
chain
A
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
1272
score
50.0
distance
153.99902
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
1049
score
54.54545454545454
distance
169.17723
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
1049
score
54.54545454545454
distance
169.17723
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
649
score
54.54545454545454
distance
172.55385
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
649
score
54.54545454545454
distance
172.55385
seq distance
False
chain
C
Details
Redox score
67.39
PDB code
7nyc
Structure name
cryoem structure of 3c9-smac
Structure deposition date
2021-03-22
Thiol separation (Å)
8.4
Half-sphere exposure sum
42
Minimum pKa
nan
% buried
nan
Peptide accession
P02748
Residue number A
101 (Residue 80 in this structure)
Residue number B
107 (Residue 86 in this structure)
Peptide name
Complement component C9
6dlw U 489 U 492
A redox-regulated disulphide may form within Complement component C9 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.
Relevent regions
EGF-like
begin
489
end
519
score
99.12023460410556
distance
2.7987509
seq distance
0
chain
U
EGF-like
begin
489
end
519
score
99.12023460410556
distance
2.7987509
seq distance
0
chain
U
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
4.497225
seq distance
415
chain
U
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
4.497225
seq distance
415
chain
U
MACPF
begin
117
end
488
score
87.6099706744868
distance
5.324965
seq distance
1
chain
U
MACPF
begin
117
end
488
score
87.6099706744868
distance
5.324965
seq distance
1
chain
U
MACPF
begin
117
end
488
score
87.6099706744868
distance
15.811487
seq distance
False
chain
V
MACPF
begin
117
end
488
score
87.6099706744868
distance
15.811487
seq distance
False
chain
V
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
17.070532
seq distance
False
chain
T
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
17.070532
seq distance
False
chain
T
EGF-like
begin
489
end
519
score
99.12023460410556
distance
20.32756
seq distance
False
chain
T
EGF-like
begin
489
end
519
score
99.12023460410556
distance
20.32756
seq distance
False
chain
T
EGF-like
begin
489
end
519
score
99.12023460410556
distance
20.762907
seq distance
False
chain
V
EGF-like
begin
489
end
519
score
99.12023460410556
distance
20.762907
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
22.792355
seq distance
84
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
22.792355
seq distance
84
chain
U
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
24.950678
seq distance
343
chain
U
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
24.950678
seq distance
343
chain
U
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
25.652584
seq distance
83
chain
U
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
25.652584
seq distance
83
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
27.417393
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
27.417393
seq distance
False
chain
V
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
28.541124
seq distance
False
chain
V
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
28.541124
seq distance
False
chain
V
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
28.659044
seq distance
False
chain
V
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
28.659044
seq distance
False
chain
V
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
29.595766
seq distance
False
chain
V
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
29.595766
seq distance
False
chain
V
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
30.920193
seq distance
False
chain
V
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
30.920193
seq distance
False
chain
V
MACPF
begin
117
end
488
score
87.6099706744868
distance
30.991898
seq distance
False
chain
A
MACPF
begin
117
end
488
score
87.6099706744868
distance
30.991898
seq distance
False
chain
A
MACPF
begin
117
end
488
score
87.6099706744868
distance
32.394398
seq distance
False
chain
T
MACPF
begin
117
end
488
score
87.6099706744868
distance
32.394398
seq distance
False
chain
T
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
33.884674
seq distance
False
chain
A
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
33.884674
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
37.16209
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
37.16209
seq distance
False
chain
T
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
39.6084
seq distance
False
chain
T
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
39.6084
seq distance
False
chain
T
LDL-receptor class A
begin
78
end
115
score
100.0
distance
41.152058
seq distance
False
chain
V
LDL-receptor class A
begin
78
end
115
score
100.0
distance
41.152058
seq distance
False
chain
V
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
42.32079
seq distance
False
chain
T
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
42.32079
seq distance
False
chain
T
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
43.309196
seq distance
307
chain
U
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
43.309196
seq distance
307
chain
U
LDL-receptor class A
begin
78
end
115
score
100.0
distance
43.536526
seq distance
374
chain
U
LDL-receptor class A
begin
78
end
115
score
100.0
distance
43.536526
seq distance
374
chain
U
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
44.00779
seq distance
False
chain
S
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
44.00779
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
44.68175
seq distance
227
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
44.68175
seq distance
227
chain
U
EGF-like
begin
489
end
519
score
99.12023460410556
distance
45.055447
seq distance
False
chain
S
EGF-like
begin
489
end
519
score
99.12023460410556
distance
45.055447
seq distance
False
chain
S
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
45.094185
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
45.094185
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
45.453648
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
45.453648
seq distance
False
chain
A
EGF-like
begin
489
end
519
score
99.12023460410556
distance
46.429863
seq distance
False
chain
A
EGF-like
begin
489
end
519
score
99.12023460410556
distance
46.429863
seq distance
False
chain
A
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
47.040764
seq distance
383
chain
U
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
47.040764
seq distance
383
chain
U
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
47.171516
seq distance
False
chain
V
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
47.171516
seq distance
False
chain
V
MACPF
begin
117
end
488
score
87.6099706744868
distance
48.467346
seq distance
False
chain
B
MACPF
begin
117
end
488
score
87.6099706744868
distance
48.467346
seq distance
False
chain
B
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
48.83792
seq distance
False
chain
A
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
48.83792
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
50.310577
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
50.310577
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
50.369263
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
50.369263
seq distance
False
chain
V
MACPF
begin
117
end
488
score
87.6099706744868
distance
51.311207
seq distance
False
chain
S
MACPF
begin
117
end
488
score
87.6099706744868
distance
51.311207
seq distance
False
chain
S
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
51.532494
seq distance
False
chain
B
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
51.532494
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
51.7043
seq distance
False
chain
V
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
51.7043
seq distance
False
chain
V
LDL-receptor class A
begin
78
end
115
score
100.0
distance
52.848354
seq distance
False
chain
A
LDL-receptor class A
begin
78
end
115
score
100.0
distance
52.848354
seq distance
False
chain
A
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
56.48174
seq distance
231
chain
U
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
56.48174
seq distance
231
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
57.145657
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
57.145657
seq distance
False
chain
S
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
57.318195
seq distance
391
chain
U
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
57.318195
seq distance
391
chain
U
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
57.562042
seq distance
False
chain
A
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
57.562042
seq distance
False
chain
A
LDL-receptor class A
begin
78
end
115
score
100.0
distance
58.115364
seq distance
False
chain
T
LDL-receptor class A
begin
78
end
115
score
100.0
distance
58.115364
seq distance
False
chain
T
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
58.742237
seq distance
False
chain
A
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
58.742237
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
58.92499
seq distance
False
chain
S
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
58.92499
seq distance
False
chain
S
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
58.938477
seq distance
False
chain
T
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
58.938477
seq distance
False
chain
T
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
59.892452
seq distance
False
chain
T
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
59.892452
seq distance
False
chain
T
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
60.374252
seq distance
False
chain
A
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
60.374252
seq distance
False
chain
A
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
63.039745
seq distance
False
chain
V
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
63.039745
seq distance
False
chain
V
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
63.698246
seq distance
False
chain
T
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
63.698246
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
63.991062
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
63.991062
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
64.04101
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
64.04101
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
64.83606
seq distance
False
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
64.83606
seq distance
False
chain
B
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
65.05543
seq distance
False
chain
S
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
65.05543
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
65.9186
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
65.9186
seq distance
False
chain
B
MACPF
begin
117
end
488
score
87.6099706744868
distance
68.24529
seq distance
False
chain
C
MACPF
begin
117
end
488
score
87.6099706744868
distance
68.24529
seq distance
False
chain
C
EGF-like
begin
489
end
519
score
99.12023460410556
distance
68.86861
seq distance
False
chain
R
EGF-like
begin
489
end
519
score
99.12023460410556
distance
68.86861
seq distance
False
chain
R
LDL-receptor class A
begin
78
end
115
score
100.0
distance
69.17543
seq distance
False
chain
B
LDL-receptor class A
begin
78
end
115
score
100.0
distance
69.17543
seq distance
False
chain
B
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
69.270096
seq distance
False
chain
S
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
69.270096
seq distance
False
chain
S
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
69.447014
seq distance
False
chain
R
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
69.447014
seq distance
False
chain
R
MACPF
begin
117
end
488
score
87.6099706744868
distance
70.595116
seq distance
False
chain
R
MACPF
begin
117
end
488
score
87.6099706744868
distance
70.595116
seq distance
False
chain
R
EGF-like
begin
489
end
519
score
99.12023460410556
distance
70.88727
seq distance
False
chain
B
EGF-like
begin
489
end
519
score
99.12023460410556
distance
70.88727
seq distance
False
chain
B
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
71.14832
seq distance
False
chain
B
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
71.14832
seq distance
False
chain
B
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
71.79777
seq distance
False
chain
C
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
71.79777
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
72.21866
seq distance
False
chain
T
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
72.21866
seq distance
False
chain
T
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
74.27838
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
74.27838
seq distance
False
chain
B
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
75.83122
seq distance
False
chain
A
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
75.83122
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
77.61035
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
77.61035
seq distance
False
chain
R
LDL-receptor class A
begin
78
end
115
score
100.0
distance
78.707726
seq distance
False
chain
S
LDL-receptor class A
begin
78
end
115
score
100.0
distance
78.707726
seq distance
False
chain
S
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
78.84699
seq distance
False
chain
R
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
78.84699
seq distance
False
chain
R
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
78.98064
seq distance
False
chain
S
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
78.98064
seq distance
False
chain
S
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
79.503654
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
79.503654
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
80.99946
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
80.99946
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
81.1178
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
81.1178
seq distance
False
chain
B
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
82.99605
seq distance
False
chain
B
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
82.99605
seq distance
False
chain
B
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
83.99916
seq distance
False
chain
R
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
83.99916
seq distance
False
chain
R
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
84.57775
seq distance
False
chain
C
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
84.57775
seq distance
False
chain
C
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
85.10834
seq distance
False
chain
S
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
85.10834
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
86.06571
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
86.06571
seq distance
False
chain
C
MACPF
begin
117
end
488
score
87.6099706744868
distance
87.489265
seq distance
False
chain
D
MACPF
begin
117
end
488
score
87.6099706744868
distance
87.489265
seq distance
False
chain
D
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
88.04157
seq distance
False
chain
R
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
88.04157
seq distance
False
chain
R
MACPF
begin
117
end
488
score
87.6099706744868
distance
89.265526
seq distance
False
chain
Q
MACPF
begin
117
end
488
score
87.6099706744868
distance
89.265526
seq distance
False
chain
Q
LDL-receptor class A
begin
78
end
115
score
100.0
distance
89.63225
seq distance
False
chain
C
LDL-receptor class A
begin
78
end
115
score
100.0
distance
89.63225
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
91.15167
seq distance
False
chain
S
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
91.15167
seq distance
False
chain
S
EGF-like
begin
489
end
519
score
99.12023460410556
distance
91.24478
seq distance
False
chain
Q
EGF-like
begin
489
end
519
score
99.12023460410556
distance
91.24478
seq distance
False
chain
Q
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
91.651405
seq distance
False
chain
B
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
91.651405
seq distance
False
chain
B
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
92.12853
seq distance
False
chain
D
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
92.12853
seq distance
False
chain
D
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
92.86555
seq distance
False
chain
C
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
92.86555
seq distance
False
chain
C
EGF-like
begin
489
end
519
score
99.12023460410556
distance
92.8892
seq distance
False
chain
C
EGF-like
begin
489
end
519
score
99.12023460410556
distance
92.8892
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
93.40618
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
93.40618
seq distance
False
chain
C
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
93.553375
seq distance
False
chain
Q
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
93.553375
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
97.10545
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
97.10545
seq distance
False
chain
Q
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
97.87309
seq distance
False
chain
Q
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
97.87309
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
98.65191
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
98.65191
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
98.77502
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
98.77502
seq distance
False
chain
C
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
99.7743
seq distance
False
chain
R
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
99.7743
seq distance
False
chain
R
LDL-receptor class A
begin
78
end
115
score
100.0
distance
99.7743
seq distance
False
chain
R
LDL-receptor class A
begin
78
end
115
score
100.0
distance
99.7743
seq distance
False
chain
R
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
100.26436
seq distance
False
chain
C
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
100.26436
seq distance
False
chain
C
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
100.3352
seq distance
False
chain
Q
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
100.3352
seq distance
False
chain
Q
MACPF
begin
117
end
488
score
87.6099706744868
distance
102.77931
seq distance
False
chain
E
MACPF
begin
117
end
488
score
87.6099706744868
distance
102.77931
seq distance
False
chain
E
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
103.176636
seq distance
False
chain
D
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
103.176636
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
104.91106
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
104.91106
seq distance
False
chain
D
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
104.95909
seq distance
False
chain
R
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
104.95909
seq distance
False
chain
R
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
106.895294
seq distance
False
chain
C
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
106.895294
seq distance
False
chain
C
MACPF
begin
117
end
488
score
87.6099706744868
distance
106.967155
seq distance
False
chain
P
MACPF
begin
117
end
488
score
87.6099706744868
distance
106.967155
seq distance
False
chain
P
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
108.10756
seq distance
False
chain
C
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
108.10756
seq distance
False
chain
C
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
109.05737
seq distance
False
chain
Q
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
109.05737
seq distance
False
chain
Q
LDL-receptor class A
begin
78
end
115
score
100.0
distance
109.78836
seq distance
False
chain
D
LDL-receptor class A
begin
78
end
115
score
100.0
distance
109.78836
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
110.99135
seq distance
False
chain
R
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
110.99135
seq distance
False
chain
R
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
111.43128
seq distance
False
chain
E
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
111.43128
seq distance
False
chain
E
EGF-like
begin
489
end
519
score
99.12023460410556
distance
111.85896
seq distance
False
chain
P
EGF-like
begin
489
end
519
score
99.12023460410556
distance
111.85896
seq distance
False
chain
P
EGF-like
begin
489
end
519
score
99.12023460410556
distance
112.596596
seq distance
False
chain
D
EGF-like
begin
489
end
519
score
99.12023460410556
distance
112.596596
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
113.20413
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
113.20413
seq distance
False
chain
D
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
113.40428
seq distance
False
chain
D
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
113.40428
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
114.92413
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
114.92413
seq distance
False
chain
P
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
115.26248
seq distance
False
chain
P
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
115.26248
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
115.54469
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
115.54469
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
115.66155
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
115.66155
seq distance
False
chain
D
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
115.783646
seq distance
False
chain
P
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
115.783646
seq distance
False
chain
P
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
116.56362
seq distance
False
chain
P
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
116.56362
seq distance
False
chain
P
MACPF
begin
117
end
488
score
87.6099706744868
distance
116.65297
seq distance
False
chain
F
MACPF
begin
117
end
488
score
87.6099706744868
distance
116.65297
seq distance
False
chain
F
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
119.840576
seq distance
False
chain
D
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
119.840576
seq distance
False
chain
D
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
119.969315
seq distance
False
chain
E
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
119.969315
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
120.13922
seq distance
False
chain
Q
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
120.13922
seq distance
False
chain
Q
LDL-receptor class A
begin
78
end
115
score
100.0
distance
120.13922
seq distance
False
chain
Q
LDL-receptor class A
begin
78
end
115
score
100.0
distance
120.13922
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
121.84765
seq distance
False
chain
E
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
121.84765
seq distance
False
chain
E
MACPF
begin
117
end
488
score
87.6099706744868
distance
121.92084
seq distance
False
chain
O
MACPF
begin
117
end
488
score
87.6099706744868
distance
121.92084
seq distance
False
chain
O
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
123.18711
seq distance
False
chain
Q
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
123.18711
seq distance
False
chain
Q
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
123.897804
seq distance
False
chain
D
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
123.897804
seq distance
False
chain
D
LDL-receptor class A
begin
78
end
115
score
100.0
distance
127.68788
seq distance
False
chain
E
LDL-receptor class A
begin
78
end
115
score
100.0
distance
127.68788
seq distance
False
chain
E
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
128.13655
seq distance
False
chain
P
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
128.13655
seq distance
False
chain
P
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
128.2232
seq distance
False
chain
D
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
128.2232
seq distance
False
chain
D
MACPF
begin
117
end
488
score
87.6099706744868
distance
128.26518
seq distance
False
chain
G
MACPF
begin
117
end
488
score
87.6099706744868
distance
128.26518
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
128.96016
seq distance
False
chain
F
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
128.96016
seq distance
False
chain
F
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
130.06883
seq distance
False
chain
Q
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
130.06883
seq distance
False
chain
Q
EGF-like
begin
489
end
519
score
99.12023460410556
distance
130.09225
seq distance
False
chain
E
EGF-like
begin
489
end
519
score
99.12023460410556
distance
130.09225
seq distance
False
chain
E
EGF-like
begin
489
end
519
score
99.12023460410556
distance
130.24615
seq distance
False
chain
O
EGF-like
begin
489
end
519
score
99.12023460410556
distance
130.24615
seq distance
False
chain
O
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
130.51913
seq distance
False
chain
O
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
130.51913
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
130.5772
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
130.5772
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
130.86606
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
130.86606
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
130.95099
seq distance
False
chain
E
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
130.95099
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
131.23448
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
131.23448
seq distance
False
chain
E
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
131.65884
seq distance
False
chain
O
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
131.65884
seq distance
False
chain
O
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
131.98941
seq distance
False
chain
E
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
131.98941
seq distance
False
chain
E
MACPF
begin
117
end
488
score
87.6099706744868
distance
133.57184
seq distance
False
chain
N
MACPF
begin
117
end
488
score
87.6099706744868
distance
133.57184
seq distance
False
chain
N
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
134.52164
seq distance
False
chain
F
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
134.52164
seq distance
False
chain
F
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
135.66406
seq distance
False
chain
O
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
135.66406
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
136.46066
seq distance
False
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
136.46066
seq distance
False
chain
F
MACPF
begin
117
end
488
score
87.6099706744868
distance
137.42502
seq distance
False
chain
H
MACPF
begin
117
end
488
score
87.6099706744868
distance
137.42502
seq distance
False
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
137.79407
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
137.79407
seq distance
False
chain
E
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
138.17441
seq distance
False
chain
E
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
138.17441
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
138.6817
seq distance
False
chain
P
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
138.6817
seq distance
False
chain
P
LDL-receptor class A
begin
78
end
115
score
100.0
distance
138.6817
seq distance
False
chain
P
LDL-receptor class A
begin
78
end
115
score
100.0
distance
138.6817
seq distance
False
chain
P
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
139.25252
seq distance
False
chain
P
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
139.25252
seq distance
False
chain
P
MACPF
begin
117
end
488
score
87.6099706744868
distance
141.93845
seq distance
False
chain
M
MACPF
begin
117
end
488
score
87.6099706744868
distance
141.93845
seq distance
False
chain
M
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
143.26204
seq distance
False
chain
N
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
143.26204
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
143.689
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
143.689
seq distance
False
chain
N
LDL-receptor class A
begin
78
end
115
score
100.0
distance
143.7249
seq distance
False
chain
F
LDL-receptor class A
begin
78
end
115
score
100.0
distance
143.7249
seq distance
False
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
144.03023
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
144.03023
seq distance
False
chain
N
MACPF
begin
117
end
488
score
87.6099706744868
distance
144.05466
seq distance
False
chain
I
MACPF
begin
117
end
488
score
87.6099706744868
distance
144.05466
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
144.09035
seq distance
False
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
144.09035
seq distance
False
chain
F
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
144.17
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
144.17
seq distance
False
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
144.85092
seq distance
False
chain
O
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
144.85092
seq distance
False
chain
O
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
144.89937
seq distance
False
chain
N
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
144.89937
seq distance
False
chain
N
EGF-like
begin
489
end
519
score
99.12023460410556
distance
145.00227
seq distance
False
chain
F
EGF-like
begin
489
end
519
score
99.12023460410556
distance
145.00227
seq distance
False
chain
F
EGF-like
begin
489
end
519
score
99.12023460410556
distance
146.00732
seq distance
False
chain
N
EGF-like
begin
489
end
519
score
99.12023460410556
distance
146.00732
seq distance
False
chain
N
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
146.48534
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
146.48534
seq distance
False
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
146.90274
seq distance
False
chain
E
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
146.90274
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
147.0661
seq distance
False
chain
P
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
147.0661
seq distance
False
chain
P
MACPF
begin
117
end
488
score
87.6099706744868
distance
147.47456
seq distance
False
chain
L
MACPF
begin
117
end
488
score
87.6099706744868
distance
147.47456
seq distance
False
chain
L
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
147.63626
seq distance
False
chain
F
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
147.63626
seq distance
False
chain
F
MACPF
begin
117
end
488
score
87.6099706744868
distance
148.01245
seq distance
False
chain
J
MACPF
begin
117
end
488
score
87.6099706744868
distance
148.01245
seq distance
False
chain
J
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
148.13332
seq distance
False
chain
F
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
148.13332
seq distance
False
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
148.41768
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
148.41768
seq distance
False
chain
G
MACPF
begin
117
end
488
score
87.6099706744868
distance
149.16768
seq distance
False
chain
K
MACPF
begin
117
end
488
score
87.6099706744868
distance
149.16768
seq distance
False
chain
K
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
150.35722
seq distance
False
chain
F
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
150.35722
seq distance
False
chain
F
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
152.71245
seq distance
False
chain
O
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
152.71245
seq distance
False
chain
O
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
152.7901
seq distance
False
chain
N
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
152.7901
seq distance
False
chain
N
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
153.21082
seq distance
False
chain
M
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
153.21082
seq distance
False
chain
M
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
153.71141
seq distance
False
chain
F
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
153.71141
seq distance
False
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
153.97552
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
153.97552
seq distance
False
chain
M
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
154.46523
seq distance
False
chain
O
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
154.46523
seq distance
False
chain
O
LDL-receptor class A
begin
78
end
115
score
100.0
distance
154.46523
seq distance
False
chain
O
LDL-receptor class A
begin
78
end
115
score
100.0
distance
154.46523
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
154.66727
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
154.66727
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
154.72955
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
154.72955
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
155.57341
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
155.57341
seq distance
False
chain
H
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
155.83307
seq distance
False
chain
M
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
155.83307
seq distance
False
chain
M
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
156.66617
seq distance
False
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
156.66617
seq distance
False
chain
H
EGF-like
begin
489
end
519
score
99.12023460410556
distance
157.02612
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
99.12023460410556
distance
157.02612
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
157.43796
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
157.43796
seq distance
False
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
157.52997
seq distance
False
chain
G
LDL-receptor class A
begin
78
end
115
score
100.0
distance
157.52997
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
99.12023460410556
distance
158.57863
seq distance
False
chain
M
EGF-like
begin
489
end
519
score
99.12023460410556
distance
158.57863
seq distance
False
chain
M
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
158.7906
seq distance
False
chain
N
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
158.7906
seq distance
False
chain
N
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
160.08987
seq distance
False
chain
G
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
160.08987
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
160.13048
seq distance
False
chain
L
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
160.13048
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
161.199
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
161.199
seq distance
False
chain
L
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
161.30586
seq distance
False
chain
O
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
161.30586
seq distance
False
chain
O
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
161.42819
seq distance
False
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
161.42819
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
161.56927
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
161.56927
seq distance
False
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
161.78062
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
161.78062
seq distance
False
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
162.24669
seq distance
False
chain
F
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
162.24669
seq distance
False
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
162.4519
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
162.4519
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
162.52911
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
162.52911
seq distance
False
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
163.24355
seq distance
False
chain
N
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
163.24355
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
163.30714
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
163.30714
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
163.87994
seq distance
False
chain
K
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
163.87994
seq distance
False
chain
K
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
164.07747
seq distance
False
chain
L
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
164.07747
seq distance
False
chain
L
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
164.36699
seq distance
False
chain
J
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
164.36699
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
165.21509
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
165.21509
seq distance
False
chain
K
EGF-like
begin
489
end
519
score
99.12023460410556
distance
165.88782
seq distance
False
chain
H
EGF-like
begin
489
end
519
score
99.12023460410556
distance
165.88782
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
165.9274
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
165.9274
seq distance
False
chain
J
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
166.13712
seq distance
False
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
166.13712
seq distance
False
chain
I
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
166.80516
seq distance
False
chain
M
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
166.80516
seq distance
False
chain
M
EGF-like
begin
489
end
519
score
99.12023460410556
distance
167.00093
seq distance
False
chain
L
EGF-like
begin
489
end
519
score
99.12023460410556
distance
167.00093
seq distance
False
chain
L
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
167.02376
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
167.02376
seq distance
False
chain
G
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
167.02397
seq distance
False
chain
H
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
167.02397
seq distance
False
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
167.22209
seq distance
False
chain
N
LDL-receptor class A
begin
78
end
115
score
100.0
distance
167.22209
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
167.2302
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
167.2302
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
167.26315
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
167.26315
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
167.63504
seq distance
False
chain
N
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
167.63504
seq distance
False
chain
N
LDL-receptor class A
begin
78
end
115
score
100.0
distance
168.67053
seq distance
False
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
168.67053
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
168.85593
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
168.85593
seq distance
False
chain
J
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
169.44743
seq distance
False
chain
K
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
169.44743
seq distance
False
chain
K
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
169.63281
seq distance
False
chain
M
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
169.63281
seq distance
False
chain
M
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
170.61688
seq distance
False
chain
M
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
170.61688
seq distance
False
chain
M
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
170.93478
seq distance
False
chain
I
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
170.93478
seq distance
False
chain
I
EGF-like
begin
489
end
519
score
99.12023460410556
distance
171.3821
seq distance
False
chain
I
EGF-like
begin
489
end
519
score
99.12023460410556
distance
171.3821
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
171.5683
seq distance
False
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
171.5683
seq distance
False
chain
H
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
171.76393
seq distance
False
chain
J
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
171.76393
seq distance
False
chain
J
EGF-like
begin
489
end
519
score
99.12023460410556
distance
171.95143
seq distance
False
chain
K
EGF-like
begin
489
end
519
score
99.12023460410556
distance
171.95143
seq distance
False
chain
K
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
172.38655
seq distance
False
chain
J
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
172.38655
seq distance
False
chain
J
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
172.84903
seq distance
False
chain
N
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
172.84903
seq distance
False
chain
N
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
173.21837
seq distance
False
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
173.21837
seq distance
False
chain
H
EGF-like
begin
489
end
519
score
99.12023460410556
distance
173.42728
seq distance
False
chain
J
EGF-like
begin
489
end
519
score
99.12023460410556
distance
173.42728
seq distance
False
chain
J
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
174.30801
seq distance
False
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
174.30801
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
174.64316
seq distance
False
chain
L
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
174.64316
seq distance
False
chain
L
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
175.23975
seq distance
False
chain
K
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
175.23975
seq distance
False
chain
K
LDL-receptor class A
begin
78
end
115
score
100.0
distance
176.31514
seq distance
False
chain
M
LDL-receptor class A
begin
78
end
115
score
100.0
distance
176.31514
seq distance
False
chain
M
LDL-receptor class A
begin
78
end
115
score
100.0
distance
176.8131
seq distance
False
chain
I
LDL-receptor class A
begin
78
end
115
score
100.0
distance
176.8131
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
177.13957
seq distance
False
chain
L
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
177.13957
seq distance
False
chain
L
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
177.36093
seq distance
False
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
177.36093
seq distance
False
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
177.44067
seq distance
False
chain
L
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
177.44067
seq distance
False
chain
L
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
177.80652
seq distance
False
chain
M
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
177.80652
seq distance
False
chain
M
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
178.31322
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
178.31322
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
181.13747
seq distance
False
chain
K
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
181.13747
seq distance
False
chain
K
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
181.35214
seq distance
False
chain
M
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
181.35214
seq distance
False
chain
M
LDL-receptor class A
begin
78
end
115
score
100.0
distance
181.49464
seq distance
False
chain
L
LDL-receptor class A
begin
78
end
115
score
100.0
distance
181.49464
seq distance
False
chain
L
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
181.53368
seq distance
False
chain
J
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
181.53368
seq distance
False
chain
J
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
181.60301
seq distance
False
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
181.60301
seq distance
False
chain
I
LDL-receptor class A
begin
78
end
115
score
100.0
distance
181.74664
seq distance
False
chain
J
LDL-receptor class A
begin
78
end
115
score
100.0
distance
181.74664
seq distance
False
chain
J
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
182.82616
seq distance
False
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
182.82616
seq distance
False
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
183.31969
seq distance
False
chain
K
LDL-receptor class A
begin
78
end
115
score
100.0
distance
183.31969
seq distance
False
chain
K
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
184.43405
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
184.43405
seq distance
False
chain
I
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
184.4771
seq distance
False
chain
K
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
184.4771
seq distance
False
chain
K
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
184.71706
seq distance
False
chain
L
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
184.71706
seq distance
False
chain
L
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
186.58449
seq distance
False
chain
L
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
186.58449
seq distance
False
chain
L
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
186.71048
seq distance
False
chain
J
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
186.71048
seq distance
False
chain
J
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
187.21399
seq distance
False
chain
I
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
187.21399
seq distance
False
chain
I
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
187.7608
seq distance
False
chain
J
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
187.7608
seq distance
False
chain
J
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
188.07329
seq distance
False
chain
J
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
188.07329
seq distance
False
chain
J
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
188.16716
seq distance
False
chain
K
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
188.16716
seq distance
False
chain
K
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
188.38524
seq distance
False
chain
K
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
188.38524
seq distance
False
chain
K
Details
Redox score
66.79
PDB code
6dlw
Structure name
complement component polyc9
Structure deposition date
2018-06-03
Thiol separation (Å)
8.71
Half-sphere exposure sum
57
Minimum pKa
nan
% buried
nan
Peptide accession
P02748
Residue number A
510 (Residue 489 in this structure)
Residue number B
513 (Residue 492 in this structure)
Peptide name
Complement component C9
6dlw O 57 O 489
A redox-regulated disulphide may form within Complement component C9 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.
Relevent regions
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
2.7592313
seq distance
0
chain
O
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
2.7592313
seq distance
0
chain
O
EGF-like
begin
489
end
519
score
99.12023460410556
distance
2.8093498
seq distance
0
chain
O
EGF-like
begin
489
end
519
score
99.12023460410556
distance
2.8093498
seq distance
0
chain
O
MACPF
begin
117
end
488
score
87.6099706744868
distance
5.3244834
seq distance
1
chain
O
MACPF
begin
117
end
488
score
87.6099706744868
distance
5.3244834
seq distance
1
chain
O
MACPF
begin
117
end
488
score
87.6099706744868
distance
11.946288
seq distance
False
chain
P
MACPF
begin
117
end
488
score
87.6099706744868
distance
11.946288
seq distance
False
chain
P
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
17.0703
seq distance
False
chain
N
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
17.0703
seq distance
False
chain
N
EGF-like
begin
489
end
519
score
99.12023460410556
distance
22.604239
seq distance
False
chain
P
EGF-like
begin
489
end
519
score
99.12023460410556
distance
22.604239
seq distance
False
chain
P
EGF-like
begin
489
end
519
score
99.12023460410556
distance
23.096643
seq distance
False
chain
N
EGF-like
begin
489
end
519
score
99.12023460410556
distance
23.096643
seq distance
False
chain
N
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
23.975561
seq distance
False
chain
P
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
23.975561
seq distance
False
chain
P
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
24.487982
seq distance
89
chain
O
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
24.487982
seq distance
89
chain
O
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
25.138794
seq distance
False
chain
P
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
25.138794
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
26.600323
seq distance
84
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
26.600323
seq distance
84
chain
O
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
28.567251
seq distance
83
chain
O
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
28.567251
seq distance
83
chain
O
MACPF
begin
117
end
488
score
87.6099706744868
distance
28.785856
seq distance
False
chain
Q
MACPF
begin
117
end
488
score
87.6099706744868
distance
28.785856
seq distance
False
chain
Q
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
29.089884
seq distance
False
chain
P
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
29.089884
seq distance
False
chain
P
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
30.081633
seq distance
False
chain
Q
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
30.081633
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
31.53823
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
31.53823
seq distance
False
chain
P
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
31.978292
seq distance
False
chain
P
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
31.978292
seq distance
False
chain
P
MACPF
begin
117
end
488
score
87.6099706744868
distance
32.39451
seq distance
False
chain
N
MACPF
begin
117
end
488
score
87.6099706744868
distance
32.39451
seq distance
False
chain
N
LDL-receptor class A
begin
78
end
115
score
100.0
distance
34.769558
seq distance
False
chain
P
LDL-receptor class A
begin
78
end
115
score
100.0
distance
34.769558
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
39.652504
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
39.652504
seq distance
False
chain
N
LDL-receptor class A
begin
78
end
115
score
100.0
distance
40.28065
seq distance
21
chain
O
LDL-receptor class A
begin
78
end
115
score
100.0
distance
40.28065
seq distance
21
chain
O
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
41.317165
seq distance
False
chain
P
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
41.317165
seq distance
False
chain
P
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
41.63842
seq distance
False
chain
N
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
41.63842
seq distance
False
chain
N
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
42.319477
seq distance
False
chain
N
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
42.319477
seq distance
False
chain
N
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
43.309547
seq distance
125
chain
O
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
43.309547
seq distance
125
chain
O
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
43.911026
seq distance
49
chain
O
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
43.911026
seq distance
49
chain
O
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
44.00711
seq distance
False
chain
M
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
44.00711
seq distance
False
chain
M
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
44.16044
seq distance
False
chain
Q
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
44.16044
seq distance
False
chain
Q
LDL-receptor class A
begin
78
end
115
score
100.0
distance
45.68507
seq distance
False
chain
Q
LDL-receptor class A
begin
78
end
115
score
100.0
distance
45.68507
seq distance
False
chain
Q
MACPF
begin
117
end
488
score
87.6099706744868
distance
46.725674
seq distance
False
chain
R
MACPF
begin
117
end
488
score
87.6099706744868
distance
46.725674
seq distance
False
chain
R
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
46.845753
seq distance
False
chain
P
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
46.845753
seq distance
False
chain
P
EGF-like
begin
489
end
519
score
99.12023460410556
distance
47.234676
seq distance
False
chain
M
EGF-like
begin
489
end
519
score
99.12023460410556
distance
47.234676
seq distance
False
chain
M
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
47.440655
seq distance
False
chain
R
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
47.440655
seq distance
False
chain
R
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
47.57129
seq distance
False
chain
Q
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
47.57129
seq distance
False
chain
Q
EGF-like
begin
489
end
519
score
99.12023460410556
distance
47.688892
seq distance
False
chain
Q
EGF-like
begin
489
end
519
score
99.12023460410556
distance
47.688892
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
48.49271
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
48.49271
seq distance
False
chain
Q
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
52.405537
seq distance
False
chain
Q
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
52.405537
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
53.322395
seq distance
205
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
53.322395
seq distance
205
chain
O
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
53.728508
seq distance
False
chain
Q
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
53.728508
seq distance
False
chain
Q
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
54.03963
seq distance
False
chain
Q
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
54.03963
seq distance
False
chain
Q
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
55.22336
seq distance
41
chain
O
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
55.22336
seq distance
41
chain
O
MACPF
begin
117
end
488
score
87.6099706744868
distance
56.16053
seq distance
False
chain
M
MACPF
begin
117
end
488
score
87.6099706744868
distance
56.16053
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
58.004406
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
58.004406
seq distance
False
chain
N
LDL-receptor class A
begin
78
end
115
score
100.0
distance
58.021847
seq distance
False
chain
N
LDL-receptor class A
begin
78
end
115
score
100.0
distance
58.021847
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
58.768204
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
58.768204
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
59.310173
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
59.310173
seq distance
False
chain
M
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
59.700035
seq distance
False
chain
N
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
59.700035
seq distance
False
chain
N
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
60.827686
seq distance
False
chain
M
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
60.827686
seq distance
False
chain
M
LDL-receptor class A
begin
78
end
115
score
100.0
distance
62.694088
seq distance
False
chain
R
LDL-receptor class A
begin
78
end
115
score
100.0
distance
62.694088
seq distance
False
chain
R
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
63.6972
seq distance
False
chain
N
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
63.6972
seq distance
False
chain
N
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
65.049286
seq distance
False
chain
M
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
65.049286
seq distance
False
chain
M
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
65.070724
seq distance
201
chain
O
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
65.070724
seq distance
201
chain
O
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
66.99318
seq distance
False
chain
R
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
66.99318
seq distance
False
chain
R
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
67.01576
seq distance
False
chain
N
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
67.01576
seq distance
False
chain
N
MACPF
begin
117
end
488
score
87.6099706744868
distance
67.289
seq distance
False
chain
S
MACPF
begin
117
end
488
score
87.6099706744868
distance
67.289
seq distance
False
chain
S
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
67.932434
seq distance
False
chain
R
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
67.932434
seq distance
False
chain
R
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
68.25803
seq distance
False
chain
R
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
68.25803
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
68.505844
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
68.505844
seq distance
False
chain
R
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
69.102295
seq distance
False
chain
S
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
69.102295
seq distance
False
chain
S
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
70.20111
seq distance
False
chain
L
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
70.20111
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
70.50795
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
70.50795
seq distance
False
chain
M
EGF-like
begin
489
end
519
score
99.12023460410556
distance
71.312485
seq distance
False
chain
L
EGF-like
begin
489
end
519
score
99.12023460410556
distance
71.312485
seq distance
False
chain
L
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
71.413506
seq distance
False
chain
P
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
71.413506
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
71.718994
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
71.718994
seq distance
False
chain
Q
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
72.21804
seq distance
False
chain
N
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
72.21804
seq distance
False
chain
N
EGF-like
begin
489
end
519
score
99.12023460410556
distance
72.61855
seq distance
False
chain
R
EGF-like
begin
489
end
519
score
99.12023460410556
distance
72.61855
seq distance
False
chain
R
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
73.94866
seq distance
False
chain
R
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
73.94866
seq distance
False
chain
R
MACPF
begin
117
end
488
score
87.6099706744868
distance
75.33149
seq distance
False
chain
L
MACPF
begin
117
end
488
score
87.6099706744868
distance
75.33149
seq distance
False
chain
L
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
76.45699
seq distance
False
chain
M
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
76.45699
seq distance
False
chain
M
LDL-receptor class A
begin
78
end
115
score
100.0
distance
78.69997
seq distance
False
chain
M
LDL-receptor class A
begin
78
end
115
score
100.0
distance
78.69997
seq distance
False
chain
M
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
78.97581
seq distance
False
chain
M
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
78.97581
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
79.929146
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
79.929146
seq distance
False
chain
L
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
80.98476
seq distance
False
chain
L
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
80.98476
seq distance
False
chain
L
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
81.74176
seq distance
False
chain
R
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
81.74176
seq distance
False
chain
R
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
83.75589
seq distance
False
chain
Q
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
83.75589
seq distance
False
chain
Q
LDL-receptor class A
begin
78
end
115
score
100.0
distance
84.097145
seq distance
False
chain
S
LDL-receptor class A
begin
78
end
115
score
100.0
distance
84.097145
seq distance
False
chain
S
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
85.10588
seq distance
False
chain
M
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
85.10588
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
86.79975
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
86.79975
seq distance
False
chain
L
MACPF
begin
117
end
488
score
87.6099706744868
distance
87.01865
seq distance
False
chain
T
MACPF
begin
117
end
488
score
87.6099706744868
distance
87.01865
seq distance
False
chain
T
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
87.10068
seq distance
False
chain
S
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
87.10068
seq distance
False
chain
S
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
88.04175
seq distance
False
chain
L
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
88.04175
seq distance
False
chain
L
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
88.20147
seq distance
False
chain
S
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
88.20147
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
88.20608
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
88.20608
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
88.95774
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
88.95774
seq distance
False
chain
S
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
90.48502
seq distance
False
chain
L
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
90.48502
seq distance
False
chain
L
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
90.951935
seq distance
False
chain
T
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
90.951935
seq distance
False
chain
T
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
91.14704
seq distance
False
chain
M
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
91.14704
seq distance
False
chain
M
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
91.39469
seq distance
False
chain
S
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
91.39469
seq distance
False
chain
S
EGF-like
begin
489
end
519
score
99.12023460410556
distance
93.93848
seq distance
False
chain
K
EGF-like
begin
489
end
519
score
99.12023460410556
distance
93.93848
seq distance
False
chain
K
MACPF
begin
117
end
488
score
87.6099706744868
distance
94.26237
seq distance
False
chain
K
MACPF
begin
117
end
488
score
87.6099706744868
distance
94.26237
seq distance
False
chain
K
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
95.00957
seq distance
False
chain
K
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
95.00957
seq distance
False
chain
K
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
95.63679
seq distance
False
chain
S
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
95.63679
seq distance
False
chain
S
EGF-like
begin
489
end
519
score
99.12023460410556
distance
96.43502
seq distance
False
chain
S
EGF-like
begin
489
end
519
score
99.12023460410556
distance
96.43502
seq distance
False
chain
S
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
99.14361
seq distance
False
chain
R
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
99.14361
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
99.75351
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
99.75351
seq distance
False
chain
K
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
99.77285
seq distance
False
chain
L
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
99.77285
seq distance
False
chain
L
LDL-receptor class A
begin
78
end
115
score
100.0
distance
99.77285
seq distance
False
chain
L
LDL-receptor class A
begin
78
end
115
score
100.0
distance
99.77285
seq distance
False
chain
L
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
100.37561
seq distance
False
chain
K
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
100.37561
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
104.14933
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
104.14933
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
105.585724
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
105.585724
seq distance
False
chain
S
LDL-receptor class A
begin
78
end
115
score
100.0
distance
105.60937
seq distance
False
chain
T
LDL-receptor class A
begin
78
end
115
score
100.0
distance
105.60937
seq distance
False
chain
T
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
105.735176
seq distance
False
chain
L
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
105.735176
seq distance
False
chain
L
MACPF
begin
117
end
488
score
87.6099706744868
distance
105.831924
seq distance
False
chain
U
MACPF
begin
117
end
488
score
87.6099706744868
distance
105.831924
seq distance
False
chain
U
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
106.31952
seq distance
False
chain
T
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
106.31952
seq distance
False
chain
T
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
106.443275
seq distance
False
chain
K
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
106.443275
seq distance
False
chain
K
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
107.43062
seq distance
False
chain
S
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
107.43062
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
108.3879
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
108.3879
seq distance
False
chain
T
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
108.87769
seq distance
False
chain
T
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
108.87769
seq distance
False
chain
T
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
109.82321
seq distance
False
chain
K
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
109.82321
seq distance
False
chain
K
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
110.99002
seq distance
False
chain
L
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
110.99002
seq distance
False
chain
L
MACPF
begin
117
end
488
score
87.6099706744868
distance
111.44651
seq distance
False
chain
J
MACPF
begin
117
end
488
score
87.6099706744868
distance
111.44651
seq distance
False
chain
J
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
111.63548
seq distance
False
chain
U
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
111.63548
seq distance
False
chain
U
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
113.39987
seq distance
False
chain
T
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
113.39987
seq distance
False
chain
T
EGF-like
begin
489
end
519
score
99.12023460410556
distance
114.93684
seq distance
False
chain
J
EGF-like
begin
489
end
519
score
99.12023460410556
distance
114.93684
seq distance
False
chain
J
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
115.38047
seq distance
False
chain
S
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
115.38047
seq distance
False
chain
S
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
116.85617
seq distance
False
chain
T
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
116.85617
seq distance
False
chain
T
EGF-like
begin
489
end
519
score
99.12023460410556
distance
117.00561
seq distance
False
chain
T
EGF-like
begin
489
end
519
score
99.12023460410556
distance
117.00561
seq distance
False
chain
T
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
117.893074
seq distance
False
chain
J
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
117.893074
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
117.958496
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
117.958496
seq distance
False
chain
J
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
118.17064
seq distance
False
chain
J
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
118.17064
seq distance
False
chain
J
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
120.13393
seq distance
False
chain
K
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
120.13393
seq distance
False
chain
K
LDL-receptor class A
begin
78
end
115
score
100.0
distance
120.13393
seq distance
False
chain
K
LDL-receptor class A
begin
78
end
115
score
100.0
distance
120.13393
seq distance
False
chain
K
MACPF
begin
117
end
488
score
87.6099706744868
distance
120.708954
seq distance
False
chain
V
MACPF
begin
117
end
488
score
87.6099706744868
distance
120.708954
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
121.00891
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
121.00891
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
122.3464
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
122.3464
seq distance
False
chain
T
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
122.56072
seq distance
False
chain
J
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
122.56072
seq distance
False
chain
J
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
123.868546
seq distance
False
chain
U
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
123.868546
seq distance
False
chain
U
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
124.6762
seq distance
False
chain
K
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
124.6762
seq distance
False
chain
K
LDL-receptor class A
begin
78
end
115
score
100.0
distance
125.515305
seq distance
False
chain
U
LDL-receptor class A
begin
78
end
115
score
100.0
distance
125.515305
seq distance
False
chain
U
MACPF
begin
117
end
488
score
87.6099706744868
distance
125.5687
seq distance
False
chain
I
MACPF
begin
117
end
488
score
87.6099706744868
distance
125.5687
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
126.056946
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
126.056946
seq distance
False
chain
U
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
128.67331
seq distance
False
chain
U
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
128.67331
seq distance
False
chain
U
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
129.6492
seq distance
False
chain
J
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
129.6492
seq distance
False
chain
J
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
130.06302
seq distance
False
chain
K
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
130.06302
seq distance
False
chain
K
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
130.38115
seq distance
False
chain
V
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
130.38115
seq distance
False
chain
V
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
130.44171
seq distance
False
chain
T
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
130.44171
seq distance
False
chain
T
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
131.05493
seq distance
False
chain
T
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
131.05493
seq distance
False
chain
T
MACPF
begin
117
end
488
score
87.6099706744868
distance
132.69347
seq distance
False
chain
A
MACPF
begin
117
end
488
score
87.6099706744868
distance
132.69347
seq distance
False
chain
A
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
133.32088
seq distance
False
chain
U
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
133.32088
seq distance
False
chain
U
EGF-like
begin
489
end
519
score
99.12023460410556
distance
133.7483
seq distance
False
chain
I
EGF-like
begin
489
end
519
score
99.12023460410556
distance
133.7483
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
133.83517
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
133.83517
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
134.01155
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
134.01155
seq distance
False
chain
I
EGF-like
begin
489
end
519
score
99.12023460410556
distance
135.0311
seq distance
False
chain
U
EGF-like
begin
489
end
519
score
99.12023460410556
distance
135.0311
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
136.4214
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
136.4214
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
136.5054
seq distance
False
chain
U
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
136.5054
seq distance
False
chain
U
MACPF
begin
117
end
488
score
87.6099706744868
distance
137.52777
seq distance
False
chain
H
MACPF
begin
117
end
488
score
87.6099706744868
distance
137.52777
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
137.61697
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
137.61697
seq distance
False
chain
U
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
137.67975
seq distance
False
chain
I
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
137.67975
seq distance
False
chain
I
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
138.38902
seq distance
False
chain
I
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
138.38902
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
138.93532
seq distance
False
chain
J
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
138.93532
seq distance
False
chain
J
LDL-receptor class A
begin
78
end
115
score
100.0
distance
138.93532
seq distance
False
chain
J
LDL-receptor class A
begin
78
end
115
score
100.0
distance
138.93532
seq distance
False
chain
J
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
138.94154
seq distance
False
chain
V
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
138.94154
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
141.05258
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
141.05258
seq distance
False
chain
V
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
141.34827
seq distance
False
chain
J
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
141.34827
seq distance
False
chain
J
MACPF
begin
117
end
488
score
87.6099706744868
distance
141.94798
seq distance
False
chain
B
MACPF
begin
117
end
488
score
87.6099706744868
distance
141.94798
seq distance
False
chain
B
LDL-receptor class A
begin
78
end
115
score
100.0
distance
143.12323
seq distance
False
chain
V
LDL-receptor class A
begin
78
end
115
score
100.0
distance
143.12323
seq distance
False
chain
V
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
145.29918
seq distance
False
chain
U
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
145.29918
seq distance
False
chain
U
MACPF
begin
117
end
488
score
87.6099706744868
distance
146.32239
seq distance
False
chain
G
MACPF
begin
117
end
488
score
87.6099706744868
distance
146.32239
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
146.62022
seq distance
False
chain
V
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
146.62022
seq distance
False
chain
V
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
146.76826
seq distance
False
chain
A
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
146.76826
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
146.96796
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
146.96796
seq distance
False
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
147.01837
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
147.01837
seq distance
False
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
147.38907
seq distance
False
chain
J
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
147.38907
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
147.5102
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
147.5102
seq distance
False
chain
H
MACPF
begin
117
end
488
score
87.6099706744868
distance
148.61955
seq distance
False
chain
C
MACPF
begin
117
end
488
score
87.6099706744868
distance
148.61955
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
149.77205
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
149.77205
seq distance
False
chain
H
EGF-like
begin
489
end
519
score
99.12023460410556
distance
149.93552
seq distance
False
chain
H
EGF-like
begin
489
end
519
score
99.12023460410556
distance
149.93552
seq distance
False
chain
H
EGF-like
begin
489
end
519
score
99.12023460410556
distance
150.12006
seq distance
False
chain
V
EGF-like
begin
489
end
519
score
99.12023460410556
distance
150.12006
seq distance
False
chain
V
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
150.60457
seq distance
False
chain
U
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
150.60457
seq distance
False
chain
U
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
150.63516
seq distance
False
chain
V
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
150.63516
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
150.76501
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
150.76501
seq distance
False
chain
V
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
151.06009
seq distance
False
chain
H
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
151.06009
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
151.09933
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
151.09933
seq distance
False
chain
A
MACPF
begin
117
end
488
score
87.6099706744868
distance
151.81946
seq distance
False
chain
F
MACPF
begin
117
end
488
score
87.6099706744868
distance
151.81946
seq distance
False
chain
F
MACPF
begin
117
end
488
score
87.6099706744868
distance
152.55376
seq distance
False
chain
D
MACPF
begin
117
end
488
score
87.6099706744868
distance
152.55376
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
153.1872
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
153.1872
seq distance
False
chain
A
MACPF
begin
117
end
488
score
87.6099706744868
distance
153.62416
seq distance
False
chain
E
MACPF
begin
117
end
488
score
87.6099706744868
distance
153.62416
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
153.84882
seq distance
False
chain
V
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
153.84882
seq distance
False
chain
V
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
155.33887
seq distance
False
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
155.33887
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
155.49553
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
155.49553
seq distance
False
chain
I
LDL-receptor class A
begin
78
end
115
score
100.0
distance
155.49553
seq distance
False
chain
I
LDL-receptor class A
begin
78
end
115
score
100.0
distance
155.49553
seq distance
False
chain
I
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
156.07188
seq distance
False
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
156.07188
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
157.252
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
157.252
seq distance
False
chain
G
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
157.47328
seq distance
False
chain
V
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
157.47328
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
158.13094
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
158.13094
seq distance
False
chain
G
LDL-receptor class A
begin
78
end
115
score
100.0
distance
158.309
seq distance
False
chain
A
LDL-receptor class A
begin
78
end
115
score
100.0
distance
158.309
seq distance
False
chain
A
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
160.25565
seq distance
False
chain
B
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
160.25565
seq distance
False
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
160.28067
seq distance
False
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
160.28067
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
160.59601
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
160.59601
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
161.35374
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
161.35374
seq distance
False
chain
A
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
161.51678
seq distance
False
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
161.51678
seq distance
False
chain
H
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
162.1467
seq distance
False
chain
G
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
162.1467
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
162.21774
seq distance
False
chain
A
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
162.21774
seq distance
False
chain
A
EGF-like
begin
489
end
519
score
99.12023460410556
distance
162.27708
seq distance
False
chain
A
EGF-like
begin
489
end
519
score
99.12023460410556
distance
162.27708
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
162.29048
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
162.29048
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
162.35204
seq distance
False
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
162.35204
seq distance
False
chain
I
EGF-like
begin
489
end
519
score
99.12023460410556
distance
163.13272
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
99.12023460410556
distance
163.13272
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
164.44762
seq distance
False
chain
F
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
164.44762
seq distance
False
chain
F
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
165.03778
seq distance
False
chain
A
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
165.03778
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
165.6343
seq distance
False
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
165.6343
seq distance
False
chain
F
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
166.2969
seq distance
False
chain
C
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
166.2969
seq distance
False
chain
C
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
166.31949
seq distance
False
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
166.31949
seq distance
False
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
166.94829
seq distance
False
chain
V
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
166.94829
seq distance
False
chain
V
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
167.11641
seq distance
False
chain
A
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
167.11641
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
168.17259
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
168.17259
seq distance
False
chain
C
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
168.40692
seq distance
False
chain
E
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
168.40692
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
168.49579
seq distance
False
chain
A
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
168.49579
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
168.57785
seq distance
False
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
168.57785
seq distance
False
chain
F
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
169.03288
seq distance
False
chain
D
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
169.03288
seq distance
False
chain
D
LDL-receptor class A
begin
78
end
115
score
100.0
distance
169.09392
seq distance
False
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
169.09392
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
169.13487
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
169.13487
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
169.30527
seq distance
False
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
169.30527
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
169.86586
seq distance
False
chain
E
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
169.86586
seq distance
False
chain
E
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
169.95938
seq distance
False
chain
C
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
169.95938
seq distance
False
chain
C
LDL-receptor class A
begin
78
end
115
score
100.0
distance
170.53601
seq distance
False
chain
B
LDL-receptor class A
begin
78
end
115
score
100.0
distance
170.53601
seq distance
False
chain
B
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
170.56984
seq distance
False
chain
F
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
170.56984
seq distance
False
chain
F
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
170.57597
seq distance
False
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
170.57597
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
170.72339
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
170.72339
seq distance
False
chain
D
EGF-like
begin
489
end
519
score
99.12023460410556
distance
171.19778
seq distance
False
chain
B
EGF-like
begin
489
end
519
score
99.12023460410556
distance
171.19778
seq distance
False
chain
B
EGF-like
begin
489
end
519
score
99.12023460410556
distance
171.80528
seq distance
False
chain
F
EGF-like
begin
489
end
519
score
99.12023460410556
distance
171.80528
seq distance
False
chain
F
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
172.82309
seq distance
False
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
172.82309
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
173.53366
seq distance
False
chain
E
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
173.53366
seq distance
False
chain
E
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
173.81497
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
173.81497
seq distance
False
chain
C
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
174.01277
seq distance
False
chain
B
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
174.01277
seq distance
False
chain
B
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
174.04114
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
174.04114
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
174.48293
seq distance
False
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
174.48293
seq distance
False
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
174.79579
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
174.79579
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
175.30446
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
175.30446
seq distance
False
chain
D
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
175.4982
seq distance
False
chain
B
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
175.4982
seq distance
False
chain
B
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
176.10997
seq distance
False
chain
E
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
176.10997
seq distance
False
chain
E
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
176.26547
seq distance
False
chain
D
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
176.26547
seq distance
False
chain
D
EGF-like
begin
489
end
519
score
99.12023460410556
distance
176.68214
seq distance
False
chain
C
EGF-like
begin
489
end
519
score
99.12023460410556
distance
176.68214
seq distance
False
chain
C
EGF-like
begin
489
end
519
score
99.12023460410556
distance
176.9907
seq distance
False
chain
E
EGF-like
begin
489
end
519
score
99.12023460410556
distance
176.9907
seq distance
False
chain
E
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
177.85704
seq distance
False
chain
C
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
177.85704
seq distance
False
chain
C
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
178.3226
seq distance
False
chain
F
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
178.3226
seq distance
False
chain
F
LDL-receptor class A
begin
78
end
115
score
100.0
distance
178.53258
seq distance
False
chain
G
LDL-receptor class A
begin
78
end
115
score
100.0
distance
178.53258
seq distance
False
chain
G
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
178.57333
seq distance
False
chain
D
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
178.57333
seq distance
False
chain
D
EGF-like
begin
489
end
519
score
99.12023460410556
distance
178.6339
seq distance
False
chain
D
EGF-like
begin
489
end
519
score
99.12023460410556
distance
178.6339
seq distance
False
chain
D
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
179.07
seq distance
False
chain
E
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
179.07
seq distance
False
chain
E
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
179.20892
seq distance
False
chain
A
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
179.20892
seq distance
False
chain
A
LDL-receptor class A
begin
78
end
115
score
100.0
distance
179.57304
seq distance
False
chain
C
LDL-receptor class A
begin
78
end
115
score
100.0
distance
179.57304
seq distance
False
chain
C
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
179.87811
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
179.87811
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
179.997
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
179.997
seq distance
False
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
180.6883
seq distance
False
chain
F
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
180.6883
seq distance
False
chain
F
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
181.61496
seq distance
False
chain
F
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
181.61496
seq distance
False
chain
F
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
182.31403
seq distance
False
chain
C
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
182.31403
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
183.45357
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
183.45357
seq distance
False
chain
G
LDL-receptor class A
begin
78
end
115
score
100.0
distance
184.0337
seq distance
False
chain
F
LDL-receptor class A
begin
78
end
115
score
100.0
distance
184.0337
seq distance
False
chain
F
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
184.12453
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
184.12453
seq distance
False
chain
C
LDL-receptor class A
begin
78
end
115
score
100.0
distance
184.55869
seq distance
False
chain
D
LDL-receptor class A
begin
78
end
115
score
100.0
distance
184.55869
seq distance
False
chain
D
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
184.94212
seq distance
False
chain
E
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
184.94212
seq distance
False
chain
E
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
185.49161
seq distance
False
chain
D
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
185.49161
seq distance
False
chain
D
LDL-receptor class A
begin
78
end
115
score
100.0
distance
186.05766
seq distance
False
chain
E
LDL-receptor class A
begin
78
end
115
score
100.0
distance
186.05766
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
187.29384
seq distance
False
chain
F
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
187.29384
seq distance
False
chain
F
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
187.41368
seq distance
False
chain
C
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
187.41368
seq distance
False
chain
C
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
187.76022
seq distance
False
chain
B
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
187.76022
seq distance
False
chain
B
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
188.97401
seq distance
False
chain
E
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
188.97401
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
189.01862
seq distance
False
chain
F
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
189.01862
seq distance
False
chain
F
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
189.41862
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
189.41862
seq distance
False
chain
D
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
191.00458
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
191.00458
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
191.0206
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
191.0206
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
191.04651
seq distance
False
chain
D
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
191.04651
seq distance
False
chain
D
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
192.07849
seq distance
False
chain
C
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
192.07849
seq distance
False
chain
C
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
192.49036
seq distance
False
chain
D
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
192.49036
seq distance
False
chain
D
Details
Redox score
66.75
PDB code
6dlw
Structure name
complement component polyc9
Structure deposition date
2018-06-03
Thiol separation (Å)
8.01
Half-sphere exposure sum
64
Minimum pKa
nan
% buried
nan
Peptide accession
P02748
Residue number A
78 (Residue 57 in this structure)
Residue number B
510 (Residue 489 in this structure)
Peptide name
Complement component C9
6dlw I 492 I 505
A redox-regulated disulphide may form within Complement component C9 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.
Relevent regions
EGF-like
begin
489
end
519
score
99.12023460410556
distance
2.7876127
seq distance
0
chain
I
EGF-like
begin
489
end
519
score
99.12023460410556
distance
2.7876127
seq distance
0
chain
I
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
5.5328875
seq distance
418
chain
I
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
5.5328875
seq distance
418
chain
I
MACPF
begin
117
end
488
score
87.6099706744868
distance
5.5950255
seq distance
4
chain
I
MACPF
begin
117
end
488
score
87.6099706744868
distance
5.5950255
seq distance
4
chain
I
MACPF
begin
117
end
488
score
87.6099706744868
distance
14.385778
seq distance
False
chain
J
MACPF
begin
117
end
488
score
87.6099706744868
distance
14.385778
seq distance
False
chain
J
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
16.492882
seq distance
False
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
16.492882
seq distance
False
chain
H
EGF-like
begin
489
end
519
score
99.12023460410556
distance
20.313808
seq distance
False
chain
H
EGF-like
begin
489
end
519
score
99.12023460410556
distance
20.313808
seq distance
False
chain
H
EGF-like
begin
489
end
519
score
99.12023460410556
distance
20.771868
seq distance
False
chain
J
EGF-like
begin
489
end
519
score
99.12023460410556
distance
20.771868
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
22.792252
seq distance
87
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
22.792252
seq distance
87
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
23.399817
seq distance
346
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
23.399817
seq distance
346
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
25.65238
seq distance
86
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
25.65238
seq distance
86
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
27.414452
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
27.414452
seq distance
False
chain
J
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
27.542795
seq distance
False
chain
J
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
27.542795
seq distance
False
chain
J
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
27.836628
seq distance
False
chain
J
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
27.836628
seq distance
False
chain
J
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
28.539082
seq distance
False
chain
J
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
28.539082
seq distance
False
chain
J
MACPF
begin
117
end
488
score
87.6099706744868
distance
30.895609
seq distance
False
chain
K
MACPF
begin
117
end
488
score
87.6099706744868
distance
30.895609
seq distance
False
chain
K
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
31.31532
seq distance
False
chain
J
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
31.31532
seq distance
False
chain
J
MACPF
begin
117
end
488
score
87.6099706744868
distance
32.060036
seq distance
False
chain
H
MACPF
begin
117
end
488
score
87.6099706744868
distance
32.060036
seq distance
False
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
32.34458
seq distance
False
chain
K
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
32.34458
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
37.150803
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
37.150803
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
39.597485
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
39.597485
seq distance
False
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
40.51591
seq distance
False
chain
J
LDL-receptor class A
begin
78
end
115
score
100.0
distance
40.51591
seq distance
False
chain
J
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
40.966362
seq distance
False
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
40.966362
seq distance
False
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
41.733135
seq distance
310
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
41.733135
seq distance
310
chain
I
LDL-receptor class A
begin
78
end
115
score
100.0
distance
42.761326
seq distance
377
chain
I
LDL-receptor class A
begin
78
end
115
score
100.0
distance
42.761326
seq distance
377
chain
I
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
43.199554
seq distance
False
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
43.199554
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
44.68166
seq distance
230
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
44.68166
seq distance
230
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
44.997276
seq distance
False
chain
K
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
44.997276
seq distance
False
chain
K
EGF-like
begin
489
end
519
score
99.12023460410556
distance
45.05099
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
99.12023460410556
distance
45.05099
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
45.363968
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
45.363968
seq distance
False
chain
K
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
45.91201
seq distance
386
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
45.91201
seq distance
386
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
46.23113
seq distance
False
chain
J
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
46.23113
seq distance
False
chain
J
EGF-like
begin
489
end
519
score
99.12023460410556
distance
46.346886
seq distance
False
chain
K
EGF-like
begin
489
end
519
score
99.12023460410556
distance
46.346886
seq distance
False
chain
K
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
47.88451
seq distance
False
chain
K
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
47.88451
seq distance
False
chain
K
MACPF
begin
117
end
488
score
87.6099706744868
distance
48.35079
seq distance
False
chain
L
MACPF
begin
117
end
488
score
87.6099706744868
distance
48.35079
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
50.293167
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
50.293167
seq distance
False
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
50.34764
seq distance
False
chain
L
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
50.34764
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
50.351265
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
50.351265
seq distance
False
chain
J
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
50.65254
seq distance
False
chain
J
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
50.65254
seq distance
False
chain
J
MACPF
begin
117
end
488
score
87.6099706744868
distance
51.29846
seq distance
False
chain
G
MACPF
begin
117
end
488
score
87.6099706744868
distance
51.29846
seq distance
False
chain
G
LDL-receptor class A
begin
78
end
115
score
100.0
distance
52.028122
seq distance
False
chain
K
LDL-receptor class A
begin
78
end
115
score
100.0
distance
52.028122
seq distance
False
chain
K
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
56.118866
seq distance
394
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
56.118866
seq distance
394
chain
I
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
56.48128
seq distance
234
chain
I
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
56.48128
seq distance
234
chain
I
LDL-receptor class A
begin
78
end
115
score
100.0
distance
57.06102
seq distance
False
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
57.06102
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
57.15316
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
57.15316
seq distance
False
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
57.457607
seq distance
False
chain
K
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
57.457607
seq distance
False
chain
K
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
57.636436
seq distance
False
chain
K
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
57.636436
seq distance
False
chain
K
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
58.65809
seq distance
False
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
58.65809
seq distance
False
chain
H
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
58.922398
seq distance
False
chain
H
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
58.922398
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
58.934395
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
58.934395
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
59.35934
seq distance
False
chain
K
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
59.35934
seq distance
False
chain
K
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
62.19371
seq distance
False
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
62.19371
seq distance
False
chain
H
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
63.022907
seq distance
False
chain
J
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
63.022907
seq distance
False
chain
J
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
63.729668
seq distance
False
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
63.729668
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
63.968773
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
63.968773
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
64.073975
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
64.073975
seq distance
False
chain
K
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
64.74249
seq distance
False
chain
L
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
64.74249
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
65.82876
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
65.82876
seq distance
False
chain
L
MACPF
begin
117
end
488
score
87.6099706744868
distance
68.142815
seq distance
False
chain
M
MACPF
begin
117
end
488
score
87.6099706744868
distance
68.142815
seq distance
False
chain
M
LDL-receptor class A
begin
78
end
115
score
100.0
distance
68.29558
seq distance
False
chain
L
LDL-receptor class A
begin
78
end
115
score
100.0
distance
68.29558
seq distance
False
chain
L
EGF-like
begin
489
end
519
score
99.12023460410556
distance
68.86905
seq distance
False
chain
F
EGF-like
begin
489
end
519
score
99.12023460410556
distance
68.86905
seq distance
False
chain
F
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
69.181
seq distance
False
chain
F
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
69.181
seq distance
False
chain
F
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
69.24276
seq distance
False
chain
G
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
69.24276
seq distance
False
chain
G
MACPF
begin
117
end
488
score
87.6099706744868
distance
70.585464
seq distance
False
chain
F
MACPF
begin
117
end
488
score
87.6099706744868
distance
70.585464
seq distance
False
chain
F
EGF-like
begin
489
end
519
score
99.12023460410556
distance
70.804665
seq distance
False
chain
L
EGF-like
begin
489
end
519
score
99.12023460410556
distance
70.804665
seq distance
False
chain
L
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
70.910164
seq distance
False
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
70.910164
seq distance
False
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
70.91441
seq distance
False
chain
L
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
70.91441
seq distance
False
chain
L
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
71.55229
seq distance
False
chain
M
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
71.55229
seq distance
False
chain
M
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
73.22017
seq distance
False
chain
L
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
73.22017
seq distance
False
chain
L
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
75.878944
seq distance
False
chain
K
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
75.878944
seq distance
False
chain
K
LDL-receptor class A
begin
78
end
115
score
100.0
distance
77.51361
seq distance
False
chain
G
LDL-receptor class A
begin
78
end
115
score
100.0
distance
77.51361
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
77.615875
seq distance
False
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
77.615875
seq distance
False
chain
F
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
77.66078
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
77.66078
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
78.478
seq distance
False
chain
L
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
78.478
seq distance
False
chain
L
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
78.85401
seq distance
False
chain
F
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
78.85401
seq distance
False
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
80.98565
seq distance
False
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
80.98565
seq distance
False
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
81.10052
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
81.10052
seq distance
False
chain
L
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
82.88639
seq distance
False
chain
L
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
82.88639
seq distance
False
chain
L
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
83.582886
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
83.582886
seq distance
False
chain
G
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
83.9813
seq distance
False
chain
F
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
83.9813
seq distance
False
chain
F
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
84.50043
seq distance
False
chain
M
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
84.50043
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
85.99342
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
85.99342
seq distance
False
chain
M
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
86.61792
seq distance
False
chain
F
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
86.61792
seq distance
False
chain
F
MACPF
begin
117
end
488
score
87.6099706744868
distance
87.40882
seq distance
False
chain
N
MACPF
begin
117
end
488
score
87.6099706744868
distance
87.40882
seq distance
False
chain
N
LDL-receptor class A
begin
78
end
115
score
100.0
distance
88.6556
seq distance
False
chain
M
LDL-receptor class A
begin
78
end
115
score
100.0
distance
88.6556
seq distance
False
chain
M
MACPF
begin
117
end
488
score
87.6099706744868
distance
89.25178
seq distance
False
chain
E
MACPF
begin
117
end
488
score
87.6099706744868
distance
89.25178
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
89.74676
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
89.74676
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
99.12023460410556
distance
91.242
seq distance
False
chain
E
EGF-like
begin
489
end
519
score
99.12023460410556
distance
91.242
seq distance
False
chain
E
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
91.64844
seq distance
False
chain
L
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
91.64844
seq distance
False
chain
L
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
92.005516
seq distance
False
chain
N
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
92.005516
seq distance
False
chain
N
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
92.27221
seq distance
False
chain
M
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
92.27221
seq distance
False
chain
M
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
92.76191
seq distance
False
chain
M
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
92.76191
seq distance
False
chain
M
EGF-like
begin
489
end
519
score
99.12023460410556
distance
92.83402
seq distance
False
chain
M
EGF-like
begin
489
end
519
score
99.12023460410556
distance
92.83402
seq distance
False
chain
M
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
93.55639
seq distance
False
chain
E
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
93.55639
seq distance
False
chain
E
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
97.10438
seq distance
False
chain
E
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
97.10438
seq distance
False
chain
E
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
97.87235
seq distance
False
chain
E
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
97.87235
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
98.31665
seq distance
False
chain
F
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
98.31665
seq distance
False
chain
F
LDL-receptor class A
begin
78
end
115
score
100.0
distance
98.31665
seq distance
False
chain
F
LDL-receptor class A
begin
78
end
115
score
100.0
distance
98.31665
seq distance
False
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
98.636284
seq distance
False
chain
E
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
98.636284
seq distance
False
chain
E
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
98.777084
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
98.777084
seq distance
False
chain
M
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
99.128624
seq distance
False
chain
M
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
99.128624
seq distance
False
chain
M
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
100.31626
seq distance
False
chain
E
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
100.31626
seq distance
False
chain
E
MACPF
begin
117
end
488
score
87.6099706744868
distance
102.71727
seq distance
False
chain
O
MACPF
begin
117
end
488
score
87.6099706744868
distance
102.71727
seq distance
False
chain
O
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
103.09857
seq distance
False
chain
N
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
103.09857
seq distance
False
chain
N
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
104.11745
seq distance
False
chain
F
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
104.11745
seq distance
False
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
104.83819
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
104.83819
seq distance
False
chain
N
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
106.82505
seq distance
False
chain
M
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
106.82505
seq distance
False
chain
M
MACPF
begin
117
end
488
score
87.6099706744868
distance
106.963295
seq distance
False
chain
D
MACPF
begin
117
end
488
score
87.6099706744868
distance
106.963295
seq distance
False
chain
D
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
108.12369
seq distance
False
chain
M
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
108.12369
seq distance
False
chain
M
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
108.271194
seq distance
False
chain
E
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
108.271194
seq distance
False
chain
E
LDL-receptor class A
begin
78
end
115
score
100.0
distance
108.56726
seq distance
False
chain
N
LDL-receptor class A
begin
78
end
115
score
100.0
distance
108.56726
seq distance
False
chain
N
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
109.4503
seq distance
False
chain
F
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
109.4503
seq distance
False
chain
F
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
111.34171
seq distance
False
chain
O
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
111.34171
seq distance
False
chain
O
EGF-like
begin
489
end
519
score
99.12023460410556
distance
111.854034
seq distance
False
chain
D
EGF-like
begin
489
end
519
score
99.12023460410556
distance
111.854034
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
111.927345
seq distance
False
chain
N
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
111.927345
seq distance
False
chain
N
EGF-like
begin
489
end
519
score
99.12023460410556
distance
112.53523
seq distance
False
chain
N
EGF-like
begin
489
end
519
score
99.12023460410556
distance
112.53523
seq distance
False
chain
N
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
113.29571
seq distance
False
chain
N
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
113.29571
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
114.91563
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
114.91563
seq distance
False
chain
D
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
115.25375
seq distance
False
chain
D
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
115.25375
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
115.54162
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
115.54162
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
115.65335
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
115.65335
seq distance
False
chain
N
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
115.778824
seq distance
False
chain
D
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
115.778824
seq distance
False
chain
D
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
116.56175
seq distance
False
chain
D
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
116.56175
seq distance
False
chain
D
MACPF
begin
117
end
488
score
87.6099706744868
distance
116.589935
seq distance
False
chain
P
MACPF
begin
117
end
488
score
87.6099706744868
distance
116.589935
seq distance
False
chain
P
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
118.53879
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
118.53879
seq distance
False
chain
E
LDL-receptor class A
begin
78
end
115
score
100.0
distance
118.53879
seq distance
False
chain
E
LDL-receptor class A
begin
78
end
115
score
100.0
distance
118.53879
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
119.28923
seq distance
False
chain
N
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
119.28923
seq distance
False
chain
N
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
119.91442
seq distance
False
chain
O
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
119.91442
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
121.79581
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
121.79581
seq distance
False
chain
O
MACPF
begin
117
end
488
score
87.6099706744868
distance
121.9048
seq distance
False
chain
C
MACPF
begin
117
end
488
score
87.6099706744868
distance
121.9048
seq distance
False
chain
C
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
122.95535
seq distance
False
chain
E
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
122.95535
seq distance
False
chain
E
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
123.9057
seq distance
False
chain
N
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
123.9057
seq distance
False
chain
N
LDL-receptor class A
begin
78
end
115
score
100.0
distance
127.34441
seq distance
False
chain
O
LDL-receptor class A
begin
78
end
115
score
100.0
distance
127.34441
seq distance
False
chain
O
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
127.973076
seq distance
False
chain
D
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
127.973076
seq distance
False
chain
D
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
128.14151
seq distance
False
chain
N
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
128.14151
seq distance
False
chain
N
MACPF
begin
117
end
488
score
87.6099706744868
distance
128.20517
seq distance
False
chain
Q
MACPF
begin
117
end
488
score
87.6099706744868
distance
128.20517
seq distance
False
chain
Q
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
128.38986
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
128.38986
seq distance
False
chain
E
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
128.87015
seq distance
False
chain
P
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
128.87015
seq distance
False
chain
P
EGF-like
begin
489
end
519
score
99.12023460410556
distance
130.05162
seq distance
False
chain
O
EGF-like
begin
489
end
519
score
99.12023460410556
distance
130.05162
seq distance
False
chain
O
EGF-like
begin
489
end
519
score
99.12023460410556
distance
130.2364
seq distance
False
chain
C
EGF-like
begin
489
end
519
score
99.12023460410556
distance
130.2364
seq distance
False
chain
C
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
130.50606
seq distance
False
chain
C
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
130.50606
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
130.56453
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
130.56453
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
130.69188
seq distance
False
chain
O
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
130.69188
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
130.84908
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
130.84908
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
130.95169
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
130.95169
seq distance
False
chain
O
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
131.64214
seq distance
False
chain
C
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
131.64214
seq distance
False
chain
C
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
131.9104
seq distance
False
chain
O
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
131.9104
seq distance
False
chain
O
MACPF
begin
117
end
488
score
87.6099706744868
distance
133.5656
seq distance
False
chain
B
MACPF
begin
117
end
488
score
87.6099706744868
distance
133.5656
seq distance
False
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
134.46716
seq distance
False
chain
P
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
134.46716
seq distance
False
chain
P
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
135.65741
seq distance
False
chain
C
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
135.65741
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
136.40944
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
136.40944
seq distance
False
chain
P
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
137.20987
seq distance
False
chain
D
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
137.20987
seq distance
False
chain
D
LDL-receptor class A
begin
78
end
115
score
100.0
distance
137.20987
seq distance
False
chain
D
LDL-receptor class A
begin
78
end
115
score
100.0
distance
137.20987
seq distance
False
chain
D
MACPF
begin
117
end
488
score
87.6099706744868
distance
137.36742
seq distance
False
chain
R
MACPF
begin
117
end
488
score
87.6099706744868
distance
137.36742
seq distance
False
chain
R
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
137.69312
seq distance
False
chain
O
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
137.69312
seq distance
False
chain
O
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
138.18932
seq distance
False
chain
O
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
138.18932
seq distance
False
chain
O
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
139.241
seq distance
False
chain
D
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
139.241
seq distance
False
chain
D
MACPF
begin
117
end
488
score
87.6099706744868
distance
141.92476
seq distance
False
chain
A
MACPF
begin
117
end
488
score
87.6099706744868
distance
141.92476
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
143.25388
seq distance
False
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
143.25388
seq distance
False
chain
B
LDL-receptor class A
begin
78
end
115
score
100.0
distance
143.61284
seq distance
False
chain
P
LDL-receptor class A
begin
78
end
115
score
100.0
distance
143.61284
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
143.67993
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
143.67993
seq distance
False
chain
B
MACPF
begin
117
end
488
score
87.6099706744868
distance
144.0196
seq distance
False
chain
S
MACPF
begin
117
end
488
score
87.6099706744868
distance
144.0196
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
144.01999
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
144.01999
seq distance
False
chain
B
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
144.09166
seq distance
False
chain
Q
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
144.09166
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
144.09843
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
144.09843
seq distance
False
chain
P
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
144.84088
seq distance
False
chain
C
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
144.84088
seq distance
False
chain
C
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
144.88892
seq distance
False
chain
B
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
144.88892
seq distance
False
chain
B
EGF-like
begin
489
end
519
score
99.12023460410556
distance
144.96513
seq distance
False
chain
P
EGF-like
begin
489
end
519
score
99.12023460410556
distance
144.96513
seq distance
False
chain
P
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
145.59708
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
145.59708
seq distance
False
chain
D
EGF-like
begin
489
end
519
score
99.12023460410556
distance
145.99243
seq distance
False
chain
B
EGF-like
begin
489
end
519
score
99.12023460410556
distance
145.99243
seq distance
False
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
146.42662
seq distance
False
chain
Q
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
146.42662
seq distance
False
chain
Q
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
146.85202
seq distance
False
chain
O
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
146.85202
seq distance
False
chain
O
MACPF
begin
117
end
488
score
87.6099706744868
distance
147.48103
seq distance
False
chain
V
MACPF
begin
117
end
488
score
87.6099706744868
distance
147.48103
seq distance
False
chain
V
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
147.52061
seq distance
False
chain
P
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
147.52061
seq distance
False
chain
P
MACPF
begin
117
end
488
score
87.6099706744868
distance
147.9718
seq distance
False
chain
T
MACPF
begin
117
end
488
score
87.6099706744868
distance
147.9718
seq distance
False
chain
T
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
148.05417
seq distance
False
chain
P
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
148.05417
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
148.36064
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
148.36064
seq distance
False
chain
Q
MACPF
begin
117
end
488
score
87.6099706744868
distance
149.15193
seq distance
False
chain
U
MACPF
begin
117
end
488
score
87.6099706744868
distance
149.15193
seq distance
False
chain
U
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
150.38002
seq distance
False
chain
P
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
150.38002
seq distance
False
chain
P
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
152.69873
seq distance
False
chain
C
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
152.69873
seq distance
False
chain
C
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
152.77127
seq distance
False
chain
B
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
152.77127
seq distance
False
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
153.2017
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
153.2017
seq distance
False
chain
A
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
153.60654
seq distance
False
chain
P
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
153.60654
seq distance
False
chain
P
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
153.65947
seq distance
False
chain
C
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
153.65947
seq distance
False
chain
C
LDL-receptor class A
begin
78
end
115
score
100.0
distance
153.65947
seq distance
False
chain
C
LDL-receptor class A
begin
78
end
115
score
100.0
distance
153.65947
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
153.9648
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
153.9648
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
154.6384
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
154.6384
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
154.70053
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
154.70053
seq distance
False
chain
Q
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
155.52002
seq distance
False
chain
R
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
155.52002
seq distance
False
chain
R
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
155.80054
seq distance
False
chain
A
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
155.80054
seq distance
False
chain
A
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
156.5946
seq distance
False
chain
R
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
156.5946
seq distance
False
chain
R
EGF-like
begin
489
end
519
score
99.12023460410556
distance
156.97542
seq distance
False
chain
Q
EGF-like
begin
489
end
519
score
99.12023460410556
distance
156.97542
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
157.38553
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
157.38553
seq distance
False
chain
R
LDL-receptor class A
begin
78
end
115
score
100.0
distance
157.4454
seq distance
False
chain
Q
LDL-receptor class A
begin
78
end
115
score
100.0
distance
157.4454
seq distance
False
chain
Q
EGF-like
begin
489
end
519
score
99.12023460410556
distance
158.564
seq distance
False
chain
A
EGF-like
begin
489
end
519
score
99.12023460410556
distance
158.564
seq distance
False
chain
A
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
158.77924
seq distance
False
chain
B
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
158.77924
seq distance
False
chain
B
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
160.06905
seq distance
False
chain
Q
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
160.06905
seq distance
False
chain
Q
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
160.13695
seq distance
False
chain
V
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
160.13695
seq distance
False
chain
V
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
160.46286
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
160.46286
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
161.20909
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
161.20909
seq distance
False
chain
V
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
161.35872
seq distance
False
chain
Q
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
161.35872
seq distance
False
chain
Q
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
161.54036
seq distance
False
chain
S
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
161.54036
seq distance
False
chain
S
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
161.6944
seq distance
False
chain
Q
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
161.6944
seq distance
False
chain
Q
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
162.19917
seq distance
False
chain
P
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
162.19917
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
162.50642
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
162.50642
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
162.50735
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
162.50735
seq distance
False
chain
R
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
163.24062
seq distance
False
chain
B
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
163.24062
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
163.28133
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
163.28133
seq distance
False
chain
S
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
163.87518
seq distance
False
chain
U
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
163.87518
seq distance
False
chain
U
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
164.14565
seq distance
False
chain
V
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
164.14565
seq distance
False
chain
V
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
164.33649
seq distance
False
chain
T
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
164.33649
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
165.2148
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
165.2148
seq distance
False
chain
U
EGF-like
begin
489
end
519
score
99.12023460410556
distance
165.84265
seq distance
False
chain
R
EGF-like
begin
489
end
519
score
99.12023460410556
distance
165.84265
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
165.9005
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
165.9005
seq distance
False
chain
T
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
166.08115
seq distance
False
chain
S
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
166.08115
seq distance
False
chain
S
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
166.7988
seq distance
False
chain
A
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
166.7988
seq distance
False
chain
A
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
166.94406
seq distance
False
chain
Q
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
166.94406
seq distance
False
chain
Q
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
167.01028
seq distance
False
chain
R
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
167.01028
seq distance
False
chain
R
EGF-like
begin
489
end
519
score
99.12023460410556
distance
167.02571
seq distance
False
chain
V
EGF-like
begin
489
end
519
score
99.12023460410556
distance
167.02571
seq distance
False
chain
V
LDL-receptor class A
begin
78
end
115
score
100.0
distance
167.14728
seq distance
False
chain
B
LDL-receptor class A
begin
78
end
115
score
100.0
distance
167.14728
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
167.27884
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
167.27884
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
167.2802
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
167.2802
seq distance
False
chain
U
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
167.37811
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
167.37811
seq distance
False
chain
B
LDL-receptor class A
begin
78
end
115
score
100.0
distance
168.58931
seq distance
False
chain
R
LDL-receptor class A
begin
78
end
115
score
100.0
distance
168.58931
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
168.86804
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
168.86804
seq distance
False
chain
T
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
169.5115
seq distance
False
chain
U
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
169.5115
seq distance
False
chain
U
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
169.63118
seq distance
False
chain
A
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
169.63118
seq distance
False
chain
A
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
170.61139
seq distance
False
chain
A
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
170.61139
seq distance
False
chain
A
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
170.96454
seq distance
False
chain
S
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
170.96454
seq distance
False
chain
S
EGF-like
begin
489
end
519
score
99.12023460410556
distance
171.36665
seq distance
False
chain
S
EGF-like
begin
489
end
519
score
99.12023460410556
distance
171.36665
seq distance
False
chain
S
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
171.50348
seq distance
False
chain
R
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
171.50348
seq distance
False
chain
R
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
171.78894
seq distance
False
chain
T
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
171.78894
seq distance
False
chain
T
EGF-like
begin
489
end
519
score
99.12023460410556
distance
171.96579
seq distance
False
chain
U
EGF-like
begin
489
end
519
score
99.12023460410556
distance
171.96579
seq distance
False
chain
U
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
172.32555
seq distance
False
chain
T
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
172.32555
seq distance
False
chain
T
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
172.52258
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
172.52258
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
173.13638
seq distance
False
chain
R
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
173.13638
seq distance
False
chain
R
EGF-like
begin
489
end
519
score
99.12023460410556
distance
173.41212
seq distance
False
chain
T
EGF-like
begin
489
end
519
score
99.12023460410556
distance
173.41212
seq distance
False
chain
T
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
174.2545
seq distance
False
chain
Q
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
174.2545
seq distance
False
chain
Q
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
174.62216
seq distance
False
chain
V
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
174.62216
seq distance
False
chain
V
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
175.20372
seq distance
False
chain
U
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
175.20372
seq distance
False
chain
U
LDL-receptor class A
begin
78
end
115
score
100.0
distance
176.3207
seq distance
False
chain
A
LDL-receptor class A
begin
78
end
115
score
100.0
distance
176.3207
seq distance
False
chain
A
LDL-receptor class A
begin
78
end
115
score
100.0
distance
176.74158
seq distance
False
chain
S
LDL-receptor class A
begin
78
end
115
score
100.0
distance
176.74158
seq distance
False
chain
S
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
177.1325
seq distance
False
chain
V
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
177.1325
seq distance
False
chain
V
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
177.28445
seq distance
False
chain
R
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
177.28445
seq distance
False
chain
R
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
177.4645
seq distance
False
chain
V
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
177.4645
seq distance
False
chain
V
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
177.81259
seq distance
False
chain
A
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
177.81259
seq distance
False
chain
A
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
178.26828
seq distance
False
chain
S
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
178.26828
seq distance
False
chain
S
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
181.1162
seq distance
False
chain
U
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
181.1162
seq distance
False
chain
U
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
181.35866
seq distance
False
chain
A
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
181.35866
seq distance
False
chain
A
LDL-receptor class A
begin
78
end
115
score
100.0
distance
181.45792
seq distance
False
chain
V
LDL-receptor class A
begin
78
end
115
score
100.0
distance
181.45792
seq distance
False
chain
V
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
181.48949
seq distance
False
chain
T
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
181.48949
seq distance
False
chain
T
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
181.52983
seq distance
False
chain
S
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
181.52983
seq distance
False
chain
S
LDL-receptor class A
begin
78
end
115
score
100.0
distance
181.67456
seq distance
False
chain
T
LDL-receptor class A
begin
78
end
115
score
100.0
distance
181.67456
seq distance
False
chain
T
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
182.77762
seq distance
False
chain
R
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
182.77762
seq distance
False
chain
R
LDL-receptor class A
begin
78
end
115
score
100.0
distance
183.26578
seq distance
False
chain
U
LDL-receptor class A
begin
78
end
115
score
100.0
distance
183.26578
seq distance
False
chain
U
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
184.37076
seq distance
False
chain
S
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
184.37076
seq distance
False
chain
S
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
184.48799
seq distance
False
chain
U
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
184.48799
seq distance
False
chain
U
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
184.69014
seq distance
False
chain
V
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
184.69014
seq distance
False
chain
V
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
186.54604
seq distance
False
chain
V
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
186.54604
seq distance
False
chain
V
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
186.63628
seq distance
False
chain
T
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
186.63628
seq distance
False
chain
T
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
187.19502
seq distance
False
chain
S
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
187.19502
seq distance
False
chain
S
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
187.74533
seq distance
False
chain
T
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
187.74533
seq distance
False
chain
T
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
188.01094
seq distance
False
chain
T
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
188.01094
seq distance
False
chain
T
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
188.12315
seq distance
False
chain
U
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
188.12315
seq distance
False
chain
U
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
188.32887
seq distance
False
chain
U
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
188.32887
seq distance
False
chain
U
Details
Redox score
66
PDB code
6dlw
Structure name
complement component polyc9
Structure deposition date
2018-06-03
Thiol separation (Å)
8.47
Half-sphere exposure sum
63
Minimum pKa
nan
% buried
nan
Peptide accession
P02748
Residue number A
513 (Residue 492 in this structure)
Residue number B
526 (Residue 505 in this structure)
Peptide name
Complement component C9
6h04 H 489 H 507
A redox-regulated disulphide may form within Complement component C9 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.
Relevent regions
EGF-like
begin
489
end
519
score
100.0
distance
2.810634
seq distance
0
chain
H
EGF-like
begin
489
end
519
score
100.0
distance
2.810634
seq distance
0
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
4.526769
seq distance
415
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
4.526769
seq distance
415
chain
H
MACPF
begin
117
end
488
score
94.98411534701859
distance
5.7925577
seq distance
1
chain
H
MACPF
begin
117
end
488
score
94.98411534701859
distance
5.7925577
seq distance
1
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
15.4798975
seq distance
False
chain
P
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
15.4798975
seq distance
False
chain
P
MACPF
begin
117
end
488
score
94.98411534701859
distance
17.354801
seq distance
False
chain
I
MACPF
begin
117
end
488
score
94.98411534701859
distance
17.354801
seq distance
False
chain
I
EGF-like
begin
489
end
519
score
100.0
distance
18.91572
seq distance
False
chain
I
EGF-like
begin
489
end
519
score
100.0
distance
18.91572
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
19.834276
seq distance
84
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
19.834276
seq distance
84
chain
H
EGF-like
begin
489
end
519
score
100.0
distance
20.296368
seq distance
False
chain
P
EGF-like
begin
489
end
519
score
100.0
distance
20.296368
seq distance
False
chain
P
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
22.427011
seq distance
83
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
22.427011
seq distance
83
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
24.3757
seq distance
343
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
24.3757
seq distance
343
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
24.902859
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
24.902859
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
25.115274
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
25.115274
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
25.467815
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
25.467815
seq distance
False
chain
I
MACPF
begin
117
end
488
score
94.98411534701859
distance
28.448889
seq distance
False
chain
J
MACPF
begin
117
end
488
score
94.98411534701859
distance
28.448889
seq distance
False
chain
J
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
29.502138
seq distance
False
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
29.502138
seq distance
False
chain
I
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
29.881794
seq distance
False
chain
I
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
29.881794
seq distance
False
chain
I
MACPF
begin
117
end
488
score
94.98411534701859
distance
31.858442
seq distance
False
chain
P
MACPF
begin
117
end
488
score
94.98411534701859
distance
31.858442
seq distance
False
chain
P
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
34.215557
seq distance
False
chain
J
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
34.215557
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
34.79753
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
34.79753
seq distance
False
chain
P
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
37.404724
seq distance
False
chain
P
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
37.404724
seq distance
False
chain
P
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
42.00414
seq distance
False
chain
J
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
42.00414
seq distance
False
chain
J
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
42.027004
seq distance
False
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
42.027004
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
42.26085
seq distance
307
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
42.26085
seq distance
307
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
42.74234
seq distance
False
chain
I
LDL-receptor class A
begin
78
end
115
score
100.0
distance
42.74234
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
42.993523
seq distance
False
chain
P
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
42.993523
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
43.138393
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
43.138393
seq distance
False
chain
J
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
43.80742
seq distance
False
chain
J
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
43.80742
seq distance
False
chain
J
EGF-like
begin
489
end
519
score
100.0
distance
43.81151
seq distance
False
chain
J
EGF-like
begin
489
end
519
score
100.0
distance
43.81151
seq distance
False
chain
J
EGF-like
begin
489
end
519
score
100.0
distance
44.51242
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
100.0
distance
44.51242
seq distance
False
chain
G
LDL-receptor class A
begin
78
end
115
score
100.0
distance
44.785286
seq distance
374
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
44.785286
seq distance
374
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
45.386845
seq distance
227
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
45.386845
seq distance
227
chain
H
MACPF
begin
117
end
488
score
94.98411534701859
distance
46.083252
seq distance
False
chain
K
MACPF
begin
117
end
488
score
94.98411534701859
distance
46.083252
seq distance
False
chain
K
MACPF
begin
117
end
488
score
94.98411534701859
distance
49.236748
seq distance
False
chain
G
MACPF
begin
117
end
488
score
94.98411534701859
distance
49.236748
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
49.38908
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
49.38908
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
49.450523
seq distance
383
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
49.450523
seq distance
383
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
50.404724
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
50.404724
seq distance
False
chain
P
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
50.534523
seq distance
False
chain
K
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
50.534523
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
50.97831
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
50.97831
seq distance
False
chain
I
LDL-receptor class A
begin
78
end
115
score
100.0
distance
51.42849
seq distance
False
chain
J
LDL-receptor class A
begin
78
end
115
score
100.0
distance
51.42849
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
52.688274
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
52.688274
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
52.701553
seq distance
False
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
52.701553
seq distance
False
chain
I
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
55.11905
seq distance
False
chain
J
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
55.11905
seq distance
False
chain
J
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
55.43601
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
55.43601
seq distance
False
chain
G
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
57.358337
seq distance
231
chain
H
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
57.358337
seq distance
231
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
57.595074
seq distance
391
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
57.595074
seq distance
391
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
58.08783
seq distance
False
chain
P
LDL-receptor class A
begin
78
end
115
score
100.0
distance
58.08783
seq distance
False
chain
P
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
59.45286
seq distance
False
chain
P
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
59.45286
seq distance
False
chain
P
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
59.62192
seq distance
False
chain
J
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
59.62192
seq distance
False
chain
J
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
60.733147
seq distance
False
chain
J
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
60.733147
seq distance
False
chain
J
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
60.89414
seq distance
False
chain
P
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
60.89414
seq distance
False
chain
P
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
61.907784
seq distance
False
chain
K
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
61.907784
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
61.957874
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
61.957874
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
62.242558
seq distance
False
chain
P
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
62.242558
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
63.541878
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
63.541878
seq distance
False
chain
K
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
63.897167
seq distance
False
chain
I
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
63.897167
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
64.20605
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
64.20605
seq distance
False
chain
J
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
65.18303
seq distance
False
chain
K
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
65.18303
seq distance
False
chain
K
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
65.37333
seq distance
False
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
65.37333
seq distance
False
chain
G
MACPF
begin
117
end
488
score
94.98411534701859
distance
66.08182
seq distance
False
chain
L
MACPF
begin
117
end
488
score
94.98411534701859
distance
66.08182
seq distance
False
chain
L
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
67.67286
seq distance
False
chain
G
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
67.67286
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
100.0
distance
68.02241
seq distance
False
chain
K
EGF-like
begin
489
end
519
score
100.0
distance
68.02241
seq distance
False
chain
K
LDL-receptor class A
begin
78
end
115
score
100.0
distance
68.75932
seq distance
False
chain
K
LDL-receptor class A
begin
78
end
115
score
100.0
distance
68.75932
seq distance
False
chain
K
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
70.17695
seq distance
False
chain
L
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
70.17695
seq distance
False
chain
L
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
71.77344
seq distance
False
chain
P
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
71.77344
seq distance
False
chain
P
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
74.86754
seq distance
False
chain
K
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
74.86754
seq distance
False
chain
K
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
391
score
68.18181818181817
distance
76.28113
seq distance
False
chain
F
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
391
score
68.18181818181817
distance
76.28113
seq distance
False
chain
F
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
76.34988
seq distance
False
chain
J
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
76.34988
seq distance
False
chain
J
LDL-receptor class A
begin
78
end
115
score
100.0
distance
77.76519
seq distance
False
chain
G
LDL-receptor class A
begin
78
end
115
score
100.0
distance
77.76519
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
78.20159
seq distance
False
chain
K
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
78.20159
seq distance
False
chain
K
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
78.3009
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
78.3009
seq distance
False
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
79.67961
seq distance
False
chain
K
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
79.67961
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
80.64773
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
80.64773
seq distance
False
chain
K
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
81.73469
seq distance
False
chain
L
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
81.73469
seq distance
False
chain
L
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
82.797935
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
82.797935
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
83.596375
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
83.596375
seq distance
False
chain
L
MACPF
begin
117
end
488
score
94.98411534701859
distance
84.8746
seq distance
False
chain
M
MACPF
begin
117
end
488
score
94.98411534701859
distance
84.8746
seq distance
False
chain
M
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
86.754814
seq distance
False
chain
L
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
86.754814
seq distance
False
chain
L
LDL-receptor class A
begin
78
end
115
score
100.0
distance
88.686195
seq distance
False
chain
L
LDL-receptor class A
begin
78
end
115
score
100.0
distance
88.686195
seq distance
False
chain
L
EGF-like
begin
489
end
519
score
100.0
distance
89.78254
seq distance
False
chain
L
EGF-like
begin
489
end
519
score
100.0
distance
89.78254
seq distance
False
chain
L
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
89.92349
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
89.92349
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
90.2028
seq distance
False
chain
M
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
90.2028
seq distance
False
chain
M
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
91.836914
seq distance
False
chain
K
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
91.836914
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
370
score
68.18181818181817
distance
91.87087
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
370
score
68.18181818181817
distance
91.87087
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
93.236145
seq distance
False
chain
L
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
93.236145
seq distance
False
chain
L
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
96.066666
seq distance
False
chain
L
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
96.066666
seq distance
False
chain
L
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
93
score
77.27272727272727
distance
96.28484
seq distance
False
chain
F
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
93
score
77.27272727272727
distance
96.28484
seq distance
False
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
98.063866
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
98.063866
seq distance
False
chain
L
MACPF
begin
117
end
488
score
94.98411534701859
distance
99.69649
seq distance
False
chain
N
MACPF
begin
117
end
488
score
94.98411534701859
distance
99.69649
seq distance
False
chain
N
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
100.29462
seq distance
False
chain
M
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
100.29462
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
102.24744
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
102.24744
seq distance
False
chain
M
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
102.83367
seq distance
False
chain
L
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
102.83367
seq distance
False
chain
L
LDL-receptor class A
begin
78
end
115
score
100.0
distance
106.70991
seq distance
False
chain
M
LDL-receptor class A
begin
78
end
115
score
100.0
distance
106.70991
seq distance
False
chain
M
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
107.13232
seq distance
False
chain
M
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
107.13232
seq distance
False
chain
M
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
85
score
72.72727272727273
distance
107.50277
seq distance
False
chain
F
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
85
score
72.72727272727273
distance
107.50277
seq distance
False
chain
F
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
108.214874
seq distance
False
chain
L
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
108.214874
seq distance
False
chain
L
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
226
score
50.0
distance
108.26253
seq distance
False
chain
F
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
226
score
50.0
distance
108.26253
seq distance
False
chain
F
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
109.19802
seq distance
False
chain
N
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
109.19802
seq distance
False
chain
N
EGF-like
begin
489
end
519
score
100.0
distance
109.31143
seq distance
False
chain
M
EGF-like
begin
489
end
519
score
100.0
distance
109.31143
seq distance
False
chain
M
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
94
score
81.81818181818183
distance
109.95036
seq distance
False
chain
C
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
94
score
81.81818181818183
distance
109.95036
seq distance
False
chain
C
LDL-receptor class A
begin
83
end
96
score
70.12987012987013
distance
109.95036
seq distance
False
chain
C
LDL-receptor class A
begin
83
end
96
score
70.12987012987013
distance
109.95036
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
111.28268
seq distance
False
chain
M
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
111.28268
seq distance
False
chain
M
MACPF
begin
117
end
488
score
94.98411534701859
distance
113.19266
seq distance
False
chain
O
MACPF
begin
117
end
488
score
94.98411534701859
distance
113.19266
seq distance
False
chain
O
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
114.10339
seq distance
False
chain
M
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
114.10339
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
114.76768
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
114.76768
seq distance
False
chain
M
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
117.17946
seq distance
False
chain
N
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
117.17946
seq distance
False
chain
N
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
442
score
50.0
distance
118.45552
seq distance
False
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
442
score
50.0
distance
118.45552
seq distance
False
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
119.15707
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
119.15707
seq distance
False
chain
N
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
86
score
72.72727272727273
distance
119.53172
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
86
score
72.72727272727273
distance
119.53172
seq distance
False
chain
C
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
123.92607
seq distance
False
chain
M
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
123.92607
seq distance
False
chain
M
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
123.94466
seq distance
False
chain
M
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
123.94466
seq distance
False
chain
M
LDL-receptor class A
begin
78
end
115
score
100.0
distance
124.053825
seq distance
False
chain
N
LDL-receptor class A
begin
78
end
115
score
100.0
distance
124.053825
seq distance
False
chain
N
MACPF
begin
117
end
488
score
94.98411534701859
distance
124.744865
seq distance
False
chain
Q
MACPF
begin
117
end
488
score
94.98411534701859
distance
124.744865
seq distance
False
chain
Q
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
125.72023
seq distance
False
chain
N
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
125.72023
seq distance
False
chain
N
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
126.511765
seq distance
False
chain
O
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
126.511765
seq distance
False
chain
O
EGF-like
begin
489
end
519
score
100.0
distance
126.80526
seq distance
False
chain
N
EGF-like
begin
489
end
519
score
100.0
distance
126.80526
seq distance
False
chain
N
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
103
score
59.09090909090909
distance
128.52956
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
103
score
59.09090909090909
distance
128.52956
seq distance
False
chain
D
LDL-receptor class A
begin
151
end
170
score
51.590909090909086
distance
128.69588
seq distance
False
chain
B
LDL-receptor class A
begin
151
end
170
score
51.590909090909086
distance
128.69588
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
128.75957
seq distance
False
chain
N
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
128.75957
seq distance
False
chain
N
MACPF
begin
117
end
488
score
94.98411534701859
distance
128.98004
seq distance
False
chain
X
MACPF
begin
117
end
488
score
94.98411534701859
distance
128.98004
seq distance
False
chain
X
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
130.1011
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
130.1011
seq distance
False
chain
N
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
130.85876
seq distance
False
chain
N
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
130.85876
seq distance
False
chain
N
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
166
score
77.27272727272727
distance
131.57735
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
166
score
77.27272727272727
distance
131.57735
seq distance
False
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
131.88873
seq distance
False
chain
O
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
131.88873
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
133.79555
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
133.79555
seq distance
False
chain
O
MACPF
begin
117
end
488
score
94.98411534701859
distance
134.07037
seq distance
False
chain
R
MACPF
begin
117
end
488
score
94.98411534701859
distance
134.07037
seq distance
False
chain
R
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
158
score
63.63636363636363
distance
134.07452
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
158
score
63.63636363636363
distance
134.07452
seq distance
False
chain
B
MACPF
begin
117
end
488
score
94.98411534701859
distance
137.33923
seq distance
False
chain
W
MACPF
begin
117
end
488
score
94.98411534701859
distance
137.33923
seq distance
False
chain
W
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
138.09148
seq distance
False
chain
N
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
138.09148
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
138.26733
seq distance
False
chain
X
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
138.26733
seq distance
False
chain
X
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
138.63695
seq distance
False
chain
X
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
138.63695
seq distance
False
chain
X
LDL-receptor class A
begin
78
end
115
score
100.0
distance
139.88974
seq distance
False
chain
O
LDL-receptor class A
begin
78
end
115
score
100.0
distance
139.88974
seq distance
False
chain
O
EGF-like
begin
489
end
519
score
100.0
distance
140.38165
seq distance
False
chain
X
EGF-like
begin
489
end
519
score
100.0
distance
140.38165
seq distance
False
chain
X
MACPF
begin
117
end
488
score
94.98411534701859
distance
140.93944
seq distance
False
chain
S
MACPF
begin
117
end
488
score
94.98411534701859
distance
140.93944
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
141.15242
seq distance
False
chain
X
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
141.15242
seq distance
False
chain
X
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
141.4695
seq distance
False
chain
Q
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
141.4695
seq distance
False
chain
Q
EGF-like
begin
489
end
519
score
100.0
distance
141.84763
seq distance
False
chain
O
EGF-like
begin
489
end
519
score
100.0
distance
141.84763
seq distance
False
chain
O
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
142.0188
seq distance
False
chain
O
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
142.0188
seq distance
False
chain
O
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
142.62402
seq distance
False
chain
N
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
142.62402
seq distance
False
chain
N
MACPF
begin
117
end
488
score
94.98411534701859
distance
142.72029
seq distance
False
chain
V
MACPF
begin
117
end
488
score
94.98411534701859
distance
142.72029
seq distance
False
chain
V
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
143.35234
seq distance
False
chain
X
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
143.35234
seq distance
False
chain
X
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
143.42262
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
143.42262
seq distance
False
chain
O
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
143.86923
seq distance
False
chain
Q
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
143.86923
seq distance
False
chain
Q
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
144.63644
seq distance
False
chain
X
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
144.63644
seq distance
False
chain
X
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
144.76555
seq distance
False
chain
O
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
144.76555
seq distance
False
chain
O
MACPF
begin
117
end
488
score
94.98411534701859
distance
144.87112
seq distance
False
chain
T
MACPF
begin
117
end
488
score
94.98411534701859
distance
144.87112
seq distance
False
chain
T
MACPF
begin
117
end
488
score
94.98411534701859
distance
145.23799
seq distance
False
chain
U
MACPF
begin
117
end
488
score
94.98411534701859
distance
145.23799
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
145.67038
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
145.67038
seq distance
False
chain
Q
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
145.91837
seq distance
False
chain
O
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
145.91837
seq distance
False
chain
O
TSP type-1
begin
507
end
507
score
88.63636363636364
distance
146.7317
seq distance
False
chain
D
TSP type-1
begin
507
end
507
score
88.63636363636364
distance
146.7317
seq distance
False
chain
D
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
149.32697
seq distance
False
chain
W
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
149.32697
seq distance
False
chain
W
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
149.4277
seq distance
False
chain
W
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
149.4277
seq distance
False
chain
W
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
150.91869
seq distance
False
chain
O
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
150.91869
seq distance
False
chain
O
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
151.99745
seq distance
False
chain
X
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
151.99745
seq distance
False
chain
X
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
152.8792
seq distance
False
chain
W
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
152.8792
seq distance
False
chain
W
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
153.02997
seq distance
False
chain
R
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
153.02997
seq distance
False
chain
R
LDL-receptor class A
begin
78
end
115
score
100.0
distance
153.44498
seq distance
False
chain
Q
LDL-receptor class A
begin
78
end
115
score
100.0
distance
153.44498
seq distance
False
chain
Q
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
153.68802
seq distance
False
chain
R
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
153.68802
seq distance
False
chain
R
EGF-like
begin
489
end
519
score
100.0
distance
153.89772
seq distance
False
chain
Q
EGF-like
begin
489
end
519
score
100.0
distance
153.89772
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
154.14613
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
154.14613
seq distance
False
chain
Q
EGF-like
begin
489
end
519
score
100.0
distance
154.2378
seq distance
False
chain
W
EGF-like
begin
489
end
519
score
100.0
distance
154.2378
seq distance
False
chain
W
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
154.65198
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
154.65198
seq distance
False
chain
R
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
155.38972
seq distance
False
chain
Q
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
155.38972
seq distance
False
chain
Q
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
155.41965
seq distance
False
chain
W
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
155.41965
seq distance
False
chain
W
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
155.68271
seq distance
False
chain
X
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
155.68271
seq distance
False
chain
X
LDL-receptor class A
begin
78
end
115
score
100.0
distance
155.68271
seq distance
False
chain
X
LDL-receptor class A
begin
78
end
115
score
100.0
distance
155.68271
seq distance
False
chain
X
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
156.84686
seq distance
False
chain
V
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
156.84686
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
157.43959
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
157.43959
seq distance
False
chain
V
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
157.74341
seq distance
False
chain
X
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
157.74341
seq distance
False
chain
X
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
158.33319
seq distance
False
chain
Q
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
158.33319
seq distance
False
chain
Q
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
158.41449
seq distance
False
chain
Q
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
158.41449
seq distance
False
chain
Q
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
158.53134
seq distance
False
chain
O
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
158.53134
seq distance
False
chain
O
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
159.0905
seq distance
False
chain
S
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
159.0905
seq distance
False
chain
S
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
160.348
seq distance
False
chain
W
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
160.348
seq distance
False
chain
W
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
160.56314
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
160.56314
seq distance
False
chain
S
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
160.58936
seq distance
False
chain
Q
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
160.58936
seq distance
False
chain
Q
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
160.96198
seq distance
False
chain
U
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
160.96198
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
161.27023
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
161.27023
seq distance
False
chain
V
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
161.74509
seq distance
False
chain
T
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
161.74509
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
161.84328
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
161.84328
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
162.02544
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
162.02544
seq distance
False
chain
R
EGF-like
begin
489
end
519
score
100.0
distance
162.80223
seq distance
False
chain
R
EGF-like
begin
489
end
519
score
100.0
distance
162.80223
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
162.93852
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
162.93852
seq distance
False
chain
T
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
162.93962
seq distance
False
chain
S
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
162.93962
seq distance
False
chain
S
EGF-like
begin
489
end
519
score
100.0
distance
163.16916
seq distance
False
chain
V
EGF-like
begin
489
end
519
score
100.0
distance
163.16916
seq distance
False
chain
V
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
163.5852
seq distance
False
chain
W
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
163.5852
seq distance
False
chain
W
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
164.39468
seq distance
False
chain
V
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
164.39468
seq distance
False
chain
V
LDL-receptor class A
begin
78
end
115
score
100.0
distance
164.44373
seq distance
False
chain
R
LDL-receptor class A
begin
78
end
115
score
100.0
distance
164.44373
seq distance
False
chain
R
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
165.68338
seq distance
False
chain
W
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
165.68338
seq distance
False
chain
W
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
165.68936
seq distance
False
chain
R
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
165.68936
seq distance
False
chain
R
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
165.83673
seq distance
False
chain
X
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
165.83673
seq distance
False
chain
X
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
166.45879
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
166.45879
seq distance
False
chain
U
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
166.68369
seq distance
False
chain
W
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
166.68369
seq distance
False
chain
W
LDL-receptor class A
begin
78
end
115
score
100.0
distance
166.68369
seq distance
False
chain
W
LDL-receptor class A
begin
78
end
115
score
100.0
distance
166.68369
seq distance
False
chain
W
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
167.0215
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
167.0215
seq distance
False
chain
S
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
167.77141
seq distance
False
chain
R
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
167.77141
seq distance
False
chain
R
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
167.90134
seq distance
False
chain
R
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
167.90134
seq distance
False
chain
R
EGF-like
begin
489
end
519
score
100.0
distance
168.38972
seq distance
False
chain
S
EGF-like
begin
489
end
519
score
100.0
distance
168.38972
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
168.4633
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
168.4633
seq distance
False
chain
T
EGF-like
begin
489
end
519
score
100.0
distance
168.49115
seq distance
False
chain
U
EGF-like
begin
489
end
519
score
100.0
distance
168.49115
seq distance
False
chain
U
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
168.92215
seq distance
False
chain
T
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
168.92215
seq distance
False
chain
T
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
169.44252
seq distance
False
chain
R
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
169.44252
seq distance
False
chain
R
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
170.1498
seq distance
False
chain
U
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
170.1498
seq distance
False
chain
U
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
170.2819
seq distance
False
chain
V
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
170.2819
seq distance
False
chain
V
EGF-like
begin
489
end
519
score
100.0
distance
170.29813
seq distance
False
chain
T
EGF-like
begin
489
end
519
score
100.0
distance
170.29813
seq distance
False
chain
T
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
171.01385
seq distance
False
chain
Q
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
171.01385
seq distance
False
chain
Q
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
171.37906
seq distance
False
chain
V
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
171.37906
seq distance
False
chain
V
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
171.45813
seq distance
False
chain
U
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
171.45813
seq distance
False
chain
U
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
171.85687
seq distance
False
chain
S
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
171.85687
seq distance
False
chain
S
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
171.91327
seq distance
False
chain
V
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
171.91327
seq distance
False
chain
V
LDL-receptor class A
begin
78
end
115
score
100.0
distance
172.37082
seq distance
False
chain
S
LDL-receptor class A
begin
78
end
115
score
100.0
distance
172.37082
seq distance
False
chain
S
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
172.58604
seq distance
False
chain
S
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
172.58604
seq distance
False
chain
S
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
172.5991
seq distance
False
chain
T
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
172.5991
seq distance
False
chain
T
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
173.6772
seq distance
False
chain
V
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
173.6772
seq distance
False
chain
V
LDL-receptor class A
begin
78
end
115
score
100.0
distance
173.6772
seq distance
False
chain
V
LDL-receptor class A
begin
78
end
115
score
100.0
distance
173.6772
seq distance
False
chain
V
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
174.34253
seq distance
False
chain
S
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
174.34253
seq distance
False
chain
S
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
174.9039
seq distance
False
chain
W
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
174.9039
seq distance
False
chain
W
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
175.48872
seq distance
False
chain
U
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
175.48872
seq distance
False
chain
U
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
175.91847
seq distance
False
chain
T
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
175.91847
seq distance
False
chain
T
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
1290
score
50.0
distance
176.51001
seq distance
False
chain
A
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
1290
score
50.0
distance
176.51001
seq distance
False
chain
A
LDL-receptor class A
begin
78
end
115
score
100.0
distance
177.10579
seq distance
False
chain
T
LDL-receptor class A
begin
78
end
115
score
100.0
distance
177.10579
seq distance
False
chain
T
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
177.3551
seq distance
False
chain
U
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
177.3551
seq distance
False
chain
U
LDL-receptor class A
begin
78
end
115
score
100.0
distance
177.3551
seq distance
False
chain
U
LDL-receptor class A
begin
78
end
115
score
100.0
distance
177.3551
seq distance
False
chain
U
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
177.3688
seq distance
False
chain
S
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
177.3688
seq distance
False
chain
S
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
177.57324
seq distance
False
chain
T
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
177.57324
seq distance
False
chain
T
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
178.99449
seq distance
False
chain
R
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
178.99449
seq distance
False
chain
R
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
179.46268
seq distance
False
chain
U
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
179.46268
seq distance
False
chain
U
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
180.83762
seq distance
False
chain
V
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
180.83762
seq distance
False
chain
V
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
182.0618
seq distance
False
chain
T
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
182.0618
seq distance
False
chain
T
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
183.19768
seq distance
False
chain
S
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
183.19768
seq distance
False
chain
S
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
183.2865
seq distance
False
chain
U
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
183.2865
seq distance
False
chain
U
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
183.42274
seq distance
False
chain
T
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
183.42274
seq distance
False
chain
T
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
1067
score
54.54545454545454
distance
187.62285
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
1067
score
54.54545454545454
distance
187.62285
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
671
score
54.54545454545454
distance
209.46756
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
671
score
54.54545454545454
distance
209.46756
seq distance
False
chain
D
Details
Redox score
65.77
PDB code
6h04
Structure name
closed conformation of the membrane attack complex
Structure deposition date
2018-07-06
Thiol separation (Å)
8.91
Half-sphere exposure sum
58
Minimum pKa
nan
% buried
nan
Peptide accession
P02748
Residue number A
510 (Residue 489 in this structure)
Residue number B
528 (Residue 507 in this structure)
Peptide name
Complement component C9
6dlw B 22 B 489
A redox-regulated disulphide may form within Complement component C9 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.
Relevent regions
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
2.7846262
seq distance
0
chain
B
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
2.7846262
seq distance
0
chain
B
EGF-like
begin
489
end
519
score
99.12023460410556
distance
2.8099027
seq distance
0
chain
B
EGF-like
begin
489
end
519
score
99.12023460410556
distance
2.8099027
seq distance
0
chain
B
MACPF
begin
117
end
488
score
87.6099706744868
distance
5.324781
seq distance
1
chain
B
MACPF
begin
117
end
488
score
87.6099706744868
distance
5.324781
seq distance
1
chain
B
MACPF
begin
117
end
488
score
87.6099706744868
distance
10.989658
seq distance
False
chain
C
MACPF
begin
117
end
488
score
87.6099706744868
distance
10.989658
seq distance
False
chain
C
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
17.081184
seq distance
False
chain
A
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
17.081184
seq distance
False
chain
A
EGF-like
begin
489
end
519
score
99.12023460410556
distance
22.065994
seq distance
False
chain
C
EGF-like
begin
489
end
519
score
99.12023460410556
distance
22.065994
seq distance
False
chain
C
EGF-like
begin
489
end
519
score
99.12023460410556
distance
23.094166
seq distance
False
chain
A
EGF-like
begin
489
end
519
score
99.12023460410556
distance
23.094166
seq distance
False
chain
A
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
23.571278
seq distance
False
chain
C
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
23.571278
seq distance
False
chain
C
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
24.346357
seq distance
False
chain
C
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
24.346357
seq distance
False
chain
C
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
24.950724
seq distance
124
chain
B
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
24.950724
seq distance
124
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
26.60039
seq distance
84
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
26.60039
seq distance
84
chain
B
MACPF
begin
117
end
488
score
87.6099706744868
distance
28.420097
seq distance
False
chain
D
MACPF
begin
117
end
488
score
87.6099706744868
distance
28.420097
seq distance
False
chain
D
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
28.567259
seq distance
83
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
28.567259
seq distance
83
chain
B
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
29.598997
seq distance
False
chain
C
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
29.598997
seq distance
False
chain
C
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
30.691044
seq distance
False
chain
D
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
30.691044
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
31.529743
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
31.529743
seq distance
False
chain
C
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
31.97039
seq distance
False
chain
C
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
31.97039
seq distance
False
chain
C
MACPF
begin
117
end
488
score
87.6099706744868
distance
32.40407
seq distance
False
chain
A
MACPF
begin
117
end
488
score
87.6099706744868
distance
32.40407
seq distance
False
chain
A
LDL-receptor class A
begin
78
end
115
score
100.0
distance
34.890625
seq distance
False
chain
C
LDL-receptor class A
begin
78
end
115
score
100.0
distance
34.890625
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
39.66274
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
39.66274
seq distance
False
chain
A
LDL-receptor class A
begin
78
end
115
score
100.0
distance
41.247406
seq distance
56
chain
B
LDL-receptor class A
begin
78
end
115
score
100.0
distance
41.247406
seq distance
56
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
41.611153
seq distance
False
chain
C
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
41.611153
seq distance
False
chain
C
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
41.65068
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
41.65068
seq distance
False
chain
A
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
42.348022
seq distance
False
chain
A
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
42.348022
seq distance
False
chain
A
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
43.309395
seq distance
160
chain
B
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
43.309395
seq distance
160
chain
B
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
43.83167
seq distance
False
chain
D
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
43.83167
seq distance
False
chain
D
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
44.124504
seq distance
False
chain
V
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
44.124504
seq distance
False
chain
V
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
45.00965
seq distance
84
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
45.00965
seq distance
84
chain
B
LDL-receptor class A
begin
78
end
115
score
100.0
distance
45.345116
seq distance
False
chain
D
LDL-receptor class A
begin
78
end
115
score
100.0
distance
45.345116
seq distance
False
chain
D
MACPF
begin
117
end
488
score
87.6099706744868
distance
46.845108
seq distance
False
chain
E
MACPF
begin
117
end
488
score
87.6099706744868
distance
46.845108
seq distance
False
chain
E
EGF-like
begin
489
end
519
score
99.12023460410556
distance
47.120556
seq distance
False
chain
D
EGF-like
begin
489
end
519
score
99.12023460410556
distance
47.120556
seq distance
False
chain
D
EGF-like
begin
489
end
519
score
99.12023460410556
distance
47.358654
seq distance
False
chain
V
EGF-like
begin
489
end
519
score
99.12023460410556
distance
47.358654
seq distance
False
chain
V
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
47.37887
seq distance
False
chain
E
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
47.37887
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
47.506535
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
47.506535
seq distance
False
chain
C
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
47.837517
seq distance
False
chain
D
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
47.837517
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
48.664803
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
48.664803
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
52.431477
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
52.431477
seq distance
False
chain
D
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
52.556202
seq distance
False
chain
D
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
52.556202
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
53.32205
seq distance
227
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
53.32205
seq distance
227
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
53.799156
seq distance
False
chain
D
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
53.799156
seq distance
False
chain
D
MACPF
begin
117
end
488
score
87.6099706744868
distance
56.2717
seq distance
False
chain
V
MACPF
begin
117
end
488
score
87.6099706744868
distance
56.2717
seq distance
False
chain
V
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
56.493988
seq distance
76
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
56.493988
seq distance
76
chain
B
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
57.98016
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
57.98016
seq distance
False
chain
A
LDL-receptor class A
begin
78
end
115
score
100.0
distance
58.14995
seq distance
False
chain
A
LDL-receptor class A
begin
78
end
115
score
100.0
distance
58.14995
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
58.755314
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
58.755314
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
59.394924
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
59.394924
seq distance
False
chain
V
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
59.928272
seq distance
False
chain
A
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
59.928272
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
60.905434
seq distance
False
chain
V
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
60.905434
seq distance
False
chain
V
LDL-receptor class A
begin
78
end
115
score
100.0
distance
62.248924
seq distance
False
chain
E
LDL-receptor class A
begin
78
end
115
score
100.0
distance
62.248924
seq distance
False
chain
E
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
63.722008
seq distance
False
chain
A
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
63.722008
seq distance
False
chain
A
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
65.0712
seq distance
231
chain
B
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
65.0712
seq distance
231
chain
B
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
65.116295
seq distance
False
chain
V
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
65.116295
seq distance
False
chain
V
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
66.987305
seq distance
False
chain
A
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
66.987305
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
67.047455
seq distance
False
chain
E
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
67.047455
seq distance
False
chain
E
MACPF
begin
117
end
488
score
87.6099706744868
distance
67.236
seq distance
False
chain
F
MACPF
begin
117
end
488
score
87.6099706744868
distance
67.236
seq distance
False
chain
F
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
67.552765
seq distance
False
chain
E
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
67.552765
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
68.006065
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
68.006065
seq distance
False
chain
E
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
68.50451
seq distance
False
chain
E
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
68.50451
seq distance
False
chain
E
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
68.93144
seq distance
False
chain
F
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
68.93144
seq distance
False
chain
F
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
70.297035
seq distance
False
chain
U
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
70.297035
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
70.630585
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
70.630585
seq distance
False
chain
V
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
71.40234
seq distance
False
chain
C
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
71.40234
seq distance
False
chain
C
EGF-like
begin
489
end
519
score
99.12023460410556
distance
71.41228
seq distance
False
chain
U
EGF-like
begin
489
end
519
score
99.12023460410556
distance
71.41228
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
71.69252
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
71.69252
seq distance
False
chain
D
EGF-like
begin
489
end
519
score
99.12023460410556
distance
72.113594
seq distance
False
chain
E
EGF-like
begin
489
end
519
score
99.12023460410556
distance
72.113594
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
72.25352
seq distance
False
chain
A
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
72.25352
seq distance
False
chain
A
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
73.59627
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
73.59627
seq distance
False
chain
E
MACPF
begin
117
end
488
score
87.6099706744868
distance
75.44121
seq distance
False
chain
U
MACPF
begin
117
end
488
score
87.6099706744868
distance
75.44121
seq distance
False
chain
U
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
76.57965
seq distance
False
chain
V
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
76.57965
seq distance
False
chain
V
LDL-receptor class A
begin
78
end
115
score
100.0
distance
78.74069
seq distance
False
chain
V
LDL-receptor class A
begin
78
end
115
score
100.0
distance
78.74069
seq distance
False
chain
V
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
79.006905
seq distance
False
chain
V
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
79.006905
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
79.99595
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
79.99595
seq distance
False
chain
U
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
80.86753
seq distance
False
chain
E
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
80.86753
seq distance
False
chain
E
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
81.043175
seq distance
False
chain
U
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
81.043175
seq distance
False
chain
U
LDL-receptor class A
begin
78
end
115
score
100.0
distance
83.68613
seq distance
False
chain
F
LDL-receptor class A
begin
78
end
115
score
100.0
distance
83.68613
seq distance
False
chain
F
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
83.72975
seq distance
False
chain
D
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
83.72975
seq distance
False
chain
D
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
85.166245
seq distance
False
chain
V
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
85.166245
seq distance
False
chain
V
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
86.92589
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
86.92589
seq distance
False
chain
U
MACPF
begin
117
end
488
score
87.6099706744868
distance
87.14919
seq distance
False
chain
G
MACPF
begin
117
end
488
score
87.6099706744868
distance
87.14919
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
87.170425
seq distance
False
chain
F
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
87.170425
seq distance
False
chain
F
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
87.96543
seq distance
False
chain
F
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
87.96543
seq distance
False
chain
F
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
88.0868
seq distance
False
chain
U
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
88.0868
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
88.16241
seq distance
False
chain
E
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
88.16241
seq distance
False
chain
E
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
88.991295
seq distance
False
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
88.991295
seq distance
False
chain
F
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
90.621796
seq distance
False
chain
U
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
90.621796
seq distance
False
chain
U
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
90.87443
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
90.87443
seq distance
False
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
91.15032
seq distance
False
chain
F
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
91.15032
seq distance
False
chain
F
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
91.17449
seq distance
False
chain
V
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
91.17449
seq distance
False
chain
V
EGF-like
begin
489
end
519
score
99.12023460410556
distance
94.02495
seq distance
False
chain
T
EGF-like
begin
489
end
519
score
99.12023460410556
distance
94.02495
seq distance
False
chain
T
MACPF
begin
117
end
488
score
87.6099706744868
distance
94.36422
seq distance
False
chain
T
MACPF
begin
117
end
488
score
87.6099706744868
distance
94.36422
seq distance
False
chain
T
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
95.090096
seq distance
False
chain
T
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
95.090096
seq distance
False
chain
T
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
95.39198
seq distance
False
chain
F
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
95.39198
seq distance
False
chain
F
EGF-like
begin
489
end
519
score
99.12023460410556
distance
96.249886
seq distance
False
chain
F
EGF-like
begin
489
end
519
score
99.12023460410556
distance
96.249886
seq distance
False
chain
F
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
99.09749
seq distance
False
chain
E
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
99.09749
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
99.78287
seq distance
False
chain
U
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
99.78287
seq distance
False
chain
U
LDL-receptor class A
begin
78
end
115
score
100.0
distance
99.78287
seq distance
False
chain
U
LDL-receptor class A
begin
78
end
115
score
100.0
distance
99.78287
seq distance
False
chain
U
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
99.8077
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
99.8077
seq distance
False
chain
T
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
100.42377
seq distance
False
chain
T
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
100.42377
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
104.26687
seq distance
False
chain
T
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
104.26687
seq distance
False
chain
T
LDL-receptor class A
begin
78
end
115
score
100.0
distance
105.505
seq distance
False
chain
G
LDL-receptor class A
begin
78
end
115
score
100.0
distance
105.505
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
105.515114
seq distance
False
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
105.515114
seq distance
False
chain
F
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
105.76965
seq distance
False
chain
U
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
105.76965
seq distance
False
chain
U
MACPF
begin
117
end
488
score
87.6099706744868
distance
106.06972
seq distance
False
chain
H
MACPF
begin
117
end
488
score
87.6099706744868
distance
106.06972
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
106.52958
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
106.52958
seq distance
False
chain
G
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
106.57618
seq distance
False
chain
T
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
106.57618
seq distance
False
chain
T
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
107.015495
seq distance
False
chain
F
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
107.015495
seq distance
False
chain
F
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
108.57651
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
108.57651
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
108.7695
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
108.7695
seq distance
False
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
109.85643
seq distance
False
chain
T
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
109.85643
seq distance
False
chain
T
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
110.99246
seq distance
False
chain
U
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
110.99246
seq distance
False
chain
U
MACPF
begin
117
end
488
score
87.6099706744868
distance
111.485794
seq distance
False
chain
S
MACPF
begin
117
end
488
score
87.6099706744868
distance
111.485794
seq distance
False
chain
S
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
111.72146
seq distance
False
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
111.72146
seq distance
False
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
113.3665
seq distance
False
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
113.3665
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
99.12023460410556
distance
115.01199
seq distance
False
chain
S
EGF-like
begin
489
end
519
score
99.12023460410556
distance
115.01199
seq distance
False
chain
S
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
115.3047
seq distance
False
chain
F
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
115.3047
seq distance
False
chain
F
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
116.79245
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
116.79245
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
99.12023460410556
distance
117.10359
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
99.12023460410556
distance
117.10359
seq distance
False
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
117.96595
seq distance
False
chain
S
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
117.96595
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
118.00749
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
118.00749
seq distance
False
chain
S
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
118.21501
seq distance
False
chain
S
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
118.21501
seq distance
False
chain
S
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
120.13367
seq distance
False
chain
T
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
120.13367
seq distance
False
chain
T
LDL-receptor class A
begin
78
end
115
score
100.0
distance
120.13367
seq distance
False
chain
T
LDL-receptor class A
begin
78
end
115
score
100.0
distance
120.13367
seq distance
False
chain
T
MACPF
begin
117
end
488
score
87.6099706744868
distance
120.70523
seq distance
False
chain
I
MACPF
begin
117
end
488
score
87.6099706744868
distance
120.70523
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
121.10939
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
121.10939
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
122.309746
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
122.309746
seq distance
False
chain
G
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
122.67557
seq distance
False
chain
S
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
122.67557
seq distance
False
chain
S
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
124.15692
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
124.15692
seq distance
False
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
124.695526
seq distance
False
chain
T
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
124.695526
seq distance
False
chain
T
LDL-receptor class A
begin
78
end
115
score
100.0
distance
125.58884
seq distance
False
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
125.58884
seq distance
False
chain
H
MACPF
begin
117
end
488
score
87.6099706744868
distance
125.61119
seq distance
False
chain
R
MACPF
begin
117
end
488
score
87.6099706744868
distance
125.61119
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
126.220764
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
126.220764
seq distance
False
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
128.74736
seq distance
False
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
128.74736
seq distance
False
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
129.68198
seq distance
False
chain
S
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
129.68198
seq distance
False
chain
S
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
130.0521
seq distance
False
chain
T
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
130.0521
seq distance
False
chain
T
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
130.33557
seq distance
False
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
130.33557
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
130.67564
seq distance
False
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
130.67564
seq distance
False
chain
I
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
131.01508
seq distance
False
chain
G
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
131.01508
seq distance
False
chain
G
MACPF
begin
117
end
488
score
87.6099706744868
distance
132.66249
seq distance
False
chain
J
MACPF
begin
117
end
488
score
87.6099706744868
distance
132.66249
seq distance
False
chain
J
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
133.51787
seq distance
False
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
133.51787
seq distance
False
chain
H
EGF-like
begin
489
end
519
score
99.12023460410556
distance
133.8084
seq distance
False
chain
R
EGF-like
begin
489
end
519
score
99.12023460410556
distance
133.8084
seq distance
False
chain
R
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
133.87833
seq distance
False
chain
R
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
133.87833
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
134.05745
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
134.05745
seq distance
False
chain
R
EGF-like
begin
489
end
519
score
99.12023460410556
distance
135.01859
seq distance
False
chain
H
EGF-like
begin
489
end
519
score
99.12023460410556
distance
135.01859
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
136.49991
seq distance
False
chain
R
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
136.49991
seq distance
False
chain
R
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
136.65547
seq distance
False
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
136.65547
seq distance
False
chain
H
MACPF
begin
117
end
488
score
87.6099706744868
distance
137.5662
seq distance
False
chain
Q
MACPF
begin
117
end
488
score
87.6099706744868
distance
137.5662
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
137.60593
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
137.60593
seq distance
False
chain
H
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
137.76721
seq distance
False
chain
R
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
137.76721
seq distance
False
chain
R
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
138.44315
seq distance
False
chain
R
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
138.44315
seq distance
False
chain
R
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
138.93858
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
138.93858
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
138.94081
seq distance
False
chain
S
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
138.94081
seq distance
False
chain
S
LDL-receptor class A
begin
78
end
115
score
100.0
distance
138.94081
seq distance
False
chain
S
LDL-receptor class A
begin
78
end
115
score
100.0
distance
138.94081
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
141.04898
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
141.04898
seq distance
False
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
141.36671
seq distance
False
chain
S
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
141.36671
seq distance
False
chain
S
MACPF
begin
117
end
488
score
87.6099706744868
distance
141.90804
seq distance
False
chain
K
MACPF
begin
117
end
488
score
87.6099706744868
distance
141.90804
seq distance
False
chain
K
LDL-receptor class A
begin
78
end
115
score
100.0
distance
143.47473
seq distance
False
chain
I
LDL-receptor class A
begin
78
end
115
score
100.0
distance
143.47473
seq distance
False
chain
I
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
145.28955
seq distance
False
chain
H
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
145.28955
seq distance
False
chain
H
MACPF
begin
117
end
488
score
87.6099706744868
distance
146.35486
seq distance
False
chain
P
MACPF
begin
117
end
488
score
87.6099706744868
distance
146.35486
seq distance
False
chain
P
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
146.92406
seq distance
False
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
146.92406
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
147.00758
seq distance
False
chain
Q
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
147.00758
seq distance
False
chain
Q
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
147.05066
seq distance
False
chain
R
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
147.05066
seq distance
False
chain
R
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
147.23155
seq distance
False
chain
J
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
147.23155
seq distance
False
chain
J
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
147.38493
seq distance
False
chain
S
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
147.38493
seq distance
False
chain
S
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
147.55016
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
147.55016
seq distance
False
chain
Q
MACPF
begin
117
end
488
score
87.6099706744868
distance
148.58719
seq distance
False
chain
L
MACPF
begin
117
end
488
score
87.6099706744868
distance
148.58719
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
149.83075
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
149.83075
seq distance
False
chain
Q
EGF-like
begin
489
end
519
score
99.12023460410556
distance
149.98561
seq distance
False
chain
Q
EGF-like
begin
489
end
519
score
99.12023460410556
distance
149.98561
seq distance
False
chain
Q
EGF-like
begin
489
end
519
score
99.12023460410556
distance
150.11583
seq distance
False
chain
I
EGF-like
begin
489
end
519
score
99.12023460410556
distance
150.11583
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
150.7631
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
150.7631
seq distance
False
chain
I
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
150.82675
seq distance
False
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
150.82675
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
151.07135
seq distance
False
chain
J
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
151.07135
seq distance
False
chain
J
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
151.08182
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
151.08182
seq distance
False
chain
I
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
151.12344
seq distance
False
chain
Q
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
151.12344
seq distance
False
chain
Q
MACPF
begin
117
end
488
score
87.6099706744868
distance
151.8353
seq distance
False
chain
O
MACPF
begin
117
end
488
score
87.6099706744868
distance
151.8353
seq distance
False
chain
O
MACPF
begin
117
end
488
score
87.6099706744868
distance
152.53215
seq distance
False
chain
M
MACPF
begin
117
end
488
score
87.6099706744868
distance
152.53215
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
153.16315
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
153.16315
seq distance
False
chain
J
MACPF
begin
117
end
488
score
87.6099706744868
distance
153.6125
seq distance
False
chain
N
MACPF
begin
117
end
488
score
87.6099706744868
distance
153.6125
seq distance
False
chain
N
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
154.24493
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
154.24493
seq distance
False
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
155.3652
seq distance
False
chain
R
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
155.3652
seq distance
False
chain
R
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
155.51161
seq distance
False
chain
R
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
155.51161
seq distance
False
chain
R
LDL-receptor class A
begin
78
end
115
score
100.0
distance
155.51161
seq distance
False
chain
R
LDL-receptor class A
begin
78
end
115
score
100.0
distance
155.51161
seq distance
False
chain
R
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
156.11954
seq distance
False
chain
Q
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
156.11954
seq distance
False
chain
Q
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
157.28639
seq distance
False
chain
P
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
157.28639
seq distance
False
chain
P
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
157.47202
seq distance
False
chain
I
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
157.47202
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
158.1693
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
158.1693
seq distance
False
chain
P
LDL-receptor class A
begin
78
end
115
score
100.0
distance
158.80498
seq distance
False
chain
J
LDL-receptor class A
begin
78
end
115
score
100.0
distance
158.80498
seq distance
False
chain
J
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
160.24442
seq distance
False
chain
K
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
160.24442
seq distance
False
chain
K
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
160.25574
seq distance
False
chain
K
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
160.25574
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
160.6631
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
160.6631
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
161.38951
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
161.38951
seq distance
False
chain
J
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
161.55193
seq distance
False
chain
Q
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
161.55193
seq distance
False
chain
Q
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
162.22202
seq distance
False
chain
P
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
162.22202
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
162.2567
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
162.2567
seq distance
False
chain
K
EGF-like
begin
489
end
519
score
99.12023460410556
distance
162.26634
seq distance
False
chain
J
EGF-like
begin
489
end
519
score
99.12023460410556
distance
162.26634
seq distance
False
chain
J
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
162.36118
seq distance
False
chain
R
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
162.36118
seq distance
False
chain
R
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
162.67274
seq distance
False
chain
J
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
162.67274
seq distance
False
chain
J
EGF-like
begin
489
end
519
score
99.12023460410556
distance
163.18488
seq distance
False
chain
P
EGF-like
begin
489
end
519
score
99.12023460410556
distance
163.18488
seq distance
False
chain
P
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
164.47743
seq distance
False
chain
O
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
164.47743
seq distance
False
chain
O
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
165.11984
seq distance
False
chain
J
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
165.11984
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
165.66841
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
165.66841
seq distance
False
chain
O
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
166.2674
seq distance
False
chain
L
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
166.2674
seq distance
False
chain
L
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
166.34615
seq distance
False
chain
Q
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
166.34615
seq distance
False
chain
Q
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
166.94357
seq distance
False
chain
I
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
166.94357
seq distance
False
chain
I
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
167.16759
seq distance
False
chain
J
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
167.16759
seq distance
False
chain
J
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
168.14589
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
168.14589
seq distance
False
chain
L
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
168.40848
seq distance
False
chain
N
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
168.40848
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
168.66716
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
168.66716
seq distance
False
chain
O
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
169.01752
seq distance
False
chain
M
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
169.01752
seq distance
False
chain
M
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
169.0634
seq distance
False
chain
J
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
169.0634
seq distance
False
chain
J
LDL-receptor class A
begin
78
end
115
score
100.0
distance
169.11627
seq distance
False
chain
Q
LDL-receptor class A
begin
78
end
115
score
100.0
distance
169.11627
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
169.13972
seq distance
False
chain
K
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
169.13972
seq distance
False
chain
K
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
169.32965
seq distance
False
chain
Q
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
169.32965
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
169.87239
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
169.87239
seq distance
False
chain
N
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
169.91083
seq distance
False
chain
L
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
169.91083
seq distance
False
chain
L
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
170.62823
seq distance
False
chain
P
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
170.62823
seq distance
False
chain
P
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
170.6738
seq distance
False
chain
O
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
170.6738
seq distance
False
chain
O
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
170.7118
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
170.7118
seq distance
False
chain
M
LDL-receptor class A
begin
78
end
115
score
100.0
distance
171.16437
seq distance
False
chain
K
LDL-receptor class A
begin
78
end
115
score
100.0
distance
171.16437
seq distance
False
chain
K
EGF-like
begin
489
end
519
score
99.12023460410556
distance
171.17274
seq distance
False
chain
K
EGF-like
begin
489
end
519
score
99.12023460410556
distance
171.17274
seq distance
False
chain
K
EGF-like
begin
489
end
519
score
99.12023460410556
distance
171.85637
seq distance
False
chain
O
EGF-like
begin
489
end
519
score
99.12023460410556
distance
171.85637
seq distance
False
chain
O
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
172.85115
seq distance
False
chain
P
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
172.85115
seq distance
False
chain
P
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
173.5882
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
173.5882
seq distance
False
chain
N
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
173.817
seq distance
False
chain
L
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
173.817
seq distance
False
chain
L
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
174.02945
seq distance
False
chain
K
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
174.02945
seq distance
False
chain
K
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
174.05544
seq distance
False
chain
P
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
174.05544
seq distance
False
chain
P
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
174.50183
seq distance
False
chain
Q
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
174.50183
seq distance
False
chain
Q
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
175.33536
seq distance
False
chain
M
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
262
score
100.0
distance
175.33536
seq distance
False
chain
M
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
175.44507
seq distance
False
chain
K
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
175.44507
seq distance
False
chain
K
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
175.49823
seq distance
False
chain
K
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
175.49823
seq distance
False
chain
K
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
176.17953
seq distance
False
chain
N
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
176.17953
seq distance
False
chain
N
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
176.22487
seq distance
False
chain
M
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
176.22487
seq distance
False
chain
M
EGF-like
begin
489
end
519
score
99.12023460410556
distance
176.66191
seq distance
False
chain
L
EGF-like
begin
489
end
519
score
99.12023460410556
distance
176.66191
seq distance
False
chain
L
EGF-like
begin
489
end
519
score
99.12023460410556
distance
177.0121
seq distance
False
chain
N
EGF-like
begin
489
end
519
score
99.12023460410556
distance
177.0121
seq distance
False
chain
N
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
177.86832
seq distance
False
chain
L
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
177.86832
seq distance
False
chain
L
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
178.31696
seq distance
False
chain
O
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
178.31696
seq distance
False
chain
O
LDL-receptor class A
begin
78
end
115
score
100.0
distance
178.53712
seq distance
False
chain
P
LDL-receptor class A
begin
78
end
115
score
100.0
distance
178.53712
seq distance
False
chain
P
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
178.61632
seq distance
False
chain
M
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
258
score
100.0
distance
178.61632
seq distance
False
chain
M
EGF-like
begin
489
end
519
score
99.12023460410556
distance
178.63397
seq distance
False
chain
M
EGF-like
begin
489
end
519
score
99.12023460410556
distance
178.63397
seq distance
False
chain
M
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
179.03496
seq distance
False
chain
N
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
179.03496
seq distance
False
chain
N
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
179.18866
seq distance
False
chain
J
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
179.18866
seq distance
False
chain
J
LDL-receptor class A
begin
78
end
115
score
100.0
distance
179.51486
seq distance
False
chain
L
LDL-receptor class A
begin
78
end
115
score
100.0
distance
179.51486
seq distance
False
chain
L
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
180.00957
seq distance
False
chain
P
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
180.00957
seq distance
False
chain
P
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
180.13725
seq distance
False
chain
K
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
180.13725
seq distance
False
chain
K
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
180.70044
seq distance
False
chain
O
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
180.70044
seq distance
False
chain
O
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
181.66371
seq distance
False
chain
O
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
181.66371
seq distance
False
chain
O
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
182.27376
seq distance
False
chain
L
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
182.27376
seq distance
False
chain
L
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
183.4577
seq distance
False
chain
P
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
183.4577
seq distance
False
chain
P
LDL-receptor class A
begin
78
end
115
score
100.0
distance
184.00801
seq distance
False
chain
O
LDL-receptor class A
begin
78
end
115
score
100.0
distance
184.00801
seq distance
False
chain
O
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
184.18925
seq distance
False
chain
L
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
184.18925
seq distance
False
chain
L
LDL-receptor class A
begin
78
end
115
score
100.0
distance
184.50171
seq distance
False
chain
M
LDL-receptor class A
begin
78
end
115
score
100.0
distance
184.50171
seq distance
False
chain
M
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
184.92877
seq distance
False
chain
N
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
184.92877
seq distance
False
chain
N
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
185.4605
seq distance
False
chain
M
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
185.4605
seq distance
False
chain
M
LDL-receptor class A
begin
78
end
115
score
100.0
distance
186.00867
seq distance
False
chain
N
LDL-receptor class A
begin
78
end
115
score
100.0
distance
186.00867
seq distance
False
chain
N
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
187.27876
seq distance
False
chain
O
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
187.27876
seq distance
False
chain
O
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
187.35985
seq distance
False
chain
L
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
187.35985
seq distance
False
chain
L
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
187.73259
seq distance
False
chain
K
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
187.73259
seq distance
False
chain
K
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
188.98946
seq distance
False
chain
O
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
188.98946
seq distance
False
chain
O
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
188.99649
seq distance
False
chain
N
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
188.99649
seq distance
False
chain
N
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
189.35837
seq distance
False
chain
M
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
189.35837
seq distance
False
chain
M
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
190.967
seq distance
False
chain
N
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
190.967
seq distance
False
chain
N
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
190.96889
seq distance
False
chain
N
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
190.96889
seq distance
False
chain
N
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
190.99536
seq distance
False
chain
M
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
190.99536
seq distance
False
chain
M
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
192.05511
seq distance
False
chain
L
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
192.05511
seq distance
False
chain
L
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
192.48439
seq distance
False
chain
M
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
192.48439
seq distance
False
chain
M
Details
Redox score
65.43
PDB code
6dlw
Structure name
complement component polyc9
Structure deposition date
2018-06-03
Thiol separation (Å)
9.42
Half-sphere exposure sum
57
Minimum pKa
nan
% buried
nan
Peptide accession
P02748
Residue number A
43 (Residue 22 in this structure)
Residue number B
510 (Residue 489 in this structure)
Peptide name
Complement component C9
7nyc H 86 H 91
A redox-regulated disulphide may form within Complement component C9 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.
Relevent regions
LDL-receptor class A
begin
78
end
115
score
100.0
distance
2.751439
seq distance
0
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
2.751439
seq distance
0
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
5.6276116
seq distance
15
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
5.6276116
seq distance
15
chain
H
MACPF
begin
133
end
488
score
72.36338100102144
distance
6.8626194
seq distance
42
chain
H
MACPF
begin
133
end
488
score
72.36338100102144
distance
6.8626194
seq distance
42
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
11.551398
seq distance
7
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
11.551398
seq distance
7
chain
H
LDL-receptor class A
begin
80
end
115
score
98.48484848484848
distance
13.593026
seq distance
False
chain
I
LDL-receptor class A
begin
80
end
115
score
98.48484848484848
distance
13.593026
seq distance
False
chain
I
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
14.343694
seq distance
False
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
14.343694
seq distance
False
chain
G
MACPF
begin
133
end
488
score
69.38840653728295
distance
17.998968
seq distance
False
chain
G
MACPF
begin
133
end
488
score
69.38840653728295
distance
17.998968
seq distance
False
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
18.084942
seq distance
12
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
18.084942
seq distance
12
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
18.78693
seq distance
False
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
18.78693
seq distance
False
chain
I
MACPF
begin
186
end
481
score
65.83230958230959
distance
20.55313
seq distance
False
chain
I
MACPF
begin
186
end
481
score
65.83230958230959
distance
20.55313
seq distance
False
chain
I
LDL-receptor class A
begin
78
end
115
score
100.0
distance
20.938541
seq distance
False
chain
G
LDL-receptor class A
begin
78
end
115
score
100.0
distance
20.938541
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
22.123981
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
22.123981
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
26.27538
seq distance
False
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
26.27538
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
27.179222
seq distance
55
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
27.179222
seq distance
55
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
29.048132
seq distance
91
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
29.048132
seq distance
91
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
29.873598
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
29.873598
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
33.104786
seq distance
False
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
33.104786
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
98.24046920821115
distance
33.92406
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
98.24046920821115
distance
33.92406
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
34.390938
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
34.390938
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
98.24046920821115
distance
39.468407
seq distance
398
chain
H
EGF-like
begin
489
end
519
score
98.24046920821115
distance
39.468407
seq distance
398
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
41.419586
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
41.419586
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
93
score
77.27272727272727
distance
43.010742
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
93
score
77.27272727272727
distance
43.010742
seq distance
False
chain
E
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
46.92606
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
46.92606
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
47.40097
seq distance
315
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
47.40097
seq distance
315
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
49.981857
seq distance
314
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
49.981857
seq distance
314
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
50.230118
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
50.230118
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
52.105606
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
52.105606
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
85
score
72.72727272727273
distance
53.350105
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
85
score
72.72727272727273
distance
53.350105
seq distance
False
chain
E
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
54.57875
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
54.57875
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
57.741398
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
57.741398
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
391
score
68.18181818181817
distance
61.40509
seq distance
False
chain
E
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
391
score
68.18181818181817
distance
61.40509
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
94
score
81.81818181818183
distance
62.755493
seq distance
False
chain
D
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
94
score
81.81818181818183
distance
62.755493
seq distance
False
chain
D
LDL-receptor class A
begin
83
end
96
score
70.12987012987013
distance
62.755493
seq distance
False
chain
D
LDL-receptor class A
begin
83
end
96
score
70.12987012987013
distance
62.755493
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
86
score
72.72727272727273
distance
69.126526
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
86
score
72.72727272727273
distance
69.126526
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
370
score
68.18181818181817
distance
77.25327
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
370
score
68.18181818181817
distance
77.25327
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
81
score
59.09090909090909
distance
81.854256
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
81
score
59.09090909090909
distance
81.854256
seq distance
False
chain
C
LDL-receptor class A
begin
130
end
149
score
51.590909090909086
distance
86.09413
seq distance
False
chain
B
LDL-receptor class A
begin
130
end
149
score
51.590909090909086
distance
86.09413
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
137
score
63.63636363636363
distance
89.54096
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
137
score
63.63636363636363
distance
89.54096
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
145
score
77.27272727272727
distance
90.01168
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
145
score
77.27272727272727
distance
90.01168
seq distance
False
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
421
score
68.18181818181817
distance
100.52129
seq distance
False
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
421
score
68.18181818181817
distance
100.52129
seq distance
False
chain
B
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
1272
score
50.0
distance
138.0466
seq distance
False
chain
A
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
1272
score
50.0
distance
138.0466
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
649
score
54.54545454545454
distance
151.48956
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
649
score
54.54545454545454
distance
151.48956
seq distance
False
chain
C
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
1049
score
54.54545454545454
distance
155.04918
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
1049
score
54.54545454545454
distance
155.04918
seq distance
False
chain
A
Details
Redox score
65.24
PDB code
7nyc
Structure name
cryoem structure of 3c9-smac
Structure deposition date
2021-03-22
Thiol separation (Å)
8.69
Half-sphere exposure sum
60
Minimum pKa
nan
% buried
nan
Peptide accession
P02748
Residue number A
107 (Residue 86 in this structure)
Residue number B
112 (Residue 91 in this structure)
Peptide name
Complement component C9
7nyc I 80 I 104
A redox-regulated disulphide may form within Complement component C9 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.
Relevent regions
LDL-receptor class A
begin
80
end
115
score
98.48484848484848
distance
2.7966835
seq distance
0
chain
I
LDL-receptor class A
begin
80
end
115
score
98.48484848484848
distance
2.7966835
seq distance
0
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
7.533664
seq distance
2
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
7.533664
seq distance
2
chain
I
MACPF
begin
186
end
481
score
65.83230958230959
distance
9.135743
seq distance
82
chain
I
MACPF
begin
186
end
481
score
65.83230958230959
distance
9.135743
seq distance
82
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
12.138656
seq distance
6
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
12.138656
seq distance
6
chain
I
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
16.390522
seq distance
False
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
16.390522
seq distance
False
chain
H
MACPF
begin
133
end
488
score
72.36338100102144
distance
19.099207
seq distance
False
chain
H
MACPF
begin
133
end
488
score
72.36338100102144
distance
19.099207
seq distance
False
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
19.8645
seq distance
False
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
19.8645
seq distance
False
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
22.71228
seq distance
False
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
22.71228
seq distance
False
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
24.552258
seq distance
42
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
24.552258
seq distance
42
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
30.199549
seq distance
78
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
30.199549
seq distance
78
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
32.939518
seq distance
False
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
32.939518
seq distance
False
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
34.335213
seq distance
False
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
34.335213
seq distance
False
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
36.462547
seq distance
False
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
36.462547
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
98.24046920821115
distance
37.34171
seq distance
False
chain
H
EGF-like
begin
489
end
519
score
98.24046920821115
distance
37.34171
seq distance
False
chain
H
MACPF
begin
133
end
488
score
69.38840653728295
distance
44.522797
seq distance
False
chain
G
MACPF
begin
133
end
488
score
69.38840653728295
distance
44.522797
seq distance
False
chain
G
LDL-receptor class A
begin
78
end
115
score
100.0
distance
45.569782
seq distance
False
chain
G
LDL-receptor class A
begin
78
end
115
score
100.0
distance
45.569782
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
45.65565
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
45.65565
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
46.134464
seq distance
False
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
46.134464
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
46.23545
seq distance
302
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
46.23545
seq distance
302
chain
I
EGF-like
begin
489
end
519
score
98.24046920821115
distance
48.47856
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
98.24046920821115
distance
48.47856
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
49.502377
seq distance
301
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
49.502377
seq distance
301
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
49.90485
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
49.90485
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
51.720097
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
51.720097
seq distance
False
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
52.691086
seq distance
False
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
52.691086
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
57.47498
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
57.47498
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
61.370026
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
61.370026
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
62.594894
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
62.594894
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
67.360756
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
67.360756
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
93
score
77.27272727272727
distance
67.386826
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
93
score
77.27272727272727
distance
67.386826
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
85
score
72.72727272727273
distance
76.55007
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
85
score
72.72727272727273
distance
76.55007
seq distance
False
chain
E
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
391
score
68.18181818181817
distance
76.68261
seq distance
False
chain
E
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
391
score
68.18181818181817
distance
76.68261
seq distance
False
chain
E
LDL-receptor class A
begin
83
end
96
score
70.12987012987013
distance
84.893425
seq distance
False
chain
D
LDL-receptor class A
begin
83
end
96
score
70.12987012987013
distance
84.893425
seq distance
False
chain
D
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
94
score
81.81818181818183
distance
85.047806
seq distance
False
chain
D
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
94
score
81.81818181818183
distance
85.047806
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
86
score
72.72727272727273
distance
89.63086
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
86
score
72.72727272727273
distance
89.63086
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
370
score
68.18181818181817
distance
93.401634
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
370
score
68.18181818181817
distance
93.401634
seq distance
False
chain
D
LDL-receptor class A
begin
130
end
149
score
51.590909090909086
distance
99.13247
seq distance
False
chain
B
LDL-receptor class A
begin
130
end
149
score
51.590909090909086
distance
99.13247
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
81
score
59.09090909090909
distance
99.55995
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
81
score
59.09090909090909
distance
99.55995
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
137
score
63.63636363636363
distance
102.65761
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
137
score
63.63636363636363
distance
102.65761
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
145
score
77.27272727272727
distance
105.37959
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
145
score
77.27272727272727
distance
105.37959
seq distance
False
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
421
score
68.18181818181817
distance
112.11399
seq distance
False
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
421
score
68.18181818181817
distance
112.11399
seq distance
False
chain
B
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
1272
score
50.0
distance
152.79321
seq distance
False
chain
A
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
1272
score
50.0
distance
152.79321
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
1049
score
54.54545454545454
distance
167.95058
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
1049
score
54.54545454545454
distance
167.95058
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
649
score
54.54545454545454
distance
171.32246
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
649
score
54.54545454545454
distance
171.32246
seq distance
False
chain
C
Details
Redox score
64.54
PDB code
7nyc
Structure name
cryoem structure of 3c9-smac
Structure deposition date
2021-03-22
Thiol separation (Å)
9.48
Half-sphere exposure sum
50
Minimum pKa
nan
% buried
nan
Peptide accession
P02748
Residue number A
101 (Residue 80 in this structure)
Residue number B
125 (Residue 104 in this structure)
Peptide name
Complement component C9
6cxo A 21 A 509
A redox-regulated disulphide may form within Complement component C9 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.
Relevent regions
TSP type-1
begin
21
end
58
score
67.82296650717703
distance
2.7989113
seq distance
0
chain
A
TSP type-1
begin
21
end
58
score
67.82296650717703
distance
2.7989113
seq distance
0
chain
A
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
105
score
81.81818181818183
distance
15.230898
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
105
score
81.81818181818183
distance
15.230898
seq distance
False
chain
B
LDL-receptor class A
begin
82
end
108
score
72.47474747474747
distance
15.230898
seq distance
False
chain
B
LDL-receptor class A
begin
82
end
108
score
72.47474747474747
distance
15.230898
seq distance
False
chain
B
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
145
score
86.36363636363636
distance
22.094934
seq distance
124
chain
A
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
145
score
86.36363636363636
distance
22.094934
seq distance
124
chain
A
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
97
score
81.81818181818183
distance
22.604965
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
97
score
81.81818181818183
distance
22.604965
seq distance
False
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
409
score
90.9090909090909
distance
24.476908
seq distance
100
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
409
score
90.9090909090909
distance
24.476908
seq distance
100
chain
A
TSP type-1
begin
21
end
58
score
67.82296650717703
distance
29.991781
seq distance
False
chain
B
TSP type-1
begin
21
end
58
score
67.82296650717703
distance
29.991781
seq distance
False
chain
B
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
145
score
86.36363636363636
distance
30.607042
seq distance
False
chain
B
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
145
score
86.36363636363636
distance
30.607042
seq distance
False
chain
B
LDL-receptor class A
begin
80
end
112
score
69.76584022038567
distance
38.32056
seq distance
59
chain
A
LDL-receptor class A
begin
80
end
112
score
69.76584022038567
distance
38.32056
seq distance
59
chain
A
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
179
score
86.36363636363636
distance
39.476765
seq distance
False
chain
B
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
179
score
86.36363636363636
distance
39.476765
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
105
score
81.81818181818183
distance
39.966145
seq distance
84
chain
A
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
105
score
81.81818181818183
distance
39.966145
seq distance
84
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
409
score
90.9090909090909
distance
41.90703
seq distance
False
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
409
score
90.9090909090909
distance
41.90703
seq distance
False
chain
B
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
179
score
86.36363636363636
distance
43.05663
seq distance
158
chain
A
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
179
score
86.36363636363636
distance
43.05663
seq distance
158
chain
A
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
97
score
81.81818181818183
distance
52.739418
seq distance
76
chain
A
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
97
score
81.81818181818183
distance
52.739418
seq distance
76
chain
A
Details
Redox score
63.54
PDB code
6cxo
Structure name
complement component-9
Structure deposition date
2018-04-03
Thiol separation (Å)
9.43
Half-sphere exposure sum
71
Minimum pKa
nan
% buried
nan
Peptide accession
P06683
Residue number A
41 (Residue 21 in this structure)
Residue number B
529 (Residue 509 in this structure)
Peptide name
Complement component C9
7nyc H 505 H 507
A redox-regulated disulphide may form within Complement component C9 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.
Relevent regions
EGF-like
begin
489
end
519
score
98.24046920821115
distance
2.815814
seq distance
0
chain
H
EGF-like
begin
489
end
519
score
98.24046920821115
distance
2.815814
seq distance
0
chain
H
MACPF
begin
133
end
488
score
72.36338100102144
distance
4.9102325
seq distance
17
chain
H
MACPF
begin
133
end
488
score
72.36338100102144
distance
4.9102325
seq distance
17
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
6.049589
seq distance
431
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
6.049589
seq distance
431
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
15.462925
seq distance
False
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
15.462925
seq distance
False
chain
G
MACPF
begin
186
end
481
score
65.83230958230959
distance
15.6647625
seq distance
False
chain
I
MACPF
begin
186
end
481
score
65.83230958230959
distance
15.6647625
seq distance
False
chain
I
EGF-like
begin
489
end
519
score
98.24046920821115
distance
17.420336
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
98.24046920821115
distance
17.420336
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
21.381336
seq distance
100
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
21.381336
seq distance
100
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
22.785185
seq distance
359
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
22.785185
seq distance
359
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
24.198992
seq distance
99
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
24.198992
seq distance
99
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
26.883053
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
26.883053
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
27.850908
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
27.850908
seq distance
False
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
27.92542
seq distance
False
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
27.92542
seq distance
False
chain
I
MACPF
begin
133
end
488
score
69.38840653728295
distance
31.450773
seq distance
False
chain
G
MACPF
begin
133
end
488
score
69.38840653728295
distance
31.450773
seq distance
False
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
33.131287
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
33.131287
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
35.44745
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
35.44745
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
37.91118
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
37.91118
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
40.63408
seq distance
323
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
40.63408
seq distance
323
chain
H
LDL-receptor class A
begin
80
end
115
score
98.48484848484848
distance
41.63665
seq distance
False
chain
I
LDL-receptor class A
begin
80
end
115
score
98.48484848484848
distance
41.63665
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
41.86389
seq distance
False
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
41.86389
seq distance
False
chain
G
LDL-receptor class A
begin
78
end
115
score
100.0
distance
42.165764
seq distance
390
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
42.165764
seq distance
390
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
45.118896
seq distance
399
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
45.118896
seq distance
399
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
47.09703
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
47.09703
seq distance
False
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
50.67975
seq distance
False
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
50.67975
seq distance
False
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
55.36053
seq distance
407
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
55.36053
seq distance
407
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
55.881023
seq distance
False
chain
G
LDL-receptor class A
begin
78
end
115
score
100.0
distance
55.881023
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
56.366585
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
56.366585
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
391
score
68.18181818181817
distance
56.753155
seq distance
False
chain
E
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
391
score
68.18181818181817
distance
56.753155
seq distance
False
chain
E
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
60.513996
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
60.513996
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
69.96788
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
69.96788
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
93
score
77.27272727272727
distance
72.309135
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
93
score
77.27272727272727
distance
72.309135
seq distance
False
chain
E
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
370
score
68.18181818181817
distance
74.8886
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
370
score
68.18181818181817
distance
74.8886
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
85
score
72.72727272727273
distance
83.968735
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
85
score
72.72727272727273
distance
83.968735
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
94
score
81.81818181818183
distance
88.0328
seq distance
False
chain
D
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
94
score
81.81818181818183
distance
88.0328
seq distance
False
chain
D
LDL-receptor class A
begin
83
end
96
score
70.12987012987013
distance
88.0328
seq distance
False
chain
D
LDL-receptor class A
begin
83
end
96
score
70.12987012987013
distance
88.0328
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
86
score
72.72727272727273
distance
97.70722
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
86
score
72.72727272727273
distance
97.70722
seq distance
False
chain
D
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
421
score
68.18181818181817
distance
103.82901
seq distance
False
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
421
score
68.18181818181817
distance
103.82901
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
81
score
59.09090909090909
distance
108.60754
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
81
score
59.09090909090909
distance
108.60754
seq distance
False
chain
C
LDL-receptor class A
begin
130
end
149
score
51.590909090909086
distance
110.118866
seq distance
False
chain
B
LDL-receptor class A
begin
130
end
149
score
51.590909090909086
distance
110.118866
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
145
score
77.27272727272727
distance
114.20771
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
145
score
77.27272727272727
distance
114.20771
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
137
score
63.63636363636363
distance
116.37984
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
137
score
63.63636363636363
distance
116.37984
seq distance
False
chain
B
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
1272
score
50.0
distance
157.24936
seq distance
False
chain
A
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
1272
score
50.0
distance
157.24936
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
1049
score
54.54545454545454
distance
170.67668
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
1049
score
54.54545454545454
distance
170.67668
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
649
score
54.54545454545454
distance
183.42747
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
649
score
54.54545454545454
distance
183.42747
seq distance
False
chain
C
Details
Redox score
62.75
PDB code
7nyc
Structure name
cryoem structure of 3c9-smac
Structure deposition date
2021-03-22
Thiol separation (Å)
9.85
Half-sphere exposure sum
65
Minimum pKa
nan
% buried
nan
Peptide accession
P02748
Residue number A
526 (Residue 505 in this structure)
Residue number B
528 (Residue 507 in this structure)
Peptide name
Complement component C9
7nyc H 91 H 104
A redox-regulated disulphide may form within Complement component C9 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.
Relevent regions
LDL-receptor class A
begin
78
end
115
score
100.0
distance
2.7661545
seq distance
0
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
2.7661545
seq distance
0
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
5.652229
seq distance
2
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
5.652229
seq distance
2
chain
H
MACPF
begin
133
end
488
score
72.36338100102144
distance
6.8626194
seq distance
29
chain
H
MACPF
begin
133
end
488
score
72.36338100102144
distance
6.8626194
seq distance
29
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
9.590315
seq distance
6
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
9.590315
seq distance
6
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
14.343694
seq distance
False
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
14.343694
seq distance
False
chain
G
LDL-receptor class A
begin
80
end
115
score
98.48484848484848
distance
14.568359
seq distance
False
chain
I
LDL-receptor class A
begin
80
end
115
score
98.48484848484848
distance
14.568359
seq distance
False
chain
I
MACPF
begin
133
end
488
score
69.38840653728295
distance
17.998968
seq distance
False
chain
G
MACPF
begin
133
end
488
score
69.38840653728295
distance
17.998968
seq distance
False
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
18.084942
seq distance
17
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
18.084942
seq distance
17
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
19.266832
seq distance
False
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
19.266832
seq distance
False
chain
I
LDL-receptor class A
begin
78
end
115
score
100.0
distance
20.425253
seq distance
False
chain
G
LDL-receptor class A
begin
78
end
115
score
100.0
distance
20.425253
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
20.439981
seq distance
False
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
20.439981
seq distance
False
chain
G
MACPF
begin
186
end
481
score
65.83230958230959
distance
22.25232
seq distance
False
chain
I
MACPF
begin
186
end
481
score
65.83230958230959
distance
22.25232
seq distance
False
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
26.813581
seq distance
False
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
26.813581
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
27.9162
seq distance
42
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
27.9162
seq distance
42
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
28.400032
seq distance
78
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
28.400032
seq distance
78
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
30.73211
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
30.73211
seq distance
False
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
32.529865
seq distance
False
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
32.529865
seq distance
False
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
33.104786
seq distance
False
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
33.104786
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
98.24046920821115
distance
33.92406
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
98.24046920821115
distance
33.92406
seq distance
False
chain
G
EGF-like
begin
489
end
519
score
98.24046920821115
distance
39.630013
seq distance
385
chain
H
EGF-like
begin
489
end
519
score
98.24046920821115
distance
39.630013
seq distance
385
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
93
score
77.27272727272727
distance
42.07668
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
93
score
77.27272727272727
distance
42.07668
seq distance
False
chain
E
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
42.582447
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
42.582447
seq distance
False
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
45.679996
seq distance
False
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
45.679996
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
47.751266
seq distance
302
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
47.751266
seq distance
302
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
49.957554
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
49.957554
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
50.440414
seq distance
301
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
50.440414
seq distance
301
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
85
score
72.72727272727273
distance
51.522064
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
85
score
72.72727272727273
distance
51.522064
seq distance
False
chain
E
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
51.95904
seq distance
False
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
51.95904
seq distance
False
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
55.31476
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
55.31476
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
58.515793
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
58.515793
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
391
score
68.18181818181817
distance
60.61083
seq distance
False
chain
E
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
391
score
68.18181818181817
distance
60.61083
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
94
score
81.81818181818183
distance
60.975994
seq distance
False
chain
D
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
94
score
81.81818181818183
distance
60.975994
seq distance
False
chain
D
LDL-receptor class A
begin
83
end
96
score
70.12987012987013
distance
60.975994
seq distance
False
chain
D
LDL-receptor class A
begin
83
end
96
score
70.12987012987013
distance
60.975994
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
86
score
72.72727272727273
distance
67.2048
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
86
score
72.72727272727273
distance
67.2048
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
370
score
68.18181818181817
distance
76.19206
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
370
score
68.18181818181817
distance
76.19206
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
81
score
59.09090909090909
distance
79.922195
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
81
score
59.09090909090909
distance
79.922195
seq distance
False
chain
C
LDL-receptor class A
begin
130
end
149
score
51.590909090909086
distance
84.24943
seq distance
False
chain
B
LDL-receptor class A
begin
130
end
149
score
51.590909090909086
distance
84.24943
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
137
score
63.63636363636363
distance
87.637314
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
137
score
63.63636363636363
distance
87.637314
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
145
score
77.27272727272727
distance
88.12573
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
145
score
77.27272727272727
distance
88.12573
seq distance
False
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
421
score
68.18181818181817
distance
99.12866
seq distance
False
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
421
score
68.18181818181817
distance
99.12866
seq distance
False
chain
B
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
1272
score
50.0
distance
136.19077
seq distance
False
chain
A
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
1272
score
50.0
distance
136.19077
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
649
score
54.54545454545454
distance
149.51021
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
649
score
54.54545454545454
distance
149.51021
seq distance
False
chain
C
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
1049
score
54.54545454545454
distance
153.25183
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
1049
score
54.54545454545454
distance
153.25183
seq distance
False
chain
A
Details
Redox score
62.54
PDB code
7nyc
Structure name
cryoem structure of 3c9-smac
Structure deposition date
2021-03-22
Thiol separation (Å)
9.62
Half-sphere exposure sum
73
Minimum pKa
nan
% buried
nan
Peptide accession
P02748
Residue number A
112 (Residue 91 in this structure)
Residue number B
125 (Residue 104 in this structure)
Peptide name
Complement component C9
7nyc G 57 G 505
A redox-regulated disulphide may form within Complement component C9 at these cysteines. However, the redox score of this cysteine pair is lower than any known redox-active disulphide.
Relevent regions
EGF-like
begin
489
end
519
score
98.24046920821115
distance
2.8089435
seq distance
0
chain
G
EGF-like
begin
489
end
519
score
98.24046920821115
distance
2.8089435
seq distance
0
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
2.8630092
seq distance
0
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
2.8630092
seq distance
0
chain
G
MACPF
begin
133
end
488
score
69.38840653728295
distance
4.7978263
seq distance
17
chain
G
MACPF
begin
133
end
488
score
69.38840653728295
distance
4.7978263
seq distance
17
chain
G
MACPF
begin
133
end
488
score
72.36338100102144
distance
12.015514
seq distance
False
chain
H
MACPF
begin
133
end
488
score
72.36338100102144
distance
12.015514
seq distance
False
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
21.589283
seq distance
False
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
21.589283
seq distance
False
chain
H
EGF-like
begin
489
end
519
score
98.24046920821115
distance
22.126528
seq distance
False
chain
H
EGF-like
begin
489
end
519
score
98.24046920821115
distance
22.126528
seq distance
False
chain
H
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
24.710077
seq distance
89
chain
G
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
24.710077
seq distance
89
chain
G
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
25.830315
seq distance
False
chain
H
TSP type-1
begin
21
end
74
score
99.4949494949495
distance
25.830315
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
26.667196
seq distance
100
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
26.667196
seq distance
100
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
28.165016
seq distance
99
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
28.165016
seq distance
99
chain
G
MACPF
begin
186
end
481
score
65.83230958230959
distance
28.296167
seq distance
False
chain
I
MACPF
begin
186
end
481
score
65.83230958230959
distance
28.296167
seq distance
False
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
28.970154
seq distance
False
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
28.970154
seq distance
False
chain
H
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
29.246511
seq distance
False
chain
I
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
29.246511
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
31.18254
seq distance
False
chain
H
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
31.18254
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
31.232313
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
31.232313
seq distance
False
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
33.270367
seq distance
False
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
33.270367
seq distance
False
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
39.288918
seq distance
False
chain
H
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
39.288918
seq distance
False
chain
H
LDL-receptor class A
begin
78
end
115
score
100.0
distance
39.431015
seq distance
21
chain
G
LDL-receptor class A
begin
78
end
115
score
100.0
distance
39.431015
seq distance
21
chain
G
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
391
score
68.18181818181817
distance
41.026176
seq distance
False
chain
E
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
391
score
68.18181818181817
distance
41.026176
seq distance
False
chain
E
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
41.456806
seq distance
125
chain
G
In dbSNP:rs13361416.
original residue
I
variation residue
V
position
182
score
100.0
distance
41.456806
seq distance
125
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
41.48186
seq distance
49
chain
G
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
41.48186
seq distance
49
chain
G
LDL-receptor class A
begin
80
end
115
score
98.48484848484848
distance
44.46148
seq distance
False
chain
I
LDL-receptor class A
begin
80
end
115
score
98.48484848484848
distance
44.46148
seq distance
False
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
45.2378
seq distance
False
chain
H
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
45.2378
seq distance
False
chain
H
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
47.088783
seq distance
False
chain
I
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
406
score
100.0
distance
47.088783
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
47.62331
seq distance
False
chain
I
In ARMD15; dbSNP:rs34882957.
original residue
P
variation residue
S
position
146
score
100.0
distance
47.62331
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
48.08585
seq distance
False
chain
I
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
405
score
100.0
distance
48.08585
seq distance
False
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
50.78056
seq distance
False
chain
I
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
50.78056
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
53.409874
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
106
score
100.0
distance
53.409874
seq distance
False
chain
I
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
93
score
77.27272727272727
distance
53.650948
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
93
score
77.27272727272727
distance
53.650948
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
53.9418
seq distance
41
chain
G
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
98
score
100.0
distance
53.9418
seq distance
41
chain
G
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
370
score
68.18181818181817
distance
58.725925
seq distance
False
chain
D
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-283.
original residue
V
variation residue
C
position
370
score
68.18181818181817
distance
58.725925
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
85
score
72.72727272727273
distance
66.10327
seq distance
False
chain
E
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
85
score
72.72727272727273
distance
66.10327
seq distance
False
chain
E
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
94
score
81.81818181818183
distance
68.78897
seq distance
False
chain
D
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
94
score
81.81818181818183
distance
68.78897
seq distance
False
chain
D
LDL-receptor class A
begin
83
end
96
score
70.12987012987013
distance
68.78897
seq distance
False
chain
D
LDL-receptor class A
begin
83
end
96
score
70.12987012987013
distance
68.78897
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
86
score
72.72727272727273
distance
80.42504
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
86
score
72.72727272727273
distance
80.42504
seq distance
False
chain
D
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
81
score
59.09090909090909
distance
92.707924
seq distance
False
chain
C
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
81
score
59.09090909090909
distance
92.707924
seq distance
False
chain
C
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
421
score
68.18181818181817
distance
93.6891
seq distance
False
chain
B
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
421
score
68.18181818181817
distance
93.6891
seq distance
False
chain
B
LDL-receptor class A
begin
130
end
149
score
51.590909090909086
distance
97.93571
seq distance
False
chain
B
LDL-receptor class A
begin
130
end
149
score
51.590909090909086
distance
97.93571
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
145
score
77.27272727272727
distance
99.669525
seq distance
False
chain
B
In dbSNP:rs696763.
original residue
D
variation residue
Y
position
145
score
77.27272727272727
distance
99.669525
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
137
score
63.63636363636363
distance
104.30912
seq distance
False
chain
B
In C9D; dbSNP:rs121909593.
original residue
C
variation residue
G
position
137
score
63.63636363636363
distance
104.30912
seq distance
False
chain
B
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
1272
score
50.0
distance
142.12491
seq distance
False
chain
A
In dbSNP:rs34625111.
original residue
T
variation residue
S
position
1272
score
50.0
distance
142.12491
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
1049
score
54.54545454545454
distance
157.62982
seq distance
False
chain
A
In dbSNP:rs34421659.
original residue
S
variation residue
T
position
1049
score
54.54545454545454
distance
157.62982
seq distance
False
chain
A
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
649
score
54.54545454545454
distance
164.25885
seq distance
False
chain
C
Creates an artifactual disulfide bond that prevents the conformation change required for oligomerization and pore formation; when associated with C-427.
original residue
F
variation residue
C
position
649
score
54.54545454545454
distance
164.25885
seq distance
False
chain
C
Details
Redox score
62.35
PDB code
7nyc
Structure name
cryoem structure of 3c9-smac
Structure deposition date
2021-03-22
Thiol separation (Å)
9.86
Half-sphere exposure sum
70
Minimum pKa
nan
% buried
nan
Peptide accession
P02748
Residue number A
78 (Residue 57 in this structure)
Residue number B
526 (Residue 505 in this structure)
Peptide name
Complement component C9
If this tool was useful for finding a disulphide, please cite: